Eosinophils, a type of white blood cell, help fight infections and play a role in your body's immune response. Normally your blood doesn't have a large number of eosinophils. In eosinophilic disorders, their levels can become elevated and over-reactive causing them to build up in organs and tissues. Learn more about eosinophilic disorders.
Eosinophils
Image by Iceclanl
Eosinophilic Disorders
Eosinophils
Image by NIAID
Eosinophils
Eosinophil function, relationship to disease, and location in the human body.
Image by NIAID
Eosinophilic Disorders
Eosinophils are a type of white blood cell. They help fight off infections and play a role in your body's immune response. They can also build up and cause inflammation.
Normally your blood doesn't have a large number of eosinophils. Your body may produce more of them in response to
Allergic disorders
Skin conditions
Parasitic and fungal infections
Autoimmune diseases
Some cancers
Bone marrow disorders
In some conditions, the eosinophils can move outside the bloodstream and build up in organs and tissues. This can happen in many different parts of the body, including the esophagus, heart, lungs, blood, and intestines. Treatment of eosinophilic disorders can vary, depending on the cause and which part of the body is affected. Steroids are often part of the treatment.
Source: National Institute of Health (NIH)
Additional Materials (10)
A blood film from a patient with allergic reaction showing eosinophilia
Image by Prof. Erhabor Osaro
Eosinophilic Disorders... Made simple
Video by MadBlasta/YouTube
Blood Eosinophil cc
Video by SimplyAandP/YouTube
Blood Cell Bakery--Eosinophils
Video by sciencegoddess1/YouTube
3D illustration of a eosinophil
Image by Blausen.com staff (2014). "Medical gallery of Blausen Medical 2014". WikiJournal of Medicine 1 (2). DOI:10.15347/wjm/2014.010. ISSN 2002-4436.
Gus and Phil (APFED)
Video by APFED/YouTube
Twins and genetics related to eosinophilic esophagitis
Video by Cincinnati Children's/YouTube
Can seasonal allergies cause eosinophilic esophagitis?
Video by APFED/YouTube
What are the symptoms of eosinophilic esophagitis?
Video by APFED/YouTube
What are the available treatment options for eosinophilic esophagitis?
Video by APFED/YouTube
A blood film from a patient with allergic reaction showing eosinophilia
Prof. Erhabor Osaro
2:14
Eosinophilic Disorders... Made simple
MadBlasta/YouTube
1:31
Blood Eosinophil cc
SimplyAandP/YouTube
1:08
Blood Cell Bakery--Eosinophils
sciencegoddess1/YouTube
3D illustration of a eosinophil
Blausen.com staff (2014). "Medical gallery of Blausen Medical 2014". WikiJournal of Medicine 1 (2). DOI:10.15347/wjm/2014.010. ISSN 2002-4436.
3:32
Gus and Phil (APFED)
APFED/YouTube
3:56
Twins and genetics related to eosinophilic esophagitis
Cincinnati Children's/YouTube
1:31
Can seasonal allergies cause eosinophilic esophagitis?
APFED/YouTube
3:01
What are the symptoms of eosinophilic esophagitis?
APFED/YouTube
5:27
What are the available treatment options for eosinophilic esophagitis?
APFED/YouTube
Eosinophil Count
Eosinophil Count
Also called: Eosinophils (Complete Blood Count), Eosinophils, Eosins, Eos, Eosinopenia Test, Eosinophilia Test
This test measures the amount of eosinophils in a sample of your blood. Eosinophils are a type of white blood cell. They help fight off infections and play a role in your body's immune response. An abnormal level of eosinophils in the blood could indicate a number of issues, including infection, allergic reaction, and asthma.
Eosinophil Count
Also called: Eosinophils (Complete Blood Count), Eosinophils, Eosins, Eos, Eosinopenia Test, Eosinophilia Test
This test measures the amount of eosinophils in a sample of your blood. Eosinophils are a type of white blood cell. They help fight off infections and play a role in your body's immune response. An abnormal level of eosinophils in the blood could indicate a number of issues, including infection, allergic reaction, and asthma.
{"label":"Eosinophils (percentage) reference range","scale":"lin","step":0.01,"hideunits":false,"items":[{"flag":"borderline","label":{"short":"Low","long":"Low","orientation":"horizontal"},"values":{"min":0,"max":1},"text":"Low levels of eosinophils is known as eosinopenia. Unless alcohol abuse or Cushing\u2019s disease is suspected, low levels of eosinophils are not usually of concern unless other white cell counts are also abnormally low.","conditions":["Alcohol intoxication","Severe infections","Sepsis","Hormone-secreting tumors","Cushing\u2019s disease","Use of corticosteroids"]},{"flag":"normal","label":{"short":"Normal","long":"Normal","orientation":"horizontal"},"values":{"min":1,"max":4},"text":"Normally your blood doesn't have a large number of eosinophils, accounting for 1% to 4% of the total circulating white blood cells.","conditions":[]},{"flag":"abnormal","label":{"short":"High","long":"High","orientation":"horizontal"},"values":{"min":4,"max":10},"text":"A high eosinophil count, known as eosinophilia, may indicate an allergic condition or an infection.","conditions":["Addison disease","Allergic reaction","Cancer","Chronic myelogenous leukemia","Collagen vascular disease","Hypereosinophilic syndromes","Parasitic infection"]}],"units":[{"printSymbol":"%{WBCs}","code":"%{WBCs}","name":"percent of white blood cells"}],"value":2.5}[{"borderline":0},{"normal":0},{"abnormal":0}]
Use the slider below to see how your results affect your
health.
%{WBCs}
1
4
Your result is Normal.
Normally your blood doesn't have a large number of eosinophils, accounting for 1% to 4% of the total circulating white blood cells.
Related conditions
{"label":"Eosinophils (absolute count) reference range","scale":"lin","step":0.01,"hideunits":false,"items":[{"flag":"normal","label":{"short":"Normal","long":"Normal","orientation":"horizontal"},"values":{"min":0,"max":0.45},"text":"About 1 to 4 percent of all white blood cells are eosinophils. A normal eosinophil count for adults usually is less than 450 eosinophils per microliter of blood.","conditions":[]},{"flag":"abnormal","label":{"short":" High","long":" High","orientation":"horizontal"},"values":{"min":0.45,"max":1.5},"text":"A high eosinophil count, known as eosinophilia, may indicate an allergic condition or an infection.","conditions":["Addison disease","Allergic reaction","Cancer","Chronic myelogenous leukemia","Collagen vascular disease","Hypereosinophilic syndromes","Parasitic infection"]},{"flag":"abnormal","label":{"short":"Very high","long":"Very high","orientation":"horizontal"},"values":{"min":1.5,"max":10},"text":"A high eosinophil count, known as eosinophilia, may indicate an allergic condition or an infection.","conditions":["Addison disease","Allergic reaction","Cancer","Chronic myelogenous leukemia","Collagen vascular disease","Hypereosinophilic syndromes","Parasitic infection"]}],"units":[{"printSymbol":"10\u00b3\/\u03bcL","code":"10*3\/uL","name":"thousand per microliter"}],"value":0.22}[{"normal":0},{"abnormal":0},{"abnormal":1}]
Use the slider below to see how your results affect your
health.
10³/μL
0.45
1.5
Your result is Normal.
About 1 to 4 percent of all white blood cells are eosinophils. A normal eosinophil count for adults usually is less than 450 eosinophils per microliter of blood.
Related conditions
An eosinophil is a type of immune cell that has granules (small particles) with enzymes that are released during infections, allergic reactions, and asthma. They can also build up and cause inflammation. An eosinophil is a type of white blood cell and a type of granulocyte.
Normally your blood doesn't have a large number of eosinophils, accounting for 1% to 4% of the total circulating white blood cells. Eosinophils become active when you have certain allergic diseases, infections, and other medical conditions. In some conditions, the eosinophils can move outside the bloodstream and build up in organs and tissues. This can happen in many different parts of the body, including the esophagus, heart, lungs, blood, and intestines.
The number of eosinophil in your blood is measured as part of a blood differential test.
A blood differential test is often part of a general physical exam. Because the different types of white blood cell do different jobs, measuring them separately can give your health care provider important information about your health.
The test can also help diagnose a variety of medical conditions, such as:
Infections
Autoimmune diseases
Inflammatory diseases
Leukemia and other types of cancer
A health care professional will take a blood sample from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial. You may feel a little sting when the needle goes in or out. This usually takes less than five minutes.
No special preparation is necessary.
There is very little risk to having a blood test. After the test, some people experience mild pain, dizziness, or bruising. These symptoms usually go away quickly.
The results can be expressed as a percentage (of the total number of all white blood cells) or as an absolute value.
A higher than normal eosinophil count, known as eosinophilia, is usually due to:
Addison disease
Allergies (such as allergic rhinitis, eczema, or atopic dermatitis)
Asthma
Parasitic infestation
Fungus infection
Leukemia or other blood disorders
Hypereosinophilic syndrome
A lower than normal eosinophil count, known as eosinopenia, is less frequent and may be the consequence of:
Alcohol intoxication
Severe infections (e.g., sepsis)
Hormone-secreting tumors
Treatment with drugs known as corticosteroids
Your symptoms may vary depending on the affected organs:
Skin: you may have a rash.
Throat: pain or itchiness.
Eyes: redness, itchiness.
Lungs: shortness of breath, cough, and wheezing.
Stomach: pain.
Intestines: diarrhea.
Nevertheless, a slightly elevated or low eosinophils count does not usually cause any symptoms, and this is an accidental finding when a complete blood count test is done for any other reason.
Idiopathic hypereosinophilic syndrome is an uncommon condition in which the eosinophil count is very high, reaching levels of 1500 cells per microliter, for more than 6 months without a doctor being able to find a cause for it.
The increased number of eosinophils inflame tissues and can even cause organ damage to the lungs, heart, liver, nervous system, or skin. A small percentage of people can improve without any medical intervention; but without treatment, it can be fatal in up to 80% of people.
Blood Differential: MedlinePlus Medical Test [accessed on Jan 22, 2024]
Eosinophilic Disorders | Eosinophilia | MedlinePlus. National Library of Medicine. Mar 29, 2017 [accessed on Jan 22, 2024]
Blood differential test: MedlinePlus Medical Encyclopedia [accessed on Jan 22, 2024]
Differential Blood Count: Reference Range, Interpretation, Collection and Panels. Oct 24, 2023 [accessed on Jan 22, 2024]
White Blood Cell (WBC) Differential - Testing.com. Aug 7, 2022 [accessed on Jan 22, 2024]
DALE.DAVID. Eosinophilic Disorders - Blood Disorders - Merck Manuals Consumer Version [accessed on Jan 22, 2024]
Eosinophil count - absolute: MedlinePlus Medical Encyclopedia [accessed on Jan 22, 2024]
Normal reference ranges can vary depending on the laboratory and the method used for testing. You must use the range supplied by the laboratory that performed your test to evaluate whether your results are "within normal limits."
Additional Materials (9)
Eosinophilic Disorders... Made simple
Video by MadBlasta/YouTube
Blood Cell Bakery--Eosinophils
Video by sciencegoddess1/YouTube
What Does My White Blood Cell Count Tell My Healthcare Team?
Video by Diverse Health Hub/YouTube
Granulocytes
Diagram showing the cell line plasma cells come from
Image by Cancer Research UK uploader
Granulocytes
Granulocytes can be distinguished by the number of lobes in their nuclei and the staining properties of their granules. (credit “neutrophil” micrograph: modification of work by Ed Uthman)
Image by CNX/OpenStax
Eosinophils
Histological blood smear of an Eosinophil surrounded by Red Blood Cells and Platelets
Image by Iceclanl
Eosinophils
On the left there is a segmented polymorphonuclear neutrophil, on the right and below is one eosinophil leucocyte. For comparison the red blood cell have a diameter of 7-8 micrometers. The picture was taken with a Nikon Eclipse 600 microscope, magnification was 1000x.
Image by Davidcsaba Dr. David Csaba L.
Eosinophils
Eosinophil function, relationship to disease, and location in the human body.
Image by NIAID
Eosinophil
Visualization of a eosinophil. A type of white blood cell responsible for combating infection. They make up 2% of all white blood cells.
Image by TheVisualMD
2:14
Eosinophilic Disorders... Made simple
MadBlasta/YouTube
1:08
Blood Cell Bakery--Eosinophils
sciencegoddess1/YouTube
5:01
What Does My White Blood Cell Count Tell My Healthcare Team?
Diverse Health Hub/YouTube
Granulocytes
Cancer Research UK uploader
Granulocytes
CNX/OpenStax
Eosinophils
Iceclanl
Eosinophils
Davidcsaba Dr. David Csaba L.
Eosinophils
NIAID
Eosinophil
TheVisualMD
Eosinophil
3D illustration of a eosinophil
Image by Blausen.com staff (2014). "Medical gallery of Blausen Medical 2014". WikiJournal of Medicine 1 (2). DOI:10.15347/wjm/2014.010. ISSN 2002-4436.
3D illustration of a eosinophil
Image by Blausen.com staff (2014). "Medical gallery of Blausen Medical 2014". WikiJournal of Medicine 1 (2). DOI:10.15347/wjm/2014.010. ISSN 2002-4436.
Eosinophil
Leukocyte that responds to parasites and is involved in the allergic response.
Phagocytosis and Inflammation
The first cytokines to be produced are pro-inflammatory; that is, they encourage inflammation, the localized redness, swelling, heat, and pain that result from the movement of leukocytes and fluid through increasingly permeable capillaries to a site of infection. The population of leukocytes that arrives at an infection site depends on the nature of the infecting pathogen. Both macrophages and dendritic cells engulf pathogens and cellular debris through phagocytosis. A neutrophil is also a phagocytic leukocyte that engulfs and digests pathogens. Neutrophils, shown in Figure, are the most abundant leukocytes of the immune system. Neutrophils have a nucleus with two to five lobes, and they contain organelles, called lysosomes, that digest engulfed pathogens. An eosinophil is a leukocyte that works with other eosinophils to surround a parasite; it is involved in the allergic response and in protection against helminthes (parasitic worms).
The characteristics and location of cells involved in the innate immune system are described. (credit: modification of work by NIH)
Neutrophils and eosinophils are particularly important leukocytes that engulf large pathogens, such as bacteria and fungi. A mast cellis a leukocyte that produces inflammatory molecules, such as histamine, in response to large pathogens. A basophil is a leukocyte that, like a neutrophil, releases chemicals to stimulate the inflammatory response as illustrated in Figure. Basophils are also involved in allergy and hypersensitivity responses and induce specific types of inflammatory responses. Eosinophils and basophils produce additional inflammatory mediators to recruit more leukocytes. A hypersensitive immune response to harmless antigens, such as in pollen, often involves the release of histamine by basophils and mast cells.
In response to a cut, mast cells secrete histamines that cause nearby capillaries to dilate. Neutrophils and monocytes leave the capillaries. Monocytes mature into macrophages. Neutrophils, dendritic cells and macrophages release chemicals to stimulate the inflammatory response. Neutrophils and macrophages also consume invading bacteria by phagocytosis.
Cytokines also send feedback to cells of the nervous system to bring about the overall symptoms of feeling sick, which include lethargy, muscle pain, and nausea. These effects may have evolved because the symptoms encourage the individual to rest and prevent them from spreading the infection to others. Cytokines also increase the core body temperature, causing a fever, which causes the liver to withhold iron from the blood. Without iron, certain pathogens, such as some bacteria, are unable to replicate; this is called nutritional immunity.
The characteristics and location of cells involved in the innate immune system are described. (credit: modification of work by NIH)
Source: CNX OpenStax
Additional Materials (7)
Eosinophil
Visualization of a eosinophil. A type of white blood cell responsible for combating infection. They make up 2% of all white blood cells.
Image by TheVisualMD
Eosinophilia
Drawing of an eosinophil white blood cell
Image by Iceclanl
Eosinophil under a microscope from a blood smear
Eosinophil under a microscope from a blood smear. (400x)
Image by Bobjgalindo
Blood Eosinophil cc
Video by SimplyAandP/YouTube
Immune System - Natural Killer Cell
Video by Kyle Thornthwaite/YouTube
Blood 6- Eosinophils
Video by Wendy Riggs/YouTube
What is Blood?
Video by americasbloodcenters/YouTube
Eosinophil
TheVisualMD
Eosinophilia
Iceclanl
Eosinophil under a microscope from a blood smear
Bobjgalindo
1:31
Blood Eosinophil cc
SimplyAandP/YouTube
3:02
Immune System - Natural Killer Cell
Kyle Thornthwaite/YouTube
4:04
Blood 6- Eosinophils
Wendy Riggs/YouTube
2:24
What is Blood?
americasbloodcenters/YouTube
Eosinophilic Esophagitis (EoE)
Eosinophilic Esophagitis
Image by Samir
Eosinophilic Esophagitis
Endoscopic picture of multi-ring esophagus seen in a patient with eosinophilic esophagitis
Image by Samir
What Is Eosinophilic Esophagitis (EoE)?
Eosinophilic esophagitis (EoE) is a chronic disease of the esophagus. Your esophagus is the muscular tube that carries food and liquids from your mouth to the stomach. If you have EoE, white blood cells called eosinophils build up in your esophagus. This causes damage and inflammation, which can cause pain and may lead to trouble swallowing and food getting stuck in your throat.
EoE is rare. But because it is a newly recognized disease, more people are now getting diagnosed with it. Some people who think that they have reflux (GERD) may actually have EoE.
Source: National Institutes of Health
Additional Materials (27)
Eosinophilic Esophagitis
Barium swallow showing the effects of eosinophilic esophagitis.
Image by JVinocur
Endoscopic image of patient with eosinophilic esophagitis showing multiple rings and linear furrows.
Endoscopic image of patient with eosinophilic esophagitis showing multiple rings and linear furrows.
Image by Samir
Eosinophilic Esophagitis - Jeffrey Alexander, M.D. - Mayo Clinic
Video by Mayo Clinic/YouTube
All About EoE
Video by APFED/YouTube
What are the symptoms of eosinophilic esophagitis?
Video by APFED/YouTube
What are the available treatment options for eosinophilic esophagitis?
Video by APFED/YouTube
Treatments for Eosinophilic Esophagitis (EoE) - Dr. Aliza Solomon
Video by NewYork-Presbyterian Hospital/YouTube
Understanding Eosinophilic Esophagitis, Kevin Ghassemi, MD | UCLAMDChat
Video by UCLA Health/YouTube
Eosinophilic Esophagitis (EoE) - Dr. Aliza Solomon
Video by NewYork-Presbyterian Hospital/YouTube
Endoscopic Appearance of Eosinophilic Esophagitis
Video by Video Journal and Encyclopedia of GI Endoscopy/YouTube
Can seasonal allergies cause eosinophilic esophagitis?
Video by APFED/YouTube
A patient's experience with eosinophilic esophagitis.
Video by Swedish/YouTube
Eosinophilic Esophagitis
Video by ClevelandClinicCME/YouTube
Mayo Clinic Minute: Treating eosinophilic esophagitis with special diet
Video by Mayo Clinic/YouTube
Diagnosis and treatment of eosinophilic esophagitis
Video by Ohio State Wexner Medical Center/YouTube
Twins and genetics related to eosinophilic esophagitis
Video by Cincinnati Children's/YouTube
What is EoE (for adult patients)?
Video by AmerGastroAssn/YouTube
Identification of eosinophilic esophagitis-associated genes
Video by Journal of Clinical Investigation/YouTube
Eosinophilic Esophagitis - Laura Wozniak, MD | Pediatric Grand Rounds
Video by David Geffen School of Medicine at UCLA/YouTube
Mayo Clinic Minute: What is eosinophilic esophagitis and why is it becoming more common?
Elimination Diet Effectively Treats Eosinophilic Esophagitis in Adults...
AmerGastroAssn/YouTube
1:37
What does the Food Allergen Labeling and Consumer Protection Act require?
APFED/YouTube
2:46
Hard to Swallow EOE - Mayo Clinic
Mayo Clinic/YouTube
1:51
How to use a liquid topical steroid for EoE
Children's Hospital Colorado/YouTube
1:19
How is it determined if eosinophils and eosinophil peroxidase proteins are present in the esophagus
APFED/YouTube
Eosinophilic Cystitis
Eosinophilic cystitis, low mag
Eosinophilic cystitis, intermed. mag
Eosinophilic cystitis, high mag.1
1
2
3
Eosinophilic Cystitis
Interactive by CoRus13
Eosinophilic cystitis, low mag
Eosinophilic cystitis, intermed. mag
Eosinophilic cystitis, high mag.1
1
2
3
Eosinophilic Cystitis
Eosinophilic cystitis showing edematous and chronically inflamed lamina propria with numerous eosinophils.
Interactive by CoRus13
What Is Eosinophilic Cystitis?
Eosinophilic cystitis (EC) is a rare inflammatory bladder condition caused by the build up of eosinophils in the bladder. The exact cause of this condition is not known. However, EC has been found in those with allergies and asthma, and in those with a history of bladder trauma or infection, open bladder surgery, or surgery for a bladder tumor. EC has also been found in those who take certain medications.
Source: Genetic and Rare Diseases (GARD) Information Center
Additional Materials (7)
Eosinophilic cystitis
Eosinophilic cystitis showing prominent eosinophils in the muscularis propria. H&E Stain.
Image by CoRus13/Wikimedia
What is Cystitis?
Video by Animation Point/YouTube
Eosinophilic Disorders... Made simple
Video by MadBlasta/YouTube
Cystitis Review in 4 minutes, All you need to know
Video by Medicosis Perfectionalis/YouTube
Eosinophilic cystitis, low mag
Eosinophilic cystitis showing edematous and chronically inflamed lamina propria with numerous eosinophils. H&E Stain.
Image by CoRus13/Wikimedia
Eosinophilic cystitis, intermed. mag
Eosinophilic cystitis showing edematous and chronically inflamed lamina propria with numerous eosinophils. H&E Stain.
Image by CoRus13/Wikimedia
Eosinophilic cystitis, high mag.1
Eosinophilic cystitis showing edematous and chronically inflamed lamina propria with numerous eosinophils. H&E Stain.
Image by CoRus13/Wikimedia
Eosinophilic cystitis
CoRus13/Wikimedia
3:28
What is Cystitis?
Animation Point/YouTube
2:14
Eosinophilic Disorders... Made simple
MadBlasta/YouTube
3:35
Cystitis Review in 4 minutes, All you need to know
Medicosis Perfectionalis/YouTube
Eosinophilic cystitis, low mag
CoRus13/Wikimedia
Eosinophilic cystitis, intermed. mag
CoRus13/Wikimedia
Eosinophilic cystitis, high mag.1
CoRus13/Wikimedia
Eosinophilic Fasciitis
Nodular fasciitis
Image by Nephron/Wikimedia
Nodular fasciitis
Very high magnification micrograph of nodular fasciitis. H&E stain.
The images show:
Tissue culture-like pattern - haphazardly arranged spindle cells.
Red blood cell extravasation.
Inflammatory cells (predominantly lymphocytes).Other features - not seen:
Thick keloid-like collagen.
Giant cells.Related images
Low mag.
Intermed. mag.
High mag.
Very high mag.
Another case:
Low mag.
Intermed. mag.
High mag.
Very high mag.
Image by Nephron/Wikimedia
What Is Eosinophilic Fasciitis?
Eosinophilic fasciitis is a very rare condition in which muscle tissue underneath the skin, called fascia, becomes swollen and thick. Rapid swelling can occur in the hands, arms, legs, and feet. People with this condition have a buildup of eosinophils, a type of white blood cell, in the affected fascia and muscles. The exact cause of this condition is unknown. Corticosteroids and other immune-suppressing medications are used to relieve the symptoms. Eosinophilic fasciitis is similar in appearance to scleroderma. However, in contrast with systemic sclerosis, internal organ involvement in eosinophilic fasciitis is generally absent. Some researchers believe that eosinophilic fasciitis may be a variant of morphea (localized scleroderma).
Source: Genetic and Rare Diseases (GARD) Information Center
Additional Materials (2)
Histopathology of ischemic fasciitis
Histopathology of a ischemic fasciitis from the coccygeal region, H&E stain. Detail from a whole slide scan.
Image by Original by Rajendra Singh, Kamran Mirza, Kurt SchabergAnnotated by Mikael Häggström, M.D. Author info - Reusing images- Conflicts of interest: None
Mikael Häggström, M.D./Wikimedia
What is Eosinophilic Fasciitis?
Video by APFED/YouTube
Histopathology of ischemic fasciitis
Original by Rajendra Singh, Kamran Mirza, Kurt SchabergAnnotated by Mikael Häggström, M.D. Author info - Reusing images- Conflicts of interest: None
Mikael Häggström, M.D./Wikimedia
2:27
What is Eosinophilic Fasciitis?
APFED/YouTube
Eosinophilic Gastroenteritis
Eosinophilic gastroenteritis
Image by Countincr at English Wikipedia
Eosinophilic gastroenteritis
Eosinophilic gastroenteritis _ Contrast-enhanced spiral CT revealing ascites and concentric thickening of colon and ileum.
Image by Countincr at English Wikipedia
What Is Eosinophilic Gastroenteritis?
Eosinophilic gastroenteritis occurs when certain white blood cells known as eosinophils get into the digestive tract and cause damage. Symptoms of eosinophilic gastroenteritis usually start in adulthood and may include stomach pain, nausea, vomiting, and the inability to absorb nutrients from food. Sometimes, a blockage in the intestines occurs. In most people, symptoms occur from time to time and may go away completely with treatment. The exact cause of eosinophilic gastroenteritis is unknown, but it may be due to an abnormal response of the immune system to food allergies. Diagnosis is based on the symptoms, a clinical exam, laboratory tests, and by excluding other more common conditions. Treatment is focused on managing the symptoms and includes diet and medication.
Source: Genetic and Rare Diseases (GARD) Information Center
Additional Materials (6)
Eosinophilic Gastroenteritis
Video by Lewis Hassell/YouTube
Eosinophilic Gastrointestinal Diseases
Video by APFED/YouTube
Eosinophilic Disorders... Made simple
Video by MadBlasta/YouTube
The HELP Video Guide To Gastroenteritis
Video by PatientEducationHELP/YouTube
What is gastroenteritis?
Video by Premier Health/YouTube
Blood Eosinophil cc
Video by SimplyAandP/YouTube
9:23
Eosinophilic Gastroenteritis
Lewis Hassell/YouTube
19:12
Eosinophilic Gastrointestinal Diseases
APFED/YouTube
2:14
Eosinophilic Disorders... Made simple
MadBlasta/YouTube
3:01
The HELP Video Guide To Gastroenteritis
PatientEducationHELP/YouTube
1:01
What is gastroenteritis?
Premier Health/YouTube
1:31
Blood Eosinophil cc
SimplyAandP/YouTube
Eosinophil Peroxidase Deficiency
3D model of the horseradish peroxidase protein.
Image by Manuel Almagro Rivas/Wikimedia
3D model of the horseradish peroxidase protein.
Image by Manuel Almagro Rivas/Wikimedia
What Is Eosinophil Peroxidase Deficiency?
Eosinophil peroxidase deficiency is a condition that affects certain white blood cells called eosinophils but causes no health problems in affected individuals. Eosinophils aid in the body's immune response. During a normal immune response, these cells are turned on (activated), and they travel to the area of injury or inflammation. The cells then release proteins and other compounds that have a toxic effect on severely damaged cells or invading organisms. One of these proteins is called eosinophil peroxidase. In eosinophil peroxidase deficiency, eosinophils have little or no eosinophil peroxidase. A lack of this protein does not seem to affect the eosinophils' ability to carry out an immune response.
Because eosinophil peroxidase deficiency does not cause any health problems, this condition is often diagnosed when blood tests are done for other reasons or when a family member has been diagnosed with the condition.
Source: MedlinePlus Genetics
Eosinophilic Granulomatosis with Polyangiitis
Churg-Strauss Syndrome
Image by Yale Rosen from USA/Wikimedia
Churg-Strauss Syndrome
Churg-Strauss Syndrome is a rare systemic vasculitis that is usually accompanied by peripheral eosinophilia and asthma.
Dense mixed inflammatory infiltrate adjacent to a necrotic blood vessel containing a large number of eosinphiles.
Image by Yale Rosen from USA/Wikimedia
What Is Eosinophilic Granulomatosis with Polyangiitis?
Eosinophilic granulomatosis with polyangiitis (Churg Strauss syndrome) is a condition characterized by asthma, high levels of eosinophils (a type of white blood cell that helps fight infection), and inflammation of small to medium sized blood vessels (vasculitis). The inflamed vessels can affect various organ systems including the lungs, gastrointestinal tract, skin, heart and nervous system. The exact cause of eosinophilic granulomatosis with polyangiitis is unknown, but it is thought to be an autoimmune disorder.
Treatment may involve the use of glucocorticoids (steroids) and/or other immunosuppressive therapies. As of December 2017, mepolizumab (Nucala) became the first therapy approved specifically to treat eosinophilic granulomatosis with polyangiitis. When added to traditional steroid or immunosuppressive therapy, mepolizumab has been found to increase remission rate and time in remission for 50% of people with eosinophilic granulomatosis with polyangiitis.
Source: Genetic and Rare Diseases (GARD) Information Center
Additional Materials (5)
CHURG STRAUSS SYNDROME, Causes, Signs and Symptoms, Diagnosis and Treatment.
Video by Medical Centric/YouTube
Churg-Strauss syndrome | Circulatory System and Disease | NCLEX-RN | Khan Academy
Video by khanacademymedicine/YouTube
Eosinophilic Disorders... Made simple
Video by MadBlasta/YouTube
Gus and Phil (APFED)
Video by APFED/YouTube
Eosinophilic Granulomatosis with Polyangiitis (EGPA) | Churg-Strauss Syndrome, Autoimmune Vasculitis
Video by JJ Medicine/YouTube
5:40
CHURG STRAUSS SYNDROME, Causes, Signs and Symptoms, Diagnosis and Treatment.
Medical Centric/YouTube
4:05
Churg-Strauss syndrome | Circulatory System and Disease | NCLEX-RN | Khan Academy
khanacademymedicine/YouTube
2:14
Eosinophilic Disorders... Made simple
MadBlasta/YouTube
3:32
Gus and Phil (APFED)
APFED/YouTube
10:39
Eosinophilic Granulomatosis with Polyangiitis (EGPA) | Churg-Strauss Syndrome, Autoimmune Vasculitis
JJ Medicine/YouTube
Eosinophilic Asthma
Asthma - Mild and Chronic
Image by NIAID
Asthma - Mild and Chronic
Asthma - Mild and Chronic - Asthma sufferers have trouble breathing because of the narrowing of the airways in their lungs, an example of which is shown in the upper left. In chronic asthma (lower left), repeated cycles of inflammation, damage, and repair lead to airway remodeling and fibrosis, the buildup of collagen and other materials. A signaling molecule known as NF-κB can significantly reduce chronic asthma (lower right).
Image by NIAID
Eosinophilic Asthma
Asthma is a prevalent chronic non-communicable disease, affecting approximately 300 million people worldwide. It is characterized by significant airway inflammation, hyperresponsiveness, obstruction, and remodeling. Eosinophilic asthma, a subtype of asthma, involves the accumulation of eosinophils in the airways. These eosinophils release mediators and cytokines, contributing to severe airway inflammation and tissue damage. Emerging evidence suggests that targeting eosinophils could reduce airway remodeling and slow the progression of asthma. To achieve this, it is essential to understand the immunopathology of asthma, identify specific eosinophil-associated biomarkers, and categorize patients more accurately based on the clinical characteristics (phenotypes) and underlying pathobiological mechanisms (endotypes). This review delves into the role of eosinophils in exacerbating severe asthma, exploring various phenotypes and endotypes, as well as biomarkers. It also examines the current and emerging biological agents that target eosinophils in eosinophilic asthma. By focusing on these aspects, both researchers and clinicians can advance the development of targeted therapies to combat eosinophilic pathology in severe asthma.
Source: Musaddique Hussain* and Gang Liu* - Cells
Additional Materials (5)
Constricted airways in case of Asthma causing difficulty in breathing.
During recovery from an Asthma attack, it may appear pus-like due to high levels of white blood cells called eosinophils.
Image by Scientific Animations, Inc.
What is Eosinophilic Asthma?
Video by APFED/YouTube
Is it more than “just asthma”? Understanding the sources of underlying inflammation
Video by Science Animated/YouTube
eosinophils in asthma
Video by Walter Jahn/YouTube
What Is Severe Asthma?
Video by Scientific Animations/YouTube
Constricted airways in case of Asthma causing difficulty in breathing.
Scientific Animations, Inc.
7:51
What is Eosinophilic Asthma?
APFED/YouTube
2:19
Is it more than “just asthma”? Understanding the sources of underlying inflammation
Send this HealthJournal to your friends or across your social medias.
Eosinophilic Disorders
Eosinophils, a type of white blood cell, help fight infections and play a role in your body's immune response. Normally your blood doesn't have a large number of eosinophils. In eosinophilic disorders, their levels can become elevated and over-reactive causing them to build up in organs and tissues. Learn more about eosinophilic disorders.