Your throat is a tube that carries food to your esophagus and air to your windpipe and larynx. The technical name for your throat is the pharynx.

Throat problems are common. You've probably had a sore throat. The cause is usually a viral infection, but other causes include allergies, infection with strep bacteria or the leaking of stomach acids back up into the esophagus, called GERD.

Other problems that affect the throat include

• Tonsillitis - inflammation of the tonsils
• Cancer
• Croup - inflammation, usually in small children, which causes a barking cough
• Laryngitis - swelling of the voice box, which can cause a hoarse voice or loss of voice

Most throat problems are minor and go away on their own. Treatments, when needed, depend on the problem.

Adenoids are a patch of tissue that is high up in the throat, just behind the nose. They, along with the tonsils, are part of the lymphatic system. The lymphatic system clears away infection and keeps body fluids in balance. The adenoids and tonsils work by trapping germs coming in through the mouth and nose.

Adenoids usually start to shrink after about age 5. By the teenage years, they are almost completely gone. By then, the body has other ways to fight germs.

What are enlarged adenoids?

Enlarged adenoids are adenoids that are swollen. It is a common problem in children.

Croup is an inflammation of the vocal cords (larynx) and windpipe (trachea). It causes difficulty breathing, a barking cough, and a hoarse voice. The cause is usually a virus, often parainfluenza virus. Other causes include allergies and reflux.

Croup often starts out like a cold. But then the vocal cords and windpipe become swollen, causing the hoarseness and the cough. There may also be a fever and high-pitched noisy sounds when breathing. The symptoms are usually worse at night, and last for about three to five days.Children between the ages of 6 months and 3 years have the highest risk of getting croup. They may also have more severe symptoms. Croup is more common in the fall and winter.

Most cases of viral croup are mild and can be treated at home. Rarely, croup can become serious and interfere with your child's breathing. If you are worried about your child's breathing, call your health care provider right away.

Your mouth is one of the most important parts of your body. It has many different functions. It allows you to

• Take in food and drink
• Breathe in air
• Start digestion, with your teeth chewing the food you eat and your salivary glands releasing saliva to help break down the food
• Speak and sing
• Show emotion, by smiling or pouting

Any problem that affects your mouth can make it hard to eat, drink, or even smile. Some common mouth problems include

• Cold sores - painful sores on the lips and around the mouth, caused by a virus
• Canker sores - painful sores in the mouth, caused by bacteria or viruses
• Thrush - a yeast infection that causes white patches in your mouth
• Leukoplakia - white patches of excess cell growth on the cheeks, gums or tongue, common in smokers
• Dry mouth - a lack of enough saliva, caused by some medicines and certain diseases
• Gum or tooth problems
• Bad breath

Treatment for mouth disorders varies, depending on the problem. If a mouth problem is caused by some other disease, treating that disease can help. It is also important to keep your mouth clean and healthy by brushing, flossing, and not using tobacco.

Your throat is a tube that carries food to your esophagus and air to your windpipe and larynx (also called the voice box). The technical name for the throat is pharynx.

You can have a sore throat for many reasons. Often, colds and flu cause sore throats. Other causes can include:

• Allergies
• Mononucleosis
• Smoking
• Strep throat
• Tonsillitis

Treatment depends on the cause. Sucking on lozenges, drinking lots of liquids, and gargling may ease the pain. Over-the-counter pain relievers can also help, but children should not take aspirin.

Many disorders can affect our ability to speak and communicate. They range from saying sounds incorrectly to being completely unable to speak or understand speech. Causes include

• Hearing disorders and deafness
• Voice problems, such as dysphonia or those caused by cleft lip or palate
• Speech problems like stuttering
• Developmental disabilities
• Learning disorders
• Autism spectrum disorder
• Brain injury
• Stroke

Some speech and communication problems may be genetic. Often, no one knows the causes. By first grade, about 5 percent of children have noticeable speech disorders. Speech and language therapy can help.

If you have a swallowing disorder, you may have difficulty or pain when swallowing. Some people cannot swallow at all. Others may have trouble swallowing liquids, foods, or saliva. This makes it hard to eat. Often, it can be difficult to take in enough calories and fluids to nourish your body.

Anyone can have a swallowing disorder, but it is more likely in the elderly. It often happens because of other conditions, including

• Nervous system disorders, such as Parkinson's disease and cerebral palsy
• Problems with your esophagus, including GERD (gastroesophageal reflux disease)
• Stroke
• Head or spinal cord injury
• Cancer of the head, neck, or esophagus

Medicines can help some people, while others may need surgery. Swallowing treatment with a speech-language pathologist can help. You may find it helpful to change your diet or hold your head or neck in a certain way when you eat. In very serious cases, people may need feeding tubes.

What is tonsillitis?

Tonsillitis is an inflammation (swelling) of the tonsils. Sometimes along with tonsillitis, the adenoids are also swollen.

What are tonsils?

Tonsils are lumps of tissue at the back of the throat. There are two of them, one on each side. Along with the adenoids, tonsils are part of the lymphatic system. The lymphatic system clears away infection and keeps body fluids in balance. Tonsils and adenoids work by trapping the germs coming in through the mouth and nose.

Voice is the sound made by air passing from your lungs through your larynx, or voice box. In your larynx are your vocal cords, two bands of muscle that vibrate to make sound. For most of us, our voices play a big part in who we are, what we do, and how we communicate. Like fingerprints, each person's voice is unique.

Many things we do can injure our vocal cords. Talking too much, screaming, constantly clearing your throat, or smoking can make you hoarse. They can also lead to problems such as nodules, polyps, and sores on the vocal cords. Other causes of voice disorders include infections, upward movement of stomach acids into the throat, growths due to a virus, cancer, and diseases that paralyze the vocal cords.

Signs that your voice isn't healthy include

• Your voice has become hoarse or raspy
• You've lost the ability to hit some high notes when singing
• Your voice suddenly sounds deeper
• Your throat often feels raw, achy, or strained
• It's become an effort to talk

Treatment for voice disorders varies depending on the cause. Most voice problems can be successfully treated when diagnosed early.

Inflammation of the EPIGLOTTIS.

Signs and Symptoms of Respiratory Infection

Microbial diseases of the respiratory system typically result in an acute inflammatory response. These infections can be grouped by the location affected and have names ending in “itis”, which literally means inflammation of. For instance, rhinitis is an inflammation of the nasal cavities, often characteristic of the common cold. Rhinitis may also be associated with hay fever allergies or other irritants. Inflammation of the sinuses is called sinusitis inflammation of the ear is called otitis. Otitis media is an inflammation of the middle ear. A variety of microbes can cause pharyngitis, commonly known as a sore throat. An inflammation of the larynx is called laryngitis. The resulting inflammation may interfere with vocal cord function, causing voice loss. When tonsils are inflamed, it is called tonsillitis. Chronic cases of tonsillitis may be treated surgically with tonsillectomy. More rarely, the epiglottis can be infected, a condition called epiglottitis. In the lower respiratory system, the inflammation of the bronchial tubes results in bronchitis. Most serious of all is pneumonia, in which the alveoli in the lungs are infected and become inflamed. Pus and edema accumulate and fill the alveoli with fluids (called consolidations). This reduces the lungs’ ability to exchange gases and often results in a productive cough expelling phlegm and mucus. Cases of pneumonia can range from mild to life-threatening, and remain an important cause of mortality in the very young and very old.

Acute types of coxsackievirus infections or ECHOVIRUS INFECTIONS that usually affect children during the summer and are characterized by vesiculoulcerative lesions on the MUCOUS MEMBRANES of the THROAT; DYSPHAGIA; VOMITING, and FEVER.

Laryngitis is one of the most common causes of hoarseness. It can be due to temporary swelling of the vocal folds from a cold, an upper respiratory infection, or allergies. Your doctor will treat laryngitis according to its cause. If it's due to a cold or upper respiratory infection, your doctor might recommend rest, fluids, and nonprescription pain relievers. Allergies might be treated similarly, with the addition of over-the-counter allergy medicines.

Laryngitis is an inflammation of the larynx or the voice box. The larynx is a hollow tube, made up of muscle and cartilage. The larynx prevents the entry of foreign matter or food into the lower airway. It allows air into the lungs, connects the pharynx to the trachea, and holds the voice box. The voice box contains the vocal chords. The vocal chords are attached to muscle and cartilage on top of the larynx. Vocal chords are made up of two tissue membranes, covered with mucus. Vocal chords vibrate and modulate the flow of air being expelled from the lungs during speech or singing.

Strep throat is a bacterial infection caused by group A Streptococcus or "group A strep." In addition to a sore throat, symptoms can include pain when swallowing, a fever, red and swollen tonsils, tiny red spots on the roof of the mouth, or swollen lymph nodes in the front of the neck. Your doctor can do a quick strep test to see if group A strep bacteria are causing your sore throat. If the test is positive, your doctor can prescribe antibiotics. Antibiotics help you feel better sooner, prevent serious health problems, and help prevent spreading the infection to others.

Key Facts

• Strep throat is an infection in the throat and tonsils caused by group A Streptococcus bacteria (called “group A strep”). However, viruses — not bacteria — cause most sore throats.
• Group A strep bacteria spread through contact with droplets from an infected person’s cough or sneeze. If you touch your mouth, nose, or eyes after touching something that has these droplets on it, you may become ill.
• No one, not even a doctor, can diagnose strep throat just by looking at your throat. Doctors can swab your throat to see if you have strep throat.
• People with strep throat should stay home from work, school, or daycare until they no longer have a fever and have taken antibiotics for at least 12 hours.
• Antibiotics taken for strep throat reduce your symptoms and the length of time you’re sick, prevent long-term health problems, and help prevent spreading the infection to friends and family members.

Prevention Tips

• Wash your hands often.
• Cover your mouth and nose when coughing or sneezing.
• Do not drink from the same glass, eat from the same plate, or share utensils with someone who is sick.
• If you have strep throat, stay home from work, school, or daycare until you no longer have a fever and have taken antibiotics for at least 12 hours. This will help keep others from getting sick.

A common upper respiratory infection, streptococcal pharyngitis (strep throat) is caused by Streptococcus pyogenes. This gram-positive bacterium appears as chains of cocci, as seen below. Rebecca Lancefield serologically classified streptococci in the 1930s using carbohydrate antigens from the bacterial cell walls. S. pyogenes is the sole member of the Lancefield group A streptococci and is often referred to as GAS, or group A strep.

Similar to streptococcal infections of the skin, the mucosal membranes of the pharynx are damaged by the release of a variety of exoenzymes and exotoxins by this extracellular pathogen. Many strains of S. pyogenes can degrade connective tissues by using hyaluronidase, collagenase and streptokinase. Streptokinase activates plasmin, which leads to degradation of fibrin and, in turn, dissolution of blood clots, which assists in the spread of the pathogen. Released toxins include streptolysins that can destroy red and white blood cells. The classic signs of streptococcal pharyngitis are a fever higher than 38 °C (100.4 °F); intense pharyngeal pain; erythema associated with pharyngeal inflammation; and swollen, dark-red palatine tonsils, often dotted with patches of pus; and petechiae (microcapillary hemorrhages) on the soft or hard palate (roof of the mouth) (Figure). The submandibular lymph nodes beneath the angle of the jaw are also often swollen during strep throat.

Some strains of group A streptococci produce erythrogenic toxin. This exotoxin is encoded by a temperate bacteriophage (bacterial virus) and is an example of phage conversion. The toxin attacks the plasma membranes of capillary endothelial cells and leads to scarlet fever (or scarlatina), a disseminated fine red rash on the skin, and strawberry tongue, a red rash on the tongue (Figure). Severe cases may even lead to streptococcal toxic shock syndrome (STSS), which results from massive superantigen production that leads to septic shock and death.

S. pyogenes can be easily spread by direct contact or droplet transmission through coughing and sneezing. The disease can be diagnosed quickly using a rapid enzyme immunoassay for the group A antigen. However, due to a significant rate of false-negative results (up to 30%), culture identification is still the gold standard to confirm pharyngitis due to S. pyogenes. S. pyogenes can be identified as a catalase-negative, beta hemolytic bacterium that is susceptible to 0.04 units of bacitracin. Antibiotic resistance is limited for this bacterium, so most β-lactams remain effective; oral amoxicillin and intramuscular penicillin G are those most commonly prescribed.

Sequelae of S. pyogenes Infections

One reason strep throat infections are aggressively treated with antibiotics is because they can lead to serious sequelae, later clinical consequences of a primary infection. It is estimated that 1%–3% of untreated S. pyogenes infections can be followed by nonsuppurative (without the production of pus) sequelae that develop 1–3 weeks after the acute infection has resolved. Two such sequelae are acute rheumatic fever and acute glomerulonephritis.

Acute rheumatic fever can follow pharyngitis caused by specific rheumatogenic strains of S. pyogenes (strains 1, 3, 5, 6, and 18). Although the exact mechanism responsible for this sequela remains unclear, molecular mimicry between the M protein of rheumatogenic strains of S. pyogenes and heart tissue is thought to initiate the autoimmune attack. The most serious and lethal clinical manifestation of rheumatic fever is damage to and inflammation of the heart (carditis). Acute glomerulonephritis also results from an immune response to streptococcal antigens following pharyngitis and cutaneous infections. Acute glomerulonephritis develops within 6–10 days after pharyngitis, but can take up to 21 days after a cutaneous infection. Similar to acute rheumatic fever, there are strong associations between specific nephritogenic strains of S. pyogenes and acute glomerulonephritis, and evidence suggests a role for antigen mimicry and autoimmunity. However, the primary mechanism of acute glomerulonephritis appears to be the formation of immune complexes between S. pyogenes antigens and antibodies, and their deposition between endothelial cells of the glomeruli of kidney. Inflammatory response against the immune complexes leads to damage and inflammation of the glomeruli (glomerulonephritis).