What Is Kartagener Syndrome?
Source: Genetic and Rare Diseases (GARD) Information Center
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Kartagener Syndrome
Dextrocardia Bronchiectasis and Sinusitis; Siewert Syndrome; Immotile Cilia Syndrome Kartagener Type; Primary Ciliary Dyskinesia with Situs Inversus
Kartagener syndrome is a rare genetic disorder that primarily affects the respiratory and reproductive systems. It is a type of primary ciliary dyskinesia that is also characterized by situs inversus totalis (mirror-image reversal of internal organs). Explore the symptoms and genetics of this condition.
Baby Sitting Showing Respiratory System
Image by TheVisualMD
34 year-old white male with situs inversus due to his Kartagener's syndrome.
Image by Jer5150
Source: Genetic and Rare Diseases (GARD) Information Center
Respiratory Tract / Infected Upper Respiratory Track
Normal vs Infected Upper Respiratory Tract
Interactive by TheVisualMD
Respiratory Tract / Infected Upper Respiratory Track
Source: Genetic and Rare Diseases (GARD) Information Center
Mutation
Image by National Human Genome Research Institute (NHGRI)
Source: Genetic and Rare Diseases (GARD) Information Center
Autosomal recessive inheritance diagram
Image by Kashmiri, based on earlier work by Domaina
Source: Genetic and Rare Diseases (GARD) Information Center
Biopsy
Image by Hellerhoff
Source: Genetic and Rare Diseases (GARD) Information Center
Bottle of Doxycycline
Image by NIAID
There is currently no cure for Kartagener syndrome. Treatment varies based on the signs and symptoms present in each person. Airway clearance therapy, similar to that used in cystic fibrosis, can loosen thick, sticky mucus so it can be cleared away. Antibiotics may be prescribed to treat respiratory, sinus, and middle ear infections and may be given on a long-term basis in people with chronic or frequent infections. Surgery to insert ear tubes may be recommended in children with chronic ear infections that are resistant to antibiotics. In people with severe lung disease, lung transplantation may be an option.
Source: Genetic and Rare Diseases (GARD) Information Center
Respiratory System
Image by TheVisualMD
Source: Genetic and Rare Diseases (GARD) Information Center
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