Kyrle disease is rare condition that affects the skin. People with this condition generally develop large papules with central keratin (a protein found in the skin, hair and nails) plugs throughout their body. These lesions are typically not painful but may cause severe itching. Although it can affect both men and women throughout life, the average age of onset is 30 years. The cause of the disease is currently unknown; however, it is often associated with certain conditions such as diabetes mellitus, kidney disease, liver abnormalities, and congestive heart failure. In some families, the condition appears to be inherited but an underlying genetic cause has not been identified. Treatment aims to address the associated signs and symptoms and any additional disease that may be present. Lesions often heal spontaneously but new ones continue to develop.

Kyrle disease is primarily characterized by large skin papules with central keratin (a protein found in the skin, hair and nails) plugs. These lesions are most commonly found on the legs, but may also develop on the arms or head and neck region. They can remain as distinct papules or join together into larger plaques. Although some people report no symptoms associated with the skin lesions, many experience tenderness and/or severe itching.

In some families, the condition appears to be inherited but an underlying genetic cause has not been identified.

In some families, Kyrle disease does appear to be inherited. Although the underlying genetic cause has not been identified, some studies suggest that the condition may follow an autosomal recessive pattern in these families.

A diagnosis of Kyrle disease is often suspected based on the presence of characteristic signs and symptoms on physical examination. The deep penetration of the keratin plugs, the size and irregularity of the papules, the age of onset and the location of the skin lesions can help differentiate Kyrle disease from other conditions that are associated with similar skin findings. A workup for Kyrle disease should also include an evaluation for any underlying diseases that can be associated with the condition.

Other treatment options specifically target the signs and symptoms associated with Kyrle disease. For example, medicated lotions, sedating antihistamines, and topical corticosteroids may be prescribed in people with severe itching. UV light therapy is reportedly particularly helpful for people with widespread lesions or severe itching from renal or hepatic disease. Carbon dioxide laser or cryosurgery may be helpful for some people with a few lesions.