Cancer of the Fallopian Tube, Fallopian Tube Neoplasms
Fallopian tube cancer develops in the tubes that connect a woman's ovaries and uterus. It is very rare and accounts for only 1-2% of all gynecologic cancers.
Fallopian tube cancer develops in the tubes that connect a woman's ovaries and uterus. It is very rare and accounts for only 1-2% of all gynecologic cancers.
Fallopian tube cancer occurs when normal cells in one or both tubes change and grow in an uncontrolled way, forming a mass called a tumor. Cancer can begin in any of the different cell types that make up the fallopian tubes. The most common type is called adenocarcinoma (a cancer of cells from glands). Leiomyosarcoma (a cancer of smooth muscle cells) and transitional cell carcinoma (a cancer of the cells lining the fallopian tubes) are more rare.
While some fallopian tube cancers actually begin in the tubes themselves, fallopian tube cancer is more often the result of cancer spreading from other parts of the body to the tubes. For example, the fallopian tubes are a common site of metastasis (spread) of cancers that started in the ovaries, uterus, endometrium, (the tissue lining the uterus) appendix, or colon.
Women with fallopian tube cancer may experience symptoms, although some affected women may have no symptoms at all. The signs of fallopian tube cancer are often non-specific, meaning that they can also be signs of other medical conditions that are not cancer. Signs and symptoms of fallopian tube cancer can include: irregular or heavy vaginal bleeding (especially after menopause); occasional abdominal or pelvic pain or feeling of pressure; vaginal discharge that may be clear, white, or tinged with blood; and a pelvic mass or lump.
Doctors use many tests to diagnose cancer of the fallopian tubes. Some of these tests may include: pelvic examination, transvaginal ultrasound, a blood test that measures the tumor marker CA-125, computed tomography (CT or CAT) scan, and magnetic resonance imaging (MRI).
Fallopian tube cancer can be best treated when detected early. If the cancer has spread to the walls of the tubes or outside of the tubes, then there is a lower chance that the disease can be treated successfully. The stage of the cancer determines the type of treatment needed. Most women will need surgery and some will go on to have chemotherapy and/or radiation therapy.
Source: Genetic and Rare Diseases (GARD) Information Center
Additional Materials (5)
Fallopian tube cancer
A new study offers additional evidence that, in many women with ovarian cancer, the disease may originate in the fallopian tubes.
Image by Carolyn Hruban
Stage 3A Ovarian, Fallopian Tube, and Primary Peritoneal Cancer
3D medical animation still showing fallopian tube.
3D medical animation still showing cross section view of fallopian tube highlighted with yellow lines.
Image by Scientific Animations, Inc.
Fallopian Tube and Ovary: Medical visualization of a cross-section of the ovary, as well as the associated fallopian tube; seen inside the cross-section are a developing follicle, corpus luteum, and corpus albicans
Fallopian Tube and Ovary: Medical visualization of a cross-section of the ovary, as well as the associated fallopian tube; seen inside the cross-section are a developing follicle, corpus luteum, and corpus albicans.
3D medical animation still showing fallopian tube.
Scientific Animations, Inc.
Fallopian Tube and Ovary: Medical visualization of a cross-section of the ovary, as well as the associated fallopian tube; seen inside the cross-section are a developing follicle, corpus luteum, and corpus albicans
Cervix and Nearby Organs . Description The location of the cervix and nearby organs and lymph nodes, as well as a close-up view of the ovaries, fallopian tubes, uterus, cervix, and upper vagina.
Image by Don Bliss (Illustrator) NCI/NIH
What Are Ovarian Epithelial, Fallopian Tube, and Primary Peritoneal Cancer?
Ovarian epithelial cancer, fallopian tube cancer, and primary peritoneal cancer are diseases in which malignant (cancer) cells form in the tissue covering the ovary or lining the fallopian tube or peritoneum.
The ovaries are a pair of organs in the female reproductive system. They are in the pelvis, one on each side of the uterus (the hollow, pear-shaped organ where a fetus grows). Each ovary is about the size and shape of an almond. The ovaries make eggs and female hormones (chemicals that control the way certain cells or organs work).
The fallopian tubes are a pair of long, slender tubes, one on each side of the uterus. Eggs pass from the ovaries, through the fallopian tubes, to the uterus. Cancer sometimes begins at the end of the fallopian tube near the ovary and spreads to the ovary.
The peritoneum is the tissue that lines the abdominal wall and covers organs in the abdomen. Primary peritoneal cancer is cancer that forms in the peritoneum and has not spread there from another part of the body. Cancer sometimes begins in the peritoneum and spreads to the ovary.
Anatomy of the female reproductive system. The organs in the female reproductive system include the uterus, ovaries, fallopian tubes, cervix, and vagina. The uterus has a muscular outer layer called the myometrium and an inner lining called the endometrium.
Ovarian epithelial cancer is one type of cancer that affects the ovary.
Ovarian epithelial cancer, fallopian tube cancer, and primary peritoneal cancer form in the same type of tissue and are treated the same way.
Source: PDQ® Adult Treatment Editorial Board. PDQ Ovarian Epithelial, Fallopian Tube, and Primary Peritoneal Cancer Treatment. Bethesda, MD: National Cancer Institute.
Additional Materials (1)
Ovarian Cancer
Ovarian cancer is the deadliest of gynecologic cancers. More than 21,000 new cases of ovarian cancer are diagnosed each year, with more than 15,000 deaths. A particular blood protein called cancer antigen 125 (CA-125) is often elevated in women with ovarian cancer, though small amounts of CA-125 are produced by normal tissues throughout the body and levels of CA-125 can be elevated by other conditions. The CA-125 test is used primarily to monitor the effectiveness of treatment for ovarian cancer. There are three different kinds of ovarian cancer: the most common type is epithelial ovarian cancer (90%) which originates from the surface epithelium of the ovary and is more likely to affect older women; germ cell ovarian cancer (5%), which originates from the cells that produce eggs and is more likely to affect younger women; and stromal ovarian cancer (5%), which originates from the connective tissue within the ovary. After age, the most important risk factor for ovarian cancer is family history. Ovarian cancer is relatively uncommon, but is the fifth leading cause of cancer death in women, partly due to diagnosis difficulty; its symptoms are vague, and ovarian cancer can shed cells that can invade other internal organs long before the presence of disease is even suspected.
Image by TheVisualMD
Ovarian Cancer
TheVisualMD
The Peritoneum
What are the types of peritoneal dialysis?
Image by TheVisualMD
What are the types of peritoneal dialysis?
Peritoneal dialysis uses the lining of the abdomen (peritoneum), which is rich in arteries and veins, as a filter. Dialysis fluid is placed into the abdominal cavity through a permanent access port in the abdomen. The fluid remains there long enough for all the wastes in the blood to be transferred to the dialysis fluid, which is then drained out of the abdomen.
Image by TheVisualMD
The Peritoneum
The digestive organs within the abdominal cavity are held in place by the peritoneum, a broad serous membranous sac made up of squamous epithelial tissue surrounded by connective tissue. It is composed of two different regions: the parietal peritoneum, which lines the abdominal wall, and the visceral peritoneum, which envelopes the abdominal organs (image). The peritoneal cavity is the space bounded by the visceral and parietal peritoneal surfaces. A few milliliters of watery fluid act as a lubricant to minimize friction between the serosal surfaces of the peritoneum.
The Peritoneum
Figure 23.4 The Peritoneum A cross-section of the abdomen shows the relationship between abdominal organs and the peritoneum (darker lines).
A cross-section of the abdomen shows the relationship between abdominal organs and the peritoneum (darker lines).
The visceral peritoneum includes multiple large folds that envelope various abdominal organs, holding them to the dorsal surface of the body wall. Within these folds are blood vessels, lymphatic vessels, and nerves that innervate the organs with which they are in contact, supplying their adjacent organs. The five major peritoneal folds are described in the Table below. Note that during fetal development, certain digestive structures, including the first portion of the small intestine (called the duodenum), the pancreas, and portions of the large intestine (the ascending and descending colon, and the rectum) remain completely or partially posterior to the peritoneum. Thus, the location of these organs is described as retroperitoneal .
The Five Major Peritoneal Folds
Fold
Description
Greater omentum
Apron-like structure that lies superficial to the small intestine and transverse colon; a site of fat deposition in people who are overweight
Falciform ligament
Anchors the liver to the anterior abdominal wall and inferior border of the diaphragm
Lesser omentum
Suspends the stomach from the inferior border of the liver; provides a pathway for structures connecting to the liver
Mesentery
Vertical band of tissue anterior to the lumbar vertebrae and anchoring all of the small intestine except the initial portion (the duodenum)
Mesocolon
Attaches two portions of the large intestine (the transverse and sigmoid colon) to the posterior abdominal wall
DISORDERS OF THE...
Digestive System: Peritonitis
Inflammation of the peritoneum is called peritonitis. Chemical peritonitis can develop any time the wall of the alimentary canal is breached, allowing the contents of the lumen entry into the peritoneal cavity. For example, when an ulcer perforates the stomach wall, gastric juices spill into the peritoneal cavity. Hemorrhagic peritonitis occurs after a ruptured tubal pregnancy or traumatic injury to the liver or spleen fills the peritoneal cavity with blood. Even more severe peritonitis is associated with bacterial infections seen with appendicitis, colonic diverticulitis, and pelvic inflammatory disease (infection of uterine tubes, usually by sexually transmitted bacteria). Peritonitis is life threatening and often results in emergency surgery to correct the underlying problem and intensive antibiotic therapy. When your great grandparents and even your parents were young, the mortality from peritonitis was high. Aggressive surgery, improvements in anesthesia safety, the advance of critical care expertise, and antibiotics have greatly improved the mortality rate from this condition. Even so, the mortality rate still ranges from 30 to 40 percent.
Source: CNX OpenStax
Additional Materials (13)
Peritoneal Cavity - Part 1 - Anatomy Tutorial
Video by AnatomyZone/YouTube
The Peritoneum
A cross-section of the abdomen shows the relationship between abdominal organs and the peritoneum (darker lines).
Image by CNX Openstax
General Distribution of the Peritoneum
Cross section through the abdomen showing the continuity of the parietal and visceral peritoneum through the mesentery and the principal muscles that contribute to the abdominal wall.
Image by Dennis M DePace, PhD/Wikimedia
Mesentery
Mesentery
Image by Anatomist90
Mesentery
Horizontal disposition of the peritoneum in the lower part of the abdomen.
Image by Henry Vandyke Carter
Mesentery - structure of the gut wall
The general structure of the gut wall
Image by Auawise at English Wikipedia
Peritoneal Cavity
Cross section of the Peritoneal Cavity
Image by Dr. Johannes Sobotta
Peritoneum - 3D Schematic Anatomy & Relations
Video by About Medicine/YouTube
Peritoneum tutorial
Video by The Noted Anatomist/YouTube
Tracing the peritoneum in sections - simplified
Video by Human Anatomy Education/YouTube
4.3 what makes understanding the peritoneum so difficult?
Video by Centre for Innovation - Leiden University/YouTube
4.4 The relation of the peritoneum to the gut
Video by Centre for Innovation - Leiden University/YouTube
4.1 Introduction the peritoneum
Video by Centre for Innovation - Leiden University/YouTube
8:28
Peritoneal Cavity - Part 1 - Anatomy Tutorial
AnatomyZone/YouTube
The Peritoneum
CNX Openstax
General Distribution of the Peritoneum
Dennis M DePace, PhD/Wikimedia
Mesentery
Anatomist90
Mesentery
Henry Vandyke Carter
Mesentery - structure of the gut wall
Auawise at English Wikipedia
Peritoneal Cavity
Dr. Johannes Sobotta
5:10
Peritoneum - 3D Schematic Anatomy & Relations
About Medicine/YouTube
24:42
Peritoneum tutorial
The Noted Anatomist/YouTube
32:05
Tracing the peritoneum in sections - simplified
Human Anatomy Education/YouTube
4:46
4.3 what makes understanding the peritoneum so difficult?
Centre for Innovation - Leiden University/YouTube
6:20
4.4 The relation of the peritoneum to the gut
Centre for Innovation - Leiden University/YouTube
2:53
4.1 Introduction the peritoneum
Centre for Innovation - Leiden University/YouTube
Treatment
Monoclonal Antibody
Image by TheVisualMD
Monoclonal Antibody
Monoclonal Antibody
Image by TheVisualMD
How Are Ovarian Epithelial, Fallopian Tube, and Primary Peritoneal Cancer Treated?
Treatment Option Overview
KEY POINTS
There are different types of treatment for patients with ovarian epithelial cancer.
Three kinds of standard treatment are used.
Surgery
Chemotherapy
Targeted therapy
New types of treatment are being tested in clinical trials.
Radiation therapy
Immunotherapy
Treatment for ovarian epithelial, fallopian tube, and primary peritoneal cancer may cause side effects.
Patients may want to think about taking part in a clinical trial.
Patients can enter clinical trials before, during, or after starting their cancer treatment.
Follow-up tests may be needed.
There are different types of treatment for patients with ovarian epithelial cancer.
Different types of treatment are available for patients with ovarian epithelial cancer. Some treatments are standard, and some are being tested in clinical trials. A treatment clinical trial is a research study meant to help improve current treatments or obtain information on new treatments for patients with cancer. When clinical trials show that a new treatment is better than the treatment currently used as standard treatment, the new treatment may become the standard treatment. Patients with any stage of ovarian cancer may want to think about taking part in a clinical trial. Some clinical trials are open only to patients who have not started treatment.
Three kinds of standard treatment are used.
Surgery
Most patients have surgery to remove as much of the tumor as possible. Different types of surgery may include:
Hysterectomy: Surgery to remove the uterus and, sometimes, the cervix. When only the uterus is removed, it is called a partial hysterectomy. When both the uterus and the cervix are removed, it is called a total hysterectomy. If the uterus and cervix are taken out through the vagina, the operation is called a vaginal hysterectomy. If the uterus and cervix are taken out through a large incision (cut) in the abdomen, the operation is called a total abdominal hysterectomy. If the uterus and cervix are taken out through a small incision (cut) in the abdomen using a laparoscope, the operation is called a total laparoscopic hysterectomy.Hysterectomy. The uterus is surgically removed with or without other organs or tissues. In a total hysterectomy, the uterus and cervix are removed. In a total hysterectomy with salpingo-oophorectomy, (a) the uterus plus one (unilateral) ovary and fallopian tube are removed; or (b) the uterus plus both (bilateral) ovaries and fallopian tubes are removed. In a radical hysterectomy, the uterus, cervix, both ovaries, both fallopian tubes, and nearby tissue are removed. These procedures are done using a low transverse incision or a vertical incision.
Unilateral salpingo-oophorectomy: A surgical procedure to remove one ovary and one fallopian tube.
Bilateral salpingo-oophorectomy: A surgical procedure to remove both ovaries and both fallopian tubes.
Omentectomy: A surgical procedure to remove the omentum (tissue in the peritoneum that contains blood vessels, nerves, lymph vessels, and lymph nodes).
Lymph node biopsy: The removal of all or part of a lymph node. A pathologist views the lymph node tissue under a microscope to check for cancer cells.
Chemotherapy
Chemotherapy is a cancer treatment that uses drugs to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. When chemotherapy is taken by mouth or injected into a vein or muscle, the drugs enter the bloodstream and can reach cancer cells throughout the body (systemic chemotherapy). When chemotherapy is placed directly into the cerebrospinal fluid, an organ, or a body cavity such as the abdomen, the drugs mainly affect cancer cells in those areas (regional chemotherapy).
A type of regional chemotherapy used to treat ovarian cancer is intraperitoneal (IP) chemotherapy. In IP chemotherapy, the anticancer drugs are carried directly into the peritoneal cavity (the space that contains the abdominal organs) through a thin tube.
Hyperthermic intraperitoneal chemotherapy (HIPEC) is a treatment used during surgery that is being studied for ovarian cancer. After the surgeon has removed as much tumor tissue as possible, warmed chemotherapy is sent directly into the peritoneal cavity.
Treatment with more than one anticancer drug is called combination chemotherapy.
The way the chemotherapy is given depends on the type and stage of the cancer being treated.
Targeted therapy
Targeted therapy is a type of treatment that uses drugs or other substances to identify and attack specific cancer cells.
Monoclonal antibodies are immune system proteins made in the laboratory to treat many diseases, including cancer. As a cancer treatment, these antibodies can attach to a specific target on cancer cells or other cells that may help cancer cells grow. The antibodies are able to then kill the cancer cells, block their growth, or keep them from spreading. Monoclonal antibodies are given by infusion. They may be used alone or to carry drugs, toxins, or radioactive material directly to cancer cells. Monoclonal antibodies may be used in combination with chemotherapy as adjuvant therapy.
Bevacizumab is a monoclonal antibody and angiogenesis inhibitor that may be used with chemotherapy to treat ovarian epithelial cancer, fallopian tube cancer, or primary peritoneal cancer that has recurred (come back). It binds to a protein called vascular endothelial growth factor (VEGF) and may prevent the growth of new blood vessels that tumors need to grow. Other angiogenesis inhibitors are being studied in the treatment of advanced or recurrent ovarian cancer.
Poly (ADP-ribose) polymerase inhibitors (PARP inhibitors) are targeted therapy drugs that block DNA repair and may cause cancer cells to die. Olaparib, rucaparib, and niraparib are PARP inhibitors that may be used as maintenance therapy to treat certain types of ovarian epithelial cancer, fallopian tube cancer, or primary peritoneal cancer that have recurred. Veliparib is a PARP inhibitor that is being studied in combination with chemotherapy to treat advanced ovarian cancer.
Radiation therapy
Radiation therapy is a cancer treatment that uses high-energy x-rays or other types of radiation to kill cancer cells or keep them from growing. Some women receive a treatment called intraperitoneal radiation therapy, in which radioactive liquid is put directly in the abdomen through a catheter. Intraperitoneal radiation therapy is being studied to treat advanced ovarian cancer.
Immunotherapy
Immunotherapy is a treatment that uses the patient’s immune system to fight cancer. Substances made by the body or made in a laboratory are used to boost, direct, or restore the body’s natural defenses against cancer. This cancer treatment is a type of biologic therapy.
Vaccine therapy is a cancer treatment that uses a substance or group of substances to stimulate the immune system to find the tumor and kill it. Vaccine therapy is being studied to treat advanced ovarian cancer.
Treatment for ovarian epithelial, fallopian tube, and primary peritoneal cancer may cause side effects.
Patients may want to think about taking part in a clinical trial.
For some patients, taking part in a clinical trial may be the best treatment choice. Clinical trials are part of the cancer research process. Clinical trials are done to find out if new cancer treatments are safe and effective or better than the standard treatment.
Many of today's standard treatments for cancer are based on earlier clinical trials. Patients who take part in a clinical trial may receive the standard treatment or be among the first to receive a new treatment.
Patients who take part in clinical trials also help improve the way cancer will be treated in the future. Even when clinical trials do not lead to effective new treatments, they often answer important questions and help move research forward.
Patients can enter clinical trials before, during, or after starting their cancer treatment.
Some clinical trials only include patients who have not yet received treatment. Other trials test treatments for patients whose cancer has not gotten better. There are also clinical trials that test new ways to stop cancer from recurring (coming back) or reduce the side effects of cancer treatment.
Follow-up tests may be needed.
Some of the tests that were done to diagnose the cancer or to find out the stage of the cancer may be repeated. Some tests will be repeated in order to see how well the treatment is working. Decisions about whether to continue, change, or stop treatment may be based on the results of these tests.
Some of the tests will continue to be done from time to time after treatment has ended. The results of these tests can show if your condition has changed or if the cancer has recurred (come back). These tests are sometimes called follow-up tests or check-ups.
Treatment of Early Ovarian Epithelial and Fallopian Tube Cancer
Treatment of early ovarian epithelial cancer or fallopian tube cancer may include the following:
Hysterectomy, bilateral salpingo-oophorectomy, and omentectomy. Lymph nodes and other tissues in the pelvis and abdomen are removed and checked under a microscope for cancer cells. Chemotherapy may be given after surgery.
Unilateral salpingo-oophorectomy may be done in certain women who wish to have children. Chemotherapy may be given after surgery.
Treatment of Advanced Ovarian Epithelial, Fallopian Tube, and Primary Peritoneal Cancer
Treatment of advanced ovarian epithelial cancer, fallopian tube cancer, or primary peritoneal cancer may include the following:
Hysterectomy, bilateral salpingo-oophorectomy, and omentectomy. Lymph nodes and other tissues in the pelvis and abdomen are removed and checked under a microscope to look for cancer cells. Surgery is followed by one of the following:
Intravenous chemotherapy.
Intraperitoneal chemotherapy.
Chemotherapy and targeted therapy (bevacizumab).
Chemotherapy and targeted therapy with a poly (ADP-ribose) polymerase (PARP) inhibitor.
Chemotherapy and targeted therapy followed by surgery (possibly followed by intraperitoneal chemotherapy).
Chemotherapy alone for patients who cannot have surgery.
Targeted therapy with a PARP inhibitor (olaparib, rucaparib, niraparib).
A clinical trial of targeted therapy with a PARP inhibitor (veliparib).
Treatment of Recurrent or Persistent Ovarian Epithelial, Fallopian Tube, and Primary Peritoneal Cancer
Treatment of recurrent ovarian epithelial cancer, fallopian tube cancer, or primary peritoneal cancer may include the following:
Chemotherapy using one or more anticancer drugs.
Targeted therapy with a poly (ADP-ribose) polymerase (PARP) inhibitor (olaparib, rucaparib, or niraparib) with or without chemotherapy.
A clinical trial of hyperthermic intraperitoneal chemotherapy (HIPEC) during surgery.
A clinical trial of a new treatment.
Source: PDQ® Adult Treatment Editorial Board. PDQ Ovarian Epithelial, Fallopian Tube, and Primary Peritoneal Cancer Treatment. Bethesda, MD: National Cancer Institute.
Additional Materials (5)
What is T-cell adoptive transfer Immunotherapy?
Cancer specific T-cells can be obtained by fragmentation and isolation of tumour infiltrating lymphocytes, or by genetically engineering cells from peripheral blood. The cells are activated and grown prior to transfusion into the recipient (tumour bearer).
Image by Simon Caulton
Finding New Ways to Help the Immune System Fight Cancer
Researchers are tapping into the innate immune system by harnessing dendritic cells to activate T-cell immunity, helping macrophages engulf cancer cells, and engineering natural killer cells to target cancer. Researchers are also investigating the gut microbiome’s role in immunity and targeting the microbiome for cancer therapy.
Image by National Cancer Institute (NCI)
Tumor microenvironment
Tumor cells can either be eliminated by the immune system or escape detection. During the elimination phase, immune effector cells such as natural killer cells, with the help of dendritic and CD4+ T-cells, are able to recognize and eliminate tumor cells (left). As a result of heterogeneity, however, tumor cells which are less immunogenic are able to escape immunosurveillance (right).
Image by Frontiers in Oncology
Genomic information
This image was created by the NHS HEE Genomics Education Programme. For further information and resources please visit our website www.genomicseducation.hee.nhs.uk
Image by NHS HEE Genomics Education Programme
How Monoclonal Antibodies Treat Cancer
Video by National Cancer Institute/YouTube
What is T-cell adoptive transfer Immunotherapy?
Simon Caulton
Finding New Ways to Help the Immune System Fight Cancer
National Cancer Institute (NCI)
Tumor microenvironment
Frontiers in Oncology
Genomic information
NHS HEE Genomics Education Programme
3:20
How Monoclonal Antibodies Treat Cancer
National Cancer Institute/YouTube
Medicines
Cross Section Uterus and Ovary, Fallopian Tube, Fimbria
Image by TheVisualMD
Cross Section Uterus and Ovary, Fallopian Tube, Fimbria
Cross Section Uterus and Ovary, Fallopian Tube, Fimbria
Image by TheVisualMD
FDA-Approved Treatments for Fallopian Tube Cancer
The medication(s) listed below have been approved by the Food and Drug Administration (FDA) as orphan products for treatment of this condition.
Bevacizumab(Brand name: Avastin) - Manufactured by Genentech, Inc. FDA-approved indication: June 2018 approved in combination with carboplatin and paclitaxel, followed by Avastin as a single agent, to treat patients with stage III or IV epithelial ovarian, fallopian tube, or primary peritoneal cancer following initial surgical resection. December 2016 approved either in combination with carboplatin and paclitaxel or in combination with carboplatin and gemcitabine, followed by Avastin as a single agent, to treat patients with platinum-sensitive recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer.
Olaparib(Brand name: Lynparza) - Manufactured by AstraZeneca Pharmaceuticals LP FDA-approved indication: December 2018, olaparib (Lynparza) received expanded approval for the maintenance treatment of adult patients with deleterious or suspected deleterious germline or somatic BRCA-mutated (gBRCAm or sBRCAm) advanced epithelial ovarian, fallopian tube or primary peritoneal cancer who are in complete or partial response to first-line platinum based chemotherapy. Select patients with gBRCAm advanced epithelial ovarian, fallopian tube or primary peritoneal cancer for therapy based on FDA-approved companion diagnostic for Lynparza. Original approval was in August 2017.
Rucaparib(Brand name: Rubraca) - Manufactured by Clovis Oncology, Inc. FDA-approved indication: April 2018 approved for the maintenance treatment of adult patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in complete or partial response to platinum-based chemotherapy.
Niraparib(Brand name: Zejula) - Manufactured by Tesaro, Inc. FDA-approved indication: Indicated for maintenance treatment of adult patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in a complete or partial response to platinum-based chemotherapy.
Source: Genetic and Rare Diseases Information Center (GARD)
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Fallopian Tube Cancer
Fallopian tube cancer develops in the tubes that connect a woman's ovaries and uterus. It is very rare and accounts for only 1-2% of all gynecologic cancers.