What Is Disseminated Peritoneal Leiomyomatosis?
Disseminated peritoneal leiomyomatosis (DPL) is a rare condition whichis characterized by nodules or small lumps of smooth muscle cells located onthe peritoneum (lining of the abdominal wall) and abdominal organs.Thecondition is usually benign (noncancerous) but in rare cases has becomecancerous. Although it can be seen in post-menopausal women and veryrarely in men, DPL occurs most often in women of childbearing age. Mostwomen with DPL are pregnant, taking the birth control pill, or have uterine leioyomas or estrogen-secreting tumors. Some people with DPL have nosigns or symptoms of the condition. Whenpresent, symptoms may include abdominal and pelvic pain; rectal or vaginalbleeding; and less commonly constipation. The cause of DPL is unknown but maybe linked to hormonal and genetic factors.Some cases of DPL resolve when hormone levels are returned to normal. However, surgery may be suggested based on the size and location of thetumor.
Source: Genetic and Rare Diseases (GARD) Information Center