Ménétrier disease is a gastrointestinal condition characterized by overgrowth of the mucous cells (foveola) in the mucous membrane lining the stomach, causing enlarged gastric folds. This leads to excessive mucus production, causing protein loss from the stomach and low or absent levels of stomach acid. Symptoms may include pain in the upper middle region of the stomach, nausea, vomiting, and diarrhea. The cause of Ménétrier disease is largely not known, although some cases are associated with infection, particularly pediatric cases, which can be caused by CMV infections. Treatment may include medications such as cetuximab and gastrectomy in severe cases.

Helicobacter pylori (H. pylori) infection in adults. In addition, some have suggested that overexpression of a type of growth factor called the transforming growth factor-α, which is found in a specific part of the stomach, called the superficial gastric epithelium, might play a role.

Helicobacter pylori (H. Pylori) infection; medications such as Gastric antisecretory agents (protein pump inhibitors), octreotide, and cetuximab; and a gastrectomy.

Although it has been suggested that patients with Ménétrier disease may be at an increased risk of developing stomach cancer; the risk remains uncertain. Studies estimate that between 2% and 15% of individuals with Ménétrier disease may develop stomach cancer in their lifetime. Given this potential, some authors suggest surveillance with annual or biannual endoscopy.