Currently, there are three main types of COVID-19 vaccines that are approved or authorized for use in the United States: mRNA, viral vector, and protein subunit. Each type of vaccine prompts our bodies to recognize and help protect us from the virus that causes COVID-19.
None of these vaccines can give you COVID-19.
- Vaccines do not use any live virus.
- Vaccines cannot cause infection with the virus that causes COVID-19 or other viruses.
They do not affect or interact with our DNA.
- These vaccines do not enter the nucleus of the cell where our DNA (genetic material) is located, so it cannot change or influence our genes.
mRNA vaccines (Pfizer-BioNTech or Moderna)
To trigger an immune response, many vaccines put a weakened or inactivated germ into our bodies. Not mRNA vaccines. Instead, mRNA vaccines use mRNA created in a laboratory to teach our cells how to make a protein—or even just a piece of a protein—that triggers an immune response inside our bodies. This immune response, which produces antibodies, is what helps protect us from getting sick from that germ in the future.
Protein subunit vaccines (Novavax)
Protein subunit vaccines contain pieces (proteins) of the virus that causes COVID-19. These virus pieces are the spike protein. The vaccine also contains another ingredient called an adjuvant that helps the immune system respond to that spike protein in the future. Once the immune system knows how to respond to the spike protein, the immune system will be able to respond quickly to the actual virus spike protein and protect you against COVID-19.
Viral vector vaccines (Johnson & Johnson’s Janssen)
Viral vector COVID-19 vaccines use a modified version of a different virus (a vector virus) to deliver important instructions to our cells.
Developing COVID-19 Vaccines
While COVID-19 vaccines were developed rapidly, all steps have been taken to ensure their safety and effectiveness. Bringing a new vaccine to the public involves many steps including:
- vaccine development,
- clinical trials,
- U.S. Food and Drug Administration (FDA) authorization or approval.
As vaccines are distributed outside of clinical trials, monitoring systems are used to make sure that COVID-19 vaccines are safe.
Initial Development
New vaccines are first developed in laboratories. Scientists have been working for many years to develop vaccines against coronaviruses, such as those that cause severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). SARS-CoV-2, the virus that causes COVID-19, is related to these other coronaviruses. The knowledge that was gained through past research on coronavirus vaccines helped speed up the initial development of the current COVID-19 vaccines.
Clinical Trials
After initial laboratory development, vaccines go through three phases of clinical trials to make sure they are safe and effective. No trial phases have been skipped.
The clinical trials for COVID-19 vaccines have involved tens of thousands of volunteers of different ages, races, and ethnicities.
Clinical trials for vaccines compare outcomes (such as how many people get sick) between people who are vaccinated and people who are not. Results from these trials have shown that COVID-19 vaccines are safe and effective, especially against severe illness, hospitalization, and death.
Authorization or Approval
Before vaccines are made available to people in real-world settings, FDA assesses the findings from clinical trials. Initially, they determined that COVID-19 vaccines met FDA’s safety and effectiveness standards and granted those vaccines Emergency Use Authorizations (EUAs). The EUAs allowed the vaccines to be quickly distributed for use while maintaining the same high safety standards required for all vaccines.
FDA has granted full approval for some COVID-19 vaccines. Before granting approval, FDA reviewed evidence that built on the data and information submitted to support the EUA. This included:
- preclinical and clinical trial data and information,
- as well as details of the manufacturing process,
- vaccine testing results to ensure vaccine quality, and
- inspections of the sites where the vaccine is made.
These vaccines were found to meet the high standards for safety, effectiveness, and manufacturing quality FDA requires of an approved product.
Tracking Safety Using Vaccine Monitoring Systems
Hundreds of millions of people in the United States have received COVID-19 vaccines under the most intense safety monitoring in U.S. history.
Several monitoring systems continue to track outcomes from COVID-19 vaccines to ensure their safety. Some people have no side effects. Many people have reported common side effects after COVID-19 vaccination, like pain or swelling at the injection site, a headache, chills, or fever. These reactions are common and are normal signs that your body is building protection.
Reports of serious adverse events after vaccination are rare. CDC and FDA continue to closely monitor several reporting systems, like the
- Vaccine Adverse Event Reporting System (VAERS),
- Vaccine Safety Datalink (VSD), and
- v-safe, which help look for safety issues now that the vaccines are being given to patients in real-world settings across the country.
CDC provides timely updates on selected serious adverse events reported after COVID-19 vaccination.