Lemierre syndrome is a rare and potentially life-threatening complication of a certain type of bacterial infection in the throat, ears, salivary glands (parotitis), sinuses, or teeth. It can affect anyone, but especially previously-healthy adolescents and young adults. Learn about symptoms, causes and treatment.
Fusobacterium Infections
Image by CDC/ Dr. Lillian V. Holdeman
About
Lemierre Syndrome: Two Preschool Children with Cerebral Infarcts
Image by Libertas Academica from Auckland, New Zealand/Wikimedia
Lemierre Syndrome: Two Preschool Children with Cerebral Infarcts
Figure 2 from Lemierre Syndrome: Two Preschool Children with Cerebral Infarcts Published in Clinical Medicine Insights: Pediatrics
Image by Libertas Academica from Auckland, New Zealand/Wikimedia
What Is Lemierre Syndrome?
Lemierre syndrome is a rare and potentially life-threatening complication of bacterial infections that usually affects previously-healthy adolescents and young adults. It most commonly develops in association with a bacterial throat infection, but it may develop in association with an infection involving the ears, salivary glands (parotitis), sinuses, or teeth; or in association with an Epstein-Barr infection. The bacteria typically responsible for infection in Lemierre syndrome is Fusobacterium necrophorum, although a variety of bacteria can be responsible. In people with Lemierre syndrome, the initial infection spreads into tissues and deep spaces within the neck, leading to the formation of an infected blot clot (septic thrombophlebitis), sometimes made up of pus, in the internal jugular vein (the blood vessel that carries blood away from the brain, face, and neck). In addition to worsening symptoms of the initial infection, symptoms at this stage of the disease typically include persistent fever and chills (rigors), as well as pain, tenderness and swelling of the throat and neck. The infected clot then circulates in the blood (septicemia), resulting in the infection also spreading to the lungs (most commonly), skeletal system, and/or other parts of the body such as the spleen, liver, kidney, heart, or brain. This can lead to life-threatening complications such as respiratory distress syndrome due to pulmonary emboli (blood clots in the lung), damage to other affected organs, and/or septic shock (in about 7% of cases).
Lemierre syndrome may be diagnosed based on signs and symptoms, various blood tests, and imaging studies. Because most throat infections in young, healthy people do not cause severe health problems, diagnosis and treatment may be delayed. The main treatment involves intravenous antibiotic therapy over several weeks, but surgery may be necessary when there is abscess formation, respiratory distress, or severe clotting in the chest or brain. The long-term outlook and chance of survival in people with Lemierre syndrome varies depending on how much the syndrome progresses, but even with appropriate treatment, it is fatal in some cases.
Source: Genetic and Rare Diseases (GARD) Information Center
Additional Materials (5)
Understanding Lemmiere's Syndrome
Video by WDTNTV/YouTube
Lemierre's Syndrome
Video by 3dnamedical/YouTube
Imaging Mastery Series: The Carotid Space - Lemierre’s Syndrome
Video by MRI Online/YouTube
Case of the Week: Lemierre's Syndrome
Video by RSNA Case Collection/YouTube
Lemierre’s syndrome – video abstract 95050
Video by Dove Medical Press/YouTube
2:14
Understanding Lemmiere's Syndrome
WDTNTV/YouTube
0:21
Lemierre's Syndrome
3dnamedical/YouTube
3:38
Imaging Mastery Series: The Carotid Space - Lemierre’s Syndrome
MRI Online/YouTube
4:59
Case of the Week: Lemierre's Syndrome
RSNA Case Collection/YouTube
2:52
Lemierre’s syndrome – video abstract 95050
Dove Medical Press/YouTube
Causes
Fusobacterium novum
Image by Dr.V.R.Dowell/Wikimedia
Fusobacterium novum
en:Fusobacterium novum after being cultured in a thioglycollate medium.
Obtained from the CDC Public Health Image Library.
Image credit: CDC/Dr. V. R. Dowell, Jr. (PHIL #2965), 1972.
Image by Dr.V.R.Dowell/Wikimedia
What Causes Lemierre Syndrome?
Fusobacterium necrophorum (F. necrophorum). This bacteria is normally present in healthy people in various parts of the body (including the throat, digestive tract, and female genitals). The bacteria may cause invasive disease by releasing toxins into surrounding tissue. It has also been speculated that in some cases, other bacteria (or a virus) may be responsible for the initial infection prior to the onset of Lemierre syndrome, leading to conditions that favor the growth and invasion of F. necrophorum into surrounding tissues. Bacteria other than F. necrophorum that have been reported in case studies include Streptococcus species (“strep”), Bacteroides species, Staphylococcus aureus, and Klebsiella pneumoniae. The Epstein-Barr virus has also been reported in people prior to the onset of Lemierre syndrome.
Source: Genetic and Rare Diseases Information Center (GARD)
Symptoms
Anatomy of the mouth, showing inflamed tonsils in a sore throat.
Image by c
Anatomy of the mouth, showing inflamed tonsils in a sore throat.
Anatomy of the mouth, showing inflamed tonsils in a sore throat.
When you have a sore throat, your tonsils often hurt and are usually red and swollen.
Image by c
What Are the Signs and Symptoms of Lemierre Syndrome?
In people with Lemierre syndrome, the initial infection spreads into tissues and deep spaces within the neck, leading to the formation of an infected blot clot (septic thrombophlebitis), sometimes made up of pus, in the internal jugular vein (the blood vessel that carries blood away from the brain, face, and neck). In addition to worsening symptoms of the initial infection, symptoms at this stage of the disease typically include persistent fever and chills (rigors), as well as pain, tenderness and swelling of the throat and neck. The infected clot then circulates in the blood (septicemia), resulting in the infection also spreading to the lungs (most commonly), skeletal system, and/or other parts of the body such as the spleen, liver, kidney, heart, or brain.
Source: Genetic and Rare Diseases Information Center (GARD)
Diagnosis
Blood Test
Image by BarocoF/Pixabay
Blood Test
Blood, Sample, Test Tube, Rack
Image by BarocoF/Pixabay
How Is Lemierre Syndrome Diagnosed?
F. necrophorum bacteria, which often prompts a high suspicion for Lemierre syndrome. In some cases, blood cultures are negative due to difficulties that can be associated with culturing anaerobic bacteria.
Imaging studies may include a chest X-ray, which may detect septic emboli, abscesses, or other lung complications. Imaging studies to specifically evaluate septic thrombosis of the internal jugular vein may include ultrasound, CT scan of the neck with contrast, and magnetic resonance imaging (MRI). Magnetic resonance venography (MRV) has the highest sensitivity for detecting internal jugular thrombosis.
Source: Genetic and Rare Diseases Information Center (GARD)
Additional Materials (1)
Blood test
Blood test
Image by tyfn
Blood test
tyfn
Complete Blood Count
Complete Blood Count
Also called: CBC, Full Blood Count, Blood Cell Count, Hemotology Panel
A complete blood count (CBC) is often part of a routine exam. It is used to measure different parts and features of your blood. A CBC can help detect a variety of disorders including infections, anemia, diseases of the immune system, and blood cancers.
Complete Blood Count
Also called: CBC, Full Blood Count, Blood Cell Count, Hemotology Panel
A complete blood count (CBC) is often part of a routine exam. It is used to measure different parts and features of your blood. A CBC can help detect a variety of disorders including infections, anemia, diseases of the immune system, and blood cancers.
A complete blood count, or CBC, is a blood test that measures many different parts and features of your blood, including:
Red blood cells, which carry oxygen from your lungs to the rest of your body.
White blood cells, which fight infections and other diseases. There are five major types of white blood cells. A CBC test measures the total number of white cells in your blood. A different test called a CBC with differential measures the number of each type of these white blood cells.
Platelets, which stop bleeding by helping your blood to clot.
Hemoglobin, a protein in red blood cells that carries oxygen from your lungs to the rest of your body.
Hematocrit, a measurement of how much of your blood is made up of red blood cells.
Mean corpuscular volume (MCV), a measure of the average size of your red blood cells.
Other names for a complete blood count: CBC, full blood count, blood cell count
A complete blood count is a common blood test that is often part of a routine checkup. Complete blood counts can help detect a variety of disorders including infections, anemia, diseases of the immune system, and blood cancers.
Your health care provider may have ordered a complete blood count as part of your checkup or to monitor your overall health. The test may also be used to:
Help diagnose blood diseases, infection, immune system disorders, or other medical conditions
Check for changes in an existing blood disorder
A health care professional will take a blood sample from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial. You may feel a little sting when the needle goes in or out. This usually takes less than five minutes.
Usually there is no special preparation necessary for a complete blood count. But if your provider ordered other tests on your blood sample, you may need to fast (not eat or drink) for several hours before the test. Your provider will let you know if there are any special instructions to follow.
There is very little risk to having a blood test. You may experience slight pain or bruising at the spot where the needle went in, but most symptoms go away quickly.
A CBC counts the cells in your blood. There are many reasons your levels may not be in the normal range. For example:
Abnormal levels of red blood cells, hemoglobin, or hematocrit may be a sign of anemia, heart disease, or too little iron in your body.
Low white cell count may be a sign of an autoimmune disorder, bone marrow disorder, or cancer.
High white cell count may be a sign of an infection or a reaction to medicine.
If any of your levels are abnormal, it doesn't always mean you have a medical condition that needs treatment. Diet, activity level, medicines, a menstrual period, not drinking enough water, and other factors can affect the results. Talk with your provider to learn what your results mean.
A complete blood count is only one tool your health care provider uses to learn about your health. Your provider will consider your medical history, symptoms, and other factors to make a diagnosis. You may also need additional tests.
Complete Blood Count (CBC): MedlinePlus Medical Test [accessed on Jan 20, 2024]
Blood Tests - Blood Tests | NHLBI, NIH. Mar 24, 2022 [accessed on Jan 20, 2024]
Additional Materials (25)
Reticulocyte Count, Hemorrhage/Chronic Blood Loss
Reticulocytes are immature red blood cells (RBCs) released into the bloodstream from the bone marrow in which they developed. Normally, only a tiny percentage red blood cells circulating in the bloodstream are reticulocytes. The reticulocyte count rises, however, when bone marrow is called upon to produce more RBCs, in conditions such as heavy bleeding or certain types of anemia.
Image by TheVisualMD
Blood sample
During the blood collection process, medical personnel gather additional blood samples to test for an array of blood disorders and communicable diseases. Every unit of blood is rigorously tested before approved for transfusion into a patient.
Image by United States Marine Corps
Phlebotomy
Venipuncture (blood draw / collection) in the left arm of a male.
Image by MatthewLammers
Blood and Related Conditions
Blood and Related Conditions : Anemia results when there are too few red blood cells circulating in the bloodstream to deliver adequate oxygen to body tissues. There are different types and causes of anemia, including malnutrition, chronic bleeding, and diseases that result in red blood cells either being destroyed too quickly or produced too slowly.
Image by TheVisualMD
Components of Blood
Components of Blood : Our blood is composed of many different components, the largest categories being red and white blood cells (blood-clotting platelets are another key component) and the liquid portion known as blood plasma. A Complete Blood Count (CBC) includes several of the most basic, yet important, measurements of these components.
Image by TheVisualMD
Blood fractionation
Vial of separated blood. The middle layer is a type of sterile goo which separates the blood from the rest of what's drawn.
Image by Wheeler Cowperthwaite from Reno, USA
Whole Blood
A Red Cross whole blood donation before any separation
Image by Whoisjohngalt
White Blood Cells Rotation
This rotational interactive features five white blood cells. At the top left is a neutrophil (purple nucleus); center is a Monocyte-macrophage (orange nucleus); top right is a Lymphocyte (red nucleus); bottom left a Basophil (green nucleus); and bottom right an Eosinophil (yellow nucleus). These molecules are all part of a white blood cell count test. A white blood cell count is an important measure of this key component of the immune system; when the body is under attack, more WBCs are produced. White blood cells (also called leukocytes or WBCs) are in the front lines in the fight against harmful viruses, bacteria and even fungus. A white blood cell count is an important measure of this key component of the immune system; when the body is under attack, more WBCs are produced. Other factors, however, may also affect WBC counts, including allergies, chemotherapy, and other drugs, as well as leukemia.
Image by TheVisualMD
Medical Checkups
Image by TheVisualMD
Medical Checkups
Most doctors believe that people should have regular checkups as a part of preventive treatment. Regular health exams can help find problems before they begin, or in their early stages, when the chances of successful treatment are best.
Blood Pressure Reading: Photo Copyright 2005, James Gathany
Image by TheVisualMD
This browser does not support the video element.
Complete Blood Count, and Baselining Your Health
Video Topics : Our lifeblood consists of many components and a complete blood count (CBC) includes measurements of the fundamental elements. The largest categories are red and white blood cells (RBCs and WBCs) and cell fragments called platelets, which play roles in blood clotting. There are 20-30 trillion red blood cells in the body of an adult, each with a lifespan of about 100 days (RBCs contain an iron-containing protein called hemoglobin that enables them to carry oxygen to tissues throughout the body and then return carbon dioxide to the lungs). WBCs are in the front lines in the body's ongoing fight against harmful viruses, bacteria and even fungus; when a pathogen enters the body, WBCs mobilize in a coordinated defense response to eliminate, neutralize or mark the invader for destruction. The liquid portion of blood is called plasma and it carries nutrients, electrolytes, waste products, and hormones.
Video by TheVisualMD
Full Blood Count – what it tells your doctor about your health
Video by Pathology Tests Explained/YouTube
Complete Blood Count (CBC)
Video by Medicosis Perfectionalis/YouTube
Complete Blood Count
Video by Tom Wade MD/YouTube
high white blood cell count Video
Video by itbestshop/YouTube
Complete Blood Count pt1
Video by Med Immersion/YouTube
Complete Blood Count pt2
Video by Med Immersion/YouTube
This browser does not support the video element.
Normal Red Blood Cell (RBC) Count
An animation simulating a view of a healthy count of red blood cells as viewed in a slide projector or under a microscope. Initially, the screen in white with a circular black vignette along its borders. Then a still showing red blood cells slides up from the bottom left filling the screen and then comes into focus. The red blood cells resemble those taken from an scanning electron micrograph (SEM) and fill up the given space on the screen.
Video by TheVisualMD
This browser does not support the video element.
Anemic Blood Flow
Camera is stationary as it focuses on a capillary in a cell bed demonstrating anemic blood flow and it's lower red blood cell count.
Video by TheVisualMD
This browser does not support the video element.
Anemic Red Blood Cell (RBC) Count
An animation simulating a view of an unhealthy count of red blood cells as viewed in a slide projector or under a microscope. Initially, the screen in white with a circular black vignette along its borders. Then a still showing red blood cells on a light red background slides up from the bottom left filling the screen and then comes into focus. The red blood cells resemble those taken from an scanning electron micrograph (SEM). There are only a few red blood cells in this slide indicative of the low amount typical of some one who is anemic.
Video by TheVisualMD
This browser does not support the video element.
Anemic Red Blood Cell (RBC) Count
An animation simulating a close-up of an unhealthy count of red blood cells as viewed in a slide projector or under a microscope. Initially, the screen in white with a circular black vignette along its borders. Then a still showing red blood cells on a light red background slides up from the bottom left filling the screen and then comes into focus. Throughout the animation, the slide jitters a little. The red blood cells resemble those taken from an scanning electron micrograph (SEM). In this close up there are a few red blood cells along with a few white blood cells.
Video by TheVisualMD
Why Blood Tests Can Save Your Life
Video by Seeker+/YouTube
Introduction to lab values and normal ranges | Health & Medicine | Khan Academy
Video by khanacademymedicine/YouTube
Low blood counts and the risk of infection in cancer patients | Norton Cancer Institute
Video by Norton Healthcare/YouTube
Dr. Erba Describes Proper Diagnostic Testing of CML
Video by OncLiveTV/YouTube
Reticulocyte Count, Hemorrhage/Chronic Blood Loss
TheVisualMD
Blood sample
United States Marine Corps
Phlebotomy
MatthewLammers
Blood and Related Conditions
TheVisualMD
Components of Blood
TheVisualMD
Blood fractionation
Wheeler Cowperthwaite from Reno, USA
Whole Blood
Whoisjohngalt
White Blood Cells Rotation
TheVisualMD
Medical Checkups
TheVisualMD
Medical Checkups
TheVisualMD
2:12
Complete Blood Count, and Baselining Your Health
TheVisualMD
4:18
Full Blood Count – what it tells your doctor about your health
Pathology Tests Explained/YouTube
7:04
Complete Blood Count (CBC)
Medicosis Perfectionalis/YouTube
4:11
Complete Blood Count
Tom Wade MD/YouTube
8:22
high white blood cell count Video
itbestshop/YouTube
16:12
Complete Blood Count pt1
Med Immersion/YouTube
22:14
Complete Blood Count pt2
Med Immersion/YouTube
0:06
Normal Red Blood Cell (RBC) Count
TheVisualMD
0:07
Anemic Blood Flow
TheVisualMD
0:14
Anemic Red Blood Cell (RBC) Count
TheVisualMD
0:14
Anemic Red Blood Cell (RBC) Count
TheVisualMD
8:29
Why Blood Tests Can Save Your Life
Seeker+/YouTube
10:42
Introduction to lab values and normal ranges | Health & Medicine | Khan Academy
khanacademymedicine/YouTube
1:32
Low blood counts and the risk of infection in cancer patients | Norton Cancer Institute
Norton Healthcare/YouTube
2:39
Dr. Erba Describes Proper Diagnostic Testing of CML
OncLiveTV/YouTube
Red Blood Cells
Red Blood Cell (RBC) Count
Also called: Erythrocyte Count, RBC Count, Red Blood Count, Red Blood Cell Count, Red Count
A red blood cell (RBC) count is a blood test that measures the number of red blood cells in your blood. Red blood cells carry oxygen from your lungs to the rest of your body. An abnormal RBC count can be a sign of a serious health problem.
Red Blood Cell (RBC) Count
Also called: Erythrocyte Count, RBC Count, Red Blood Count, Red Blood Cell Count, Red Count
A red blood cell (RBC) count is a blood test that measures the number of red blood cells in your blood. Red blood cells carry oxygen from your lungs to the rest of your body. An abnormal RBC count can be a sign of a serious health problem.
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Use the slider below to see how your results affect your
health.
(10<sup>6</sup>)/μL
3.9
5.5
Your result is Low.
If your RBC count, hemoglobin, and hematocrit levels are low, you have anemia (a condition where the blood is unable to transport enough oxygen to the tissues and organs).
Related conditions
A red blood cell (RBC) count measures the number of red blood cells, also known as erythrocytes, in your blood. Red blood cells carry oxygen from your lungs to every cell in your body. Your cells need oxygen to grow, reproduce, and stay healthy. An RBC count that is higher or lower than normal is often the first sign of an illness. So the test may allow you to get treatment even before you have symptoms.
Other names: erythrocyte count, red count
A red blood cell (RBC) count is almost always part of a complete blood count, a group of tests that measure many different parts and features of your blood. The RBC measurement is used to help diagnose red blood cell disorders, such as anemia, a condition in which your body does not make enough healthy red blood cells.
You may get this test as part of a complete blood count, which is often included in a routine checkup. You may also need this test if you have symptoms of a low or high red blood cell count.
Symptoms of a low red blood cell count include:
Weakness
Fatigue
Pale skin
Rapid heartbeat
Symptoms of a high red blood cell count include:
Headache
Dizziness
Vision problems
A health care professional will take a blood sample from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial. You may feel a little sting when the needle goes in or out. This usually takes less than five minutes.
You don't need any special preparations for a red blood cell (RBC) count.
There is very little risk to having a blood test. There may be slight pain or bruising at the spot where the needle was put in, but most symptoms go away quickly.
Your results will show whether you have a normal red blood cell count or a count that is too low or too high.
A low red blood cell count can be a sign of:
Anemia
Leukemia, a type of blood cancer
Malnutrition, a condition in which your body does not get the calories, vitamins, and/or minerals needed for good health
Multiple myeloma, a cancer of the bone marrow
Kidney failure
It may also be a sign of pregnancy.
A high red blood cell count can be a sign of:
Dehydration
Heart disease
Polycythemia vera, a bone marrow disease that causes too many red blood cells to be made
Scarring of the lungs, often due to cigarette smoking
Lung disease
Kidney cancer
If you have questions about your results, talk to your health care provider.
If results showed you had a low or a high red blood cell count, you may need more tests to help make a diagnosis. These include:
Reticulocyte count, a test that counts the number of reticulocytes in the blood. Reticulocytes are red blood cells that are still developing. These are also known as immature red blood cells.
Iron tests, which measure iron levels in the blood. Iron is essential for making red blood cells.
Vitamin B test, which measures the amount of one or more B vitamins in the blood. B vitamins are important for making red blood cells.
Red Blood Cell (RBC) Count: MedlinePlus Medical Test [accessed on Jan 20, 2024]
RBC count: MedlinePlus Medical Encyclopedia [accessed on Jan 20, 2024]
Red Blood Cell Count (RBC) Test - Testing.com. Sep 27, 2022 [accessed on Jan 20, 2024]
Normal reference ranges can vary depending on the laboratory and the method used for testing. You must use the range supplied by the laboratory that performed your test to evaluate whether your results are "within normal limits."
Additional Materials (19)
Red blood cells
Red blood cells
Image by John Kalekos of Massachusetts image distribution for Science and Learning
Red Blood Cell
This image shows two red blood cells. The red blood cell is also called an erythrocyte: erythro is Greek for \"red,\" cyte is Latin for \"cell.\" The disc-shaped RBCs have the critical job of transporting oxygen from the lungs to the body's cells and bringing carbon dioxide from the cells back to the lungs to be expelled.
Image by TheVisualMD
Red Blood Cell in Capillary
The cardiovascular system is vast network of arteries, veins and vessels that would extend 60,000 miles if stretched end-to-end. All but a tiny fraction of this vessel network is invisible to the naked eye. The smallest capillaries (from latin "hairlike") are so narrow that red blood cells must pass through in single file. Higher than normal blood iron levels have been linked to heart disease and the reason is believed to be the oxidative stress the excess iron places on the walls of the blood vessels. It is the biological counterpart of rust. There are 20-30 trillion red blood cells (RBCs) in an adult's body. The life span of RBCs, which are produced in bone marrow, is about 100 days, which means that 2 million die (and are replaced) each second, but in that short lifetime they can make 75,000 round trips between lungs, heart and tissues in the body.
Image by TheVisualMD
Blood Smear Showing Reduced Red Blood Cell Count
Individual blood cells were first detected and described in the 17th century. Later, red blood cells (RBCs) were counted manually from a blood smear, a thin film of blood prepared on a glass slide and examined under a microscope (blood analysis is now automated, though smears are still used to detect visible abnormalities and to check or confirm the results of other tests). Anemia results when there are too few RBCs in circulation because they are being destroyed too quickly or produced too slowly. Anemia can be temporary or long term and range from mild to severe. Folate (also known as vitamin B9) is necessary for red blood cell production and the prevention of anemia, as well as the metabolism of carbohydrates. But folate also plays key roles in the synthesis and maintenance of DNA and is especially important in cell division and growth in fetal development (deficiencies of the vitamin in pregnancy is a common cause of birth defects). Pernicious anemia is a disorder in which the body's loses its ability to utilize folate and vitamin B12.
Image by TheVisualMD
Red Blood Cell (RBC)
There are 20-30 trillion red blood cells (RBCs) in an adult's body. The life span of RBCs, which are produced in bone marrow, is about 100 days, which means that 2 million die (and are replaced) each second. In their short lifetimes, however, red blood cells can make 75,000 round trips between lungs, heart and tissues in the body.
Image by TheVisualMD
Red Blood Cell
The RBC is disc-shaped and concave on both sides. The concave shape increases the cells' surface area, which allows them to distribute more oxygen to the body's cells. The shape also enables the cells to bunch together more compactly, helping them travel through the bloodstream more efficiently. Some RBCs are a bit thicker or thinner, wider or longer than others, but can change their shape to suit the demands of their environment. The cell membranes of the RBCs are protein meshes that give them flexibility, allowing them to navigate the twists and turns of the blood vessel network. The nearly 300 million hemoglobin molecules contained within each RBC easily move and slide past each other within the cell, adjusting their positions to conform to the RBC's shifting shape. Diameter : 7 μm
Image by TheVisualMD
Capillary Revealing Red Blood Cell
A portion of a capillary wall has been cut away to reveal the red blood cells flowing within.
Image by TheVisualMD
Red Blood Cell and White Blood Cell
Medical visualization of red blood cells and leukocytes.
Image by TheVisualMD
Blood Smear Showing Normal Red Blood Cell Count
Individual blood cells were first detected and described in the 17th century. Later, red blood cells were counted manually from a blood smear, a thin film of blood prepared on a glass slide and examined under a microscope. Blood analysis is now automated, though blood smears are still used to detect visible abnormalities and to check or confirm the results of other tests. There are normally between 4.2-5.8 million red blood cells per microliter (about a drop), which means there are 20-30 trillion red blood cells circulating through the body of an adult.
Image by TheVisualMD
Tubule of Nephron Revealing Many Red Blood Cell
This image shows the cut distal convoluted tubule of nephron with surrounding capillaries cut to reveal many red blood cells and healthy amounts of Erythopoeitin, EPO, (yellow particles). Erythropoeitin, EPO, is produced by the endothelial cells of the capillaries and the fibroblasts in the interstitial tissue surrounding the distal tubules. Normally, the kidneys produce EPO in response to low oxygen levels in order to stimulate red blood cell production in the bone marrow. A normal amount of red blood cells allows for the delivery of an adequate supply of oxygen.
Image by TheVisualMD
Red Blood Cell in Capillary
This image shows red blood cells traveling through capillaries, the smallest blood vessels in the body.
Image by TheVisualMD
Tubule of Nephron Revealing Few Red Blood Cell
Our kidneys are remarkable filters. Each day, they filter about 200 quarts of blood to extract about 2 quarts of wastes, which is then eliminated as urine. The kidneys' delicate filtration units are called nephrons; each kidney has about a million nephrons, and within each nephron are dense forests of tiny capillaries called glomeruli, which remove waste products from the blood while preventing the loss of other components, including proteins, electrolytes and blood cells. The glomerular filtration rate is the amount of blood that is filtered by the glomeruli per minute.
Image by TheVisualMD
This browser does not support the video element.
Complete Blood Count, and Baselining Your Health
Video Topics : Our lifeblood consists of many components and a complete blood count (CBC) includes measurements of the fundamental elements. The largest categories are red and white blood cells (RBCs and WBCs) and cell fragments called platelets, which play roles in blood clotting. There are 20-30 trillion red blood cells in the body of an adult, each with a lifespan of about 100 days (RBCs contain an iron-containing protein called hemoglobin that enables them to carry oxygen to tissues throughout the body and then return carbon dioxide to the lungs). WBCs are in the front lines in the body's ongoing fight against harmful viruses, bacteria and even fungus; when a pathogen enters the body, WBCs mobilize in a coordinated defense response to eliminate, neutralize or mark the invader for destruction. The liquid portion of blood is called plasma and it carries nutrients, electrolytes, waste products, and hormones.
Video by TheVisualMD
Red Blood Cell (RBC) Indices (Anemia Labs)
Video by Nursing School Explained/YouTube
WellnessFX: Red Blood Cell Indices Part 1 with Bryan Walsh
Video by WellnessFX/YouTube
WellnessFX: Red Blood Cell Indices Part 2 with Bryan Walsh
Video by WellnessFX/YouTube
Red Blood Cells Nursing Considerations, Normal Range, Nursing Care, Lab Values Nursing
Video by NURSINGcom/YouTube
This browser does not support the video element.
Flowing Red Blood Cell (RBC)
Animation of red blood cells flowoing quicly through a blood vessel. The camera is positioned in the lumen of the vessel and the rbc's are flowing towards the viewer. The rbc and and lumen are rendered with muted colors to give it a softer look.
Video by TheVisualMD
This browser does not support the video element.
Red Blood Cell Development
This video explains red blood cell development, following a pluripotent stem cell to red blood cell.
Video by TheVisualMD
Red blood cells
John Kalekos of Massachusetts image distribution for Science and Learning
Red Blood Cell
TheVisualMD
Red Blood Cell in Capillary
TheVisualMD
Blood Smear Showing Reduced Red Blood Cell Count
TheVisualMD
Red Blood Cell (RBC)
TheVisualMD
Red Blood Cell
TheVisualMD
Capillary Revealing Red Blood Cell
TheVisualMD
Red Blood Cell and White Blood Cell
TheVisualMD
Blood Smear Showing Normal Red Blood Cell Count
TheVisualMD
Tubule of Nephron Revealing Many Red Blood Cell
TheVisualMD
Red Blood Cell in Capillary
TheVisualMD
Tubule of Nephron Revealing Few Red Blood Cell
TheVisualMD
2:12
Complete Blood Count, and Baselining Your Health
TheVisualMD
7:45
Red Blood Cell (RBC) Indices (Anemia Labs)
Nursing School Explained/YouTube
33:35
WellnessFX: Red Blood Cell Indices Part 1 with Bryan Walsh
WellnessFX/YouTube
28:05
WellnessFX: Red Blood Cell Indices Part 2 with Bryan Walsh
WellnessFX/YouTube
3:01
Red Blood Cells Nursing Considerations, Normal Range, Nursing Care, Lab Values Nursing
NURSINGcom/YouTube
0:12
Flowing Red Blood Cell (RBC)
TheVisualMD
0:31
Red Blood Cell Development
TheVisualMD
White Blood Cells
White Blood Count (WBC)
Also called: WBC, WBC Blood Test, White Blood Count, White Blood Cell Count, Leukocyte Count, Leukopenia Test, Leukocytosis Test
A white blood count measures the number of white cells in your blood. White blood cells are part of the immune system. A count that is too high or too low can indicate an infection, immune system disorder, or another health problem.
White Blood Count (WBC)
Also called: WBC, WBC Blood Test, White Blood Count, White Blood Cell Count, Leukocyte Count, Leukopenia Test, Leukocytosis Test
A white blood count measures the number of white cells in your blood. White blood cells are part of the immune system. A count that is too high or too low can indicate an infection, immune system disorder, or another health problem.
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A low white blood cell count, called leukopenia, can result from a number of conditions and diseases, such as immune deficiencies, severe infections, and bone marrow disorders, among others.
Related conditions
A white blood count measures the number of white cells in your blood. White blood cells are part of the immune system. They help your body fight off infections and other diseases.
When you get sick, your body makes more white blood cells to fight the bacteria, viruses, or other foreign substances causing your illness. This increases your white blood count.
Other diseases can cause your body to make fewer white blood cells than you need. This lowers your white blood count. Diseases that can lower your white blood count include some types of cancer and HIV/AIDS, a viral disease that attacks white blood cells. Certain medicines, including chemotherapy, may also lower the number of your white blood cells.
There are five major types of white blood cells:
Neutrophils
Lymphocytes
Monocytes
Eosinophils
Basophils
A white blood count measures the total number of these cells in your blood. Another test, called a blood differential, measures the amount of each type of white blood cell.
Other names: WBC count, white cell count, white blood cell count
A white blood count is most often used to help diagnose disorders related to having a high white blood cell count or low white blood cell count.
Disorders related to having a high white blood count include:
Autoimmune and inflammatory diseases, conditions that cause the immune system to attack healthy tissues
Bacterial or viral infections
Cancers such as leukemia and Hodgkin disease
Allergic reactions
Disorders related to having a low white blood count include:
Diseases of the immune system, such as HIV/AIDS
Lymphoma, a cancer of the bone marrow
Diseases of the liver or spleen
A white blood count can show if the number of your white blood cells is too high or too low, but it can't confirm a diagnosis. So it is usually done along with other tests, such as a complete blood count, blood differential, blood smear, and/or bone marrow test.
You may need this test if you have signs of an infection, inflammation, or autoimmune disease. Symptoms of infection include:
Fever
Chills
Body aches
Headache
Symptoms of inflammation and autoimmune diseases will be different, depending on the area of inflammation and type of disease.
You may also need this test if you have a disease that weakens your immune system or are taking medicine that lowers your immune response. If the test shows your white blood count is getting too low, your provider may be able to adjust your treatment.
Your newborn or older child may also be tested as part of a routine screening, or if they have symptoms of a white blood cell disorder.
A health care professional will take a blood sample from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial. You may feel a little sting when the needle goes in or out.
To test children, a health care provider will take a sample from the heel (newborns and young babies) or the fingertip (older babies and children). The provider will clean the heel or fingertip with alcohol and poke the site with a small needle. The provider will collect a few drops of blood and put a bandage on the site.
You don't need any special preparations for a white blood count.
After a blood test, you may have slight pain or bruising at the spot where the needle was put in, but most symptoms go away quickly.
There is very little risk to your baby or child with a needle stick test. Your child may feel a little pinch when the site is poked, and a small bruise may form at the site. This should go away quickly.
A high white blood count may mean you have one of the following conditions:
A bacterial or viral infection
An inflammatory disease such as rheumatoid arthritis
An allergy
Leukemia or Hodgkin disease
Tissue damage from a burn injury or surgery
A low white blood count may mean you have one of the following conditions:
Bone marrow damage. This may be caused by infection, disease, or treatments such as chemotherapy.
Cancers that affect the bone marrow
An autoimmune disorder, such as lupus (or SLE)
HIV/AIDS
If you are already being treated for a white blood cell disorder, your results may show if your treatment is working or whether your condition has improved.
If you have questions about your results, talk to your health care provider.
White blood count results are often compared with results of other blood tests, including a blood differential. A blood differential test shows the amount of each type of white blood cell, such as neutrophils or lymphocytes. Neutrophils mostly target bacterial infections. Lymphocytes mostly target viral infections.
A higher than normal amount of neutrophils is known as neutrophilia.
A lower than normal amount is known as neutropenia.
A higher than normal amount of lymphocytes is known as lymphocytosis.
A lower normal amount is known as lymphopenia.
White Blood Count (WBC): MedlinePlus Medical Test [accessed on Jan 20, 2024]
WBC count: MedlinePlus Medical Encyclopedia [accessed on Jan 20, 2024]
White Blood Cell Count (WBC Blood Test) - Testing.com. Sep 28, 2022 [accessed on Jan 20, 2024]
Normal reference ranges can vary depending on the laboratory and the method used for testing. You must use the range supplied by the laboratory that performed your test to evaluate whether your results are "within normal limits."
Additional Materials (37)
White Blood Cell Count: Bone Marrow
Disease or damage to the bone marrow, caused by infection, cancer, radiation treatment, or chemotherapy can lower white blood cell count by impairing the marrow's ability to produce new white blood cells.
Image by TheVisualMD
White Blood Cells, Bone Marrow
Bone marrow is constantly producing blood cells, including white blood cells and red blood cells as well platelets, which are cell fragments important for blood clotting. Disease and disorders of the bone marrow can, in turn, affect the production of blood cells. Both cancer and cancer treatment (chemotherapy and radiation) can also have an impact on the bone marrow's ability to produce blood cells.
Image by TheVisualMD
This browser does not support the video element.
Complete Blood Count, and Baselining Your Health
Video Topics : Our lifeblood consists of many components and a complete blood count (CBC) includes measurements of the fundamental elements. The largest categories are red and white blood cells (RBCs and WBCs) and cell fragments called platelets, which play roles in blood clotting. There are 20-30 trillion red blood cells in the body of an adult, each with a lifespan of about 100 days (RBCs contain an iron-containing protein called hemoglobin that enables them to carry oxygen to tissues throughout the body and then return carbon dioxide to the lungs). WBCs are in the front lines in the body's ongoing fight against harmful viruses, bacteria and even fungus; when a pathogen enters the body, WBCs mobilize in a coordinated defense response to eliminate, neutralize or mark the invader for destruction. The liquid portion of blood is called plasma and it carries nutrients, electrolytes, waste products, and hormones.
Video by TheVisualMD
The Immune System Explained I – Bacteria Infection
Video by Kurzgesagt – In a Nutshell/YouTube
Immune Response to Bacteria
Video by NIAID/YouTube
Immunology - Adaptive Immune System
Video by Armando Hasudungan/YouTube
Immune System - Natural Killer Cell
Video by Kyle Thornthwaite/YouTube
Your Immune System: Natural Born Killer - Crash Course Biology #32
Video by CrashCourse/YouTube
White Blood Cell and Red Blood Cell
Medical visualization of blood cells. Depicted are numerous red blood cells and a single white blood cell.
Image by TheVisualMD
White Blood Cell and Red Blood Cell
Medical visualization of blood cells. Depicted are numerous red blood cells and a single white blood cell.
Image by TheVisualMD
Red Blood Cell and White Blood Cell
Visualization of red blood cells and a white blood cell
Image by TheVisualMD
Sensitive content
This media may include sensitive content
Blood cells (from left to right: erythrocyte, thrombocyte, leukocyte)
A single drop of blood contains millions of red blood cells, white blood cells, and platelets. One of each type is shown here, isolated from a scanning electron micrograph.
Image by Electron Microscopy Facility at The National Cancer Institute at Frederick (NCI-Frederick)
Bone structure
Anatomy of the bone. The bone is made up of compact bone, spongy bone, and bone marrow. Compact bone makes up the outer layer of the bone. Spongy bone is found mostly at the ends of bones and contains red marrow. Bone marrow is found in the center of most bones and has many blood vessels. There are two types of bone marrow: red and yellow. Red marrow contains blood stem cells that can become red blood cells, white blood cells, or platelets. Yellow marrow is made mostly of fat.
Image by Smart Servier website
Blood Cells
Formed Elements of Blood
Image by Blausen.com staff (2014). \"Medical gallery of Blausen Medical 2014\"
Phagocytosis - C-reactive protein (CRP) is a substance made by the liver that is released into the bloodstream by inflammation and infection as part of the body's immune response.
C-reactive protein (CRP) is a substance made by the liver that is released into the bloodstream by inflammation and infection as part of the body's immune response. White blood cells are also mobilized by the immune system and CRP is believed to enhance the activity of the white blood cells called macrophages. Each type of white blood cell has its own specialized immune functions; macrophages, for example, basically engulf and \"eat\" foreign invaders such as bacteria, viruses and fungi. Macrophages in the spleen and the liver weed out old and defective red blood cells and break them into recyclables (iron, heme, and some globin) and wastes (such as bilirubin). The bilirubin is then used by the liver to produce bile, which is stored in the gallbladder and released into the small intestine to aid digestion.
Image by TheVisualMD
White blood cells
Immune cells surrounding hair follicles in mouse skin. These hair follicles are home to a diverse array of commensal bacteria.
Image by NIAID
Neutrophil
Neutrophil function, relationship to disease, and location in the human body. Credit: NIAID
Image by NIAID
Innate immune system
Image by US Gov
Macrophage Capturing Foreign Antigen
Cell-mediated immunity is an immune response that does not involve antibodies or complement but rather involves the activation of macrophages, natural killer cells (NK), antigen-specific cytotoxic T-lymphocytes, and the release of various cytokines in response to an antigen. Macrophages are white blood cells that engulf and digest cellular debris and pathogens
Image by TheVisualMD
Mast Cell
Mast cells produce histamine. Histamine is known for its role in inflammation. It affects a variety of behavior patterns including the sleep-wake cycle and food intake. Antihistamines may work at odds with inflammation and depression.
Image by TheVisualMD
Leukocytes
Image by OpenStax College
Innate immune system
Illustration of the Innate Immune System responding to injury.
Image by OpenStax College
Eosinophilia
Drawing of an eosinophil white blood cell
Image by Iceclanl
Two neutrophils among many red blood cells. Neutrophils are one type of cell affected by chronic granulomatous disease.
Image by Uploaded by Mgiganteus
Eosinophils
Eosinophil function, relationship to disease, and location in the human body.
Image by NIAID
Sensitive content
This media may include sensitive content
Blood Cells
This is a scanning electron microscope image from normal circulating human blood. One can see red blood cells, several white blood cells including lymphocytes, amonocyte, a neutrophil, and many small disc-shaped platelets. Red cells are nonnucleated and contain hemoglobin, an important protein that contains iron and allows the cell to carry oxygen to other parts of the body. They also carry carbon dioxide away from peripheral tissue to the lungs where it can be exhaled. The infection-fighting white blood cells are classified in two main groups: granular and agranular. All blood cells are formed in the bone marrow. There are two types of agranulocytes: lymphocytes, which fight disease by producing antibodies and thus destroying foreign material, and monocytes. Platelets are tiny cells formed in bone marrow and are necessary for blood clotting.
Image by Bruce Wetzel (photographer). Harry Schaefer (photographer), National Cancer Institute
Immune System and Autoimmune Diseases
Normally, an individual's immune system learns to identify and ignore all of the distinctive little structures found on that individual's own cells. Sometimes, however, it will make a mistake and identify its own body as foreign. If that happens, the immune system produces antibodies that attempt to destroy the body's own cells in the same way it would try to destroy a foreign invader.
Image by TheVisualMD
Eosinophils
Drawing of an eosinophil white blood cell
Image by BruceBlaus
Eosinophils
On the left there is a segmented polymorphonuclear neutrophil, on the right and below is one eosinophil leucocyte. For comparison the red blood cell have a diameter of 7-8 micrometers. The picture was taken with a Nikon Eclipse 600 microscope, magnification was 1000x.
Image by Davidcsaba Dr. David Csaba L.
Neutrophil action - Inflammation
Neutrophil granulocyte migrates from the blood vessel to the matrix, secreting proteolytic enzymes, in order to dissolve intercellular connections (for improvement of its mobility) and envelop bacteria through Phagocytosis.
Image by Uwe Thormann/Wikimedia
Neutrophil
Image by BruceBlaus
White Blood Cells
A type of immune cell. Most white blood cells are made in the bone marrow and are found in the blood and lymph tissue. White blood cells help the body fight infections and other diseases. Granulocytes, monocytes, and lymphocytes are white blood cells.
Image by Blausen.com staff (2014). "Medical gallery of Blausen Medical 2014"
high white blood cell count Video
Video by itbestshop/YouTube
What Are White Blood Cells | Health | Biology | FuseSchool
Video by FuseSchool - Global Education/YouTube
Learning to Decode Your Blood Test Results for Chronic Lymphocytic Leukemia (CLL)
Video by CLL Society/YouTube
WellnessFX: White Blood Cells And Differential with Bryan Walsh
Video by WellnessFX/YouTube
White Blood Count
White Blood Count
Image by TheVisualMD
White Blood Cell Count: Bone Marrow
TheVisualMD
White Blood Cells, Bone Marrow
TheVisualMD
2:12
Complete Blood Count, and Baselining Your Health
TheVisualMD
6:49
The Immune System Explained I – Bacteria Infection
Kurzgesagt – In a Nutshell/YouTube
1:47
Immune Response to Bacteria
NIAID/YouTube
14:59
Immunology - Adaptive Immune System
Armando Hasudungan/YouTube
3:02
Immune System - Natural Killer Cell
Kyle Thornthwaite/YouTube
15:02
Your Immune System: Natural Born Killer - Crash Course Biology #32
CrashCourse/YouTube
White Blood Cell and Red Blood Cell
TheVisualMD
White Blood Cell and Red Blood Cell
TheVisualMD
Red Blood Cell and White Blood Cell
TheVisualMD
Sensitive content
This media may include sensitive content
Blood cells (from left to right: erythrocyte, thrombocyte, leukocyte)
Electron Microscopy Facility at The National Cancer Institute at Frederick (NCI-Frederick)
Bone structure
Smart Servier website
Blood Cells
Blausen.com staff (2014). \"Medical gallery of Blausen Medical 2014\"
Phagocytosis - C-reactive protein (CRP) is a substance made by the liver that is released into the bloodstream by inflammation and infection as part of the body's immune response.
TheVisualMD
White blood cells
NIAID
Neutrophil
NIAID
Innate immune system
US Gov
Macrophage Capturing Foreign Antigen
TheVisualMD
Mast Cell
TheVisualMD
Leukocytes
OpenStax College
Innate immune system
OpenStax College
Eosinophilia
Iceclanl
Two neutrophils among many red blood cells. Neutrophils are one type of cell affected by chronic granulomatous disease.
Uploaded by Mgiganteus
Eosinophils
NIAID
Sensitive content
This media may include sensitive content
Blood Cells
Bruce Wetzel (photographer). Harry Schaefer (photographer), National Cancer Institute
Immune System and Autoimmune Diseases
TheVisualMD
Eosinophils
BruceBlaus
Eosinophils
Davidcsaba Dr. David Csaba L.
Neutrophil action - Inflammation
Uwe Thormann/Wikimedia
Neutrophil
BruceBlaus
White Blood Cells
Blausen.com staff (2014). "Medical gallery of Blausen Medical 2014"
8:22
high white blood cell count Video
itbestshop/YouTube
3:12
What Are White Blood Cells | Health | Biology | FuseSchool
FuseSchool - Global Education/YouTube
1:17:17
Learning to Decode Your Blood Test Results for Chronic Lymphocytic Leukemia (CLL)
CLL Society/YouTube
16:52
WellnessFX: White Blood Cells And Differential with Bryan Walsh
A platelet count test measures the number of platelets in your blood. Platelets, also known as thrombocytes, are small blood cells that are essential for blood clotting. Platelets may be counted to monitor or diagnose diseases, or to look for the cause of too much bleeding or clotting.
A platelet count test measures the number of platelets in your blood. Platelets, also known as thrombocytes, are small blood cells that are essential for blood clotting. Platelets may be counted to monitor or diagnose diseases, or to look for the cause of too much bleeding or clotting.
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Use the slider below to see how your results affect your
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(10³)/μL
50
150
450
Your result is Very low.
A lower-than-normal platelet count is called thrombocytopenia. This condition can cause you to bleed too much after a cut or other injury that causes bleeding. If your platelet count is very low, your risk for bleeding is higher. Even every day activities can cause bleeding. Thrombocytopenia can be life-threatening, especially if you have serious bleeding or bleeding in your brain.
Related conditions
Platelets, also known as thrombocytes, are small blood cells that are essential for blood clotting. Clotting is the process that helps you stop bleeding after an injury. There are two types of platelet tests: a platelet count test and platelet function tests.
A platelet count test measures the number of platelets in your blood. A lower than normal platelet count is called thrombocytopenia. This condition can cause you to bleed too much after a cut or other injury that causes bleeding. A higher than normal platelet count is called thrombocytosis. This can make your blood clot more than you need it to. Blood clots can be dangerous because they can block blood flow.
Other names: platelet count, thrombocyte count
A platelet count is most often used to monitor or diagnose conditions that cause too much bleeding or too much clotting. A platelet count may be included in a complete blood count, a test that is often done as part of a regular checkup.
You may need platelet count testing if you have symptoms of having too few or too many platelets.
Symptoms of too few platelets include:
Prolonged bleeding after a minor cut or injury
Nosebleeds
Unexplained bruising
Pinpoint sized red spots on the skin, known as petechiae
Purplish spots on the skin, known as purpura. These may be caused by bleeding under the skin.
Heavy and/or prolonged menstrual periods
Symptoms of too many platelets include:
Numbness of hands and feet
Headache
Dizziness
Weakness
Most platelet tests are done on a blood sample.
During the test, a health care professional will take a blood sample from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial. You may feel a little sting when the needle goes in or out. This usually takes less than five minutes.
You don't need any special preparations for a platelet count test.
There is very little risk to having a blood test. You may have slight pain or bruising at the spot where the needle was put in, but most symptoms go away quickly.
If your results show a lower than normal platelet count (thrombocytopenia), it may indicate:
A cancer that affects the blood, such as leukemia or lymphoma
A viral infection, such as mononucleosis, hepatitis, or measles
An autoimmune disease. This is a disorder that causes the body to attack its own healthy tissues, which can include platelets.
Infection or damage to the bone marrow
Cirrhosis
Vitamin B12 deficiency
Gestational thrombocytopenia, a common, but mild, low-platelet condition affecting pregnant women. It is not known to cause any harm to a mother or her unborn baby. It usually gets better on its own during pregnancy or after birth.
If your results show a higher than normal platelet count (thrombocytosis), it may indicate:
Certain types of cancer, such as lung cancer or breast cancer
Anemia
Inflammatory bowel disease
Rheumatoid arthritis
A viral or bacterial infection
Platelet Tests: MedlinePlus Medical Test [accessed on Jan 20, 2024]
Platelet Count (PLT) Blood Test - Testing.com. Dec 19, 2023 [accessed on Jan 20, 2024]
Platelet count: MedlinePlus Medical Encyclopedia [accessed on Jan 20, 2024]
Normal reference ranges can vary depending on the laboratory and the method used for testing. You must use the range supplied by the laboratory that performed your test to evaluate whether your results are "within normal limits."
Additional Materials (8)
Platelet Development
Illustration of Platelet Development
Image by OpenStax College
Sensitive content
This media may include sensitive content
Platelet Disorders
From left to right: erythrocyte, thrombocyte, leukocyte
Image by Electron Microscopy Facility at The National Cancer Institute at Frederick (NCI-Frederick)
Scheme of a blood sample after centrifugation
scheme of a blood sample after centrifugation
Image by KnuteKnudsen (talk)
Decode Your Blood Test: Platelets 💉 | Merck Manual Consumer Version
Video by Merck Manuals/YouTube
This browser does not support the video element.
Complete Blood Count, and Baselining Your Health
Video Topics : Our lifeblood consists of many components and a complete blood count (CBC) includes measurements of the fundamental elements. The largest categories are red and white blood cells (RBCs and WBCs) and cell fragments called platelets, which play roles in blood clotting. There are 20-30 trillion red blood cells in the body of an adult, each with a lifespan of about 100 days (RBCs contain an iron-containing protein called hemoglobin that enables them to carry oxygen to tissues throughout the body and then return carbon dioxide to the lungs). WBCs are in the front lines in the body's ongoing fight against harmful viruses, bacteria and even fungus; when a pathogen enters the body, WBCs mobilize in a coordinated defense response to eliminate, neutralize or mark the invader for destruction. The liquid portion of blood is called plasma and it carries nutrients, electrolytes, waste products, and hormones.
Video by TheVisualMD
Platelets Nursing Considerations, Normal Range, Nursing Care, Lab Values Nursing
Video by NURSINGcom/YouTube
Platelets Explained in Two Minutes
Video by American Red Cross/YouTube
The life and times of RBCs and platelets
Video by khanacademymedicine/YouTube
Platelet Development
OpenStax College
Sensitive content
This media may include sensitive content
Platelet Disorders
Electron Microscopy Facility at The National Cancer Institute at Frederick (NCI-Frederick)
Scheme of a blood sample after centrifugation
KnuteKnudsen (talk)
0:48
Decode Your Blood Test: Platelets 💉 | Merck Manual Consumer Version
Merck Manuals/YouTube
2:12
Complete Blood Count, and Baselining Your Health
TheVisualMD
3:54
Platelets Nursing Considerations, Normal Range, Nursing Care, Lab Values Nursing
NURSINGcom/YouTube
1:47
Platelets Explained in Two Minutes
American Red Cross/YouTube
10:35
The life and times of RBCs and platelets
khanacademymedicine/YouTube
Hemoglobin
Hemoglobin Blood Test
Also called: Hemoglobin, Hgb
A hemoglobin test measures the levels of hemoglobin in your blood. Hemoglobin is an iron-rich protein in red blood cells that carries oxygen. Abnormal levels may mean you have anemia or another blood disorder.
Hemoglobin Blood Test
Also called: Hemoglobin, Hgb
A hemoglobin test measures the levels of hemoglobin in your blood. Hemoglobin is an iron-rich protein in red blood cells that carries oxygen. Abnormal levels may mean you have anemia or another blood disorder.
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Use the slider below to see how your results affect your
health.
g/dL
13.8
17.2
Your result is Low.
Low levels of hemoglobin indicate that there is a shortage of red blood cells; this can be the result of RBCs being lost or destroyed too quickly or produced too slowly.
Related conditions
A hemoglobin test measures the levels of hemoglobin in your blood. Hemoglobin is a protein in your red blood cells that carries oxygen from your lungs to the rest of your body. If your hemoglobin levels are abnormal, it may be a sign that you have a blood disorder.
Other names: Hb, Hgb
A hemoglobin test is often used to check for anemia, a condition in which your body has fewer red blood cells than normal. If you have anemia, the cells in your body don't get all the oxygen they need. Hemoglobin tests are measured as part of a complete blood count (CBC).
Your health care provider may order the test as part of a routine exam, or if you have:
Symptoms of anemia, which include weakness, dizziness, and cold hands and feet
A family history of thalassemia, sickle cell anemia, or other inherited blood disorder
A diet low in iron and other minerals
A long-term infection
Excessive blood loss from an injury or surgical procedure
A health care professional will take a blood sample from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial. You may feel a little sting when the needle goes in or out. This usually takes less than five minutes.
You don't need any special preparation for a hemoglobin test. If your health care provider has ordered other tests on your blood sample, you may need to fast (not eat or drink) for several hours before the test. Your health care provider will let you know if there are any special instructions to follow.
There is very little risk to having a blood test. After the test, some people experience mild pain, dizziness, or bruising. These symptoms usually go away quickly.
There are many reasons your hemoglobin levels may not be in the normal range.
Low hemoglobin levels may be a sign of:
Different types of anemia
Thalassemia
Iron deficiency
Liver disease
Cancer and other diseases
High hemoglobin levels may be a sign of:
Lung disease
Heart disease
Polycythemia vera, a disorder in which your body makes too many red blood cells. It can cause headaches, fatigue, and shortness of breath.
If any of your levels are abnormal, it doesn't always mean you have a medical condition that needs treatment. Diet, activity level, medicines, a menstrual period, and other factors can affect the results. You may also have higher than normal hemoglobin levels if you live in a high altitude area. Talk with your provider to learn what your results mean.
Some forms of anemia are mild, while other types of anemia can be serious and even life threatening if not treated. If you are diagnosed with anemia, be sure to talk to your health care provider to find out the best treatment plan for you.
Hemoglobin Test: MedlinePlus Medical Test [accessed on Jan 20, 2024]
Hemoglobin: MedlinePlus Medical Encyclopedia [accessed on Jan 20, 2024]
Hemoglobin - Health Encyclopedia - University of Rochester Medical Center [accessed on Jan 20, 2024]
Normal reference ranges can vary depending on the laboratory and the method used for testing. You must use the range supplied by the laboratory that performed your test to evaluate whether your results are "within normal limits."
Additional Materials (16)
Hemoglobin | Human anatomy and physiology | Health & Medicine | Khan Academy
Video by Khan Academy/YouTube
Blood, Part 2 - There Will Be Blood: Crash Course A&P #30
Video by CrashCourse/YouTube
Haemoglobin
Video by Wellcome Trust/YouTube
Hemoglobin A1c & Diabetes
Video by DiabeTV/YouTube
Hemoglobin Molecule
Molecule of hemoglobin.
Image by TheVisualMD
Hemoglobin A1C Molecule
Hemoglobin is a protein found inside red blood cells that carries oxygen from the lungs to cells throughout the body. Hemoglobin also binds with glucose. Diabetics have too much glucose in the bloodstream and this extra glucose binds (or glycates) with hemoglobin. Glycated hemoglobin usually stays glycated for the life of the red blood cell (about 3 months). Therefore, the percentage of hemoglobin that is glycated (measured as A1C) reflects glucose levels that have affected red blood cells up to 3 months in the past. The hemoglobin A1C test measures the percentage of hemoglobin bound to blood sugar (glucose); the test is used to diagnose type 1 and type 2 diabetes. Because the test results reflect average blood sugar levels over a period of 2-3 months (rather than daily fluctuations), the hemoglobin A1C test is also used to gauge how well patients are managing their diabetes over time.
Image by TheVisualMD
Hemoglobin A1C: Red Blood Cells
Red blood cells use the iron-rich protein hemoglobin to carry oxygen from the lungs to cells throughout the body and return carbon dioxide to the lungs. The percentage of hemoglobin bound to blood glucose (hemoglobin A1C) is used to diagnose diabetes.
Image by TheVisualMD
Hemoglobin of Red Blood Cell
Hemoglobin is an iron-containing protein found in red blood cells that binds oxygen and carbon dioxide for transport and delivery to different parts of the body.
Image by TheVisualMD
Hemoglobin Molecule
Hemoglobin is an iron-rich protein that is packed inside RBCs. It is a structurally complex molecule that can change shape to either hold or release oxygen, depending on the body's need. There are close to 300 million hemoglobin molecules within each RBC.
Image by TheVisualMD
Hemoglobin Molecule Heme Group
A heme group in a hemoglobin molecule consists of an iron atom bound equally to four nitrogen atoms, all lying in one plane. The iron atom is the site of oxygen binding.
Image by TheVisualMD
This browser does not support the video element.
Hemoglobin Within Red Blood Cell (RBC)
A red blood cell rushes toward the camera, the camera enters the cell to focus on all of the hemoglobin molecules within
Video by TheVisualMD
Hemoglobin, Carbon Monoxide
Hemoglobin is an iron-containing protein that enables red blood cells to deliver oxygen from the lungs to cells throughout the body. But the same binding site on the hemoglobin molecule has an even stronger affinity for carbon monoxide, which is why we are so susceptible to poisoning by this deadly gas; carbon monoxide grabs all the binding sites and starves the body's tissues of oxygen
Image by TheVisualMD
This browser does not support the video element.
Hemoglobin A1c
The hemoglobin A1c test measures the percentage of hemoglobin bound to blood sugar (glucose); the test is used to diagnose type 1 and type 2 diabetes. Because the test results reflect average blood sugar levels over a period of 2-3 months (rather than daily fluctuations), the hemoglobin A1C test is also used to gauge how well patients are managing their diabetes over time.
Video by TheVisualMD
Hemoglobin A1c
The hemoglobin A1c test measures the percentage of hemoglobin bound to blood sugar (glucose); the test is used to diagnose type 1 and type 2 diabetes. Because the test results reflect average blood sugar levels over a period of 2-3 months (rather than daily fluctuations), the hemoglobin A1C test is also used to gauge how well patients are managing their diabetes over time.
Image by TheVisualMD
Hemoglobin: O2 Binding Hemoglobin
Hemoglobin normally binds to life-sustaining oxygen. But the same binding site on the hemoglobin molecule has an even stronger affinity for carbon monoxide, which is why we are so susceptible to poisoning by this deadly gas.
Image by TheVisualMD
HemoglobinA1C
Hemoglobin Test for O2 Binding Hemoglobin : A hemoglobin test is a measurement of your blood's oxygen-carrying capacity. High levels of hemoglobin can be the result of dehydration, lung disease and other conditions. Low levels of hemoglobin indicate that there is a shortage of red blood cells; this can be the result of RBCs being lost or destroyed too quickly or produced too slowly. Hemoglobin is an iron-containing protein that enables red blood cells to deliver oxygen from the lungs to cells throughout the body. But the same binding site on the hemoglobin molecule has an even stronger affinity for carbon monoxide, which is why we are so susceptible to poisoning by this deadly gas; carbon monoxide grabs all the binding sites and starves the body's tissues of oxygen.
Image by TheVisualMD
14:34
Hemoglobin | Human anatomy and physiology | Health & Medicine | Khan Academy
Khan Academy/YouTube
10:01
Blood, Part 2 - There Will Be Blood: Crash Course A&P #30
CrashCourse/YouTube
5:31
Haemoglobin
Wellcome Trust/YouTube
1:43
Hemoglobin A1c & Diabetes
DiabeTV/YouTube
Hemoglobin Molecule
TheVisualMD
Hemoglobin A1C Molecule
TheVisualMD
Hemoglobin A1C: Red Blood Cells
TheVisualMD
Hemoglobin of Red Blood Cell
TheVisualMD
Hemoglobin Molecule
TheVisualMD
Hemoglobin Molecule Heme Group
TheVisualMD
0:27
Hemoglobin Within Red Blood Cell (RBC)
TheVisualMD
Hemoglobin, Carbon Monoxide
TheVisualMD
0:27
Hemoglobin A1c
TheVisualMD
Hemoglobin A1c
TheVisualMD
Hemoglobin: O2 Binding Hemoglobin
TheVisualMD
HemoglobinA1C
TheVisualMD
Hematocrit
Hematocrit Blood Test
Also called: Hematrocit, HCT, Crit, Packed Cell Volume, PCV
Hematocrit is a blood test that measures how much of a person's blood is made up of red blood cells. Hematocrit levels that are too high or too low can be a sign of a blood disorder, dehydration, or other medical conditions that affect your blood.
Hematocrit Blood Test
Also called: Hematrocit, HCT, Crit, Packed Cell Volume, PCV
Hematocrit is a blood test that measures how much of a person's blood is made up of red blood cells. Hematocrit levels that are too high or too low can be a sign of a blood disorder, dehydration, or other medical conditions that affect your blood.
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Use the slider below to see how your results affect your
health.
%
40.7
50.3
Your result is Low.
A hematocrit level below the normal range, meaning the person has too few red blood cells, is called anemia.
Related conditions
A hematocrit test is a blood test that measures how much of your blood is made up of red blood cells. Red blood cells carry oxygen from your lungs to the rest of your body. The other parts of your blood include white blood cells (to help fight infection), platelets (to help make blood clots to stop bleeding), and a liquid called plasma.
Hematocrit levels that are too high or too low can be a sign of a blood disorder, dehydration, or other medical conditions that affect your blood.
Other names: HCT, packed cell volume, PCV, Crit; H and H (Hemoglobin and Hematocrit)
A hematocrit test is often part of a complete blood count (CBC). A CBC is a common blood test that measures the different parts of your blood. It is used to check your general health. It may also be used to help diagnose blood disorders, including anemia, a condition in which you don't have enough red blood cells, and polycythemia, an uncommon disorder in which you have too many red blood cells and your blood becomes too thick.
Your health care provider may order a hematocrit test as part of your regular checkup or to monitor your health if you are being treated for cancer or have an ongoing health condition. Your provider may also order this test if you have symptoms of a red blood cell disorder, such as anemia or polycythemia:
Symptoms of anemia (too few red blood cells) may include:
Shortness of breath
Weakness or fatigue
Headache
Dizziness
Arrhythmia (a problem with the rate or rhythm of your heartbeat)
Symptoms of polycythemia (too many red blood cells) may include:
Headache
Feeling light-headed or dizzy
Shortness of breath
Weakness or fatigue
Skin symptoms such as itching after a shower or bath, burning, or a red face
Heavy sweating, especially during sleep
Blurred or double vision and blind spots
Bleeding gums and heavy bleeding from small cuts
A health care professional will take a blood sample from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial. You may feel a little sting when the needle goes in or out. This usually takes less than five minutes.
You don't need any special preparations for a hematocrit test. If your provider has ordered more tests on your blood sample, you may need to fast (not eat or drink) for several hours before the test. Your provider will let you know if there are any special instructions to follow.
There is very little risk to having a hematocrit test or other type of blood test. You may have slight pain or bruising at the spot where the needle was put in, but most symptoms go away quickly.
Your hematocrit test results are reported as a number. That number is the percentage of your blood that's made of red blood cells. For example, if your hematocrit test result is 42, it means that 42% of your blood is red blood cells and the rest is white blood cells, platelets, and blood plasma.
A hematocrit level that's lower than normal may be a sign that:
Your body doesn't have enough red blood cells (anemia). There are many types of anemia that can be caused by different medical conditions.
Your body is making too many white blood cells, which may be caused by:
Bone marrow disease
Certain cancers, including leukemia, lymphoma, multiple myeloma, or cancers that spread to the bone marrow from other parts of the body
A hematocrit level that's higher than normal may be a sign that:
Your body is making too many red blood cells, which may be caused by:
Lung disease
Congenital heart disease
Heart failure
Polycythemia
Your blood plasma level is too low, which may be caused by:
Dehydration, the most common cause of a high hematocrit
Shock
If your results are not in the normal range, it doesn't always mean that you have a medical condition that needs treatment. Living at high altitudes where there's less oxygen in the air may cause a high hematocrit. That's because your body responds to low oxygen levels by making more red blood cells so that you get the oxygen you need.
Pregnancy can cause a low hematocrit. That's because the body has more fluid than normal during pregnancy, which decreases the percentage that's made of red blood cells.
To learn what your test results mean, talk with your provider.
Normal hematocrit levels will be different depending on your sex, age, and the altitude where you live. Ask your provider what hematocrit level is normal for you.
Hematocrit Test: MedlinePlus Medical Test [accessed on Jan 20, 2024]
Hematocrit: MedlinePlus Medical Encyclopedia [accessed on Jan 20, 2024]
Hematrocit Blood Test - Testing.com. Sep 13, 2022 [accessed on Jan 20, 2024]
Normal reference ranges can vary depending on the laboratory and the method used for testing. You must use the range supplied by the laboratory that performed your test to evaluate whether your results are "within normal limits."
Additional Materials (30)
This browser does not support the video element.
Complete Blood Count, and Baselining Your Health
Video Topics : Our lifeblood consists of many components and a complete blood count (CBC) includes measurements of the fundamental elements. The largest categories are red and white blood cells (RBCs and WBCs) and cell fragments called platelets, which play roles in blood clotting. There are 20-30 trillion red blood cells in the body of an adult, each with a lifespan of about 100 days (RBCs contain an iron-containing protein called hemoglobin that enables them to carry oxygen to tissues throughout the body and then return carbon dioxide to the lungs). WBCs are in the front lines in the body's ongoing fight against harmful viruses, bacteria and even fungus; when a pathogen enters the body, WBCs mobilize in a coordinated defense response to eliminate, neutralize or mark the invader for destruction. The liquid portion of blood is called plasma and it carries nutrients, electrolytes, waste products, and hormones.
Video by TheVisualMD
Vial of Centrifuged Blood
Blood is made up of red and white blood cell (as well as platelets), suspended in a liquid known as blood plasma. Plasma, which makes up 55% of our blood's volume, is a clear liquid (mainly water) that transports food molecules, hormones, waste as well as a wide range of dissolved chemicals. Red cells, which normally make up 40-50% of total blood volume, are produced continuously in our bone marrow at the rate of about 2-3 million cells per second. White cells make up a very small part of blood's volume-normally only about 1% in healthy people. This image shows two vials of centrifuged blood. The left vial shows healthy amount of red blood cells in female (36-44%) ; The right vial shows healthy amount of red blood cells in male (41-50%). The hematocrit (along with the hemoglobin test) is the central test to diagnosing anemia in that it indicates the amount of RBCs in the blood.
Image by TheVisualMD
Red Blood Cells, Bone Marrow
A skeleton may have a dry and lifeless Halloween image, but bone is actually dynamic, living tissue. Bone is not uniformly solid; within its interior is a network of cavities that house blood vessels and marrow. Bone marrow, particularly in larger bones, is where stem cells give rise to red blood cells (erythrocytes) as well as white blood cells (leukocytes) and blood clotting agents (platelets). As the source of blood cells, the bone marrow is critical to health. Disease or damage to bone marrow can result in either too many or too few blood cells.
Hematocrit Nursing Considerations, Normal Range, Nursing Care, Lab Values Nursing
Video by NURSINGcom/YouTube
Hematocrit, Dehydration
Blood is composed of cells (primarily red blood cells, but also white blood cells and cell fragments called platelets) along with a liquid portion known as plasma. The ratio of the volume of red blood cells to the volume of plasma is an important health indicator and is known as the hematocrit. The most common cause of a high hematocrit is dehydration, which is usually temporary and easily remedied by increasing fluid intake, thereby restores the balance between RBCs and blood plasma volume.
Image by TheVisualMD
Hematocrit, Anemia
Blood is composed of cells (primarily red blood cells, but also white blood cells and cell fragments called platelets) along with a liquid portion known as plasma. The ratio of the volume of red blood cells to the volume of plasma is an important health indicator and is known as the hematocrit. A low hematocrit usually indicates anemia, which occurs when red blood cells are being either destroyed too quickly or produced too slowly; with fewer red blood cells, less oxygen is delivered to body tissues.
Image by TheVisualMD
Vial of Blood for Hematocrit Test
This image is a vial of blood that has been centrifuged (and thus separated) to determine hematocrit. This vial shows, from top to bottom, 55% plasma, <1% white blood cells, <1% platelets , 45% red blood cells. Hematocrit measures how much of the blood, by volume, is taken up by RBCs. A normal range for hematocrit is 41 to 50 percent in men and 36 to 44 percent in women. In many cases, a reading below the normal range for hematocrit will lead to a diagnosis of CKD-related anemia.This other diagnostic test is the hemoglobin test, which measures the amount of hemoglobin molecules in the blood and is a good indicator of the body's ability to carry oxygen throughout the body.
Image by TheVisualMD
Hematocrit: Bone Marrow
Bone marrow produces about 2 million red blood cells (RBCs) a second to maintain a healthy hematocrit. Many conditions, including kidney disease, chemotherapy, and dietary deficiencies, can reduce RBC production, while others can result in too many RBCs.
Image by TheVisualMD
Hematocrit: Blood Cells
The hematocrit is another way to look at the health of red blood cells (RBCs). Blood is composed of cells (primarily RBCs) and a liquid portion called plasma. The proportions of RBCs and plasma must be kept in balance and this is what the hematocrit measures.
Image by TheVisualMD
Blood
Components of Blood : Blood is mostly made up of plasma and red and white blood cells. But it also contains many other substances as well, like platelets, hormones, nutrients such as glucose, and fats like cholesterol. Blood is the fluid of life, transporting oxygen from the lungs to body tissue and carbon dioxide from body tissue to the lungs.
Image by TheVisualMD
Hematocrit
Hematocrit Blood Vials : If you are at risk for cardiovascular disease, your doctor may order a cholesterol and triglyceride level test as well as a complete blood count (CBC). Abnormal results may be the first clue in determining risk of and in diagnosing cardiovascular disease.
Image by TheVisualMD
Blood Smear Showing Reduced Red Blood Cell Count
Individual blood cells were first detected and described in the 17th century. Later, red blood cells (RBCs) were counted manually from a blood smear, a thin film of blood prepared on a glass slide and examined under a microscope (blood analysis is now automated, though smears are still used to detect visible abnormalities and to check or confirm the results of other tests). Anemia results when there are too few RBCs in circulation because they are being destroyed too quickly or produced too slowly. Anemia can be temporary or long term and range from mild to severe. Folate (also known as vitamin B9) is necessary for red blood cell production and the prevention of anemia, as well as the metabolism of carbohydrates. But folate also plays key roles in the synthesis and maintenance of DNA and is especially important in cell division and growth in fetal development (deficiencies of the vitamin in pregnancy is a common cause of birth defects). Pernicious anemia is a disorder in which the body's loses its ability to utilize folate and vitamin B12.
Image by TheVisualMD
Blood Smear Showing Normal Red Blood Cell Count
Individual blood cells were first detected and described in the 17th century. Later, red blood cells were counted manually from a blood smear, a thin film of blood prepared on a glass slide and examined under a microscope. Blood analysis is now automated, though blood smears are still used to detect visible abnormalities and to check or confirm the results of other tests. There are normally between 4.2-5.8 million red blood cells per microliter (about a drop), which means there are 20-30 trillion red blood cells circulating through the body of an adult.
Image by TheVisualMD
This browser does not support the video element.
Red Blood Cells Carry Oxygen
This video focuses on one of the main components of blood, the red blood cell and its function to carry oxygen. The video begins with revealing the red blood cells and the heart that pumps the oxygenated blood to the rest of the body. Hemoglobin is the protein molecule found in these red blood cells that enable blood to transport oxygen. If the blood's capacity to transport oxygen to the tissues is reduced due to a decrease in the number of red blood cells, anemia may occur.
Video by TheVisualMD
Components of Blood
Components of Blood : Our blood is composed of many different components, the largest categories being red and white blood cells (blood-clotting platelets are another key component) and the liquid portion known as blood plasma. A Complete Blood Count (CBC) includes several of the most basic, yet important, measurements of these components.
Image by TheVisualMD
Blood and Related Conditions
Blood and Related Conditions : Anemia results when there are too few red blood cells circulating in the bloodstream to deliver adequate oxygen to body tissues. There are different types and causes of anemia, including malnutrition, chronic bleeding, and diseases that result in red blood cells either being destroyed too quickly or produced too slowly.
Image by TheVisualMD
Pellet of Lymphocyte Cells Created in the Centrifuge
This photograph shows Wendy Watford, Ph.D. holding a test tube containing isolated lymphocyte cells. The cells were spun in a centrifuge to create a pellet at the bottom of the test tube. The cells will be labeled with CFSE dye, which will stain the membranes of the cells. After culturing the cells for three days she will determine the number of cell divisions that have taken place by measuring the dilution of the CFSE dye. The purpose of the work is to measure the proliferation of lymphocytes under various conditions. The principal investigator for this work is John J. O’Shea, M.D., NIAMS Scientific Director.
Image by NIAMS/Photographer: Rhoda Baer
Red Blood Cells
Digital holographic microscopy (DHM) image of red blood cells.
Image by Egelberg (talk)
Test Tube
Between 5,000 and 8,000 blood serum, fecal, urine, viral and respiratory samples arrive six days a week from U.S. Air Force hospitals and clinics worldwide, as well as some other Department of Defense facilities, for analysis at the Epidemiology Laboratory Service, also known as the "Epi Lab" at the 711th Human Performance Wing’s United States Air Force School of Aerospace Medicine and Public Health at Wright Patterson AFB, Ohio.The lab is a Department of Defense reference laboratory offering clinical diagnostic, public health, and force health screening and testing. (U.S. Air Force photo by J.M. Eddins Jr.)
Image by U.S. Air Force photo by J.M. Eddins Jr.
Phlebotomy
This image was uploaded as part of Wiki Loves e-textbooks contest in Poland.
Image by Sean Michael Ragan
Red Blood Cells Carry Oxygen
This video focuses on one of the main components of blood, the red blood cell and its function to carry oxygen. The video begins with revealing the red blood cells and the heart that pumps the oxygenated blood to the rest of the body. Hemoglobin is the protein molecule found in these red blood cells that enable blood to transport oxygen. If the blood's capacity to transport oxygen to the tissues is reduced due to a decrease in the number of red blood cells, anemia may occur.
Image by TheVisualMD
Composition of Blood
Composition of Blood
Image by OpenStax College
Hematology | Hematocrit
Video by Ninja Nerd/YouTube
Erythrocyte indices (Hemoglobin, Hematocrit, MCV, MCH & MCHC) What Do These Lab Tests Mean?
Video by Medicosis Perfectionalis/YouTube
How to Interpret RBC Indices (e.g. hemoglobin vs. hematocrit, MCV, RDW)
Video by Strong Medicine/YouTube
Haematocrit or PCV
Video by LabsforLifeProject/YouTube
Packed cell volume/ Hematocrit
Video by Pathology Simplified/YouTube
Fetal hemoglobin and hematocrit | Human anatomy and physiology | Health & Medicine | Khan Academy
Also called: MCV, MCV Blood Test, Mean Corpuscular Volume, Mean RBC Volume
A mean corpuscular volume (MCV) blood test measures the size of your red blood cells. If blood cells are too small or too large, it may indicate a blood disorder.
MCV (Mean Corpuscular Volume) Test
Also called: MCV, MCV Blood Test, Mean Corpuscular Volume, Mean RBC Volume
A mean corpuscular volume (MCV) blood test measures the size of your red blood cells. If blood cells are too small or too large, it may indicate a blood disorder.
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Use the slider below to see how your results affect your
health.
fL
76
96
Your result is Low.
A low MCV indicates that the red blood cells are smaller than normal, or microcytic.
Related conditions
MCV stands for mean corpuscular volume. An MCV blood test measures the average size of your red blood cells.
Red blood cells carry oxygen from your lungs to every cell in your body. Your cells need oxygen to grow, reproduce, and stay healthy. If your red blood cells are too small or too large, it could be a sign of a blood disorder such as anemia, a lack of certain vitamins, or other medical conditions.
Other names: CBC with differential
An MCV blood test is often part of a complete blood count (CBC). A CBC is a common blood test that measures many parts of your blood, including red blood cells. It is used to check your general health.
An MCV test may also be used with other tests to help diagnose or monitor certain blood disorders, including anemia. There are many types of anemia. An MCV test can help diagnose which type of anemia you have.
Your health care provider may order a complete blood count, which includes an MCV test, as part of your regular checkup. You may also have the test if you have a chronic (long-lasting) condition that could lead to anemia or if you have the symptoms of anemia:
Shortness of breath
Weakness or fatigue
Headache
Dizziness
Arrhythmia (a problem with the rate or rhythm of your heartbeat)
During the test, a health care professional will take a blood sample from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial. You may feel a little sting when the needle goes in or out. This usually takes less than five minutes.
You don't need any special preparations for an MCV blood test. If your provider has ordered more tests on your blood sample, you may need to fast (not eat or drink) for several hours before the test. Your provider will let you know if there are any special instructions to follow.
There is very little risk to having a blood test. You may have slight pain or bruising at the spot where the needle was put in, but most symptoms go away quickly.
An MCV test alone cannot diagnose any disease. Your provider will use the results of your MCV, other test results, and your medical history to make a diagnosis.
If your results show that your red blood cells are smaller than normal, it may be a sign of:
Certain types of anemia, including iron-deficiency anemia, the most common type
Thalassemia, an uncommon genetic condition
If your results show that your red blood cells are larger than normal, it may be a sign of:
Pernicious anemia, which may be caused by:
A lack of vitamin B12
A disease that affects your body's ability to use vitamin B12, such as certain autoimmune diseases, celiac disease, or Crohn's disease.
Anemia caused by a lack of folic acid
Liver disease
It's also possible to have anemia with a normal MCV. This may happen if anemia is caused by conditions, such as:
A sudden loss of blood
Kidney failure
Aplastic anemia (uncommon)
If your MCV levels are not in the normal range, it doesn't always mean that you have a medical problem that needs treatment. Diet, activity level, medicines, a menstrual period, and other conditions can affect the test results. Talk with your health care provider to learn what your results mean.
If your provider thinks you may have anemia or another blood disorder, you may have other red blood cell tests with an MCV. These tests may include a red blood cell count and measurements of hemoglobin. All together, these tests are called red blood cell indices.
MCV (Mean Corpuscular Volume): MedlinePlus Medical Test [accessed on Jan 20, 2024]
Normal reference ranges can vary depending on the laboratory and the method used for testing. You must use the range supplied by the laboratory that performed your test to evaluate whether your results are "within normal limits."
Additional Materials (22)
Microcytic, normocytic, and macrocytic anemias | NCLEX-RN | Khan Academy
Video by khanacademymedicine/YouTube
Non-megaloblastic Macrocytic Anemia
Video by Medicosis Perfectionalis/YouTube
Microcytic anemia | Hematologic System Diseases | NCLEX-RN | Khan Academy
Video by khanacademymedicine/YouTube
Living with and Managing Iron-Deficiency Anemia
Video by NHLBI/YouTube
Hemolytic Anemia
Video by DrER.tv/YouTube
Medical School - Anemia Made Easy
Video by iMedicalSchool/YouTube
Iron deficency anemia diagnosis | Hematologic System Diseases | NCLEX-RN | Khan Academy
WellnessFX: Red Blood Cell Indices Part 1 with Bryan Walsh
Video by WellnessFX/YouTube
WellnessFX: Red Blood Cell Indices Part 2 with Bryan Walsh
Video by WellnessFX/YouTube
Blood Brain Barrier Endothelium
The blood-brain barrier keeps potentially toxic substances from entering the brain. The semipermeable membrane formed by the tightly spaced cells of capillaries in this area selectively screens out large molecules, while permitting the transport of essential nutrients such as glucose. The endothelium is the cellular lining of the blood vessel and is made up of endothelial cells connected to one another by tight junctions. These are the strongest cell-to-cell adhesions in the body. Toxic materials being transported in the blood are too large to pass through these junctions and exit the blood. Therefore, the brain is protected from exposure to many harmful substances. The barrier is does not, however, prevent fat-soluble materials from entering the brain; this includes alcohol and nicotine.
Image by TheVisualMD
Normal Blood Glucose Levels in Capillary
This image depicts a healthy capillary with normal glucose (pink) and insulin (yellow) levels. Capillaries, the smallest blood vessels in your body, are where nutrients are transferred from blood to cells, and waste from cells to blood. The body's cells depend on sugar in the blood, which is derived from carbohydrates, for food and energy. Allowing for the innumerable differences among individuals, the threshold for a normal blood-sugar (glucose) level in healthy people is 100 mg/dL; that is, 100 milligrams of glucose per deciliter of blood. Lower-than-normal levels characterize hypoglycemia and higher than normal levels characterize hyperglycemia.
Image by TheVisualMD
Cross-Section of Healthy Capillary Blood Vessel with Normal Glucose and Insulin Levels
This image depicts a healthy capillary. Capillaries are the smallest blood vessels in your body and are where the transfer of nutrients from blood to cells and wastes from cells to the blood takes place.The cells of the body depend on sugar in the blood, derived from carbohydrates, for food and energy. Allowing for the innumerable differences among individuals, the threshold for a normal blood-sugar (glucose) level in healthy people is 100 mg/dL; that is, 100 milligrams of glucose per deciliter of blood. Lower-than-normal levels characterize hypoglycemia and higher than normal levels hyperglycemia.
Image by TheVisualMD
Blood Vessels in the Brain
The Blood Brain Barrier and Astrocytes type 1
Image by Ben Brahim Mohammed
Cross-Section of Damaged Capillary Blood Vessel with Very High Glucose and Insulin Levels
This image depicts an unhealthy, damaged capillary with very high levels of insulin and glucose. Capillaries, the smallest blood vessels in your body, are where nutrients are transferred from blood to cells, and waste from cells to the blood The body's cells depend on sugar (glucose) in the blood, which is derived from carbohydrates, for food and energy. Without insulin, glucose is not able to enter cells to be used as fuel. Allowing for the innumerable differences among individuals, the threshold for a normal blood-sugar (glucose) level in healthy people is 100 mg/dL; that is, 100 milligrams of glucose per deciliter of blood. Higher than normal levels lead to hyperglycemia. Hyperglycemia is the hallmark of prediabetes (between 100 and 125 mg/dL) and diabetes (126 mg/dL and higher). It is caused by either too little insulin being released by the pancreas or the body's inability to use insulin properly. Hyperglycemia leads to microangiopathy, marked by endothelial cell apoptosis (programmed cell death), accumulation of AGEs (advanced glycation end products), and thickening of the basement membrane, which can lead to development of lesions, vasoconstriction, and altered vessel function
Blood Components
This image highlights the vital components of blood: 55% plasma Plasma is the liquid river that transports every blood cell to its destination. Oxygen-carrying RBCs couldn't move through arteries, veins and capillaries without it. Even though it is a watery, almost clear fluid, plasma contains many important substances, including blood-clotting agents called platelets and protective proteins called antibodies which help us fight infection. When the clotting agents are removed from blood plasma, it is called serum, which is essential in many life-saving medical situations such as transplant surgery and trauma. <1% white blood cells (wbcs or leukocytes) Some leukocytes are produced in the bone marrow, while others are generated in lymph nodes scattered throughout the body. They are far less numerous than their sister RBCs, but leukocytes are the bedrock of the immune system and are the body's front line of defense. Different types of leukocytes fight infections in different ways. Some target bacterial or fungal infections, while others respond to parasitic threats or allergic reactions. <1% platelets Platelets perform the vital function of clotting blood at wound sites. They are small, even in comparison to the other cells of your blood, but they pack a wallop when it comes to healing a scrape or staunching a more serious wound. When you cut yourself shaving, platelets arrive on the scene like your personal emergency medical team, creating a natural bandage of clotted blood, which eventually forms a scab. 45% red blood cells rbcs or erythrocytes) RBCs are produced in the bone marrow and perform the fundamental task of delivering oxygen to all of the body's cells. The vial is an example of the hematocrit, one of many tests that make up the complete blood count (CBC). Hematocrit measures the volume of RBCs in your blood. A normal hematocrit reading for women is between 36 to 44 percent; for men it's 41 to 50 percent.
Image by TheVisualMD
Test Tube Containing Blood
Visualization of a test tube containing blood. Blood comprises of 55% plasma, 1% platelets and white blood cells, and 45% red blood cells.
Image by TheVisualMD
Blood Smear Showing Reduced Red Blood Cell Count
Individual blood cells were first detected and described in the 17th century. Later, red blood cells (RBCs) were counted manually from a blood smear, a thin film of blood prepared on a glass slide and examined under a microscope (blood analysis is now automated, though smears are still used to detect visible abnormalities and to check or confirm the results of other tests). Anemia results when there are too few RBCs in circulation because they are being destroyed too quickly or produced too slowly. Anemia can be temporary or long term and range from mild to severe. Folate (also known as vitamin B9) is necessary for red blood cell production and the prevention of anemia, as well as the metabolism of carbohydrates. But folate also plays key roles in the synthesis and maintenance of DNA and is especially important in cell division and growth in fetal development (deficiencies of the vitamin in pregnancy is a common cause of birth defects). Pernicious anemia is a disorder in which the body's loses its ability to utilize folate and vitamin B12.
Image by TheVisualMD
Red Blood Cell in Capillary
The cardiovascular system is vast network of arteries, veins and vessels that would extend 60,000 miles if stretched end-to-end. All but a tiny fraction of this vessel network is invisible to the naked eye. The smallest capillaries (from latin "hairlike") are so narrow that red blood cells must pass through in single file. Higher than normal blood iron levels have been linked to heart disease and the reason is believed to be the oxidative stress the excess iron places on the walls of the blood vessels. It is the biological counterpart of rust. There are 20-30 trillion red blood cells (RBCs) in an adult's body. The life span of RBCs, which are produced in bone marrow, is about 100 days, which means that 2 million die (and are replaced) each second, but in that short lifetime they can make 75,000 round trips between lungs, heart and tissues in the body.
Image by TheVisualMD
Kidney and Stem Cell Creating Red Blood Cell. B12 is critical for the creation of red blood cells.
We are used to thinking of our kidneys mostly as hardworking filters that rid our bodies of wastes and excess water. But the kidneys are also constantly monitoring and adjusting levels of key substances in the blood, depending on what the body needs. Specialized cells in the kidney that are very sensitive to low oxygen levels, for example, produce a hormone called erythropoietin (EPO), which in turn promotes the production of red blood cells in the bone marrow. The boost in red blood cells increases the oxygen-carrying capacity of the blood.
Image by TheVisualMD
Healthy Capillary Blood Vessel
Cross-section of Healthy Capillary Blood Vessel with Normal Glucose and Insulin Levels
Cross-Section of Damaged Capillary Blood Vessel with Very High Glucose and Insulin Levels
1
2
3
Healthy Capillary Blood Vessel and and Damaged Capillary Blood Vessel Caused by High Levels of Blood Glucose
1) Healthy Capillary Blood Vessel - This image depicts a healthy capillary. Capillaries are the smallest blood vessels in your body. They can be so thin in diameter that blood cells have to bend in order to pass through. Capillaries are where the transfer of nutrients from the blood to cells, and the transfer of waste from cells to blood, takes place. In a healthy body, the blood vessels are smooth and elastic.
2) Cross-Section of Healthy Capillary Blood Vessel with Normal Glucose and Insulin Levels - This image depicts a healthy capillary. The body's cells depend on sugar in the blood, which is derived from carbohydrates, for food and energy. Allowing for the innumerable differences among individuals, the threshold for a normal blood sugar (glucose, pink) level in healthy people is 100 mg/dL; that is, 100 milligrams of glucose per deciliter of blood. Lower-than-normal levels characterize hypoglycemia and higher-than-normal levels characterize hyperglycemia. Without insulin (yellow), glucose is not able to enter cells to be used as fuel. Because of this, healthy insulin levels are a key factor in keeping blood glucose levels normal.
3) Cross-Section of Damaged Capillary Blood Vessel with Very High Glucose and Insulin Levels - This image depicts an unhealthy, damaged capillary with very high levels of insulin and glucose. Higher than normal levels of blood glucose lead to hyperglycemia. Hyperglycemia is the hallmark of prediabetes (between 100 and 125 mg/dL) and diabetes (126 mg/dL and higher). It is caused by either too little insulin being released by the pancreas or the body's inability to use insulin properly. Hyperglycemia leads to microangiopathy, marked by endothelial cell apoptosis (programmed cell death), accumulation of AGEs (advanced glycation end products), and thickening of the basement membrane, which can lead to the development of lesions, vasoconstriction, and altered vessel function
Interactive by TheVisualMD
5:57
Microcytic, normocytic, and macrocytic anemias | NCLEX-RN | Khan Academy
khanacademymedicine/YouTube
4:39
Non-megaloblastic Macrocytic Anemia
Medicosis Perfectionalis/YouTube
9:42
Microcytic anemia | Hematologic System Diseases | NCLEX-RN | Khan Academy
khanacademymedicine/YouTube
3:56
Living with and Managing Iron-Deficiency Anemia
NHLBI/YouTube
3:24
Hemolytic Anemia
DrER.tv/YouTube
3:16
Medical School - Anemia Made Easy
iMedicalSchool/YouTube
9:54
Iron deficency anemia diagnosis | Hematologic System Diseases | NCLEX-RN | Khan Academy
WellnessFX: Red Blood Cell Indices Part 1 with Bryan Walsh
WellnessFX/YouTube
28:05
WellnessFX: Red Blood Cell Indices Part 2 with Bryan Walsh
WellnessFX/YouTube
Blood Brain Barrier Endothelium
TheVisualMD
Normal Blood Glucose Levels in Capillary
TheVisualMD
Cross-Section of Healthy Capillary Blood Vessel with Normal Glucose and Insulin Levels
TheVisualMD
Blood Vessels in the Brain
Ben Brahim Mohammed
Cross-Section of Damaged Capillary Blood Vessel with Very High Glucose and Insulin Levels
Blood Components
TheVisualMD
Test Tube Containing Blood
TheVisualMD
Blood Smear Showing Reduced Red Blood Cell Count
TheVisualMD
Red Blood Cell in Capillary
TheVisualMD
Kidney and Stem Cell Creating Red Blood Cell. B12 is critical for the creation of red blood cells.
TheVisualMD
Healthy Capillary Blood Vessel and and Damaged Capillary Blood Vessel Caused by High Levels of Blood Glucose
TheVisualMD
C-Reactive Protein Test
C-Reactive Protein Test
Also called: CRP
A c-reactive protein test checks for inflammation in the body. Inflammation can be caused by infection, injury, or chronic disease.
C-Reactive Protein Test
Also called: CRP
A c-reactive protein test checks for inflammation in the body. Inflammation can be caused by infection, injury, or chronic disease.
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Use the slider below to see how your results affect your
health.
mg/L
10
Your result is Normal.
Test results may vary depending on your age, gender, health history, the lab and the method used for the test.
Related conditions
A c-reactive protein test measures the level of c-reactive protein (CRP) in your blood. CRP is a protein made by your liver. It's sent into your bloodstream in response to inflammation. Inflammation is your body's way of protecting your tissues if you've been injured or have an infection. It can cause pain, redness, and swelling in the injured or affected area. Some autoimmune disorders and chronic diseases can also cause inflammation.
Normally, you have low levels of c-reactive protein in your blood. High levels may be sign of a serious infection or other disorder.
A CRP test may be used to find or monitor conditions that cause inflammation. These include:
Bacterial infections, such as sepsis, a severe and sometimes life-threatening condition
A fungal infection
Inflammatory bowel disease, a disorder that causes swelling and bleeding in the intestines
An autoimmune disorder such as lupus or rheumatoid arthritis
An infection of the bone called osteomyelitis
You may need this test if you have symptoms of a serious bacterial infection. Symptoms include:
Fever
Chills
Rapid breathing
Rapid heart rate
Nausea and vomiting
If you've already been diagnosed with an infection or have a chronic disease, this test may be used to monitor your treatment. CRP levels rise and fall depending on how much inflammation you have. If your CRP levels go down, it's a sign that your treatment for inflammation is working.
A health care professional will take a blood sample from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial. You may feel a little sting when the needle goes in or out. This process usually takes less than five minutes.
You don't need any special preparations for a CRP test.
There is very little risk to having a blood test. You may have slight pain or bruising at the spot where the needle was put in, but most symptoms go away quickly.
If your results show a high level of CRP, it probably means you have some type of inflammation in your body. A CRP test doesn't explain the cause or location of the inflammation. So if your results are not normal, your health care provider may order more tests to figure out why you have inflammation.
A higher than normal CRP level does not necessarily mean you have a medical condition needing treatment. There are other factors that can raise your CRP levels. These include cigarette smoking, obesity, and lack of exercise.
If you have questions about your results, talk to your health care provider.
A CRP test is sometimes confused with a high-sensitivity-(hs) CRP test. Although they both measure CRP, they are used to diagnose different conditions. An hs-CRP test measures much lower levels of CRP. It is used to check for risk of heart disease.
Normal reference ranges can vary depending on the laboratory and the method used for testing. You must use the range supplied by the laboratory that performed your test to evaluate whether your results are "within normal limits."
Additional Materials (20)
This browser does not support the video element.
Cardiovascular Inflammation
Heart disease is the number one killer of men and women in the U.S. The most common cause of heart attack, stroke, and cardiovascular death is atherosclerosis. Atherosclerosis is a chronic inflammatory response in the walls of arteries that leads to the hardening of arterial walls and the buildup of fatty deposits called plaques, or atheromas. Although the process of inflammation can be beneficial in other parts of the body, chronic inflammation within arterial walls is problematic as it seems to promote this underlying growth of plaque. The combination of arterial inflammation and the growth of plaque can lead to the rupture of the plaque, and result in a blood clot. Blood clots can lead to dangerous conditions such as heart attack or stroke.
Video by TheVisualMD
C-Reactive Protein (CRP) Molecule
C-reactive protein (CRP) is a substance made by the liver; infection and inflammation can trigger the release of CRP within hours. Elevated CRP levels are also seen after a heart attack or surgery. Levels can jump 1000-fold in response to acute inflammation, often rising before the appearance of pain, fever or other clinical symptoms. The high sensitivity version of the test (hs-CRP) measures the same molecule, but in very small amounts, and is used to assess the risk of heart disease in otherwise healthy people. The C-reactive protein (CRP) test is a general test for inflammation in the body; it can indicate that inflammation is present, but cannot determine the location or cause. The test is sometimes used to monitor flare-ups of inflammatory diseases such as rheumatoid arthritis or lupus. A version of the test called high-sensitivity C-reactive protein (hs-CRP) is used to evaluate a person's risk for heart disease.
Image by TheVisualMD
C Reactive Protein: Liver and Heart
C-Reactive protein is synthesized by the liver in response to either signals from fat cells (adipocytes) or when there is inflammation throughout the body.
Image by TheVisualMD
Lipoprotein (a) or Lp(a), Heart Attack
LDL, HDL and total cholesterol have become standard biomarkers for heart disease. And yet half of all people who suffer heart attacks have normal cholesterol levels. For that reason, researchers have looked for other biomarkers that might help identify people at risk for cardiovascular disease. Lp(a) is a lipoprotein that closely resembles LDL, and like LDL, elevated levels of Lp(a) are associated with a higher risk of heart disease. Unlike LDL, however, Lp(a) levels are believed to be largely genetic.
Image by TheVisualMD
NBC Nightly News and C-Reactive Protein
Video by SAVI Health/YouTube
CRP Nursing Considerations, Normal Range, Nursing Care, Lab Values Nursing
Video by NURSINGcom/YouTube
CRP And Homocysteine Inflammation Markers, How Do They Relate To Coronary Artery Disease? - Dr. Lyel
Video by EmpowHER/YouTube
CRP High Sensitivity Cardiac Risk Assessment from Walk-in Lab
Video by Walk-In Lab LLC/YouTube
What Can Give False Readings on an hs-CRP Test? : Health Tips
Video by ehowhealth/YouTube
CRP Indicates Heart Disease Risk Video - Brigham and Women's Hospital
Video by Brigham And Women's Hospital/YouTube
C Reactive Protein: Fat cells
Researchers have found that fat cells trigger the production of C-reactive protein (CRP), which is why individuals who are overweight or obese tend to have chronically higher levels of CRP. High levels of CRP are sometimes treated with aspirin or statins.
Image by TheVisualMD
C-reactive Protein, Atherosclerosis and Heart Disease
C-reactive protein (CRP) is a substance made by the liver that is released into the bloodstream by inflammation. CRP levels also seem to be associated with an increased risk of heart disease and atherosclerosis, in which fatty deposits called plaque build up inside the arteries. For this reason, a high sensitivity C-reactive protein test (hs-CRP) is increasingly ordered along with other tests as part of a cardiovascular risk profile (other components of the profile include cholesterol, triglycerides, blood pressure, glucose levels, lifestyle and family history).
Image by TheVisualMD
C-reactive Protein, Fat cells
C-reactive protein (CRP) is a substance made by the liver that is released into the bloodstream by inflammation and infection as part of the body's immune response. Researchers have found, however, that fat cells also seem to trigger the production of C-reactive protein (CRP), which is why individuals who are overweight or obese tend to have chronically higher levels of CRP.
Image by TheVisualMD
What is C-Reactive Protein & How to Lower it? – Dr.Berg
Video by Dr. Eric Berg DC/YouTube
C-reactive protein
Video by University of Rochester Introductory Biochemistry (Bio250H)/YouTube
C-Reactive Protein (CRP) | Inflammation | Acute phase reactant
Video by Medicosis Perfectionalis/YouTube
C-reactive protein
C-reactive protein drawn from PDB: 1GNH by JFW | T@lk
Different white blood cells have specialized immune functions; certain WBCs, for example, are able to ingest harmful foreign particles, including pathogens, in a process called phagocytosis. CRP is believed to enhance this defense mechanism.
Image by TheVisualMD
The C-Reactive Protein (CRP) blood test and what the results can mean
Video by Pathology Tests Explained/YouTube
4:26
Cardiovascular Inflammation
TheVisualMD
C-Reactive Protein (CRP) Molecule
TheVisualMD
C Reactive Protein: Liver and Heart
TheVisualMD
Lipoprotein (a) or Lp(a), Heart Attack
TheVisualMD
2:33
NBC Nightly News and C-Reactive Protein
SAVI Health/YouTube
1:33
CRP Nursing Considerations, Normal Range, Nursing Care, Lab Values Nursing
NURSINGcom/YouTube
2:12
CRP And Homocysteine Inflammation Markers, How Do They Relate To Coronary Artery Disease? - Dr. Lyel
EmpowHER/YouTube
1:51
CRP High Sensitivity Cardiac Risk Assessment from Walk-in Lab
Walk-In Lab LLC/YouTube
2:25
What Can Give False Readings on an hs-CRP Test? : Health Tips
ehowhealth/YouTube
3:37
CRP Indicates Heart Disease Risk Video - Brigham and Women's Hospital
Brigham And Women's Hospital/YouTube
C Reactive Protein: Fat cells
TheVisualMD
C-reactive Protein, Atherosclerosis and Heart Disease
TheVisualMD
C-reactive Protein, Fat cells
TheVisualMD
4:26
What is C-Reactive Protein & How to Lower it? – Dr.Berg
Dr. Eric Berg DC/YouTube
5:13
C-reactive protein
University of Rochester Introductory Biochemistry (Bio250H)/YouTube
12:14
C-Reactive Protein (CRP) | Inflammation | Acute phase reactant
The C-Reactive Protein (CRP) blood test and what the results can mean
Pathology Tests Explained/YouTube
Erythrocyte Sedimentation Rate Test
Erythrocyte Sedimentation Rate Test
Also called: ESR, Westergren sedimentation rate
An erythrocyte sedimentation rate measures how quickly red blood cells settle in a test tube. It can help detect inflammation in the body.
Erythrocyte Sedimentation Rate Test
Also called: ESR, Westergren sedimentation rate
An erythrocyte sedimentation rate measures how quickly red blood cells settle in a test tube. It can help detect inflammation in the body.
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Use the slider below to see how your results affect your
health.
mm/h
5
22
40
Your result is Normal.
Normal results vary based on the laboratory and the method used.
Related conditions
An erythrocyte sedimentation rate (ESR) is a type of blood test that measures how quickly erythrocytes (red blood cells) settle at the bottom of a test tube that contains a blood sample. Normally, red blood cells settle relatively slowly. A faster-than-normal rate may indicate inflammation in the body. Inflammation is part of your immune response system. It can be a reaction to an infection or injury. Inflammation may also be a sign of a chronic disease, an immune disorder, or other medical condition.
An ESR test can help determine if you have a condition that causes inflammation. These include arthritis, vasculitis, or inflammatory bowel disease. An ESR may also be used to monitor an existing condition.
Your health care provider may order an ESR if you have symptoms of an inflammatory disorder. These include:
Headaches
Fever
Weight loss
Joint stiffness
Neck or shoulder pain
Loss of appetite
Anemia
A health care professional will take a blood sample from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial. You may feel a little sting when the needle goes in or out. This usually takes less than five minutes.
You don't need any special preparations for this test.
There is very little risk to having an ESR. You may have slight pain or bruising at the spot where the needle was put in, but most symptoms go away quickly.
If your ESR is high, it may be related to an inflammatory condition, such as:
Infection
Rheumatoid arthritis
Rheumatic fever
Vascular disease
Inflammatory bowel disease
Heart disease
Kidney disease
Certain cancers
Sometimes the ESR can be slower than normal. A slow ESR may indicate a blood disorder, such as:
Polycythemia
Sickle cell anemia
Leukocytosis, an abnormal increase in white blood cells
If your results are not in the normal range, it doesn't necessarily mean you have a medical condition that requires treatment. A moderate ESR may indicate pregnancy, menstruation, or anemia, rather than an inflammatory disease. Certain medicines and supplements can also affect your results. These include oral contraceptives, aspirin, cortisone, and vitamin A. Be sure to tell your health care provider about any drugs or supplements you are taking.
An ESR does not specifically diagnose any diseases, but it can provide information about whether or not there is inflammation in your body. If your ESR results are abnormal, your health care provider will need more information and will likely order more lab tests before making a diagnosis.
Normal reference ranges can vary depending on the laboratory and the method used for testing. You must use the range supplied by the laboratory that performed your test to evaluate whether your results are "within normal limits."
Additional Materials (6)
This browser does not support the video element.
What Is Inflammation?
Inflammation is the body's response to damage. It takes many forms. Chronic inflammation is common in overweight and obese people, because their fat cells manufacture damaging substances that trigger a reaction from the immune system's white blood cells. Keeping track of a key biomarker for inflammation, C-reactive Protein or CRP, helps doctors determine whether an overweight patient is at risk for such conditions as heart disease, dementia, diabetes, cancers, and more.
Video by TheVisualMD
Asthma - Inflammation in the Airways
Asthma is a condition in which the airways of your lungs are chronically inflamed. Allergens or other triggers can cause the smooth muscle tissue that surrounds your airways to constrict (narrow). These triggers can also prompt an inflammatory response from the immune cells that line your airways, causing them to release an excessive amount of mucus. The constriction and the mucus narrow your airways, creating symptoms that can include shortness of breath, wheezing, coughing, and chest tightness.
Image by TheVisualMD
Mast Cell
Mast cells produce histamine. Histamine is known for its role in inflammation. It affects a variety of behavior patterns including the sleep-wake cycle and food intake. Antihistamines may work at odds with inflammation and depression.
Image by TheVisualMD
Subsiding Inflammation in blood vessels
Monocytes, having matured into macrophages continue to destroy pathogens and cellular debris by ingesting them, while the inflammation process begins to subside.
Image by TheVisualMD
Basophil
Visualization of a basophil. A type of leukocyte (white blood cell) responsible for combating infection.
Image by TheVisualMD
erythrocyte sedimentation rate
Westergren pipettes in automated StaRRsed ESR analyzer
Image by MechESR
1:57
What Is Inflammation?
TheVisualMD
Asthma - Inflammation in the Airways
TheVisualMD
Mast Cell
TheVisualMD
Subsiding Inflammation in blood vessels
TheVisualMD
Basophil
TheVisualMD
erythrocyte sedimentation rate
MechESR
CT Scan
CT Scan
A CT scan is a special x-ray procedure that can make detailed pictures of structures inside your body. A CT scan is commonly used to look for certain chest problems, including infection, lung cancer, and pulmonary embolism.
CT Scan
A CT scan is a special x-ray procedure that can make detailed pictures of structures inside your body. A CT scan is commonly used to look for certain chest problems, including infection, lung cancer, and pulmonary embolism.
Computed tomography, or CT, scans are medical imaging tests that use ionizing radiation to create cross-sectional (slices) pictures inside selected areas of the body from different angles. The images can show internal organs, blood vessels, soft tissues, and bones. CT scans combine a series of x-ray (radiography) images into a three-dimensional picture.
Your healthcare provider may ask for a CT scan to detect, diagnose, or plan treatment for a particular disease or injury.
Common uses of CT scan include checking for:
Tumors
Infections
Blood clots
Internal bleeding
Before the procedure
The radiologist will explain the procedure and ask you if you have any questions. Some CT procedures may use a contrast dye which allows healthcare providers to see specific organ(s). You may be asked to drink the contrast dye or you may receive it in an intravenous (IV) line in the hand or arm.
Make sure to tell your healthcare provider and the radiologist doing the test if you:
Have ever had an allergic reaction to any contrast dye.
Are pregnant or suspect that you may be pregnant.
During the Procedure
You will be asked to remove any clothing and jewelry that may interfere with the procedure.
You will be asked to lie very still on a table while it moves slowly through an x-ray machine (like a tube) taking images of your body.
The computer will organize the x-ray information to show the internal structures in detail.
CT scans usually require more exposure to radiation than common x-rays because they use a series of x-ray images. Increased exposure means a slightly higher risk of possible short-term and long-term health effects. However, CT scans provide your healthcare provider with more detailed images that can include parts of the body that may not be seen on common x-ray images. Talk to your healthcare provider to decide what type of imaging will use the least amount of radiation while providing the information and details needed for your diagnosis.
Computed Tomography (CT) Scans | Radiation | NCEH | CDC. Dec 28, 2021 [accessed on Jan 31, 2023]
Has use of CT scans in emergency departments to test for pulmonary embolism leveled off? | CDC. Centers for Disease Control and Prevention. Oct 22, 2018 [accessed on Jan 31, 2023]
Computed Tomography (CT). National Institute of Biomedical Imaging and Bioengineering [accessed on Jan 31, 2023]
Treatment
morphine, antibiotics, and anti nausea meds
Image by kenna takahashi/Wikimedia
morphine, antibiotics, and anti nausea meds
Last night around midnight my mom started feeling nauseous. She proceeded to be sick for the next 4 hours, until it was too much and we called 911. fast forward to 3pm and she is admitted to the hospital with gallstones, and most likely a cholecystectomy (gallbladder surgery) is in her near future.
She is resting comfortably now, with morphine, antibiotics, and anti nausea meds.
I have been up for almost a day, am super tired. Am so glad i was here when this all went down.
Image by kenna takahashi/Wikimedia
How Might Lemierre Syndrome Be Treated?
Surgical incision and drainage of any abscesses may be needed to control the infection. Surgical removal of infected clots is generally reserved for cases in which antibiotic therapy and drainage are not effective. Surgical treatment may also be needed for breathing problems due to pulmonary emboli; severe blood clotting elsewhere in the body (particularly the brain); mediastinitis; or to remove dead, damaged, or infected tissue (debridement).
The role of anticoagulation (the use of blood thinners) for blood clots in Lemierre syndrome is uncertain and has been controversial. While anticoagulation may help prevent new clots from forming and complications associated with thrombosis, it may cause a high risk of bleeding complications and/or aid the spread of infected material. Lemierre syndrome without evidence of extensive clotting typically resolves with appropriate antibiotic therapy and does not require anticoagulation. However, it may be recommended in severe or progressive cases with persistent sepsis, extensive clotting, clotting that extends to the cerebral sinuses, and/or when a patient does not begin to improve within 72 hours of appropriate antibiotic or surgical treatment.
Source: Genetic and Rare Diseases Information Center (GARD)
Prognosis
Prognosis Icon
Image by mcmurryjulie/Pixabay
Prognosis Icon
Image by mcmurryjulie/Pixabay
What Is the Long-Term Outlook for People with Lemierre Syndrome?
Advanced Lemierre syndrome is a life-threatening condition. The current mortality (death due to the syndrome) is estimated to be between 5% and 18%, depending on the source of the data. However, as the mortality in the pre-antibiotic era reportedly was 90%, the outlook for people with Lemierre syndrome has improved significantly due to advances in antibiotic therapy and high-level intensive care. Receiving the diagnosis as quickly as possible and starting appropriate treatment increases the chance of survival. Severe complications of Lemierre syndrome may include osteomyelitis (bone infection), meningitis, acute respiratory distress syndrome, and septic shock.
Source: Genetic and Rare Diseases Information Center (GARD)
Morgan’s Story
Real Stories From People Who Have Experienced Blood Clots - Morgan Spencer
Morgan’s Story
Donya Spencer was happy to have her 19-year-old daughter Morgan back home with her and the family for the weekend. Morgan had just returned from the University of Georgia (UGA), where she was a freshman studying economics and pre-law. They were both looking forward to catching up and spending some time together. However, at the time, neither one of them knew that Morgan was on the brink of a major health crisis.
Symptoms Leading Up to the Diagnosis
When Morgan woke up Sunday morning complaining of a sore throat, she went to a nearby urgent care center for a strep test. The doctor looked at her throat and commented that it looked and smelled like strep but did not run a strep test. She was given medicine, called a Z-pack, and returned home. On Sunday afternoon, she returned to UGA, expecting to feel better the following day.
Morgan went to class Monday, despite still not feeling well, as she believed the class was too important to miss. On Monday evening, she began feeling very cold, accompanied by extreme chills and shaking (a condition called rigors). Prompted by a call from Morgan saying she was violently shaking, Donya, Morgan’s mom, drove to Athens to bring her home to see her regular pediatrician on Tuesday morning. While they sat in the waiting room the next morning, Morgan became nauseous. Her face became pale, her lips turned blue, and she completely lost her vision. She felt like she was about to pass out. The pediatrician took some blood and tested her for flu, mononucleosis (mono), and strep throat (strep); her results were negative for all. Thinking it might be a virus, the pediatrician treated Morgan with a steroid medicine and told her to continue the Z-pack.
Morgan stayed at home Tuesday night and agreed to miss class on Wednesday so her mom could watch for any change in her symptoms. Donya did not want Morgan to return to school until she saw some improvement in her symptoms. Morgan felt a little bit better on Wednesday afternoon and still, at this point, had no fever. Insisting that she could not miss another day of class, Donya agreed to drive Morgan back to school Wednesday night. While returning home after dropping off her daughter, Donya received a call from Morgan. She was calling her mom to tell her she was having extreme rigors again. But Donya, thinking Morgan was just stressed about falling behind on schoolwork, told her daughter to try to rest. Morgan took her mother’s advice, but simply could not get warm or control her shaking.
On Thursday morning, Morgan called her mom when she got to her first class to tell her she couldn’t stop shaking and felt like she was about to pass out; then, the phone went silent. Afraid that her daughter passed out, Donya called the UGA police and asked if they could check on Morgan. She was told Morgan was already being helped by campus police and an EMT after being found shaking and disoriented by a professor. The paramedics evaluated Morgan and recommended she go to the emergency department (ED) since her heart rate was still over 140 after sitting down for 20 minutes. At the same time, Donya received a call from Morgan’s pediatrician, who explained that her blood work indicated something could be wrong with Morgan’s kidneys.
When they arrived at the ED, Morgan’s heart rate was still very high; the nurse commented that she looked septic (sepsis is an infection causing organ failure and dangerously low blood pressure). Morgan told the nurse that she felt a lump on the left side of her throat and that her throat hurt so bad it felt like she needed to have her tonsils removed. The ED doctors gave her fluids and penicillin for infection. She was again tested for mono and flu, which were negative. While in the ED, Morgan began having pain in her chest, back, and shoulders, so an EKG (a test to check for signs of possible heart conditions) was performed and she was given morphine for the pain; no imaging tests were run. Donya was worried for her daughter, but also knew this was the third doctor Morgan had seen in 5 days, so if something were wrong, surely it would have been found. Morgan was given fluids and IV (intravenous) medications, which helped her heart rate come down, helping her to rest. She was discharged from the ED that evening and, instead of taking her back to school, Donya drove her back home again.
Once home, Morgan couldn’t get to sleep. In the middle of the night, she began having extreme rigors again. Not wanting to wake her parents, she took a very hot bath and drank hot water in an attempt to warm up, but it didn’t help.
On Friday morning, Morgan’s throat was feeling better, but she began having back and shoulder pain again. Thinking the pain may be stemming from Morgan having been confined to a bed for the past few days, Donya took her daughter to see a chiropractor. The chiropractor ruled out muscular pain but commented that “something else is going on with her.” When they got home, Donya updated the pediatrician on Morgan’s condition and was instructed to watch her daughter over the weekend. By Friday afternoon, Morgan’s back pain had grown more severe. Thinking she had a kidney stone, Morgan’s parents took her to their local ED, where a doctor performed a CAT scan (a scan of a part of the body that aids in the diagnosis or detection of disease) that captured the bottom part of her lungs, showing pneumonia. The doctor recommended that Morgan be admitted, saying “It is unusual for a healthy 19-year-old to get pneumonia.” After being admitted, Morgan was given pain medication, but remained uncomfortable and in pain throughout the night. Morgan’s parents were very worried about her but had no idea how sick she truly was. Morgan would not leave the hospital for 18 days.
Diagnosis and Treatment
On Saturday morning, a pulmonologist (lung specialist) ran an array of tests that included CAT scans of her neck, heart, and lungs. As a result of these tests, the pulmonologist was able to diagnose Morgan with Lemierre’s syndrome, a rare illness that occurs when bacteria from a throat infection crosses into and infects the jugular veins. The pulmonologist also discovered Morgan had many septic blood clots in her lungs (called pulmonary embolism). Morgan had one large blood clot in her internal jugular vein, parts of which had been breaking off into her lungs, causing her upper body pain. She also had fluid in and around her lungs making it hard for her to breathe. The infection had also spread to Morgan’s bloodstream (a condition known as sepsis), causing her to run a high fever. She was transferred to the intensive care unit (ICU), where she stayed for 3 days. “The first night was the scariest night of my life,” Donya said. She was so sick, and I was terrified that she would die.”
Morgan fought hard, but her recovery was very slow. Once stable and out of ICU, she spent a couple weeks on an intermediate care floor, where she was under the care of many doctors, including pulmonologists, infectious disease specialists, hematologists (blood specialists), ear, nose, and throat specialists, and pain management specialists. It took weeks for the strong IV antibiotics to fight the infection. She was in terrible pain, so she was given strong pain medication. She coughed constantly and was very scared when she coughed up a lot of blood. “That was the only time I really thought—I’m going to die,” Morgan said. Because she was on a medication to prevent and treat blood clots, they had to draw her blood every 6 hours to make sure the right amount of medication was in her blood. She was also given oxygen to help her breathe.
It was a very tough recovery. For the first couple of weeks, she could barely stand. After 18 days, she was finally able to go home. She continued IV antibiotics for another 4 weeks from home and was prescribed an oral medication to prevent the blood clots from getting larger. She was very weak and lost more than 20 pounds.
Impact of Her Condition
Lemierre’s syndrome took a toll not only on Morgan’s body, it took an emotional toll on her as well. Morgan had always been healthy, playing sports all her life. Now, things most of us take for granted, such as being able to go to the bathroom by yourself or being able to walk, were very difficult for her. She was forced to withdraw from all but one class for the fall semester, which was very upsetting for her, as prior to her diagnosis, Morgan was doing exceptionally well academically. She was unable to return to her dorm for months, as her doctors were worried that even catching a cold could be detrimental to Morgan’s recovery. This meant she had to miss out on football games, sorority events, and the start of college life, which was devastating for her.
Knowledge & Awareness of Lemierre’s Syndrome
Prior to her diagnosis, Morgan and her family had never heard of Lemierre’s syndrome. No one in her family had ever experienced anything like this. “Apparently it is very rare. Only about 4 in every 1 million people develop Lemierre’s Syndrome,” says Donya. Lemierre’s used to be more common, with a very high mortality rate in the pre-antibiotic era. With the widespread use of antibiotics, it all but went away. But cases have been on the rise, and it typically strikes otherwise healthy young adults. After some research, Morgan and her family were able to find two Facebook groups dedicated to supporting people with this rare illness. Reading other people’s stories was both helpful and scary for them, as many with Lemierre’s have had long-lasting effects.
Front Row: Kayla, Donya, & Morgan Spencer Back Row: Nicholas, James, & Jack Spencer
How Is She Doing Now?
Overall, Morgan is doing very well. Life has finally returned to normal. The blood clots in Morgan’s lungs have been reabsorbed by her body. She continues to have some back pain, which her doctors say may be from the scar tissue or due to a damaged nerve from thoracentesis (a procedure she had done to remove excess fluid from the space between her lungs and chest wall).
Morgan’s and Donya’s Tips for Others
Both Morgan and Donya agree they want to spread awareness of this condition. They want all healthcare providers to know about Lemierre’s syndrome so that patients can be diagnosed as quickly as possible. They want everyone to know that this illness exists and can affect anyone, but especially the young college student. When asked what advice they would give to others, they urged others to:
See a doctor immediately if they have a sore throat, lump on one side of the throat, pain or swelling on one side of the neck, high heart rate, fever, rigors/chills, or pain in the upper body. Know the signs and symptoms and get treatment right away.
Ask a doctor about diagnostic tests and imaging tests if they have a serious sore throat with swelling on one side of the neck.
CDC thanks Morgan for sharing her personal story.
Source: Centers for Disease Control and Prevention (CDC)
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Lemierre Syndrome
Lemierre syndrome is a rare and potentially life-threatening complication of a certain type of bacterial infection in the throat, ears, salivary glands (parotitis), sinuses, or teeth. It can affect anyone, but especially previously-healthy adolescents and young adults. Learn about symptoms, causes and treatment.