What Is Acute Fatty Liver of Pregnancy?
Source: Genetic and Rare Diseases (GARD) Information Center
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Acute Fatty Liver of Pregnancy
AFLP; Acute fatty liver gestational; Hepatic lipidosis of pregnancy; Liver disease in pregnancy
Acute fatty liver of pregnancy (AFLP) is a rare and serious complication of pregnancy. It is characterized by a build-up of fat in the liver, which can lead to liver damage.
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Healthy Liver / Fatty Liver
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Healthy Liver / Fatty Liver
Source: Genetic and Rare Diseases (GARD) Information Center
Fatty Liver
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Micrograph showing ragged red fibers, a finding seen in various types of mitochondrial diseases
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Source: Genetic and Rare Diseases (GARD) Information Center
Drawing of a percutaneous liver biopsy, showing a liver within an outline of a male body, a needle pricking the liver tissue, and a slide with the tissue sample
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The diagnosis of acute fatty liver disease of pregnancy (AFLP) is usually made based on clinical findings, includng setting, presentation, and laboratory and imaging results. Laboratory tests that may be helpful include serum aminotransferases, serum bilirubin, coagulation studies, electrolytes, serum glucose, uric acid levels, creatinine and white blood count. Imaging tests are used primarily to exclude other diagnoses. Liver biopsy is diagnostic, but not always possible during pregnancy.
Source: Genetic and Rare Diseases (GARD) Information Center
Aspartate Aminotransferase Test
Also called: AST, Serum Glutamic Oxaloacetic Transaminase, SGOT
Aspartate aminotransferase (AST) is an enzyme that can be found throughout the body, especially in the liver. When your liver is damaged, this enzyme gets released; therefore, an AST test can be used to help diagnose liver disorders.
Bilirubin Blood Test
Also called: Bilirubin, Hypobilirubinemia Test, Hyperbilirubinemia Test
A bilirubin blood test measures the levels of bilirubin in your blood. Bilirubin is a yellowish substance that is created by the breakdown (destruction) of hemoglobin, a major component of red blood cells. High bilirubin levels may be a sign of liver disease.
Coagulation Factors Test
Also called: Factor Assays, Blood Clotting Factors, Clotting Factors, Coagulation Factor Tests
Coagulation factor tests measure the levels of the proteins in the blood that help control bleeding and help determine if one or more of your coagulation factors are increased, normal, or decreased.
Fibrinogen Test
Also called: Coagulation Factor I, Factor I, Hypofibrinogenemia test
Fibrinogen, also called coagulation factor I, is a protein produced by the liver. When bleeding is detected in the body, fibrinogen is released along with other coagulation factors to form blood clots and stop the bleeding. Too much or too little fibrinogen can lead to serious health problems.
Factor II Activity Test
Also called: Coagulation factor II, Prothrombin Assay, Prothrombin
When a wound occurs in any part of the body, several factors (proteins) which are involved in the normal blood clotting process become active to stop the bleeding. A factor II activity test is used to measure the activity of prothrombin, which is one of the proteins that help your blood to clot.
Factor V Activity Test
Also called: Factor V Assay, Coagulation Factor V, Labile factor, Proaccelerin, Ac-globulin
When a wound occurs in any part of the body, several factors (proteins) which are involved in the normal blood clotting process become active to stop the bleeding. A factor V (pronounced factor five) activity test is used to measure the activity of the coagulation factor V, which is one of the proteins that help your blood to clot.
Factor VII Test
Also called: Coagulation Factor VII, Stable Factor, Proconvertin, Autoprothrombin, Factor VII Activity
When a wound occurs in any part of the body, several factors (proteins) which are involved in the normal blood clotting process become active to stop the bleeding. A factor VII (pronounced factor seven) test is used to measure the activity of the coagulation factor VII, which is one of the proteins that help your blood to clot.
Factor VIII Test
Also called: Antihemophilia Factor A, Hemophilic factor A, Coagulation factor VIII
When a wound occurs in any part of the body, several factors (proteins) which are involved in the normal blood clotting process become active to stop the bleeding. This test is used to measure the activity of the coagulation factor VIII, which is one of the proteins that help your blood to clot. This is useful to diagnose a condition known as hemophilia A.
Factor IX Test
Also called: Christmas factor assay, Hemophilic factor B, Coagulation factor IX, factor IX hemophilia, FIX, factor IX deficiency test
When a wound occurs in any part of the body, several factors (proteins) which are involved in the normal blood clotting process become active to stop the bleeding. A factor IX (pronounced factor nine) test is used to measure the activity of the coagulation factor IX, which is one of the proteins that help your blood to clot. If you are lacking this...
Factor X Test
Also called: Factor X Assay, Factor X Activity, Stuart Prower Factor, Coagulation Factor X
When a wound occurs in any part of the body, several factors (proteins) which are involved in the normal blood clotting process become active to stop the bleeding. A factor X (pronounced factor ten) test is used to measure the activity of the coagulation factor X, which is one of the proteins that help your blood to clot.
Factor XI Test
Also called: Coagulation Factor XI
When a wound occurs in any part of the body, several factors (proteins) which are involved in the normal blood clotting process become active to stop the bleeding. A factor XI (pronounced factor eleven) test is used to measure the activity of the coagulation factor XI, which is one of the proteins that help your blood to clot.
Factor XII Test
Also called: Coagulation factor XII, Factor XII Assay, Factor XII Activity, Hageman Factor, Surface Factor
When a wound occurs in any part of the body, several factors (proteins) which are involved in the normal blood clotting process become active to stop the bleeding. A factor XII (pronounced factor twelve) test is used to measure the activity of the coagulation factor XII, which is one of the proteins that help your blood to clot.
Factor XIII Test
Also called: Factor XIII Assay, Factor XIII Activity, Fibrin-stabilizing factor, Coagulation Factor XIII
When a wound occurs in any part of the body, several factors (proteins) which are involved in the normal blood clotting process become active to stop the bleeding. A factor XIII (pronounced factor thirteen) test is used to measure the activity of the coagulation factor XIII, which is one of the proteins that help your blood to clot.
Electrolyte Panel
Also called: Electrolytes, Lytes
An electrolyte panel measures the level of the body's main electrolytes. Electrolytes are electrically charged minerals that help control many important functions in the body. Levels that are too high or too low can indicate a serious health problem.
Sodium Blood Test
Also called: Sodium, Hyponatremia Test, Hypernatremia Test
A sodium blood test measures the amount of sodium in your blood. If your sodium blood levels are too high or too low, it may mean that you have a problem with your kidneys, dehydration, or another medical condition.
Chloride Blood Test
Also called: Chloride, Hypochloremia Test, Hyperchloremia Test
A chloride test measures the chloride in your blood. Chloride is a mineral that helps maintain the acid-base balance in your body. The test is usually part of a routine blood screening or to help determine if there is a problem with your body's electrolyte or acid-base (pH) balance.
Potassium Blood Test
Also called: Potassium, Hypokalemia Test, Hyperkalemia Test
A potassium blood test measures the potassium levels in your blood. It is often included in a series of routine blood tests called an electrolyte panel. Too much or too little potassium may indicate a serious medical problem.
Carbon Dioxide Blood Test
Also called: Carbon Dioxide, CO2, Bicarbonate, Metabolic Alkalosis Test, Metabolic Acidosis Test
A carbon dioxide (CO2) blood test measures the amount of carbon dioxide is in the blood in your veins. Too much or too little CO2 in the blood can indicate a health problem. The test is most often done as part of an electrolyte or metabolic panel.
Uric Acid Test
Also called: Urate
A uric acid test measures the amount of uric acid in a sample of blood or urine. Uric acid is a normal body waste product. High levels can cause gout, kidney disease, and other problems.
Creatinine Test
Also called: Creat, Creatinine
This test measures creatinine levels in your blood or urine. Creatinine is a waste product that is made each time you move your muscles. People who have larger muscles tend to make more creatinine than people who have smaller muscles. Abnormal levels can be a sign of kidney disease.
White Blood Count (WBC)
Also called: WBC, WBC Blood Test, White Blood Count, White Blood Cell Count, Leukocyte Count, Leukopenia Test, Leukocytosis Test
A white blood count measures the number of white cells in your blood. White blood cells are part of the immune system. A count that is too high or too low can indicate an infection, immune system disorder, or another health problem.
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Liver Biopsy
Also called: Biopsy of the Liver
A liver biopsy is a procedure that removes a small sample of liver tissue for testing. The tissue is looked at under a microscope to check for signs of damage or disease.
Healthy Liver / Fatty Liver
Cesarean Section delivery
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Treatment of acute fatty liver of pregnancy (AFLP) involves stabilizing the mother and delivery of the baby.
Source: Genetic and Rare Diseases (GARD) Information Center
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