Researchers have carried out several types of population studies to investigate the possibility of a relationship between cell phone use and the risk of tumors, both malignant (cancerous) and nonmalignant (not cancer). Epidemiologic studies (also called observational studies) are research studies in which investigators observe groups of individuals (populations) and collect information about them but do not try to change anything about the groups.
Two main types of epidemiologic studies—cohort studies and case-control studies—have been used to examine associations between cell phone use and cancer risk. In a case–control study, cell phone use is compared between people who have tumors and people who don’t. In a cohort study, a large group of people who do not have cancer at the beginning of the study is followed over time and tumor development in people who did and didn’t use cell phones is compared. Cohort studies are limited by the fact that they may only be able to look at cell phone subscribers, who are not necessarily the cell phone users.
The tumors that have been investigated in epidemiologic studies include malignant brain tumors, such as gliomas, as well as nonmalignant tumors, such as acoustic neuroma (tumors in the cells of the nerve responsible for hearing that are also known as vestibular schwannomas), meningiomas (usually nonmalignant tumors in the membranes that cover and protect the brain and spinal cord), parotid gland tumors (tumors in the salivary glands), skin cancer, and thyroid gland tumors.
Three large epidemiologic studies have examined the possible association between cell phone use and cancer: Interphone, a case–control study; the Danish Study, a cohort study; and the Million Women Study, another cohort study. These studies have been critically evaluated in reviews reported in 2015 and in 2019. The findings of these studies are mixed, but overall, they do not show an association between cell phone use and cancer.
Interphone Case–Control Study
How the study was done: This is the largest case–control study of cell phone use and the risk of head and neck tumors. It was conducted by a consortium of researchers from 13 countries. The data came from questionnaires that were completed by study participants in Europe, Israel, Canada, Australia, New Zealand, and Japan.
What the study showed: Most published analyses from this study have shown no increases overall in brain or other central nervous system cancers (glioma and meningioma) related to higher amounts of cell phone use. One analysis showed a statistically significant, although small, increase in the risk of glioma among study participants who spent the most total time on cell phone calls. However, for a variety of reasons the researchers considered this finding inconclusive.
An analysis of data from all 13 countries reported a statistically significant association between intracranial distribution of tumors within the brain and self-reported location of the phone. However, the authors of this study noted that it is not possible to draw firm conclusions about cause and effect based on their findings.
An analysis of data from five Northern European countries showed an increased risk of acoustic neuroma in those who had used a cell phone for 10 or more years.
In subsequent analyses of Interphone data, investigators investigated whether tumors were more likely to form in areas of the brain with the highest exposure. One analysis showed no relationship between tumor location and level of radiation. However, another found evidence that glioma and, to a lesser extent, meningioma were more likely to develop where exposure was highest.
Danish Cohort Study
How the study was done: This cohort study linked billing information from more than 358,000 cell phone subscribers with brain tumor incidence data from the Danish Cancer Registry.
What the study showed: No association was observed between cell phone use and the incidence of glioma, meningioma, or acoustic neuroma, even among people who had been cell phone subscribers for 13 or more years.
Million Women Cohort Study
How the study was done: This prospective cohort study conducted in the United Kingdom used data obtained from questionnaires that were completed by study participants.
What the study showed: Self-reported cell phone use was not associated with an increased risk of glioma, meningioma, or non-central nervous system tumors. Although the original published findings reported an association with an increased risk of acoustic neuroma (21), it was not observed with additional years of follow-up of the cohort.
Other Epidemiologic Studies
In addition to these three large studies, other, smaller epidemiologic studies have looked for associations between cell phone use and individual cancers in both adults and children. These include:
- Two NCI-sponsored case–control studies, each conducted in multiple US academic medical centers or hospitals between 1994 and 1998 that used data from questionnaires or computer-assisted personal interviews (24). Neither study showed a relationship between cell phone use and the risk of glioma, meningioma, or acoustic neuroma in adults.
- The CERENAT study, another case–control study conducted in multiple areas in France from 2004 to 2006 using data collected in face-to-face interviews using standardized questionnaires. This study found no association for either gliomas or meningiomas when comparing adults who were regular cell phone users with non-users. However, the heaviest users had significantly increased risks of both gliomas and meningiomas.
- A pooled analysis of two case–control studies conducted in Sweden that reported statistically significant trends of increasing brain cancer risk for the total amount of cell phone use and the years of use among people who began using cell phones before age 20.
- Another case–control study in Sweden, part of the Interphone pooled studies, did not find an increased risk of brain cancer among long-term cell phone users between the ages of 20 and 69.
- The CEFALO study, an international case–control study of children diagnosed with brain cancer between ages 7 and 19, found no relationship between their cell phone use and risk for brain cancer.
- The MOBI-Kids study, a large international case–control study of young people ages 10 to 24 years diagnosed with brain tumors, found no evidence of an association between wireless phone use and the risk of brain tumors.
- A population-based case–control study conducted in Connecticut found no association between cell phone use and the risk of thyroid cancer.