Some of the same medicines people take to treat HIV can also be taken to prevent HIV. If you have HIV, your doctor should prescribe medicine to treat HIV, called antiretroviral therapy, or ART. People with HIV who take HIV medicine as prescribed and keep an undetectable viral load can stay healthy and prevent HIV transmission.
If you don’t have HIV but are at high risk for getting it, your doctor may prescribe medicines to reduce your chances of getting it. This is called pre-exposure prophylaxis, or PrEP. If taken as prescribed, PrEP is highly effective for preventing HIV. If you have a recent possible exposure to HIV, your doctor can prescribe the same medicines used for PrEP to reduce your chances of getting HIV. This is called post-exposure prophylaxis, or PEP.
Antiretroviral Therapy (ART) for Treating HIV
What is ART? The medicines used to treat HIV infection are called antiretrovirals. Antiretroviral therapy, or ART, refers to taking these medicines to treat HIV infection.
What we know about ART
ART can reduce the amount of HIV (called "viral load") in your blood to very low levels. This is called viral suppression. ART can reduce a person’s viral load to such a low level that current lab tests can’t detect it. This is called an undetectable viral load. ART can be prescribed only by a health care provider.
ART slows the progression of HIV and helps protect your immune system . ART can keep you healthy for a long time.
ART also prevents HIV transmission through sex. People who take ART as prescribed and keep an undetectable viral load (or stay virally suppressed) will not transmit HIV through sex. Getting and keeping an undetectable viral load is a 100% effective way to prevent getting or transmitting HIV from sex.
ART can also prevent HIV transmission from mother to baby during pregnancy, labor, and delivery. If a woman takes HIV medicine as prescribed throughout pregnancy, labor, and delivery and received HIV medicine for her baby for 4-6 weeks after delivery, the risk of transmitting HIV to her baby can be 1% or less. Having an undetectable viral load substantially reduces, but does not eliminate, the risk of transmitting HIV to an infant from breastfeeding. Current recommendation in the United States is that mothers with HIV should not breastfeed their infants.
ART may also prevent transmission from injection drug use. We don’t have data about whether having an undetectable viral load prevents HIV transmission through sharing needles, syringes, or other injection equipment (for example, cookers). It is reasonable to assume it reduces the risk by some amount, but we don’t know how much.
What you can do
If you have HIV, it is important that you start medical care and begin HIV treatment right away. ART is recommended for all people with HIV, regardless of how long they’ve had the virus or how healthy they are. ART slows the progression of HIV and helps protect your immune system . ART can keep you healthy for a long time and prevent sexual transmission of HIV as long as you keep an undetectable viral load.
If you’re taking ART, visit your health care provider regularly and always take your medicine as prescribed to keep your viral load as low as possible. If your viral load doesn’t go down with ART, talk to your health care provider about your treatment options or get a second opinion from a doctor who specializes in HIV.
If you’re HIV-negative and have a partner with HIV, encourage your partner to get in care and always take ART as prescribed to live a longer, healthier life and reduce the chances of transmitting HIV to you.
Health insurance will generally cover part or all of the cost for medicine used to treat HIV.
Even if the partner with HIV has an undetectable viral load, you or your sex partner(s) may want to use additional prevention options. Using a condom the right way every time you have sex can protect you from other STDs. Using condoms or having the HIV-negative partner take medicine as prescribed to prevent HIV (called pre-exposure prophylaxis or PrEP) can provide added peace of mind. Also consider using additional prevention methods if the partner with HIV
- Is unsure, for any reason, that they have an undetectable viral load
- Has a higher viral load (200 copies/ml of blood or greater)
- Has trouble taking HIV medicine regularly
- Missed some doses since their last viral load test
- Has stopped taking HIV medicine or may do so in the future
You and your partner(s) should learn about all the available prevention options and make the decisions that are right for both of you.
If the partner with HIV does not have an undetectable viral load—or it does not stay undetectable—you can take other steps to prevent HIV transmission. The following actions are highly effective for preventing HIV:
- Use condoms the right way every time you have sex you have anal or vaginal sex.
- Choose sexual activities with little to no risk, like oral sex.
- The HIV-negative partner can take medicine to prevent HIV, called pre-exposure prophylaxis or PrEP.
- If the HIV-negative partner might have been recently exposed to HIV—for example, if the condom breaks during sex and the partner with HIV doesn’t have an undetectable viral load—they should talk to a health care provider right away (within 3 days) about taking medicine (called post-exposure prophylaxis (PEP)) to prevent getting HIV.
- Never share needles, syringes, or other equipment to inject drugs.
If either partner has other sexually transmitted diseases (STDs), getting treatment for those STDs can also help lower the risk of getting or transmitting HIV.
Pre-exposure Prophylaxis (PrEP) for Preventing HIV
What is pre-exposure prophylaxis? Pre-exposure prophylaxis (or PrEP) is medicine that can reduce your chance of getting HIV from sex or injection drug use. PrEP can be pills or shots.
What we know about PrEP
PrEP can be pills or shots that reduce your chances of getting HIV from sex or injection drug use. Studies have shown that PrEP is highly effective for preventing HIV if it’s taken as prescribed. PrEP is much less effective when it isn't taken consistently. When taken as prescribed, PrEP reduces the risk of getting HIV from sex by about 99%.
Among people who inject drugs, PrEP pills reduce the risk of getting HIV by at least 74% when taken as prescribed. Currently, PrEP shots are not recommended for people who inject drugs.
PrEP is for people without HIV who:
Have had anal or vaginal sex in the past 6 months and:
- Have a sexual partner with HIV (especially if the partner has an unknown or detectable viral load)
or - Have not consistently used a condom
or - Have been diagnosed with a sexually transmitted disease (STD) in the past 6 months
PrEP is also recommended for people who inject drugs and have an injection partner with HIV, or have shared needles, syringes, or other injection equipment .
Because PrEP involves taking medicine as prescribed and regular visits to a health care provider, it may not be right for everyone. And PrEP can cause side effects like nausea in some people, but these generally get better over time. These side effects aren’t life threatening.
What you can do
PrEP can significantly reduce your risk of HIV infection if taken consistently. You must take an HIV test before beginning PrEP (to be sure you don’t already have HIV) and routinely as recommended while you're taking it. You will have to visit your health care provider regularly for follow-up visits, HIV tests, and prescription refills or shots.
With telehealth (phone or video consultation with a health care provider) and mail-in self-testing, it is possible to order a specimen collection kit which contains the supplies to do the testing required to start or continue taking PrEP pills, even if an in-person appointment is not possible.
If you think you were recently exposed to HIV, there are other antiretroviral medications (called post-exposure prophylaxis or PEP) you can take to prevent getting HIV. If you have been prescribed PEP and have continued risk behavior, or have used multiple courses or PEP, talk to your doctor about taking PrEP. For PEP to work, you need to start taking it as soon as possible but always within 72 hours after the exposure. You will need to take PEP for 28 days as directed by your health care provider.
The cost of PrEP is covered by most insurance plans and state Medicaid programs. Under the Affordable Care Act, PrEP must be free under almost all health insurance plans. That means you can’t be charged for your PrEP medication or the clinic visits and lab tests you need to maintain your prescription. Help is also available through commercial assistance or co-pay assistance programs. You can also get free PrEP if you don't have insurance for prescription coverage, or co-pay assistance if you do have coverage. Some states also have their own PrEP assistance programs.
If you’re in a relationship where one partner is HIV-positive and the other is HIV-negative and you are considering getting pregnant, you should talk to your doctor about PrEP. PrEP is especially important if the partner with HIV has trouble getting or keeping an undetectable viral load.
Post-exposure Prophylaxis (PEP) for Preventing HIV after Exposure
What is post-exposure prophylaxis? Post-exposure prophylaxis (or PEP) means taking antiretroviral medicine (ART) after being possibly exposed to HIV to prevent becoming infected.
What we know about PEP
PEP should be used only in emergency situations and must be started within 72 hours after a possible exposure to HIV. PEP is safe but may cause side effects like nausea in some people. These side effects can be treated and aren’t life threatening.
Your health care provider will test you for HIV before prescribing PEP to make sure you don’t already have it and may test you for up to 6 months after you begin taking PEP to be sure you stay HIV-negative.
What you can do
If you’re HIV-negative or don’t know your HIV status and think you have recently been exposed to HIV during sex (e.g., if the condom breaks) or through sharing needles, syringes and other injection equipment (for example, cookers), talk to your health care provider or an emergency room doctor about PEP right away if you are not already taking pre-exposure prophylaxis (PrEP) as prescribed. The sooner you start PEP, the better; every hour counts. If you’re prescribed PEP, you’ll need to take it for 28 days.
Since PEP is not 100% effective, you should continue to use condoms with sex partners and safe injection practices while taking PEP. These strategies can protect you from being exposed to HIV again and reduce the chances of transmitting it if you do become infected while on PEP.
If you have HIV and have an HIV-negative partner, PEP might be an option if they’re not already taking pre-exposure prophylaxis (PrEP) and they’re exposed to HIV during sex (e.g., if you have trouble getting or keeping an undetectable viral load) or through sharing needles, syringes, and other injection equipment (for example, cookers). Encourage your partner to talk to a health care provider about PEP right away to find out if it’s right for them. The sooner someone starts PEP, the better; every hour counts.
Since PEP is not 100% effective, your partner should continue to use condoms and safe injection practices while taking PEP. These strategies can protect your partner from being exposed to HIV again.
Another way you can reduce the risk of transmitting HIV to your sex partners is if you take ART. ART is recommended for all people with HIV, regardless of how long they’ve had the virus or how healthy they are. ART reduces the amount of HIV (viral load) in the blood. If you take ART as prescribed and keep an undetectable viral load, you can stay healthy and will not transmit HIV through sex.