Hearing loss has many causes, including genetic causes (that is, caused by the instructions in the baby’s cells) and non-genetic causes (such as certain infections the mother has during pregnancy or infections affecting the newborn baby). In general, 50% to 60% of hearing loss in babies is due to genetic causes. Learn about the genetics of hearing loss.
Genetics of hearing and hearing loss
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Background
Newborn hearing screening
Image by U.S. Air Force photo/Samuel King Jr.
Newborn hearing screening
Sarah Thompson, daughter of Senior Airman Josh Thompson, 1st Special Operations Wing, has an ear bud placed in her ear prior to her newborn hearing screening. The screening measures otoacoustic emissions, which are sounds produced by the outer hair cells within the inner ear. It is common practice for babies born on base and a state-mandated procedure in Florida. (U.S. Air Force photo/Samuel King Jr.)
Image by U.S. Air Force photo/Samuel King Jr.
Introduction to Genetics and Hearing Loss
About 1 in 500 infants are born with or develop hearing loss during early childhood. Screening for hearing loss is considered standard care in the United States and in 2019 over 98% of children were screened, usually before leaving the hospital. Hearing loss has many causes, including genetic causes (that is, caused by the instructions in the baby’s cells) and non-genetic causes (such as certain infections the mother has during pregnancy or infections affecting the newborn baby). A combination of genetic and non-genetic factors also can lead to hearing loss. In general, 4 out of 5 babies with hearing loss have a genetic cause for their hearing loss, while the rest will have non-genetic cause or a combination of factors.
Source: Centers for Disease Control and Prevention (CDC)
Additional Materials (2)
Newborn hearing screening
Sarah Thompson, daughter of Senior Airman Josh Thompson, 1st Special Operations Wing, yawns as she undergoes a newborn hearing screening approximately 24 hours after her birth. The screening measures otoacoustic emissions, which are sounds produced by the outer hair cells within the inner ear. It is common practice for babies born on base and a state-mandated procedure in Florida. (U.S. Air Force photo/Samuel King Jr.)
Image by U.S. Air Force photo/Samuel King Jr.
Children with Hearing Loss
A child with hearing loss treated by My Right To Hear
Image by Nimeradeeb/Wikimedia
Newborn hearing screening
U.S. Air Force photo/Samuel King Jr.
Children with Hearing Loss
Nimeradeeb/Wikimedia
Types of Hearing Loss
Hearing Protector Test Fixture Pinna - NIOSH Acoustics Laboratory
Image by Chuck Kardous/Wikimedia
Hearing Protector Test Fixture Pinna - NIOSH Acoustics Laboratory
GRAS Type 45CA Hearing Protector Test Fixture Pinna - NIOSH Acoustics Laboratory
Image by Chuck Kardous/Wikimedia
About the Types of Hearing Loss
Types of Hearing Loss
What are the types of hearing loss? There are a few ways to talk about the different types of hearing loss.
One way is based on whether or not a baby is born with hearing loss. If the baby is born with hearing loss, it is called congenital. If the hearing loss occurs after the baby is born, it is called acquired.
Another way depends on whether or not the hearing loss gets worse over time. Hearing loss that gets worse over time is called progressive. Hearing loss that does not change is called non-progressive.
A third way depends on whether or not other conditions are present. If they are present it is syndromic, if not then it is called non-syndromic.
A fourth way depends on whether or not hearing loss runs in the family. If it does, it is called familial; if it does not, it is sporadic or de novo.
A fifth way is based on where in the ear the hearing loss occurs. If the loss occurs in the outer or middle ear it is conductive. If it occurs in the inner ear it is sensorineural. If the loss occurs in both areas, it is mixed.
Congenital or Acquired
Congenital: This means a person was born with the hearing loss. Babies born with hearing loss can be identified through a newborn hearing screening test. The test often is done before babies leave the hospitals in which they were born. The screening test does not tell the cause of the baby’s hearing loss. It can tell only whether the baby might have a hearing loss.
Acquired: This means a person could hear at birth but developed hearing loss later in life. Acquired hearing loss also can be described by the age at which it starts. If hearing loss starts before the age when children usually begin talking, it is called “prelingual,” which means “before speaking.” If hearing loss starts after the age when children begin talking, it is called “postlingual,” which means “after speaking.”
Progressive or Non-Progressive
Progressive: If the hearing loss gets worse over time, it is called “progressive.”
Non-progressive: If the hearing loss does not change over time, it is “nonprogressive” or stable.
Syndromic or Non-Syndromic
Syndromic: This means that a person has other conditions besides hearing loss. For example, some people with hearing loss also are blind. There are many different syndromes that have hearing loss as one of the conditions.
Non-syndromic: This means that the person does not have any other conditions.
Familial or Sporadic
Familial: If more than one person in a family has hearing loss, it is said to be “familial.” That is, it runs in the family.
Sporadic: If only one person in the family has hearing loss, it is called “sporadic.” That is, it does not run in the family.
Conductive or Sensorineural
The middle ear contains small bones that help send sound from the air to the inner ear. The inner ear changes these sounds into nerve signals that go to the brain. See Figure 1.
Conductive: This hearing loss is caused by changes in the outer or middle ear.
Sensorineural: This hearing loss is caused by changes in the inner ear or in the hearing nerve, or both.
Mixed: This hearing loss is both conductive and sensorineural.
How Is Hearing Loss Identified?
Hearing screening is the first step in the identification process, and it can tell if a young child might have a hearing loss. Hearing screening is easy and is not painful. In fact, babies are often asleep while being screened. It takes a very short time — usually only a few minutes. All babies should have a hearing screening no later than 1 month of age, and in the United States about 98% of newborns are screened before they leave the hospital.
There are two types of technology used to screen a newborn for hearing loss. The first is otoacoustic emissions (OAEs) and the second is auditory brainstem response (ABR). The OAE screen checks the inner ear response to sound. Because this screening does not rely on a person’s response behavior, the child can be asleep during the screening. The ABR screen checks the brain’s response to sound, and like the OAE screen, the ABR screen does not rely on a child’s response behavior, so the child can also be asleep during this screen.
If a child does not pass a hearing screening, it’s very important for the child to get a full hearing test (often called an audiologic evaluation) as soon as possible, but no later than 3 months of age.
How Do Healthcare Providers Figure Out What Caused a Person’s Hearing Loss?
Healthcare providers begin by looking at a person’s physical features, medical history, and family history. Based on this, they classify the hearing loss in the ways described earlier (congenital or acquired during prelingual or post-lingual period, progressive or non-progressive, conductive or sensorineural, syndromic or non-syndromic, and familial or sporadic). The classifications often point to certain causes. The healthcare providers might ask for more medical tests to look for signs of syndromic hearing loss, and they may arrange for genetic tests.
What Causes Hearing Loss?
Hearing loss can be caused by changes in or around genes (which are the instructions in the body’s cells), or by external events (such as injuries, illness, and certain medications), or both.
Hearing depends on the biology of the ear and the way the brain makes sense of sounds. Both of these can be influenced by genes. There are many genes involved in hearing. Genes are passed down from biological parents to their child. If a child has hearing loss, one or more genetic changes can be the cause. These genes may influence either the structure of the ear, the way the brain makes sense of sounds, or both. The child could have received the changed gene(s) from one or both parents (familial) or the changed gene occurred in the family only within the child with hearing loss (sporadic).
There are also non-genetic causes for hearing loss. For example, babies who are born too early or who need help breathing (for example, using a ventilator) are more likely to develop hearing loss than are other babies. Some infections (for example, cytomegalovirus) that the mother has during her pregnancy can cause the baby to have hearing loss. Also, some infections (for example, meningitis) that babies and children sometimes have can cause hearing loss.
Sometimes, both genes and external (i.e., non-genetic) events work together to cause hearing loss. For example, there are some medicines (known as ototoxic medications) that can cause hearing loss but only among people who also have specific gene changes.
Source: Centers for Disease Control and Prevention (CDC)
Genes and Hearing Loss
Genes and Genetic Defects
Image by TheVisualMD
Genes and Genetic Defects
Genetic testing isn't new. In the 1960s, doctors were able to test newborn babies for certain rare single-gene disorders, such as phenylketonuria (PKU), a rare metabolic disease that causes mental retardation. (PKU can be prevented with a special diet if it's detected early, which was why it was critical to test newborns.)
Image by TheVisualMD
About Genetics and Hearing Loss
What Are Genes?
Genes are the basic blocks of information that all of the body’s cells use to do what they are supposed to do. For example, genes tell heart cells how to beat, stomach cells how to digest food, and muscle cells how to move. Genes also contain the information for normal growth and development, and they help determine each person’s physical features, such as height, eye color, and hair color.
Genes are made up of a chemical called deoxyribonucleic acid (DNA). DNA is made up of two chemical chains joined together like rungs on a ladder. At each rung along the DNA chain there is a part of DNA called a base. Four different bases make up DNA, and they are called A, C, T and G, for short. The specific order, or sequence, of all the As, Cs, Ts, and Gs in DNA determines the exact information carried in each gene, like the way that a specific pattern of letters makes up the words in a sentence. Please see Figure 2 for the relationship between bases, genes, DNA, chromosomes, and cells.
What Happens When Genes Change?
When DNA bases are missing, changed, or out of order, instructions for gene are changed so that they can’t provide the information that cells need. These changes can cause various conditions, depending upon the types of changes and the genes involved. Some DNA changes can cause hearing loss with other conditions (syndromic) and/or hearing loss by itself (nonsyndromic). Even among families with hearing loss in multiple relatives, DNA changes are not always found. Scientists are working to find all of the DNA-related causes for hearing loss.
Here is an example of a gene change. Suppose part of a gene usually has the sequence GTAC. However, in some people, the sequence has changed to GTTC. This change can alter the way that the gene works so that people with this DNA change will have a particular condition. Keep in mind that not all DNA changes result in a noticeable change in the person.
How Are Genes Passed to Children?
About half of a child’s DNA comes from each parent through the egg from the mother and the sperm from the father. Thus, a child will have features similar to each parent.
Within each cell of a person’s body, the genetic instructions (DNA) are packaged into larger units called chromosomes. Each person typically has 23 pairs of chromosomes. One chromosome of each pair is from the person’s mother and the other chromosome of each pair is from the father.
Usually, human cells have 46 chromosomes that occur in 23 pairs. The first 22 pairs of chromosomes, called number 1 to 22, are the same in males and females. The 23rd pair is called the sex chromosomes. They help determine if a person is born male or female. A female has two X chromosomes, and a male has one X and one Y chromosome. A mother will give one of her two X chromosomes to each of her children. A father will give either his X or his Y chromosome. A child who gets the father’s Y chromosome will be male. A child who gets the father’s X chromosome will be female.
Figure 3 shows how children get their chromosomes and, therefore, their genes and DNA from their parents. In this figure, three of the 23 pairs of chromosomes are shown: pair #1 (green), pair #2 (yellow), and the sex chromosomes (purple and blue). The father’s chromosomes are shown in solid color, and the mother’s are striped. A child randomly gets one of each pair of chromosomes from the child’s mother (striped) and one of each pair from the father (solid). Each daughter gets an X from her mother (striped) and an X from her father (solid). Each son gets an X from his mother (striped) and a Y from his father (solid).
What Are the Different Ways Genes Can Cause Conditions in Children?
Genetic conditions can be described by the chromosome that contains the gene or DNA change. If the gene is part of one of the first 22 pairs of chromosomes, called autosomes, the genetic condition is called an “autosomal” condition. If the gene or DNA change is part of the X chromosome, the condition is called “X-linked” or “sex-linked.”
Genetic conditions can be further grouped based on who they affect in families. Changes in and around genes cause conditions to occur within members of the same family in certain patterns, called autosomal “dominant,” autosomal “recessive,” and X-linked “recessive.”
Autosomal Dominant Conditions
“Autosomal” conditions affect both males and females equally. In “dominant” conditions, the condition is passed from parent to child. Even when only one parent has a dominant condition, the condition can still be passed on to their children. When one parent has a dominant condition, each child has a 50% (1 in 2) chance of having it as well. All members of the family with one gene with the dominant change will have the condition because it takes only one gene with a dominant change to cause the condition.
Figure 4 shows how children acquire dominant conditions from their parents. In this example shown, the chromosome with the usual gene is symbolized by () and the chromosome with the dominant gene change is symbolized by (). When one parent has the dominant condition, he or she has the usual gene () and a gene with the dominant gene change (). He or she will pass on to each child one or the other. Therefore, each child has a 50% (1 in 2) chance of getting the gene with the dominant gene change and having the condition.
If the other parent has two chromosomes with the usual genes, and therefore does not have the condition, he or she will pass on to each child one of the two usual genes (). Even though a child gets one of the usual genes from the parent who does not have the condition, if he or she gets a dominant changed gene from the parent with the condition, the child also will have the condition.
Most of the time, children with autosomal dominant hearing loss will have a parent with the same dominant gene change and hearing loss. However, the child may be the first one diagnosed in the family. The parent and child may not show the same symptoms or level of hearing loss, or the symptoms may not appear at the same time. If a child has an autosomal dominant type of hearing loss, but the parents are hearing, the child may be the first in the family to have the changed gene (sporadic). When this child grows up and has children, each of the children has a 1 in 2 chance of getting the changed gene.
Autosomal Recessive Conditions
“Autosomal” conditions affect males and females equally. “Recessive” conditions are due to changes in or around genes, but they appear in families in a different way than dominant conditions. This is because people who have one recessive gene change do not have the condition. They are called “carriers.” If two carriers have a child together, there is a 25% (1 in 4) chance that the child will get two recessive changed genes, one from each parent. This child will have the recessive condition. Only children who have no usual genes will have the recessive condition.
Figure 5 shows how recessive conditions appear in families. In this example, each parent is a carrier and has a chromosome with one usual gene () and one chromosome with a recessive gene change (). Each parent will pass on to a child either the usual gene () or the gene with the recessive change (). Each has a 50% (1 in 2) chance of happening. If the child gets one usual gene () from one parent and one gene with the recessive change () from the other parent, the child will be a carrier, just like both parents. If the child gets a gene with the recessive change () from both parents, and therefore doesn’t have the usual gene, the child will have the condition. When both parents are carriers, there is a 25% (1 in 4) chance that each child will get a gene with a recessive change from both parents and, therefore, have the condition.
Two people with the same recessive condition caused by the same gene change will not necessarily have the same level of hearing loss nor will the hearing loss appear at the same age. Predicting the exact outcome of the changed genes in another person (or sibling) may not be straightforward.
X-Linked Recessive Conditions
Hearing loss can also occur as an X-linked condition. These conditions usually affect only males. In such instances, a change in or around a gene is passed in the family through female carriers who do not have the condition. However, each son of a female carrier has a 50% chance of getting the changed gene and, therefore, of having the condition.
Figure 6 shows an example of inheritance of an X-linked recessive condition. “X-linked” genes are genes that are part of the X chromosome. “Recessive” means that a person who does not have at least one usual gene will have the condition.
A female has two X chromosomes and, therefore, two of each X-linked gene. A woman who has one usual gene and one gene with a recessive change is called a carrier. A carrier does not have the condition but can pass the gene with the recessive change on to her children.
A male has only one X chromosome, which was passed down from his mother. His other sex chromosome is a Y chromosome that he received from his father. Therefore, a male has only one of every gene on the X chromosome. If the male gets his mother’s X chromosome that has the recessive gene change, he will have the condition. If he gets his mother’s X chromosome that has the usual gene, he will not have the condition. Therefore, a son of a carrier mother has a 50% chance of having the condition. A daughter of a carrier mother will similarly have a 50% chance of getting the X chromosome with the recessive gene change from her mother, but if her father has an X chromosome with the usual gene, the daughter will not have the condition, but will be a carrier, like her mother. A daughter of a carrier mother also has a 50% chance of getting the X chromosome with the usual gene from her mother, and if the daughter also gets an X chromosome with the usual gene from her father, she won’t be a carrier but instead will be a non-carrier.
Figure 7 shows X-linked inheritance from a father with the condition. A male has only one X chromosome, and if he passes the X chromosome to his child, the child will be female. If the X chromosome he passes has the recessive gene change, each daughter will be a carrier. A male has only one Y chromosome, and if the father passes the Y chromosome to his child, the child will be male. None of his sons will have the condition or be carriers, as long as the mother did not pass an X chromosome with the recessive gene.
When a male child has hearing loss caused by a changed gene that is part his X chromosome, but neither of his mother’s X chromosomes have the changed gene, she is not a carrier. In this case, the child may be the first in the family to have the changed gene (sporadic). If this child has children, then all of his daughters will get the changed gene and be carriers, and all of his sons will not get the changed gene, so they will not have the condition.
What are GJB2 and Connexin 26?
The GJB2 gene contains the instructions for a protein called Connexin 26. This protein is needed for a part of the ear called the cochlea to do its job. The cochlea is a very complex and specialized part of the body. It needs many instructions to form and work correctly. These instructions come from many genes, including GJB2, GJB3, and GJB6. Changes in any one of these genes can result in hearing loss. However, unlike other autosomal recessive causes for hearing loss where severity or progression may not be predictable, GJB2-related hearing loss can be predicted based on the specific gene change. Read more detailed information about changes in the GJB2 gene and hearing loss.
Among some populations, about 50% of children with a genetic hearing loss who do not have a syndrome will have a DNA change in the GJB2 gene. There are many different gene changes that can cause hearing loss. Most of these changes are recessive, meaning that a person can have one usual copy of the gene and one copy of the changed GJB2 gene and will have full hearing function. (Everyone has two GJB2 genes, one from each parent.) However, a person who has two changed GJB2 genes, one from each parent, will have hearing loss. This means that if both parents have just one changed GJB2 gene, they can have a child with hearing loss, even though both parents can hear. In fact, most babies with hearing loss are born to parents who can hear.
Multifactorial Conditions
Some conditions, such as hearing loss, can be caused by a combination of genetic and non-genetic factors. These conditions are said to be “multifactorial.” People who have multifactorial conditions often are born into families with no other affected members. Parents of a child with any such condition have a greater chance of having another child with the same condition than parents who do not have a child with the condition.
If a couple without hearing loss has a child with hearing loss, there are no other relatives with hearing loss, and a specific cause of the hearing loss has not been sought, the couple’s chance of having another child with hearing loss is about 18%. However, if the child has been tested for the known genetic and non-genetic causes of hearing loss and none are identified, then the child is considered to have multifactorial hearing loss. In this case, the couple’s chance of having another child with hearing loss is 3-5%.
Mitochondrial Conditions
“Mitochondrial” conditions are different from most other genetic conditions because only the mother can pass them to her children. Also, the child receives a mixture of mitochondria that have a proportion of mitochondria with and without the changed genes. The amount of each type can be very different, ranging from all mitochondria with no gene change or all with the changed genes to a combination of everything in between. If a woman has a mitochondrial condition, the chance that she will pass it on to her children depends on the particular condition and on the amount of changed mitochondrial genes that the child receives. Fathers with a mitochondrial condition do not pass it on to their children.
There are genes that exist outside of chromosomes within a person’s cells. A few genes are found on small, circular pieces of DNA in the mitochondria called the mitochondrial chromosome. Mitochondria are tiny parts of cells that make energy, and the mitochondrial genes are particularly important for cells with high energy needs, particularly in the brain, nerves, eyes, ears, heart, and muscles. Each cell has many mitochondria, and every mitochondrion has many copies of the mitochondrial chromosome. The chance that a person will have a mitochondrial condition depends on the number of mitochondrial chromosomes in each cell that have a changed gene as well as the number of cells in an organ or tissue that have many mitochondria with the changed genes.
genes on the other 23 pairs of chromosomes are passed on because children get their mitochondrial chromosomes only from their mothers. Therefore, if a woman carries changes in her mitochondrial genes, each child has a chance of having the condition ranging from a severe form to being an unaffected carrier. The chance of having symptoms of a mitochondrial condition depends on the number of mitochondrial chromosomes that were in the egg cell with the changed gene and how the mitochondrial chromosomes were distributed among the mitochondria in the egg cell. A male with a mitochondrial condition will not pass the condition to his children because mitochondria in sperm cells usually don’t get into the fertilized egg cell.
Figure 8 shows how a fertilized egg (which will grow into a baby) gets chromosomes from the mother’s egg and the father’s sperm (shown as red and blue chromosomes) but gets mitochondrial chromosomes only from the mother’s egg.
Source: Centers for Disease Control and Prevention (CDC)
Additional Materials (1)
Human genome to genes
Illustration of the human genome, from the genome to a chromosome, and from a chromosome to genes.
Image by Plociam
Human genome to genes
Plociam
GJB2 Gene
Ideogram of human chromosome 13
Image by Office of Biological and Environmental Research of the U.S. Department of Energy Office of Science, the Biological and Environmental Research Information System, Oak Ridge National Laboratory.
Ideogram of human chromosome 13
Selected genes, traits, and disorders associated with the chromosome listed; (blue and violet) regions reflecting the unique patterns of light and dark bands seen on human chromosomes stained to allow viewing through a light microscope; (red) the centromere, or constricted portion, of each chromosome; (yellow) chromosomal regions that vary in staining intensity and sometimes are called hererochromatin (meaning “different color”); (lines between yellow) variable regions, called stalks, that connect a very small chromosome arm (a “satellite”) to the chromosome.
Image by Office of Biological and Environmental Research of the U.S. Department of Energy Office of Science, the Biological and Environmental Research Information System, Oak Ridge National Laboratory.
GJB2 Gene: Gap Junction Protein Beta 2
Normal Function
The GJB2 gene provides instructions for making a protein called gap junction beta 2, more commonly known as connexin 26. Connexin 26 is a member of the connexin protein family. Connexin proteins form channels called gap junctions that permit the transport of nutrients, charged atoms (ions), and signaling molecules between adjoining cells. The size of the gap junction and the types of particles that move through it are determined by the particular connexin proteins that make up the channel. Gap junctions made with connexin 26 transport potassium ions and certain small molecules.
Connexin 26 is found in cells throughout the body, including the inner ear. Because of its presence in the inner ear, especially the snail-shaped structure called the cochlea, researchers are interested in this protein's role in hearing. Hearing requires the conversion of sound waves to electrical nerve impulses. This conversion involves many processes, including maintenance of the proper level of potassium ions in the inner ear. Some studies indicate that channels made with connexin 26 help to maintain the correct level of potassium ions. Other research suggests that connexin 26 is required for the maturation of certain cells in the cochlea.
Connexin 26 is also found in the skin. It is thought to play a role in the growth, maturation, and stability of the skin's outermost layer, the epidermis.
Health Conditions Related to Genetic Changes
Bart-Pumphrey syndrome
At least two GJB2 gene mutations have been identified in people with Bart-Pumphrey syndrome. This condition is characterized by a white discoloration of the nails (leukonychia), thickened skin on the palms of the hands and soles of the feet (palmoplantar keratoderma), wart-like growths (knuckle pads) on the knuckles of the fingers and toes, and hearing loss. The GJB2 gene mutations that cause Bart-Pumphrey syndrome replace the protein building block (amino acid) glycine with the amino acid serine at protein position 59 (Gly59Ser or G59S) or replace the amino acid asparagine with the amino acid lysine at protein position 54 (Asn54Lys or N54K). The altered protein probably disrupts the function of normal connexin 26 in cells. This disruption could affect skin growth and also impair hearing by disturbing the conversion of sound waves to nerve impulses.
Hystrix-like ichthyosis with deafness
At least one GJB2 gene mutation has been identified in people with hystrix-like ichthyosis with deafness (HID), a disorder characterized by dry, scaly skin (ichthyosis) and hearing loss that is usually profound. This mutation replaces the amino acid aspartic acid with the amino acid asparagine at protein position 50, written as Asp50Asn or D50N. The mutation is thought to result in channels that constantly leak ions, which impairs the health of the cells and increases cell death. Death of cells in the skin and the inner ear may underlie the signs and symptoms of HID.
Because the D50N mutation can also cause keratitis-ichthyosis-deafness (KID) syndrome (described below), many researchers categorize KID syndrome and HID as a single disorder, which they call KID/HID. It is not known why some people with this gene mutation have eye problems while others do not.
Keratitis-ichthyosis-deafness syndrome
At least nine GJB2 gene mutations have been identified in people with keratitis-ichthyosis-deafness (KID) syndrome, with the most common being the D50N mutation that also occurs in hystrix-like ichthyosis with deafness (described above). KID syndrome is characterized by keratitis, which is inflammation of the front surface of the eye (the cornea); thick, reddened patches of dry and scaly skin (ichthyosis); and deafness.
The GJB2 gene mutations that cause KID syndrome change single amino acids in connexin 26. The mutations are thought to result in channels that constantly leak ions, which impairs the health of the cells and increases cell death. Death of cells in the skin and the inner ear may underlie the ichthyosis and deafness that occur in KID syndrome. It is unclear how GJB2 gene mutations affect the eye.
Nonsyndromic hearing loss
Researchers have identified more than 100 GJB2 gene mutations that can cause nonsyndromic hearing loss, which is loss of hearing that is not associated with other signs and symptoms. Mutations in this gene can cause two forms of nonsyndromic hearing loss: DFNB1 and DFNA3.
DFNB1 is inherited in an autosomal recessive pattern, which means both copies of the GJB2 gene are mutated in each cell. This form of the condition accounts for about half of all cases of autosomal recessive nonsyndromic hearing loss. It is characterized by mild to profound hearing loss that is present before a child learns to speak (prelingual) and does not become more severe over time.
Some of the mutations that cause DFNB1 delete or insert DNA building blocks (base pairs) within or near the GJB2 gene. The most common mutation in many populations, particularly in people of northern European descent, deletes one base pair at position 35 in the GJB2 gene (written as 35delG). In Asian populations, a frequently reported mutation deletes a base pair at position 235 (235delC). Among people with eastern European (Ashkenazi) Jewish ancestry, the deletion of a single base pair at position 167 (167delT) is a common mutation. Less frequently, GJB2 gene mutations that cause DFNB1 replace one base pair with an incorrect one or delete a segment of DNA near the gene.
The GJB2 gene mutations that result in DFNB1 are described as "loss of function" because they lead to an altered or nonfunctional version of connexin 26, which appears to disrupt the assembly or function of gap junctions. In the inner ear, the abnormal or missing gap junctions likely alter the levels of potassium ions, which may affect the function and survival of cells that are needed for hearing.
DFNA3 is inherited in an autosomal dominant pattern, which means only one mutated copy of the GJB2 gene in each cell is sufficient to cause the condition. This form of hearing loss can be either prelingual or begin after a child learns to speak (postlingual). The hearing loss ranges from mild to profound, becomes more severe over time, and particularly affects the ability to hear high-frequency sounds.
The GJB2 gene mutations that cause DFNA3 replace one amino acid in connexin 26 with an incorrect amino acid. These mutations are described as "dominant negative," which means that they lead to an abnormal version of connexin 26 that prevents the formation of any functional gap junctions. An absence of these channels probably affects the function and survival of cells in the inner ear that are essential for hearing.
Palmoplantar keratoderma with deafness
At least nine GJB2 gene mutations have been identified in people with palmoplantar keratoderma with deafness, a condition characterized by hearing loss and unusually thick skin on the palms of the hands and soles of the feet. The GJB2 gene mutations that cause this condition change single amino acids in connexin 26. The altered protein probably disrupts the function of normal connexin 26 in cells and may interfere with the function of other connexin proteins. This disruption could affect skin growth and also impair hearing by disturbing the conversion of sound waves to nerve impulses.
Vohwinkel syndrome
At least three GJB2 gene mutations have been identified in people with Vohwinkel syndrome, a condition characterized by hearing loss and skin abnormalities. In addition to abnormal patches of skin, affected individuals develop tight bands of abnormal fibrous tissue around their fingers and toes that may cut off the circulation to the digits and result in spontaneous amputation. The GJB2 gene mutations that cause Vohwinkel syndrome change single amino acids in connexin 26. The altered protein probably disrupts the function of normal connexin 26 in cells and may interfere with the function of other connexin proteins. These abnormalities could affect skin growth and also impair hearing by disturbing the conversion of sound waves to nerve impulses.
Other Names for This Gene
CX26
CXB2_HUMAN
DFNA3
DFNB1
gap junction protein, beta 2, 26kDa
NSRD1
Genomic Location
The GJB2 gene is found on chromosome 13.
Source: MedlinePlus Genetics
Genetic Testing
Genetic testing
Image by genome.gov
Genetic testing
Genetic testing fact sheet
Image by genome.gov
About Genetic Testing for Hearing Loss
One type of genetic test involves looking at a person’s DNA to see if certain changes are present that are known to cause hearing loss. A person’s DNA sample can be obtained from different sources: (1) a small sample of a person’s blood, or (2) cheek cells from a person’s mouth using a cheek swab or from saliva. The DNA obtained from this method is sometimes unstable and might not be usable. Therefore, blood samples are the preferred source.
Once a person’s DNA sample is obtained, there are different ways to look for gene changes. In the past, tests would look at one gene at a time. If the gene change has been found in the family before, then this very specific test can focus only on that change.
Technological advances now allow scientists to read the DNA sequence of multiple genes as part of a single genetic test. This test is called a multigene sequencing panel. Only a small amount of blood is needed for this and it usually takes a few weeks to get the results. Multigene sequencing panels for hearing loss can contain hundreds of genes known to cause dominant, recessive, X-linked, and mitochondrial hearing loss, along with genes that might cause hearing loss.
Because all the genes related to hearing loss are not yet known and because many different genes may work together in different combinations to cause a certain child’s hearing loss, the results of genetic testing may not provide all the answers.
What Are the Benefits of Genetic Testing?
If a gene change is found, it might explain why the person has a condition, such as hearing loss. In some cases, knowing what the gene change is will allow doctors to predict how severe the condition might become and what other symptoms might be expected. Then, the person can get any other medical care that might be needed. Also, knowing the cause of a person’s condition will let him or her know what the chances are of passing the condition on to his or her children. It can also let other family members know the chances that they might have a child with the same condition.
What Are Some Limits of Genetic Testing?
Not all of the genes that cause hearing loss are known. So, even if a condition runs in a family, it might not be possible to find the gene change that causes it.
Some tests are hard to do. For example, the gene doesn’t sequence well, or the test does not cover all the regions where the DNA sequence can change.
Sometimes, it is not possible to tell if a change in the DNA is the cause of a condition or just a coincidence.
What Are the Risks of Genetic Testing?
Some people have strong feelings when they get the results of a genetic test. Some people feel angry, sad, or guilty if they find out that they or their child has a change in their genes. It is important to remember that everyone carries gene changes of some kind, and that a person’s DNA sequence is no one’s “fault.”
Genetic tests are different from other medical tests in that the results provide information about other members of the family, and not just the person being tested. Some family members do not want to know that a gene or DNA change runs in their family. Also, because children get their genes from their parents, genetic tests that involve several family members can reveal personal information, such as a child having been adopted or having a different biological father.
Sometimes, people are concerned about keeping the results of their medically related genetic tests private. For example, they do not want their friends, relatives, or coworkers to find out. Companies that offer genetic testing are very careful to make sure that test results are kept private. Test results ordered by a health provider in the U.S. cannot be seen by anyone who is not involved in the testing unless the person tested or his or her parents or guardians give permission.
Source: Centers for Disease Control and Prevention (CDC)
Interventions
Newborn hearing test
Image by U.S. Air Force photo/Staff Sgt. Ashley Hawkins
Newborn hearing test
LANGLEY AIR FORCE BASE, Va -- Wyatt Worsley, 3-week-old son of U.S. Navy Petty Officer 2nd Class Clayton Worsley, Norfolk Naval Base, receives a hearing test from U.S. Air Force Major Jennifer Carey, 633d Medical Group chief of audiology services, during his after birth screening July 13,. Major Carey volunteers to care for newborn patients when the labor and delivery clinic needs the extra help.
Image by U.S. Air Force photo/Staff Sgt. Ashley Hawkins
Interventions for Hearing Loss
No single treatment or intervention is the answer for every child or family. Good intervention plans will include close monitoring of the child and family needs, follow-ups to check progress, and making needed adjustments along the way to help support the child and family. There are many different options for children with hearing loss and their families. Some intervention options include the following:
Working with a professional (or team) who can help a child and family learn to communicate.
Getting a hearing device, such as a hearing aid.
Joining support groups.
Taking advantage of other resources available to children with a hearing loss and their families.
Early Intervention (0-3 years)
Hearing loss can affect a child’s ability to develop speech, language, and social skills. The earlier a child who is deaf or hard-of-hearing starts getting services, the more likely the child’s speech, language, and social skills will reach their full potential.
Early intervention program services help young children with hearing loss learn language skills and other important skills. This intervention involves a therapist, such as a speech-language pathologist, teaching communication strategies to the child and parent(s) or helping the parent or other caregivers blend extra lessons into the day.
Babies who are diagnosed early with hearing loss should begin to get intervention services as soon as possible, ideally before 6 months of age.
There are many services available through the Individuals with Disabilities Education Improvement Act 2004 (IDEA 2004). Services for children from birth through 36 months of age are called Early Intervention or Part C services. Even if a child has not been diagnosed with a hearing loss, he or she may be eligible for early intervention treatment services. The IDEA 2004 says that children under the age of 3 years (36 months) who are at risk of having developmental delays may be eligible for services. These services are provided through an early intervention system in every jurisdiction. Through this system, parents can ask for an evaluation.
Special Education (3-22 years)
Special education is instruction specifically designed to address the educational and related developmental needs of older children with disabilities or those who are experiencing developmental delays. Services for these children are provided through the public school system. These services are available through the Individuals with Disabilities Education Improvement Act 2004 (IDEA 2004), Part B.
Source: Centers for Disease Control and Prevention (CDC)
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Genetics of Hearing Loss
Hearing loss has many causes, including genetic causes (that is, caused by the instructions in the baby’s cells) and non-genetic causes (such as certain infections the mother has during pregnancy or infections affecting the newborn baby). In general, 50% to 60% of hearing loss in babies is due to genetic causes. Learn about the genetics of hearing loss.