Lymphocytic infiltrate of Jessner is a skin condition characterized by small, red, bumps on the face, neck, and upper back. The bumps usually last for several months or longer and can enlarge to create a red plaque. Typically, there are no other symptoms, although rarely, individuals may experience burning or itching. The symptoms may fluctuate between periods of worsening and periods of improvement. Some cases of lymphocytic infiltrate of Jessner have been associated with borrelia infection (the bacteria that causes Lyme disease); however, in most instances, the cause is not known. Frequently, no treatment is necessary as the bumps and plaque usually spontaneously disappear.

Lymphocytic infiltrate of Jessner may require no treatment (since it can resolve spontaneously), but some patients benefit from cosmetic camouflage, photoprotection, surgery to remove small lesions, use of steroids orally or topically, antimalarial medications such as hydroxychloroquine, cryotherapy, methotrexate, thalidomide, and/or oral auranofin.