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Nodular Nonsuppurative Panniculitis

Table of Contents

Nodular Nonsuppurative Panniculitis

NNP; Idiopathic Nodular Panniculitis; Relapsing Febrile Nodular Nonsuppurative Panniculitis; Pfeiffer-Weber-Christian Syndrome; Weber-Christian Panniculitis

Nodular nonsuppurative panniculitis describes a rare group of skin disorders characterized by tender, painful bumps below the surface of the skin (subcutaneous nodules) that usually lead to inflammation of the subcutaneous layer of fat (panniculitis). Explore symptoms and treatments.

Skin Nodule (medicine)

Image by Madhero88

Summary

Weber christian disease

Image by Samuel Freire da Silva, M.D. - Dermatology Atlas

Weber christian disease

Created by Samuel Freire da Silva, M.D. in homage to The Master And Professor Delso Bringel Calheiros. Image obtained from Dermatology Atlas

Image by Samuel Freire da Silva, M.D. - Dermatology Atlas

What Is Nodular Nonsuppurative Panniculitis?

Nodular nonsuppurative panniculitis describes a rare group of skin disorders characterized by tender, painful bumps below the surface of the skin (subcutaneous nodules) that usually lead to inflammation of the subcutaneous layer of fat (panniculitis). These nodules tend to be 1-2 centimeters in length and most often affect the legs and feet. In most people, this condition is associated with fever, a general feeling of ill health (malaise), muscle pain, and/or abdominal pain. These symptoms may subside after a few days or weeks and may recur weeks, months, or years later. The exact cause of nodular nonsuppurative panniculitis is unknown.

Source: Genetic and Rare Diseases (GARD) Information Center

Additional Materials (1)

Weber christian disease

Created by Samuel Freire da Silva, M.D. in homage to The Master And Professor Delso Bringel Calheiros. Image obtained from Dermatology Atlas

Image by Samuel Freire da Silva, M.D. - Dermatology Atlas

Weber christian disease

Samuel Freire da Silva, M.D. - Dermatology Atlas

Diagnosis

Dermatologist talks with a little girl at a local medical clinic

Image by U.S. Navy photo by Mass Communication Specialist 2nd Class Gina Wollman/Wikimedia

Dermatologist talks with a little girl at a local medical clinic

Lt. Cmdr. Nathan Uebelhoer, a dermatologist embarked aboard the amphibious assault ship USS Kearsarge (LHD 3), talks with a little girl at a local medical clinic during a community service project in support of the humanitarian assistance mission Continuing Promise 2008. Kearsarge is the primary platform for the Caribbean phase of Continuing Promise, an equal-partnership mission involving the United States, Canada, the Netherlands, Brazil, France, Nicaragua, Panama, Colombia, Dominican Republic, Trinidad and Tobago and Guyana.

Image by U.S. Navy photo by Mass Communication Specialist 2nd Class Gina Wollman/Wikimedia

How Is Nodular Nonsuppurative Pannicultis Diagnosed?

Individuals with nodular nonsuppurative panniculitis (NNP) may consult with a pediatric dermatologist and/or a pediatric rheumatologist in order to confirm the diagnosis, determine the cause of the condition and obtain treatment.

Source: Genetic and Rare Diseases (GARD) Information Center

Treatment

Prednisone: The Double-Edged Sword

Image by jsrcyclist

Prednisone: The Double-Edged Sword

It really is a wonder drug for my Crohn's Disease, however the side effects are truly horrific: en.wikipedia.org/wiki/Prednisone#Side-effects

Image by jsrcyclist

How Might Nodular Nonsuppurative Panniculitis Be Treated?

Treatment for nodular nonsuppurative panniculitis (NNP) generally aims at controlling and relieving the symptoms that an individual has. Before treatment is initiated, a work-up should be completed to determine whether the condition is secondary to another underlying disorder. If there is an underlying disorder, treatment of this disorder may relieve the symptoms of NNP. In some cases, skin lesions heal spontaneously (remission) but the lesions often later return. There is no treatment method found to be effective for all individuals with NNP. Medications used to treat the condition may include systemic steroids (such as prednisone) to suppress sudden attacks; nonsteroidal anti-inflammatory drugs (NSAIDs) to reduce fever and other signs of malaise; and/or immunosuppressive drugs. Relief of symptoms in some affected individuals has also been reported with fibrinolytic agents (medications that help prevent blood clots), hydroxychloroquine, azathioprine, thalidomide, cyclophosphamide, tetracycline, cyclosporin, mycophenolate, and clofazimine.

Source: Genetic and Rare Diseases (GARD) Information Center

Additional Materials (2)

Prednisone - A synthetic anti-inflammatory glucocorticoid derived from CORTISONE.

A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.

Image by D4duong

Prednisone 20 MG Oral Tablet

Prednisone 20 MG Oral Tablet

Image by NLM

Prednisone - A synthetic anti-inflammatory glucocorticoid derived from CORTISONE.

D4duong

Prednisone 20 MG Oral Tablet

NLM

Prognosis

Treatment and Prognosis varies depending on the type of condition and the age of symptom onset.

Image by 4144132

Treatment and Prognosis varies depending on the type of condition and the age of symptom onset.

Prognosis varies depending on the type of MND and the age of symptom onset.

Image by 4144132

What Is the Long-Term Outlook for People with Nodular Nonsuppurative Panniculitis?

It is not possible to predict the prognosis for specific individuals (including when and if remission will occur), as the prognosis widely varies in individuals with the condition. Those with primarily cutaneous (skin) involvement may experience periods of exacerbations and remission of symptoms with minimal involvement of other organs for several years before the disorder resolves. The disease tends to recur at intervals of weeks or months. In individuals with severe involvement of the heart, lungs, intestines, spleen, kidney, or adrenal glands, morbidity and mortality are significant and these individuals may not survive.

Source: Genetic and Rare Diseases (GARD) Information Center

Additional Materials (1)

Focal segmental glomerulosclerosis

High magnification micrograph of collapsing glomerulopathy. PAS stain. Collapsing glomerulopathy is considered to be a subtype of focal segmental glomerulosclerosis (FSGS).[1] It generally has a poor prognosis, when compared to other types of FSGS. It is as associated with viral infections (HIV, parvovirus B19) and toxins.

Image by Nephron

Focal segmental glomerulosclerosis

Nephron

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Nodular Nonsuppurative Panniculitis

Nodular nonsuppurative panniculitis describes a rare group of skin disorders characterized by tender, painful bumps below the surface of the skin (subcutaneous nodules) that usually lead to inflammation of the subcutaneous layer of fat (panniculitis). Explore symptoms and treatments.

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