Kikuchi disease is a benign (non-cancerous) condition of the lymph nodes. The main symptoms include swollen lymph nodes in the neck, mild fever, and night sweats. Less common symptoms include weight loss, nausea, vomiting, and sore throat. While the exact cause of this condition is unknown, infectious and autoimmune causes have been suggested. Kikuchi disease usually gets better (resolves) on its own within one to four months (although it may take up to a year), with or without treatment. However, treatments are available to relieve some of the associated signs and symptoms.

Others believe that it may be an autoimmune condition. According to this theory, Kikuchi disease occurs when one or more agents (for example, a virus) trigger a temporary immune response.

Kikuchi disease is not thought to be inherited. Most cases occur sporadically in people with no family history of the condition. Recently, a case study reporting two familial cases of Kikuchi disease was published in the literature, raising the hypothesis of genetic factors or perhaps a predisposing genetic background.

Medscape Reference, a resource for medical professionals, offers more specific information about the diagnosis of Kikuchi disease. You may be asked to register to view the information but registration is free.

Since there have been a few case reports of systemic lupus erythematosus (SLE or lupus) developing several years after recovery from Kikuchi disease, several medical researchers recommend long term follow-up to check for signs and symptoms of SLE.

Medscape Reference, a resource for medical professionals, offers more specific information regarding the treatment and management of Kikuchi disease. You may be asked to register to view the information, but registration is free.

Kikuchi disease has been found to be associated with several autoimmune diseases, especially systemic lupus erythematous (SLE or lupus). Cases include those in which SLE began before Kikuchi disease, at the same time as Kikuchi disease, and in a few cases, several years after Kikuchi disease. Therefore some medical researchers recommend long term follow up to make check for the SLE.

SLE is a chronic autoimmune disorder that may affect the skin, joints, kidneys, and other organs. Symptoms vary from person to person although almost all people with SLE have joint pain and swelling. Some develop arthritis. Other symptoms may include chest pain when taking a deep breath; general discomfort or ill feeling; and/or mouth sores.