Chromosome 15q25.2 microdeletion is a chromosome abnormality that can affect many parts of the body. People with this condition are missing a small piece (deletion) of chromosome 15 at a location designated q25.2. The signs and symptoms vary but usually include mild to moderate intellectual disability and developmental delay. Some people may also have poor growth, anemia and/or physical abnormalities. Most cases are not inherited, although affected individuals can pass the deletion on to their children. Treatment is based on the signs and symptoms present in each person.

Most people with this deletion are missing a piece of chromosome 15 that contains 27 genes. Although many of these genes are poorly understood, it is suspected that the absence of these genes contributes to the different signs and symptoms seen with this deletion.

Rarely, this deletion is passed down from parent to child. However, the symptoms and severity can vary between family members.

Please speak to your healthcare provider if you have any questions about your personal medical management plan.