Stroke is a leading cause of death for women. Stroke also kills more women than men each year. Get the facts about how stroke affects women and how to know if it's happening to you.
Woman suffering stroke and cross-section of Brain with Ischemic Stroke
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Stroke and Women
Healthy Brain cross section
Brain with Hemorrhagic Stroke, cross section
Brain with Ischemic Stroke cross section
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Normal Brain, Hemorrhagic Stroke, and Ischemic Stroke
Interactive by TheVisualMD
Healthy Brain cross section
Brain with Hemorrhagic Stroke, cross section
Brain with Ischemic Stroke cross section
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Normal Brain, Hemorrhagic Stroke, and Ischemic Stroke
1) Healthy Brain - Cross-sectional image through the frontal plane of the head of a healthy individual.
2) Hemorrhagic Stroke - Cross-sectional image through the frontal plane of the head of an individual with hemorrhagic stroke on the left side of the brain. A hemorrhagic stroke can occur when a blood vessel weakened by COVID-19 infection bursts and spills blood into the brain.
3) Ischemic Stroke - Cross-sectional image through the frontal plane of the head of an individual with ischemic stroke on the left side of the brain. An ischemic stroke occurs when a blood vessel in the brain becomes blocked or narrowed, usually due to a blood clot.
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Stroke and Women
Stroke kills about twice as many women as breast cancer each year. In fact, stroke is the third leading cause of death for women. Stroke also kills more women than men each year. A stroke can leave you permanently disabled. But many strokes are preventable and treatable. Every woman can take steps to prevent stroke by knowing her risk factors and making healthy changes.
Source: Office on Women's Health (OWH), U.S. Department of Health and Human Services
Additional Materials (15)
Woman suffering stroke and cross-section of Brain with Ischemic Stroke
Woman suffering stroke and cross-section of Brain with Ischemic Stroke
Image by TheVisualMD
Women and Stroke: The Power of Three
Video by Stroke Association/YouTube
Women and Stroke: Common Signs
Video by Health Science Channel/YouTube
Women Not Stopping for Stroke Signs
Video by Lee Health/YouTube
American Heart Association issues stroke risk guidelines for women
Video by CBSN/YouTube
Dr Cheryl Carcel: stroke differences between men and women
Video by The George Institute/YouTube
Women and Stroke - Learn the 7 Risks
Video by Renown Health/YouTube
Heart Disease in Women - Mayo Clinic
Video by Mayo Clinic/YouTube
Recognize the Signs and Symptoms of Stroke
Video by Centers for Disease Control and Prevention (CDC)/YouTube
Why are Young Women at Risk for Strokes?
Video by Lee Health/YouTube
Women & Heart Disease with Dr Karin Humphries (Part 1) FEST 2013
Video by HeartLungHealth/YouTube
Heart disease in women often undiagnosed, study finds
Video by CBC News: The National/YouTube
Women and Heart Disease
Video by Lee Health/YouTube
Diabetes: Heart disease and stroke
Video by ClearlyHealth/YouTube
Mayo Clinic Minute: Heart-healthy diet for women
Video by Mayo Clinic/YouTube
Woman suffering stroke and cross-section of Brain with Ischemic Stroke
TheVisualMD
2:04
Women and Stroke: The Power of Three
Stroke Association/YouTube
7:28
Women and Stroke: Common Signs
Health Science Channel/YouTube
1:53
Women Not Stopping for Stroke Signs
Lee Health/YouTube
1:20
American Heart Association issues stroke risk guidelines for women
CBSN/YouTube
1:54
Dr Cheryl Carcel: stroke differences between men and women
The George Institute/YouTube
1:24
Women and Stroke - Learn the 7 Risks
Renown Health/YouTube
2:06
Heart Disease in Women - Mayo Clinic
Mayo Clinic/YouTube
2:31
Recognize the Signs and Symptoms of Stroke
Centers for Disease Control and Prevention (CDC)/YouTube
1:36
Why are Young Women at Risk for Strokes?
Lee Health/YouTube
4:25
Women & Heart Disease with Dr Karin Humphries (Part 1) FEST 2013
HeartLungHealth/YouTube
3:19
Heart disease in women often undiagnosed, study finds
CBC News: The National/YouTube
1:30
Women and Heart Disease
Lee Health/YouTube
4:15
Diabetes: Heart disease and stroke
ClearlyHealth/YouTube
1:01
Mayo Clinic Minute: Heart-healthy diet for women
Mayo Clinic/YouTube
What Is Stroke?
How Stroke Occurs
Image by TheVisualMD
How Stroke Occurs
This video reveals how a stroke occurs. Some causes of stroke include arterial blockages, hemorrhages or embolism. A stroke can be described as a "brain attack," as blood circulation is cut off from a part of the brain, leading to tissue death.
Image by TheVisualMD
What Is Stroke?
A stroke is sometimes called a "brain attack." Stroke happens when blood flow to a part of the brain stops or is blocked by a blood clot or plaque, and brain cells begin to die.
Source: Office on Women's Health (OWH), U.S. Department of Health and Human Services
Additional Materials (1)
Women and Stroke: The Power of Three
Video by Stroke Association/YouTube
2:04
Women and Stroke: The Power of Three
Stroke Association/YouTube
Circulation and the Central Nervous System
Right Side
Back Side
Left Side
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Brain angiography with contrast
Interactive by TheVisualMD
Right Side
Back Side
Left Side
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Brain angiography with contrast
Cerebral angiography is a procedure that uses a special dye (contrast material) and x-rays to see how blood flows through the brain. Doctors may order this test if symptoms or signs of vascular malformation (abnormal blood vessels), aneurysm (blood-filled dilation of a blood vessel), narrowing of the arteries in the brain, and vasculitis (inflammation of blood vessels) are present. Sometimes, it is also used to confirm a brain tumor, evaluate the arteries of the head and neck before surgery, and find a clot that may have caused a stroke.
Interactive by TheVisualMD
Circulation and the Central Nervous System
The CNS is crucial to the operation of the body, and any compromise in the brain and spinal cord can lead to severe difficulties. The CNS has a privileged blood supply, as suggested by the blood-brain barrier. The function of the tissue in the CNS is crucial to the survival of the organism, so the contents of the blood cannot simply pass into the central nervous tissue. To protect this region from the toxins and pathogens that may be traveling through the blood stream, there is strict control over what can move out of the general systems and into the brain and spinal cord. Because of this privilege, the CNS needs specialized structures for the maintenance of circulation. This begins with a unique arrangement of blood vessels carrying fresh blood into the CNS. Beyond the supply of blood, the CNS filters that blood into cerebrospinal fluid (CSF), which is then circulated through the cavities of the brain and spinal cord called ventricles.
Blood Supply to the Brain
A lack of oxygen to the CNS can be devastating, and the cardiovascular system has specific regulatory reflexes to ensure that the blood supply is not interrupted. There are multiple routes for blood to get into the CNS, with specializations to protect that blood supply and to maximize the ability of the brain to get an uninterrupted perfusion.
Arterial Supply
The major artery carrying recently oxygenated blood away from the heart is the aorta. The very first branches off the aorta supply the heart with nutrients and oxygen. The next branches give rise to the common carotid arteries, which further branch into the internal carotid arteries. The external carotid arteries supply blood to the tissues on the surface of the cranium. The bases of the common carotids contain stretch receptors that immediately respond to the drop in blood pressure upon standing. The orthostatic reflex is a reaction to this change in body position, so that blood pressure is maintained against the increasing effect of gravity (orthostatic means “standing up”). Heart rate increases—a reflex of the sympathetic division of the autonomic nervous system—and this raises blood pressure.
The internal carotid artery enters the cranium through the carotid canal in the temporal bone. A second set of vessels that supply the CNS are the vertebral arteries, which are protected as they pass through the neck region by the transverse foramina of the cervical vertebrae. The vertebral arteries enter the cranium through the foramen magnum of the occipital bone. Branches off the left and right vertebral arteries merge into the anterior spinal artery supplying the anterior aspect of the spinal cord, found along the anterior median fissure. The two vertebral arteries then merge into the basilar artery, which gives rise to branches to the brain stem and cerebellum. The left and right internal carotid arteries and branches of the basilar artery all become the circle of Willis, a confluence of arteries that can maintain perfusion of the brain even if narrowing or a blockage limits flow through one part (image).
Venous Return
After passing through the CNS, blood returns to the circulation through a series of dural sinuses and veins (image). The superior sagittal sinus runs in the groove of the longitudinal fissure, where it absorbs CSF from the meninges. The superior sagittal sinus drains to the confluence of sinuses, along with the occipital sinuses and straight sinus, to then drain into the transverse sinuses. The transverse sinuses connect to the sigmoid sinuses, which then connect to the jugular veins. From there, the blood continues toward the heart to be pumped to the lungs for reoxygenation.
Protective Coverings of the Brain and Spinal Cord
The outer surface of the CNS is covered by a series of membranes composed of connective tissue called the meninges, which protect the brain. The dura mater is a thick fibrous layer and a strong protective sheath over the entire brain and spinal cord. It is anchored to the inner surface of the cranium and vertebral cavity. The arachnoid mater is a membrane of thin fibrous tissue that forms a loose sac around the CNS. Beneath the arachnoid is a thin, filamentous mesh called the arachnoid trabeculae, which looks like a spider web, giving this layer its name. Directly adjacent to the surface of the CNS is the pia mater, a thin fibrous membrane that follows the convolutions of gyri and sulci in the cerebral cortex and fits into other grooves and indentations (Figure).
Meningeal Layers of Superior Sagittal Sinus
The layers of the meninges in the longitudinal fissure of the superior sagittal sinus are shown, with the dura mater adjacent to the inner surface of the cranium, the pia mater adjacent to the surface of the brain, and the arachnoid and subarachnoid space between them. An arachnoid villus is shown emerging into the dural sinus to allow CSF to filter back into the blood for drainage.
Dura Mater
Like a thick cap covering the brain, the dura mater is a tough outer covering. The name comes from the Latin for “tough mother” to represent its physically protective role. It encloses the entire CNS and the major blood vessels that enter the cranium and vertebral cavity. It is directly attached to the inner surface of the bones of the cranium and to the very end of the vertebral cavity.
There are infoldings of the dura that fit into large crevasses of the brain. Two infoldings go through the midline separations of the cerebrum and cerebellum; one forms a shelf-like tent between the occipital lobes of the cerebrum and the cerebellum, and the other surrounds the pituitary gland. The dura also surrounds and supports the venous sinuses.
Arachnoid Mater
The middle layer of the meninges is the arachnoid, named for the spider-web–like trabeculae between it and the pia mater. The arachnoid defines a sac-like enclosure around the CNS. The trabeculae are found in the subarachnoid space, which is filled with circulating CSF. The arachnoid emerges into the dural sinuses as the arachnoid granulations, where the CSF is filtered back into the blood for drainage from the nervous system.
The subarachnoid space is filled with circulating CSF, which also provides a liquid cushion to the brain and spinal cord. Similar to clinical blood work, a sample of CSF can be withdrawn to find chemical evidence of neuropathology or metabolic traces of the biochemical functions of nervous tissue.
Pia Mater
The outer surface of the CNS is covered in the thin fibrous membrane of the pia mater. It is thought to have a continuous layer of cells providing a fluid-impermeable membrane. The name pia mater comes from the Latin for “tender mother,” suggesting the thin membrane is a gentle covering for the brain. The pia extends into every convolution of the CNS, lining the inside of the sulci in the cerebral and cerebellar cortices. At the end of the spinal cord, a thin filament extends from the inferior end of CNS at the upper lumbar region of the vertebral column to the sacral end of the vertebral column. Because the spinal cord does not extend through the lower lumbar region of the vertebral column, a needle can be inserted through the dura and arachnoid layers to withdraw CSF. This procedure is called a lumbar puncture and avoids the risk of damaging the central tissue of the spinal cord. Blood vessels that are nourishing the central nervous tissue are between the pia mater and the nervous tissue.
DISORDERS OF THE…
MeningesMeningitis is an inflammation of the meninges, the three layers of fibrous membrane that surround the CNS. Meningitis can be caused by infection by bacteria or viruses. The particular pathogens are not special to meningitis; it is just an inflammation of that specific set of tissues from what might be a broader infection. Bacterial meningitis can be caused by Streptococcus, Staphylococcus, or the tuberculosis pathogen, among many others. Viral meningitis is usually the result of common enteroviruses (such as those that cause intestinal disorders), but may be the result of the herpes virus or West Nile virus. Bacterial meningitis tends to be more severe.
The symptoms associated with meningitis can be fever, chills, nausea, vomiting, light sensitivity, soreness of the neck, or severe headache. More important are the neurological symptoms, such as changes in mental state (confusion, memory deficits, and other dementia-type symptoms). A serious risk of meningitis can be damage to peripheral structures because of the nerves that pass through the meninges. Hearing loss is a common result of meningitis.
The primary test for meningitis is a lumbar puncture. A needle inserted into the lumbar region of the spinal column through the dura mater and arachnoid membrane into the subarachnoid space can be used to withdraw the fluid for chemical testing. Fatality occurs in 5 to 40 percent of children and 20 to 50 percent of adults with bacterial meningitis. Treatment of bacterial meningitis is through antibiotics, but viral meningitis cannot be treated with antibiotics because viruses do not respond to that type of drug. Fortunately, the viral forms are milder.
The Ventricular System
Cerebrospinal fluid (CSF) circulates throughout and around the CNS. In other tissues, water and small molecules are filtered through capillaries as the major contributor to the interstitial fluid. In the brain, CSF is produced in special structures to perfuse through the nervous tissue of the CNS and is continuous with the interstitial fluid. Specifically, CSF circulates to remove metabolic wastes from the interstitial fluids of nervous tissues and return them to the blood stream. The ventricles are the open spaces within the brain where CSF circulates. In some of these spaces, CSF is produced by filtering of the blood that is performed by a specialized membrane known as a choroid plexus. The CSF circulates through all of the ventricles to eventually emerge into the subarachnoid space where it will be reabsorbed into the blood.
The Ventricles
There are four ventricles within the brain, all of which developed from the original hollow space within the neural tube, the central canal. The first two are named the lateral ventricles and are deep within the cerebrum. These ventricles are connected to the third ventricle by two openings called the interventricular foramina. The third ventricle is the space between the left and right sides of the diencephalon, which opens into the cerebral aqueduct that passes through the midbrain. The aqueduct opens into the fourth ventricle, which is the space between the cerebellum and the pons and upper medulla (image).
As the telencephalon enlarges and grows into the cranial cavity, it is limited by the space within the skull. The telencephalon is the most anterior region of what was the neural tube, but cannot grow past the limit of the frontal bone of the skull. Because the cerebrum fits into this space, it takes on a C-shaped formation, through the frontal, parietal, occipital, and finally temporal regions. The space within the telencephalon is stretched into this same C-shape. The two ventricles are in the left and right sides, and were at one time referred to as the first and second ventricles. The interventricular foramina connect the frontal region of the lateral ventricles with the third ventricle.
The third ventricle is the space bounded by the medial walls of the hypothalamus and thalamus. The two thalami touch in the center in most brains as the massa intermedia, which is surrounded by the third ventricle. The cerebral aqueduct opens just inferior to the epithalamus and passes through the midbrain. The tectum and tegmentum of the midbrain are the roof and floor of the cerebral aqueduct, respectively. The aqueduct opens up into the fourth ventricle. The floor of the fourth ventricle is the dorsal surface of the pons and upper medulla (that gray matter making a continuation of the tegmentum of the midbrain). The fourth ventricle then narrows into the central canal of the spinal cord.
The ventricular system opens up to the subarachnoid space from the fourth ventricle. The single median aperture and the pair of lateral apertures connect to the subarachnoid space so that CSF can flow through the ventricles and around the outside of the CNS. Cerebrospinal fluid is produced within the ventricles by a type of specialized membrane called a choroid plexus. Ependymal cells (one of the types of glial cells described in the introduction to the nervous system) surround blood capillaries and filter the blood to make CSF. The fluid is a clear solution with a limited amount of the constituents of blood. It is essentially water, small molecules, and electrolytes. Oxygen and carbon dioxide are dissolved into the CSF, as they are in blood, and can diffuse between the fluid and the nervous tissue.
Cerebrospinal Fluid Circulation
The choroid plexuses are found in all four ventricles. Observed in dissection, they appear as soft, fuzzy structures that may still be pink, depending on how well the circulatory system is cleared in preparation of the tissue. The CSF is produced from components extracted from the blood, so its flow out of the ventricles is tied to the pulse of cardiovascular circulation.
From the lateral ventricles, the CSF flows into the third ventricle, where more CSF is produced, and then through the cerebral aqueduct into the fourth ventricle where even more CSF is produced. A very small amount of CSF is filtered at any one of the plexuses, for a total of about 500 milliliters daily, but it is continuously made and pulses through the ventricular system, keeping the fluid moving. From the fourth ventricle, CSF can continue down the central canal of the spinal cord, but this is essentially a cul-de-sac, so more of the fluid leaves the ventricular system and moves into the subarachnoid space through the median and lateral apertures.
Within the subarachnoid space, the CSF flows around all of the CNS, providing two important functions. As with elsewhere in its circulation, the CSF picks up metabolic wastes from the nervous tissue and moves it out of the CNS. It also acts as a liquid cushion for the brain and spinal cord. By surrounding the entire system in the subarachnoid space, it provides a thin buffer around the organs within the strong, protective dura mater. The arachnoid granulations are outpocketings of the arachnoid membrane into the dural sinuses so that CSF can be reabsorbed into the blood, along with the metabolic wastes. From the dural sinuses, blood drains out of the head and neck through the jugular veins, along with the rest of the circulation for blood, to be reoxygenated by the lungs and wastes to be filtered out by the kidneys (image).
Components of CSF Circulation
Lateral ventricles
Third ventricle
Cerebral aqueduct
Fourth ventricle
Central canal
Subarachnoid space
Location in CNS
Cerebrum
Diencephalon
Midbrain
Between pons/upper medulla and cerebellum
Spinal cord
External to entire CNS
Blood vessel structure
Choroid plexus
Choroid plexus
None
Choroid plexus
None
Arachnoid granulations
DISORDERS OF THE…
Central Nervous SystemThe supply of blood to the brain is crucial to its ability to perform many functions. Without a steady supply of oxygen, and to a lesser extent glucose, the nervous tissue in the brain cannot keep up its extensive electrical activity. These nutrients get into the brain through the blood, and if blood flow is interrupted, neurological function is compromised.
The common name for a disruption of blood supply to the brain is a stroke. It is caused by a blockage to an artery in the brain. The blockage is from some type of embolus: a blood clot, a fat embolus, or an air bubble. When the blood cannot travel through the artery, the surrounding tissue that is deprived starves and dies. Strokes will often result in the loss of very specific functions. A stroke in the lateral medulla, for example, can cause a loss in the ability to swallow. Sometimes, seemingly unrelated functions will be lost because they are dependent on structures in the same region. Along with the swallowing in the previous example, a stroke in that region could affect sensory functions from the face or extremities because important white matter pathways also pass through the lateral medulla. Loss of blood flow to specific regions of the cortex can lead to the loss of specific higher functions, from the ability to recognize faces to the ability to move a particular region of the body. Severe or limited memory loss can be the result of a temporal lobe stroke.
Related to strokes are transient ischemic attacks (TIAs), which can also be called “mini-strokes.” These are events in which a physical blockage may be temporary, cutting off the blood supply and oxygen to a region, but not to the extent that it causes cell death in that region. While the neurons in that area are recovering from the event, neurological function may be lost. Function can return if the area is able to recover from the event.
Recovery from a stroke (or TIA) is strongly dependent on the speed of treatment. Often, the person who is present and notices something is wrong must then make a decision. The mnemonic FAST helps people remember what to look for when someone is dealing with sudden losses of neurological function. If someone complains of feeling “funny,” check these things quickly: Look at the person’s face. Does he or she have problems moving Face muscles and making regular facial expressions? Ask the person to raise his or her Arms above the head. Can the person lift one arm but not the other? Has the person’s Speech changed? Is he or she slurring words or having trouble saying things? If any of these things have happened, then it is Time to call for help.
Sometimes, treatment with blood-thinning drugs can alleviate the problem, and recovery is possible. If the tissue is damaged, the amazing thing about the nervous system is that it is adaptable. With physical, occupational, and speech therapy, victims of strokes can recover, or more accurately relearn, functions.
Overview
The CNS has a privileged blood supply established by the blood-brain barrier. Establishing this barrier are anatomical structures that help to protect and isolate the CNS. The arterial blood to the brain comes from the internal carotid and vertebral arteries, which both contribute to the unique circle of Willis that provides constant perfusion of the brain even if one of the blood vessels is blocked or narrowed. That blood is eventually filtered to make a separate medium, the CSF, that circulates within the spaces of the brain and then into the surrounding space defined by the meninges, the protective covering of the brain and spinal cord.
The blood that nourishes the brain and spinal cord is behind the glial-cell–enforced blood-brain barrier, which limits the exchange of material from blood vessels with the interstitial fluid of the nervous tissue. Thus, metabolic wastes are collected in cerebrospinal fluid that circulates through the CNS. This fluid is produced by filtering blood at the choroid plexuses in the four ventricles of the brain. It then circulates through the ventricles and into the subarachnoid space, between the pia mater and the arachnoid mater. From the arachnoid granulations, CSF is reabsorbed into the blood, removing the waste from the privileged central nervous tissue.
The blood, now with the reabsorbed CSF, drains out of the cranium through the dural sinuses. The dura mater is the tough outer covering of the CNS, which is anchored to the inner surface of the cranial and vertebral cavities. It surrounds the venous space known as the dural sinuses, which connect to the jugular veins, where blood drains from the head and neck.
Source: CNX OpenStax
Additional Materials (14)
Transparent Brain
Brain vasculature
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Cerebral circulation
Brain vasculature : Located within the cranium (skull), an adult human brain weighs about 3 lb (1.5 kg). The brain has many parts including the cerebrum, cerebellum, brain stem, pituitary gland, and hypothalamus. The brain acts as a control center by receiving, interpreting, and directing sensory information throughout the body. The cerebral vasculature transports oxygen, nutrients and other important substances to the brain to ensure its proper functioning.
Interactive by TheVisualMD
CSF circulation
Schematic of CSF circulation, CSF outflow systems, and the anatomy of various CSF compartments. CSF is produced by the choroid plexus in the ventricles, where it delivers growth factors to progenitor cells that originate on the surface of the ventricles, and then proliferate into neurons and migrate to form the cerebral cortex. CSF circulates from the lateral, third and fourth ventricles to the cisterns of the brain, and then flows into the subarachnoid space, where it envelops the cortical convexities of the brain (EA-CSF). Inset box: From the subarachnoid space, there is retrograde influx of CSF into the parenchyma, where CSF and interstitial fluid interact in the perivascular space, alongside blood vessels that course throughout the brain. Astrocytes lining the perivascular space aid in transporting fluid that removes inflammatory waste proteins (e.g., Aβ), which are continually secreted by neurons as byproducts of neuronal activity and would otherwise build up in the brain. Finally, fluid carrying these inflammatory waste products returns to the subarachnoid space (EA-CSF) and drains into meningeal lymphatic vessels and arachnoid granulations.
Image by Mark D. Shen/Wikimedia
Cerebrovascular System, Base of the Brain and Cranial Nerves
Your brain receives 20% of the blood that flows through your body. Disruptions to this flow cause brain damage, which is known as a stroke. High blood pressure can rupture blood vessels to the brain, causing damage to the surrounding brain tissue. Further, with interruption in the brain's circulation, the brain cells are starved of oxygen and nutrients and eventually die.
Image by TheVisualMD
Human Body Systems
Human Body Systems
Human Body Systems
Human Body Systems
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Nervous, Cardiovascular and Lymphatic Systems
Nervous, Cardiovascular and Lymphatic Systems
Interactive by TheVisualMD
Blood Brain Barrier
Protective barriers of the brain. The collective term "blood-brain barrier" is used to describe four main interfaces between the central nervous system and the periphery. (i) The blood-brain barrier proper formed by tight junctions between the endothelial cells of the cerebral vasculature. It is thought that pericytes (peri.) are sufficient to induce some barrier characteristics in endothelial cells, while astrocytes (astro.) are able to maintain the integrity of the blood-brain barrier postnatally. (ii) The blood-CSF barrier formed by tight junctions between epithelial cells of the choroid plexus epithelial cells (note the plexus vasculature is fenestrated). Resident epiplexus (epi.) immune cells are present on the CSF-surface of the plexus epithelium. (iii) The outer CSF-brain barrier and the level of the pia arachnoid, formed by tight junctions between endothelial cells of the arachnoid vessels. (iv) The inner CSF-brain barrier, present only in early development, formed by strap junctions between the neuroependymal cells lining the ventricular surfaces. In the adult this barrier is no longer present. Both the blood-brain and CSF-brain barriers extend down the spinal cord. The CSF-filled ventricular system is depicted in blue, while CNS brain tissue is in brown. The lateral ventricular choroid plexuses are shown in red. Abbreviations: astro, astrocyte; bv, blood vessel; cpec, choroid plexus epithelial cell; csf, cerebrospinal fluid; peri, pericytes.
Image by tolp HB, Liddelow SA, Sá-Pereira I, Dziegielewska KM and Saunders NR
Blood Vessels in the Brain
The Blood Brain Barrier and Astrocytes type 1
Image by Ben Brahim Mohammed
The Blood-Brain Barrier
This image shows a dense network of blood vessels (red) and nuclei (blue) obtained from mouse brain tissue that was optically cleared to look deeper into the tissue than otherwise possible. The brain’s blood vessels are nearly impermeable, allowing only the passage of key nutrients while blocking that of harmful substances. Unfortunately, this blood-brain barrier (BBB) also excludes most therapeutics. By designing drug-containing nanoparticles that can “hitchhike” across the BBB, researchers hope to finally penetrate the barrier, and deliver life-saving drugs to cancers in the brain. Pictured here is brain tissue before exposure to the experimental nanoparticles.
Image by California Institute of Technology / Emily Wyatt, Mark Davis
Embryo 56 Day Old (Week 10 Gestational Age, Week 8 Fetal Age) Blood Vessel to Brain
Computer Generated Image from Micro-MRI, actual size of embryo = 30.0 mm - This image provides a right-sided perspective of an embryo during its eighth week of development. The age is calculated from the day of fertilization. The skin has been made translucent so that internal organs can be observed. The brain is highlighted in yellow-orange. Red blood vessels branching from the functionally complete, four-chambered heart, indicated in red, extend towards the brain. In the facial region, the red circle indicates the eye. The liver, shown in pale yellow, is situated below the heart.
Image by TheVisualMD
Blood Brain Barrier Endothelium
The blood-brain barrier keeps potentially toxic substances from entering the brain. The semipermeable membrane formed by the tightly spaced cells of capillaries in this area selectively screens out large molecules, while permitting the transport of essential nutrients such as glucose. The endothelium is the cellular lining of the blood vessel and is made up of endothelial cells connected to one another by tight junctions. These are the strongest cell-to-cell adhesions in the body. Toxic materials being transported in the blood are too large to pass through these junctions and exit the blood. Therefore, the brain is protected from exposure to many harmful substances. The barrier is does not, however, prevent fat-soluble materials from entering the brain; this includes alcohol and nicotine.
Image by TheVisualMD
Circle of Willis : Brain Circulation
This inferior view shows the network of arteries serving the brain. The structure is referred to as the arterial circle or circle of Willis.
Image by OpenStax College
Striatum
Brain Anatomy Striatum
Image by BruceBlaus
Brain Vasculature
The brain receives blood from two pairs of large vessels that transport oxygen, nutrients and other vital substances: the internal carotid arteries, which arise from arteries in the neck, and the vertebral arteries, which arise from arteries in the chest. Strokes occur when blood flow to the brain is interrupted by a blockage (ischemic stroke) or rupture (hemorrhagic stroke) of a blood vessel in the brain. Each year 700,000 Americans suffer a stroke and 150,000 die; survivors often have long-term disabilities. The most common kind of blockage is caused by atherosclerosis, in which fatty deposits called plaque build up inside arteries.
Image by TheVisualMD
Brain Revealing Pituitary Gland
Exercise works to ward off depression by secreting brain chemicals, endorphins, that are responsible for feelings of pleasure and well-being
Image by TheVisualMD
Brain with visible Structures highlighting Melatonin Receptor Locations
A transparent brain is shown, highlighting the suprachiasmatic nucleus (SCN), a structure on the anterior part of the hypothalamus. The SCN contains melatonin receptors and is the brain's central timekeeping device. The image supports content about how the sleep-aid Rozerem binds directly on the melatonin receptors in the SCN to help patients fall asleep.
Image by TheVisualMD
Cerebral circulation
TheVisualMD
CSF circulation
Mark D. Shen/Wikimedia
Cerebrovascular System, Base of the Brain and Cranial Nerves
TheVisualMD
Nervous, Cardiovascular and Lymphatic Systems
TheVisualMD
Blood Brain Barrier
tolp HB, Liddelow SA, Sá-Pereira I, Dziegielewska KM and Saunders NR
Blood Vessels in the Brain
Ben Brahim Mohammed
The Blood-Brain Barrier
California Institute of Technology / Emily Wyatt, Mark Davis
Embryo 56 Day Old (Week 10 Gestational Age, Week 8 Fetal Age) Blood Vessel to Brain
TheVisualMD
Blood Brain Barrier Endothelium
TheVisualMD
Circle of Willis : Brain Circulation
OpenStax College
Striatum
BruceBlaus
Brain Vasculature
TheVisualMD
Brain Revealing Pituitary Gland
TheVisualMD
Brain with visible Structures highlighting Melatonin Receptor Locations
TheVisualMD
Aortic Arch Branches
Aorta cross section
Image by TheVisualMD
Aorta cross section
The aorta begins at the point where the left ventricle leaves the heart. It ascends, the ascending aorta, and then arches backwards, the arch of the aorta, before descending, descending aorta, behind the heart and down through the center of the chest. The descending aorta can be further categorized into the thoracic aorta and the abdominal aorta. Aortic dissection, a tear that develops in the inner layer of the aorta's arterial wall, can occur in either the ascending or descending aorta.
Image by TheVisualMD
Aortic Arch Branches
There are three major branches of the aortic arch: the brachiocephalic artery, the left common carotid artery, and the left subclavian (literally “under the clavicle”) artery. As you would expect based upon proximity to the heart, each of these vessels is classified as an elastic artery.
The brachiocephalic artery is located only on the right side of the body; there is no corresponding artery on the left. The brachiocephalic artery branches into the right subclavian artery and the right common carotid artery. The left subclavian and left common carotid arteries arise independently from the aortic arch but otherwise follow a similar pattern and distribution to the corresponding arteries on the right side.
Each subclavian artery supplies blood to the arms, chest, shoulders, back, and central nervous system. It then gives rise to three major branches: the internal thoracic artery, the vertebral artery, and the thyrocervical artery. The internal thoracic artery, or mammary artery, supplies blood to the thymus, the pericardium of the heart, and the anterior chest wall. The vertebral artery passes through the vertebral foramen in the cervical vertebrae and then through the foramen magnum into the cranial cavity to supply blood to the brain and spinal cord. The paired vertebral arteries join together to form the large basilar artery at the base of the medulla oblongata. This is an example of an anastomosis. The subclavian artery also gives rise to the thyrocervical artery that provides blood to the thyroid, the cervical region of the neck, and the upper back and shoulder.
The common carotid artery divides into internal and external carotid arteries. The right common carotid artery arises from the brachiocephalic artery and the left common carotid artery arises directly from the aortic arch. The external carotid artery supplies blood to numerous structures within the face, lower jaw, neck, esophagus, and larynx. These branches include the lingual, facial, occipital, maxillary, and superficial temporal arteries. The internal carotid artery initially forms an expansion known as the carotid sinus, containing the carotid baroreceptors and chemoreceptors. Like their counterparts in the aortic sinuses, the information provided by these receptors is critical to maintaining cardiovascular homeostasis
The internal carotid arteries along with the vertebral arteries are the two primary suppliers of blood to the human brain. Given the central role and vital importance of the brain to life, it is critical that blood supply to this organ remains uninterrupted. Recall that blood flow to the brain is remarkably constant, with approximately 20 percent of blood flow directed to this organ at any given time. When blood flow is interrupted, even for just a few seconds, a transient ischemic attack (TIA), or mini-stroke, may occur, resulting in loss of consciousness or temporary loss of neurological function. In some cases, the damage may be permanent. Loss of blood flow for longer periods, typically between 3 and 4 minutes, will likely produce irreversible brain damage or a stroke, also called a cerebrovascular accident (CVA). The locations of the arteries in the brain not only provide blood flow to the brain tissue but also prevent interruption in the flow of blood. Both the carotid and vertebral arteries branch once they enter the cranial cavity, and some of these branches form a structure known as the arterial circle (or circle of Willis), an anastomosis that is remarkably like a traffic circle that sends off branches (in this case, arterial branches to the brain). As a rule, branches to the anterior portion of the cerebrum are normally fed by the internal carotid arteries; the remainder of the brain receives blood flow from branches associated with the vertebral arteries.
The internal carotid artery continues through the carotid canal of the temporal bone and enters the base of the brain through the carotid foramen where it gives rise to several branches (Figure 20.26 and Figure 20.27). One of these branches is the anterior cerebral artery that supplies blood to the frontal lobe of the cerebrum. Another branch, the middle cerebral artery, supplies blood to the temporal and parietal lobes, which are the most common sites of CVAs. The ophthalmic artery, the third major branch, provides blood to the eyes.
The right and left anterior cerebral arteries join together to form an anastomosis called the anterior communicating artery. The initial segments of the anterior cerebral arteries and the anterior communicating artery form the anterior portion of the arterial circle. The posterior portion of the arterial circle is formed by a left and a right posterior communicating artery that branches from the posterior cerebral artery, which arises from the basilar artery. It provides blood to the posterior portion of the cerebrum and brain stem. The basilar artery is an anastomosis that begins at the junction of the two vertebral arteries and sends branches to the cerebellum and brain stem. It flows into the posterior cerebral arteries. Table 20.6 summarizes the aortic arch branches, including the major branches supplying the brain.
Figure 20.26 Arteries Supplying the Head and Neck The common carotid artery gives rise to the external and internal carotid arteries. The external carotid artery remains superficial and gives rise to many arteries of the head. The internal carotid artery first forms the carotid sinus and then reaches the brain via the carotid canal and carotid foramen, emerging into the cranium via the foramen lacerum. The vertebral artery branches from the subclavian artery and passes through the transverse foramen in the cervical vertebrae, entering the base of the skull at the vertebral foramen. The subclavian artery continues toward the arm as the axillary artery.
Figure 20.27 Arteries Serving the Brain This inferior view shows the network of arteries serving the brain. The structure is referred to as the arterial circle or circle of Willis.
Aortic Arch Branches and Brain Circulation
Vessel
Description
Brachiocephalic artery
Single vessel located on the right side of the body; the first vessel branching from the aortic arch; gives rise to the right subclavian artery and the right common carotid artery; supplies blood to the head, neck, upper limb, and wall of the thoracic region
Subclavian artery
The right subclavian artery arises from the brachiocephalic artery while the left subclavian artery arises from the aortic arch; gives rise to the internal thoracic, vertebral, and thyrocervical arteries; supplies blood to the arms, chest, shoulders, back, and central nervous system
Internal thoracic artery
Also called the mammary artery; arises from the subclavian artery; supplies blood to the thymus, pericardium of the heart, and anterior chest wall
Vertebral artery
Arises from the subclavian artery and passes through the vertebral foramen through the foramen magnum to the brain; joins with the internal carotid artery to form the arterial circle; supplies blood to the brain and spinal cord
Thyrocervical artery
Arises from the subclavian artery; supplies blood to the thyroid, the cervical region, the upper back, and shoulder
Common carotid artery
The right common carotid artery arises from the brachiocephalic artery and the left common carotid artery arises from the aortic arch; each gives rise to the external and internal carotid arteries; supplies the respective sides of the head and neck
External carotid artery
Arises from the common carotid artery; supplies blood to numerous structures within the face, lower jaw, neck, esophagus, and larynx
Internal carotid artery
Arises from the common carotid artery and begins with the carotid sinus; goes through the carotid canal of the temporal bone to the base of the brain; combines with the branches of the vertebral artery, forming the arterial circle; supplies blood to the brain
Arterial circle or circle of Willis
An anastomosis located at the base of the brain that ensures continual blood supply; formed from the branches of the internal carotid and vertebral arteries; supplies blood to the brain
Anterior cerebral artery
Arises from the internal carotid artery; supplies blood to the frontal lobe of the cerebrum
Middle cerebral artery
Another branch of the internal carotid artery; supplies blood to the temporal and parietal lobes of the cerebrum
Ophthalmic artery
Branch of the internal carotid artery; supplies blood to the eyes
Anterior communicating artery
An anastomosis of the right and left internal carotid arteries; supplies blood to the brain
Posterior communicating artery
Branches of the posterior cerebral artery that form part of the posterior portion of the arterial circle; supplies blood to the brain
Posterior cerebral artery
Branch of the basilar artery that forms a portion of the posterior segment of the arterial circle of Willis; supplies blood to the posterior portion of the cerebrum and brain stem
Basilar artery
Formed from the fusion of the two vertebral arteries; sends branches to the cerebellum, brain stem, and the posterior cerebral arteries; the main blood supply to the brain stem
Source: CNX OpenStax
Additional Materials (13)
Arteries Supplying the Head and Neck
The common carotid artery gives rise to the external and internal carotid arteries. The external carotid artery remains superficial and gives rise to many arteries of the head. The internal carotid artery first forms the carotid sinus and then reaches the brain via the carotid canal and carotid foramen, emerging into the cranium via the foramen lacerum. The vertebral artery branches from the subclavian artery and passes through the transverse foramen in the cervical vertebrae, entering the base of the skull at the vertebral foramen. The subclavian artery continues toward the arm as the axillary artery.
Image by CNX Openstax
Circle of Willis : Brain Circulation
This inferior view shows the network of arteries serving the brain. The structure is referred to as the arterial circle or circle of Willis.
Image by OpenStax College
Systemic Arteries
The major systemic arteries shown here deliver oxygenated blood throughout the body.
Image by CNX Openstax
Aorta
The aorta has distinct regions, including the ascending aorta, aortic arch, and the descending aorta, which includes the thoracic and abdominal regions.
Image by CNX Openstax
Major Arteries of the Upper Limb
The flow chart summarizes the distribution of the major arteries from the heart into the upper limb.
Image by CNX Openstax
Veins of the Head and Neck
This left lateral view shows the veins of the head and neck, including the intercranial sinuses.
Image by CNX Openstax
Veins Flowing into the Superior Vena Cava
The flow chart summarizes the distribution of the veins flowing into the superior vena cava.
Image by CNX Openstax
Venous Flow into Inferior Vena Cava
The flow chart summarizes veins that deliver blood to the inferior vena cava.
Image by CNX Openstax
AortIc arch
Heart and Aorta : Healthy heart and aorta. The aorta is the largest artery in the body. It arises from the left ventricle of the heart, bringing oxygenated blood to all parts of the body in the systemic circulation. The aorta is divided into ascending aorta, arch of aorta, and descending aorta ( thoracic and abdominal aorta ). Arch of aorta is the part that looks somewhat like an inverted "U". Ascending aorta is is the section between the heart and the arch of aorta . The descending aorta is the section from the arch of aorta to the point where it divides into common iliac arteries ( arteries that carry oxygenated blood from the abdominal aorta to the legs and feet ). The half of the descending aorta above the diaphragm is the thoracic aorta while the half of the descending aorta below the diaphragm is the abdominal aorta.
Image by Luke Guthmann
Aorta segments
Segments of the aorta, including the ascending aorta, aortic arch, descending thoracic aorta, suprarenal abdominal aorta, and infrarenal abdominal aorta
Image by Mikael Häggström, using source image by Edoarado
This browser does not support the video element.
Chest and Arm Blood Flow
Animation showing blood flowing through vessels in the chest and arm of a figure with transparent skin. The heart, as well as the subclavian, axillary, brachial, subscapular, radial, ulnar and median arteries are seen in addition to the pulmonary vessels. Black background.
Video by TheVisualMD
This browser does not support the video element.
Heart Beating Within Transparent Body
Animation showing heart beating within a figure with transparent skin and blood flowing through the body's vessels. The heart, as well as the brachiocephalic, subclavian, axillary, brachial, subscapular, radial, ulnar, median, superior mesenteric, inferior mesenteric, and ilieocolic arteries are seen in addition to the pulmonary vessels. Black background.
Video by TheVisualMD
Carotid sinus and baroreceptors look-up
Image by TheVisualMD
Arteries Supplying the Head and Neck
CNX Openstax
Circle of Willis : Brain Circulation
OpenStax College
Systemic Arteries
CNX Openstax
Aorta
CNX Openstax
Major Arteries of the Upper Limb
CNX Openstax
Veins of the Head and Neck
CNX Openstax
Veins Flowing into the Superior Vena Cava
CNX Openstax
Venous Flow into Inferior Vena Cava
CNX Openstax
AortIc arch
Luke Guthmann
Aorta segments
Mikael Häggström, using source image by Edoarado
0:12
Chest and Arm Blood Flow
TheVisualMD
0:08
Heart Beating Within Transparent Body
TheVisualMD
Carotid sinus and baroreceptors look-up
TheVisualMD
How It Affects Women
Stroke Differences with Men and Women
Image by TheVisualMD
Stroke Differences with Men and Women
Stroke Differences with Men and Women
Image by TheVisualMD
How Does Stroke Affect Women Differently Than Men?
Stroke affects women differently than men in several ways.
More women die from stroke than men.
More women have strokes later in life
After age 85, stroke affects many more women than men
It is twice as common for women between 20 and 39 to have a stroke than men of the same age
More women than men:
Have another stroke within 5 years of the first stroke
Women have unique risk factors for stroke, such as:
History of problems during pregnancy like gestational diabetes or preeclampsia
Use of hormonal birth control while smoking
Use of menopausal hormone therapy during or after menopause
Some risk factors for stroke are more common in women than in men.
These include migraine with aura, atrial fibrillation (irregular heartbeat), and diabetes.
Source: Office on Women's Health (OWH), U.S. Department of Health and Human Services
Additional Materials (4)
3 Ways a Woman's Stroke Risk Differs from Men's
Video by AdvocateHealthCare/YouTube
Women Not Stopping for Stroke Signs
Video by Lee Health/YouTube
Dr Cheryl Carcel: stroke differences between men and women
Video by The George Institute/YouTube
Women and Stroke: Common Signs
Video by Health Science Channel/YouTube
1:38
3 Ways a Woman's Stroke Risk Differs from Men's
AdvocateHealthCare/YouTube
1:53
Women Not Stopping for Stroke Signs
Lee Health/YouTube
1:54
Dr Cheryl Carcel: stroke differences between men and women
The George Institute/YouTube
7:28
Women and Stroke: Common Signs
Health Science Channel/YouTube
Types
Two types of stroke: Ischemic (L) and Hemorrhagic (R)
Image by Scientific Animations, Inc.
Two types of stroke: Ischemic (L) and Hemorrhagic (R)
Blood clot stops blood flow to an area of the brain in Ischemic (L) whereas blood leaks into brain tissue in case of Hemorrhagic(R).
Image by Scientific Animations, Inc.
What Are the Different Types of Stroke?
There are two types of stroke:
Stroke caused by a blockage of blood flow to the brain (ischemic [ih-SKEE-mik] stroke). This is the most common type of stroke. This type of stroke happens most often when an artery is clogged with plaque (atherosclerosis) or a blood clot.
Stroke caused by bleeding into the brain (hemorrhagic [hem-uh-RAJ-ik] stroke). This type of stroke happens when a blood vessel in the brain bursts, and blood bleeds into the brain. This type of stroke can be caused by an aneurysm, which is a thin or weak spot in an artery that can burst.
Both types of stroke can cause brain cells to die. Depending on which part of the brain the stroke affects, you may have problems with your speech, movement, balance, vision, or memory.
If you think you are having a stroke, call 911.
Source: Office on Women's Health (OWH), U.S. Department of Health and Human Services
Additional Materials (5)
Types of Stroke
Carotid arteries with close-up of blocked carotid resulting in an ischemic stroke, (right) Hemorrhagic stroke
Image by TheVisualMD
Types of Stroke
Video by AllHealthGo/YouTube
Two Types of Stroke: Hemorrhagic and Ischemic
Video by Emory University/YouTube
Ischemic stroke | Circulatory System and Disease | NCLEX-RN | Khan Academy
Video by khanacademymedicine/YouTube
Hemorrhagic strokes | Circulatory System and Disease | NCLEX-RN | Khan Academy
Video by khanacademymedicine/YouTube
Types of Stroke
TheVisualMD
1:26
Types of Stroke
AllHealthGo/YouTube
2:58
Two Types of Stroke: Hemorrhagic and Ischemic
Emory University/YouTube
8:23
Ischemic stroke | Circulatory System and Disease | NCLEX-RN | Khan Academy
khanacademymedicine/YouTube
7:29
Hemorrhagic strokes | Circulatory System and Disease | NCLEX-RN | Khan Academy
khanacademymedicine/YouTube
Mini-Stroke
Transient Ischemic Attack - Short Summary
Image by TheVisualMD
Transient Ischemic Attack - Short Summary
A transient ischemic attack (TIA) is a brief interruption of blood supply to part of the brain. The symptoms of a TIA resemble those of ischemic stroke, but they generally last less than an hour, and often no permanent damage is done.
Image by TheVisualMD
What Is a "Mini-Stroke"?
A "mini-stroke" is also called a transient ischemic attack (TIA, pronounced "T-I-A"). A TIA happens when, for a short time, less blood than normal gets to the brain. You may have some stroke symptoms, or you may not notice any symptoms.
A TIA usually lasts only a few minutes, although it can last up to several hours. Many people do not even know they have had a stroke. A TIA can be a warning sign of a full stroke in the future, or you can have another mini-stroke at a later time.
If you think you are having any type of stroke, call 911.
Source: Office on Women's Health (OWH), U.S. Department of Health and Human Services
Additional Materials (10)
Explaining what a mini-stroke means
Video by CNN/YouTube
Minor stroke captured on video: Watch as it happens
Video by UHNToronto/YouTube
Mini Stroke- Transient Ischemic Attack (TIA)
Video by EIRMC/YouTube
Heed The Warning of a Mini Stroke
Video by Lee Health/YouTube
Mini Stroke can Shorten Life Expectancy
Video by Lee Health/YouTube
Mini-strokes can cause permanent disability, need immediate treatment - In Depth
Video by insidermedicine/YouTube
How to Recognize, Prevent and Treat a TIA or Mini Stroke Part One
Video by Scott Theil/YouTube
Atrial fibrillation to a mini stroke – Kim’s story
Video by British Heart Foundation/YouTube
High blood pressure to a mini stroke – Jasmine’s story
Video by British Heart Foundation/YouTube
TIAs or mini strokes - what are the signs?
Video by Sunnybrook Hospital/YouTube
2:27
Explaining what a mini-stroke means
CNN/YouTube
1:23
Minor stroke captured on video: Watch as it happens
UHNToronto/YouTube
3:16
Mini Stroke- Transient Ischemic Attack (TIA)
EIRMC/YouTube
1:36
Heed The Warning of a Mini Stroke
Lee Health/YouTube
2:03
Mini Stroke can Shorten Life Expectancy
Lee Health/YouTube
1:37
Mini-strokes can cause permanent disability, need immediate treatment - In Depth
insidermedicine/YouTube
3:22
How to Recognize, Prevent and Treat a TIA or Mini Stroke Part One
Scott Theil/YouTube
2:16
Atrial fibrillation to a mini stroke – Kim’s story
British Heart Foundation/YouTube
2:45
High blood pressure to a mini stroke – Jasmine’s story
British Heart Foundation/YouTube
2:49
TIAs or mini strokes - what are the signs?
Sunnybrook Hospital/YouTube
Effects
Brain Inflammation
Image by VSRao
Brain Inflammation
Brain Inflammation
Image by VSRao
What Are the Effects of Stroke?
How stroke affects you depends on:
The type of stroke
The area of the brain where the stroke happened
The amount of brain injury
A mild stroke can cause little or no brain damage. A major stroke can cause severe brain damage and even death. Some effects of stroke may improve with time and rehabilitation.
A stroke can happen in different parts of the brain. The brain is divided into four main parts:
The right hemisphere (or half)
The left hemisphere (or half)
The cerebellum, which controls balance and coordination
The brain stem, which controls all of our body's functions that we don't think about, such as heart rate, blood pressure, sweating, or digestion.
A stroke in the right half of the brain can cause:
Problems moving the left side of your body
Problems judging distances. You may misjudge distances and fall. Or you might not be able to guide your hands to pick something up.
Impaired judgment and behavior. You may misjudge your ability to do things. You may also do things you would not normally do, such as leave your house without getting fully dressed.
Short-term memory loss. You may be able to remember events from 30 years ago, but not how to get to the place where you work today.
A stroke in the left half of the brain can cause:
Problems moving the right side of your body.
Speech and language problems. You may have trouble speaking or understanding others.
Slow and cautious behavior. You may need a lot of help to complete everyday tasks.
Memory problems. You may not remember what you did 10 minutes ago. Or you may have a hard time learning new things.
A stroke in the cerebellum can cause:
Stiffness and tightness in the upper body that can cause spasms or jerky movements
Eye problems, such as blurry or double vision
Balance problems
Dizziness, nausea (feeling sick to your stomach), and vomiting
Strokes in the brain stem are very harmful. Since impulses that start in the brain must travel through the brain stem on their way to the arms and legs, patients with a brain stem stroke may also develop paralysis.
Source: Office on Women's Health (OWH), U.S. Department of Health and Human Services
Additional Materials (9)
Human Brain Exposing Internal Structure
Human Brain Exposing Internal Structure : 3D visualization reconstructed from scanned human data of the internal structures of the brain. The left and right hemispheres have been pulled apart to reveal the structures inside of the brain. They include the thalamus, hypothalamus, hippocampus, pons, cerebellum, medulla oblongata and spinal cord.
Image by TheVisualMD
Blausen 0104 Brain x-secs SectionalPlanes
Sectional Planes of the Brain. See a related animation of this medical topic.
Image by BruceBlaus/Wikimedia
Sensitive content
This media may include sensitive content
Brain Anatomy and Functions
The brain is divided down the middle from front to back into two halves called the cerebral hemispheres. Each hemisphere is divided into four lobes: frontal, parietal, occipital, and temporal. Brain tumors located in the lobes are called supratentorial and tumors located in the cerebellum or brainstem are called infratentorial.
Image by National Cancer Institute (NCI)
This Is What A Stroke Does To Your Body
Video by Seeker/YouTube
Stroke Education - Causes and Effects
Video by Mackenzie Health/YouTube
Human Brain
Anatomical Illustration of the human brain.
Image by artlessstacey
Main anatomical plans and axes applied to the sections of the brain.
Main anatomical plans and axes applied to the sections of the brain.
Image by Zwarck
Human Brain Exposing Internal Structure
3D visualization reconstructed from scanned human data of the internal structures of the brain. The left and right hemispheres have been pulled apart to reveal the structures inside of the brain. They include the thalamus, hypothalamus, hippocampus, pons, cerebellum, medulla oblongata and spinal cord.
Image by TheVisualMD
Normal Brain cross section
This image shows a cross section through a healthy brain. Currently scientists are researching the rate tissue damage or loss in brain regions, such as the hippocampus, that are characteristically vulnerable in Alzheimer's Disease (AD). By determining the rate of tissue loss, doctors can use this information to identify cases that could progress from Mild Cognitive Impairment into AD. Other brain changes that can be observed are shrinkage in the cerebral cortex and enlargement of the ventricles.
Image by TheVisualMD
Human Brain Exposing Internal Structure
TheVisualMD
Blausen 0104 Brain x-secs SectionalPlanes
BruceBlaus/Wikimedia
Sensitive content
This media may include sensitive content
Brain Anatomy and Functions
National Cancer Institute (NCI)
4:15
This Is What A Stroke Does To Your Body
Seeker/YouTube
40:18
Stroke Education - Causes and Effects
Mackenzie Health/YouTube
Human Brain
artlessstacey
Main anatomical plans and axes applied to the sections of the brain.
Zwarck
Human Brain Exposing Internal Structure
TheVisualMD
Normal Brain cross section
TheVisualMD
How Do I Know If I'm at Risk
Women's Risk Factors for Stroke
Image by TheVisualMD
Women's Risk Factors for Stroke
Women's Risk Factors for Stroke and heart disease
Image by TheVisualMD
How Do I Know If I'm at Risk of Stroke?
A stroke can happen to anyone. Some women are more at risk because of certain health problems, family health history, age, and habits. These are called risk factors.
You can't change some risk factors, like your age, race or ethnicity, or family history. The good news is that you can control many other stroke risk factors, such as high blood pressure, diabetes, smoking, and unhealthy eating.
Source: Office on Women's Health (OWH), U.S. Department of Health and Human Services
Additional Materials (5)
Why are Young Women at Risk for Strokes?
Video by Lee Health/YouTube
American Heart Association issues stroke risk guidelines for women
Video by CBSN/YouTube
Diet Sodas And Juices Are Linked To Higher Stroke Risk, Study Says | TIME
Video by TIME/YouTube
Atrial Fibrillation Animation Explained: AFib & Risk of Stroke
Video by Thrombosis Adviser/YouTube
Are you at risk for a stroke? Learn the warning signs!
Video by National Stroke Association/YouTube
1:36
Why are Young Women at Risk for Strokes?
Lee Health/YouTube
1:20
American Heart Association issues stroke risk guidelines for women
CBSN/YouTube
1:06
Diet Sodas And Juices Are Linked To Higher Stroke Risk, Study Says | TIME
TIME/YouTube
0:59
Atrial Fibrillation Animation Explained: AFib & Risk of Stroke
Thrombosis Adviser/YouTube
2:12
Are you at risk for a stroke? Learn the warning signs!
National Stroke Association/YouTube
How Do I Know If I'm Having a Stroke?
face showing signs of stroke (facial droop)
Image by Another-anon-artist-234
face showing signs of stroke (facial droop)
black and white illustration of a patient with a face showing signs of stroke (facial droop)
Image by Another-anon-artist-234
How Do I Know If I'm Having a Stroke?
Strokes happen fast and are a medical emergency. If you think you or someone else may be having a stroke, use the F.A.S.T. test:
F—Face: Look in the mirror and smile, or ask the person to smile. Does one side of the face droop? A—Arms: Raise both arms. Does one arm drift downward? S—Speech: Repeat a simple phrase, like "Hello, my name is ____." Is the speech slurred or strange? T—Time: Act fast. If you see any of these signs, call 911 right away. Some treatments for stroke work only if given in the first 3 hours (or up to 4½ hours for some people) after symptoms appear.
Source: Office on Women's Health (OWH), U.S. Department of Health and Human Services
Additional Materials (4)
Mayo Clinic Minute: What women need to know about stroke
Video by Mayo Clinic/YouTube
Women Not Stopping for Stroke Signs
Video by Lee Health/YouTube
Women and Stroke - Learn the 7 Risks
Video by Renown Health/YouTube
Stroke Symptoms - Mayo Clinic
Video by Mayo Clinic/YouTube
1:00
Mayo Clinic Minute: What women need to know about stroke
Mayo Clinic/YouTube
1:53
Women Not Stopping for Stroke Signs
Lee Health/YouTube
1:24
Women and Stroke - Learn the 7 Risks
Renown Health/YouTube
2:53
Stroke Symptoms - Mayo Clinic
Mayo Clinic/YouTube
Diagnosis
Lateral View
Posterior View
1
2
Cerebral Angiography
Interactive by TheVisualMD
Lateral View
Posterior View
1
2
Cerebral Angiography
Cerebral angiography is a procedure that uses a special dye (contrast material) and x-rays to see how blood flows through the brain. Doctors may order this test if symptoms or signs of vascular malformation (abnormal blood vessels), aneurysm (blood-filled dilation of a blood vessel), narrowing of the arteries in the brain, and vasculitis (inflammation of blood vessels) are present. Sometimes, it is also used to confirm a brain tumor, evaluate the arteries of the head and neck before surgery, and find a clot that may have caused a stroke.
Interactive by TheVisualMD
How Is Stroke Diagnosed?
Stroke is a medical emergency. Tests for stroke usually start when you're in the ambulance, before you get to the hospital. This is one reason why it's important to call 911 for a stroke, rather than have someone drive you to the hospital. The goals of the tests are to figure out whether you've had a stroke, what type of stroke you've had, and what caused the stroke. This will help your doctors plan your treatment.
Physical and neurological exam
After you call 911 and the ambulance arrives, an ambulance worker will start the stroke exam. A doctor will continue the exam at the hospital. The ambulance worker or doctor will:
Ask you or a family memberabout your symptoms and medical history.
Do a physical exam. This includes taking your blood pressure and checking for mental alertness, numbness or weakness, or trouble speaking, seeing, or walking.
Do a neurological exam. This test checks how well your nervous system is working to show whether you have had a stroke. In this exam, the doctor will ask you questions, test your reflexes, and ask you to do simple actions. Each part of the exam tests a different part of your brain. This test can show how serious your stroke was and where in your brain the stroke might have happened.
Imaging tests for stroke
At the hospital, you will probably get at least one imaging test that allows your doctor to see inside your brain, see how much damage was done and where the stroke happened. Some imaging tests you may get include:
Computed tomography (CT) scan. A CT scan uses X-rays to take pictures of the brain. A CT scan of the head is usually one of the first tests used for a stroke. A CT scan can show bleeding in the brain or damage to brain cells. The CT scan also can find other problems that can cause stroke symptoms.
Magnetic resonance imaging (MRI). MRI uses a strong magnet and radio waves to make pictures of the brain. MRI shows brain changes caused by stroke sooner than a CT scan. MRI also can show any bleeding or blood flow problems. It can rule out other problems such as tumors that can cause symptoms similar to a stroke.
CT or MR angiogram. An angiogram is an X-ray movie of the blood vessels and blood flow through them. A dye is injected into the veins to show a detailed picture of the blood vessels after a stroke. A CT angiogram is used with a CT scanner, and a MR angiogram is used with an MRI.
Carotid ultrasound. Carotid ultrasound is a test that uses sound waves to create pictures of your carotid arteries, which supply blood to your brain. Often used with a CT or MR angiogram, the carotid ultrasound shows whether plaque has built up in your arteries and is blocking blood flow to your brain.
Trans-cranial Doppler (TCD) ultrasound. Doppler ultrasound is a test that uses sound waves to measure blood flow. Also used with a CT or MR angiogram, the TCD helps your doctor find out which artery in your brain is blocked.
Electroencephalogram (EEG). An EEG is done less often. This test records electrical activity in the brain to be sure your stroke symptoms are not caused by a seizure. Seizures can cause symptoms like movement problems and confusion. These can be mistaken for the symptoms of stroke or transient ischemic attack (TIA). During this test, you'll have sticky electrodes placed on your head, with wires attached to a machine. The machine records the electrical signals picked up by the electrodes.
Electrocardiogram (ECG or EKG). This test detects and records your heart's electrical activity. It can help your doctor find out if atrial fibrillation caused the stroke. An ECG can be done during physical activity to monitor your heart when it is working hard.
Blood tests for stroke
There is no blood test that can diagnose a stroke. However, in the hospital, your doctor or nurse may do a series of blood tests to learn the cause of your stroke symptoms:
Complete blood count (CBC). A CBC measures the overall health of your blood and helps diagnose infection, anemia, clotting problems, or other blood problems.
Serum electrolytes. This test looks at substances in your blood that carry an electric charge, called electrolytes. An electrolyte problem can cause stroke-like symptoms such as confusion or muscle weakness. Electrolytes also show whether you are dehydrated, which can cause confusion or tiredness. This test can also show whether you have kidney problems, which can change the stroke tests and treatments your doctor does.
Blood clotting tests. These tests measure how quickly your blood clots. It is also called a coagulation panel. If your blood clots too quickly, your stroke may have been caused by a clot (ischemic stroke). If your blood clots too slowly, your stroke may have been caused by bleeding (hemorrhagic stroke).
Heart attack tests. Your doctor may also order tests to see whether you have had a heart attack. Some women with stroke symptoms also have heart attack symptoms. Some heart problems can lead to a stroke.
Thyroid tests. Your doctor may measure your thyroid hormone levels with a blood test. Having hyperthyroidism raises your risk of atrial fibrillation, which can lead to stroke.
Blood glucose. This test measures the glucose (sugar) in your blood. Low blood sugar is a common complication of diabetes treatments. Low blood sugar can cause symptoms of a stroke, even when it's not a stroke.
Cholesterol tests. This test examines whether high blood cholesterol might have led to your stroke.
C-reactive protein test and blood protein test. These tests look for substances in your blood that your body releases in response to swelling or inflammation. Damage to arteries is one cause of inflammation. Your doctor might order these tests to understand your stroke risk better and to determine how to treat your stroke.
Source: Office on Women's Health (OWH), U.S. Department of Health and Human Services
Additional Materials (4)
Stroke Diagnosis and Treatment
Video by Howard County General Hospital/YouTube
Diagnosing strokes by history and physical exam | NCLEX-RN | Khan Academy
Video by khanacademymedicine/YouTube
Diagnosing strokes with lab tests | Circulatory System and Disease | NCLEX-RN | Khan Academy
Video by khanacademymedicine/YouTube
Diagnosing strokes with imaging CT, MRI, and Angiography | NCLEX-RN | Khan Academy
Video by khanacademymedicine/YouTube
6:11
Stroke Diagnosis and Treatment
Howard County General Hospital/YouTube
4:53
Diagnosing strokes by history and physical exam | NCLEX-RN | Khan Academy
khanacademymedicine/YouTube
6:20
Diagnosing strokes with lab tests | Circulatory System and Disease | NCLEX-RN | Khan Academy
khanacademymedicine/YouTube
9:30
Diagnosing strokes with imaging CT, MRI, and Angiography | NCLEX-RN | Khan Academy
Coagulation factor tests measure the levels of the proteins in the blood that help control bleeding and help determine if one or more of your coagulation factors are increased, normal, or decreased.
Coagulation factor tests measure the levels of the proteins in the blood that help control bleeding and help determine if one or more of your coagulation factors are increased, normal, or decreased.
Coagulation factors are proteins in the blood that help control bleeding. You have several different coagulation factors in your blood. When you get a cut or other injury that causes bleeding, your coagulation factors work together to form a blood clot. The clot stops you from losing too much blood. This process is called the coagulation cascade.
Coagulation factor tests are blood tests that check the function of one or more of your coagulation factors. Coagulation factors are known by Roman numerals (I, II VIII, etc.) or by name (fibrinogen, prothrombin, hemophilia A, etc.). If any of your factors are missing or defective, it can lead to heavy, uncontrolled bleeding after an injury.
A coagulation factor test is used to find out if you have a problem with any of your coagulation factors. If a problem is found, you likely have a condition known as a bleeding disorder. There are different types of bleeding disorders. Bleeding disorders are very rare. The most well-known bleeding disorder is hemophilia. Hemophilia is caused when coagulation factors VIII or IX are missing or defective.
You may be tested for one or more factors at a time.
You may need this test if you have a family history of bleeding disorders. Most bleeding disorders are inherited. That means it is passed down from one or both of your parents.
You may also need this test if your health care provider thinks you have a bleeding disorder that is not inherited. Although uncommon, other causes of bleeding disorders include:
Liver disease
Vitamin K deficiency
Blood-thinning medicines
In addition, you may need a coagulation factor test if you have symptoms of a bleeding disorder. These include:
Heavy bleeding after an injury
Easy bruising
Swelling
Pain and stiffness
An unexplained blood clot. In some bleeding disorders, the blood clots too much, rather than too little. This can be dangerous, because when a blood clot travels in your body, it can cause a heart attack, stroke, or other life-threatening conditions.
A health care professional will take a blood sample from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial. You may feel a little sting when the needle goes in or out. This usually takes less than five minutes
You don't need any special preparations for a coagulation factor test.
There is very little risk to having a blood test. You may have slight pain or bruising at the spot where the needle was put in, but most symptoms go away quickly.
If your results show one of your coagulation factors is missing or not working right, you probably have some kind of bleeding disorder. The type of disorder depends on which factor is affected. While there is no cure for inherited bleeding disorders, there are treatments available that can manage your condition.
Fibrinogen Test
Fibrinogen Test
Also called: Coagulation Factor I, Factor I, Hypofibrinogenemia test
Fibrinogen, also called coagulation factor I, is a protein produced by the liver. When bleeding is detected in the body, fibrinogen is released along with other coagulation factors to form blood clots and stop the bleeding. Too much or too little fibrinogen can lead to serious health problems.
Fibrinogen Test
Also called: Coagulation Factor I, Factor I, Hypofibrinogenemia test
Fibrinogen, also called coagulation factor I, is a protein produced by the liver. When bleeding is detected in the body, fibrinogen is released along with other coagulation factors to form blood clots and stop the bleeding. Too much or too little fibrinogen can lead to serious health problems.
{"label":"Fibrinogen Reference Range","scale":"lin","step":0.1,"hideunits":false,"units":[{"printSymbol":"mg\/dL","code":"mg\/dL","name":"milligram per deciliter"}],"items":[{"flag":"abnormal","label":{"short":"Low","long":"Low","orientation":"horizontal"},"values":{"min":0,"max":200},"text":"Low fibrinogen levels can cause excessive or prolonged bleeding.","conditions":["Disseminated intravascular coagulation (DIC)","Advanced liver disease","Severe malnutrition","Blood clotting problems","Recent blood transfusion","Fibrinogen deficiency"]},{"flag":"normal","label":{"short":"Normal","long":"Normal","orientation":"horizontal"},"values":{"min":200,"max":400},"text":"Normal results may slightly vary based on the laboratory and the method used.","conditions":[]},{"flag":"abnormal","label":{"short":"High","long":"High","orientation":"horizontal"},"values":{"min":400,"max":1000},"text":"High levels of fibrinogen can cause the blood-clotting proteins to become overactive, leading to the formation of blood clots throughout the body\u2019s vessels; this prevents blood and oxygen to reach the tissues and organs, which can eventually cause organ failure. ","conditions":["Kidney disease","Liver disease","Cirrhosis","Inflammatory conditions","Infection","Diabetes","Pregnancy\u00a0","Disseminated intravascular coagulation (DIC)"]}],"value":300}[{"abnormal":0},{"normal":0},{"abnormal":0}]
Use the slider below to see how your results affect your
health.
mg/dL
200
400
Your result is Normal.
Normal results may slightly vary based on the laboratory and the method used.
Related conditions
When bleeding occurs, a sequence of actions involving several proteins called coagulation factors takes place in the body to form blood clots. One of these proteins is called fibrinogen (factor I).
This test is used to detect how much fibrinogen is present in a sample of your blood.
Your doctor may want to order this test if you have signs or symptoms related to bleeding disorders or abnormal blood clotting. Other situations in which this test is ordered may include:
Abnormal results on other blood tests known as PTT (partial thromboplastin time), PT (prothrombin time), or TCT (thrombin clotting time).
If you have signs or symptoms of a disorder called disseminated intravascular coagulation (DIC), which is a serious and potentially life-threatening condition in which excessive clotting and bleeding can occur at the same time.
As part of screening tests for liver disease.
When you are taking medicine to prevent blood clots, to monitor the treatment effectiveness.
If a close family member has been diagnosed with a disorder known as factor I deficiency.
You should visit your doctor if you experience any of the following:
Nosebleeds
Bleeding gums or rectum
Bruises of unknown origin
A skin rash with small red or purple dots
Heavy menstrual bleeding
Blood in the stools or urine
Bleeding from wounds that do not stop on its own, or that take too much time to heal
Frequent headaches
Chest pain
Temporary vision changes
Fainting
Dizziness
Numbness or tingling in your hands and feet
A needle will be used to extract a small quantity of blood from a vein in your arm.
You may feel a little sting when the needle is inserted and extracted but otherwise is a quick procedure. You may also experience bruising and a little bleeding, as well as mild soreness for a short amount of time after the blood extraction.
You may feel a little sting when the needle is inserted and extracted but otherwise is a quick procedure. You may also experience bruising and a little bleeding, as well as mild soreness for a short amount of time after the blood extraction.
Low fibrinogen levels can cause excessive or prolonged bleeding, due to:
Disseminated intravascular coagulation (DIC)
Advanced liver disease
Severe malnutrition
Blood clotting problems
Recent blood transfusion
Factor I deficiency, which is a rare inherited (passed from parent to child) disorder that could include either afibrinogenemia (complete absence of fibrinogen) or hypofibrinogenemia (low fibrinogen levels)
High levels of fibrinogen can cause the blood-clotting proteins to become overactive, leading to the formation of blood clots throughout the body’s vessels; this prevents blood and oxygen to reach the tissues and organs, which can eventually cause organ failure.
High results may be due to:
Kidney disease
Liver disease
Cirrhosis (liver scarring)
Inflammatory conditions, such as rheumatoid arthritis
Infection
Diabetes
Pregnancy
Disseminated intravascular coagulation (DIC)
Fibrinogen [accessed on Oct 03, 2018]
Fibrinogen: Reference Range, Interpretation, Collection and Panels [accessed on Oct 03, 2018]
Factor I - Health Encyclopedia - University of Rochester Medical Center [accessed on Oct 03, 2018]
FIBTP - Clinical: Fibrinogen, Plasma [accessed on Oct 03, 2018]
Fibrinogen blood test: MedlinePlus Medical Encyclopedia [accessed on Oct 03, 2018]
Normal reference ranges can vary depending on the laboratory and the method used for testing. You must use the range supplied by the laboratory that performed your test to evaluate whether your results are "within normal limits."
Additional Materials (6)
Fibrinogen
Crystal structure of native chicken fibrinogen with two different bound ligands
Image by Jawahar Swaminathan and MSD staff at the European Bioinformatics Institute
Blood clots
Red blood cells trapped in a fibrin network in a blood clot.
Image by Fuzis
Blood clots
This medical illustration reveals how the SHELTERTM device traps and removes blood clots in the brain.
Image by Zina Deretsky, NSF
Coagulation cascade
Video by FerrosanMD/YouTube
How does a blood clot pass from the leg to the lung? Anatomy.
Video by Sam Webster/YouTube
How Blood Clots Form
Video by Vascular Cures/YouTube
Fibrinogen
Jawahar Swaminathan and MSD staff at the European Bioinformatics Institute
Blood clots
Fuzis
Blood clots
Zina Deretsky, NSF
4:51
Coagulation cascade
FerrosanMD/YouTube
14:44
How does a blood clot pass from the leg to the lung? Anatomy.
Sam Webster/YouTube
3:56
How Blood Clots Form
Vascular Cures/YouTube
Factor II Activity Test
Factor II Activity Test
Also called: Coagulation factor II, Prothrombin Assay, Prothrombin
When a wound occurs in any part of the body, several factors (proteins) which are involved in the normal blood clotting process become active to stop the bleeding. A factor II activity test is used to measure the activity of prothrombin, which is one of the proteins that help your blood to clot.
Factor II Activity Test
Also called: Coagulation factor II, Prothrombin Assay, Prothrombin
When a wound occurs in any part of the body, several factors (proteins) which are involved in the normal blood clotting process become active to stop the bleeding. A factor II activity test is used to measure the activity of prothrombin, which is one of the proteins that help your blood to clot.
{"label":"Factor II Activity Reference Range","scale":"lin","step":0.1,"hideunits":false,"units":[{"printSymbol":"%","code":"%","name":"percent"}],"items":[{"flag":"abnormal","label":{"short":"Low","long":"Low","orientation":"horizontal"},"values":{"min":0,"max":70},"text":"You have a decreased factor II activity. Therefore, your bleeding risk is increased.","conditions":["Liver disease","Vitamin K deficiency","Intake of blood thinners","Disseminated intravascular coagulation","Fat malabsorption","Congenital factor II deficiency"]},{"flag":"normal","label":{"short":"Normal","long":"Normal","orientation":"horizontal"},"values":{"min":70,"max":130},"text":"Normal results may slightly vary based on the laboratory and the method used.","conditions":[]},{"flag":"abnormal","label":{"short":"High","long":"High","orientation":"horizontal"},"values":{"min":130,"max":200},"text":"You have an increased factor II activity. Therefore, you have an increased risk of developing blood clots.","conditions":["Thrombosis","Blood clots","Prothrombin gene mutation"]}],"value":100}[{"abnormal":0},{"normal":0},{"abnormal":0}]
Use the slider below to see how your results affect your
health.
%
70
130
Your result is Normal.
Normal results may slightly vary based on the laboratory and the method used.
Related conditions
When bleeding occurs, a sequence of actions involving several proteins called coagulation factors take place in the body to form blood clots; this process is known as the coagulation cascade.
A factor II activity test measures the activity of prothrombin, which is one of the proteins involved in the coagulation cascade.
Your doctor may want to order this test in the following situations:
When previous test results, such as prothrombin time (PT) and/or partial thromboplastin time (PTT), have shown that your blood is not clotting properly.
To help diagnose a deficiency of coagulation factor II (prothrombin).
In certain cases, to monitor response to treatment in people who are taking oral anticoagulant therapy (blood-thinners), such as warfarin.
You should visit your doctor if you experience any of the following signs and symptoms:
Bruises of unknown origin
Nosebleeds
Heavy menstrual bleeding
Bleeding gums or rectum
A skin rash with small red or purple dots
Blood in the stools or urine
Wounds that do not stop bleeding on its own, or that take too much time to heal
Frequent headaches
Chest pain
Temporary vision changes
A needle will be used to extract a small quantity of blood from a vein in your arm.
No fasting or special preparations are needed; however, you should inform your healthcare provider about any medicines or supplements that you are taking.
You may feel a little sting when the needle is inserted and extracted but otherwise is a quick procedure. You may also experience bruising as well as mild soreness for a short amount of time after the blood extraction.
Since this test is mostly indicated in people with bleeding problems, the risk of bleeding might be slightly increased than it is for people without bleeding disorders.
Normal factor II activity results are:
In adults: from 70 to 130 %
In newborns and infants up to 6-months-old: from 25% to 50%, then it reaches adult levels.
Reference ranges may slightly vary based on the laboratory and the method used.
Decreased levels may be due to:
Liver disease
Low level of vitamin K
Intake of blood thinners, such as warfarin
Disseminated intravascular coagulation (excessive activity of the proteins that control blood clotting)
Fat malabsorption (impaired absorption of fat from the food)
A rare condition that is known as congenital (born with it) factor II deficiency
Increased levels may be due to:
Mutation (changes) in the prothrombin gene
Even though this condition is rare, a high factor II activity has been associated with an increased risk of thrombosis (formation of a blood clot inside a vein in your body).
Factor II assay: MedlinePlus Medical Encyclopedia [accessed on Oct 03, 2018]
Prothrombin deficiency - Genetics Home Reference - NIH [accessed on Oct 03, 2018]
F_2 - Clinical: Coagulation Factor II Activity Assay, Plasma [accessed on Oct 03, 2018]
086231: Factor II Activity | LabCorp [accessed on Oct 03, 2018]
511162: Factor II (Prothrombin), DNA Analysis | LabCorp [accessed on Oct 03, 2018]
Normal reference ranges can vary depending on the laboratory and the method used for testing. You must use the range supplied by the laboratory that performed your test to evaluate whether your results are "within normal limits."
Additional Materials (5)
Platelets, Thrombus Formation
Platelets (also known as thrombocytes) are essential to the process of blood clotting; clotting can sometimes pose dangers, though, as in the case of atherosclerosis (or \"hardening\" of the arteries). Thrombosis is the formation of a clot (thrombus) inside a blood vessel. If the clot is large or persistent enough, it can obstruct blood flow and starve tissue of oxygen. A heart attack can occur when a clot in an artery that supplies blood to the heart is blocked; a stroke can occur when blood flow to the brain is blocked.
Image by TheVisualMD
Platelet Development
Illustration of Platelet Development
Image by OpenStax College
thrombin clotting time (TCT)
Blood coagulation pathways in vivo showing the central role played by thrombin.
Clotting time of PLASMA mixed with a THROMBIN solution. It is a measure of the conversion of FIBRINOGEN to FIBRIN, which is prolonged by AFIBRINOGENEMIA, abnormal fibrinogen, or the presence of inhibitory substances, e.g., fibrin-fibrinogen degradation products, or HEPARIN. BATROXOBIN, a thrombin-like enzyme unaffected by the presence of heparin, may be used in place of thrombin. (MESH/NLM/NIH)
Image by Dr Graham Beards
Des-Gamma-Carboxy Prothrombin
Des-gamma-carboxy prothrombin (DCP) is an abnormal form of prothrombin, which is a blood-clotting protein. When a blood vessel is injured, prothrombin is converted into thrombin, an enzyme that promotes blood clotting. DCP is produced by the liver, and production may become elevated in the presence of liver tumors. Blood levels of DCP have proven useful for detecting and monitoring hepatocellular carcinoma (HCC), a cancer that begins in cells of the liver.
Image by TheVisualMD
Human prothrombin mutant 6C2W closed structure
Human prothrombin mutant S101C/A470C (PDB 6C2W) that imitates the closed conformation of prothrombin. Mutant disulfide bond (C101-C470) is shown in orange, other bonds are in yellow.
Domains/linkers (from N-terminal (N) to C-terminal (C)):
Green: Gla
White: linker 1
Blue: kringle 1
Gray: linker 2
Red: kringle 2
Black: linker 3
Purple: the residues between R271 and R320, which are removed upon activation to thrombin
Pink: enzymatic domain
Other:
Yellow: disulfide bond
Orange: artificial/mutant C101-C470 disulfide bond
Cyan: active site residues H363, D419 and S525
Gray coat: protein surface
Image by 5-HT2AR
Platelets, Thrombus Formation
TheVisualMD
Platelet Development
OpenStax College
thrombin clotting time (TCT)
Dr Graham Beards
Des-Gamma-Carboxy Prothrombin
TheVisualMD
Human prothrombin mutant 6C2W closed structure
5-HT2AR
Factor V Activity Test
Factor V Activity Test
Also called: Factor V Assay, Coagulation Factor V, Labile factor, Proaccelerin, Ac-globulin
When a wound occurs in any part of the body, several factors (proteins) which are involved in the normal blood clotting process become active to stop the bleeding. A factor V (pronounced factor five) activity test is used to measure the activity of the coagulation factor V, which is one of the proteins that help your blood to clot.
Factor V Activity Test
Also called: Factor V Assay, Coagulation Factor V, Labile factor, Proaccelerin, Ac-globulin
When a wound occurs in any part of the body, several factors (proteins) which are involved in the normal blood clotting process become active to stop the bleeding. A factor V (pronounced factor five) activity test is used to measure the activity of the coagulation factor V, which is one of the proteins that help your blood to clot.
{"label":"Factor V Activity Reference Range","scale":"lin","step":0.1,"hideunits":false,"units":[{"printSymbol":"%","code":"%","name":"percent"}],"items":[{"flag":"abnormal","label":{"short":"Low","long":"Low","orientation":"horizontal"},"values":{"min":0,"max":70},"text":"You have a decreased factor V activity. Therefore, your bleeding risk is increased.","conditions":["Liver disease","Disseminated intravascular coagulation","Treatment with certain antibiotics","Vitamin K deficiency","Intake of blood thinners","Cancer","Congenital factor V deficiency","Parahemophilia","Owren's disease"]},{"flag":"normal","label":{"short":"Normal","long":"Normal","orientation":"horizontal"},"values":{"min":70,"max":130},"text":"Normal results vary based on the laboratory and the method used.","conditions":[]},{"flag":"abnormal","label":{"short":"High","long":"High","orientation":"horizontal"},"values":{"min":130,"max":200},"text":"You have an increased factor V activity. Therefore, you may have an increased risk of developing blood clots.","conditions":["Acute illness","Stress","Inflammation","Thrombosis","Blood clots"]}],"value":100}[{"abnormal":0},{"normal":0},{"abnormal":0}]
Use the slider below to see how your results affect your
health.
%
70
130
Your result is Normal.
Normal results vary based on the laboratory and the method used.
Related conditions
When bleeding occurs, a sequence of actions involving several proteins called coagulation factors take place in the body to form blood clots; this process is known as the coagulation cascade.
A factor V activity test measures the activity of the coagulation factor V, which is one of the proteins involved in the coagulation cascade.
Your doctor may want to order this test in the following situations:
When previous test results, such as prothrombin time (PT) and/or partial thromboplastin time (PTT), have shown that your blood is not clotting properly.
To help diagnose a deficiency of coagulation factor V.
You should visit your doctor if you experience any of the following signs and symptoms:
Bruises of unknown origin
Nosebleeds
Heavy menstrual bleeding
Bleeding gums or rectum
A skin rash with small red or purple dots
Blood in the stools or urine
Wounds that do not stop bleeding on its own, or that take too much time to heal
Frequent headaches
Chest pain
Temporary vision changes
A needle will be used to extract a small quantity of blood from a vein in your arm.
No fasting or special preparations are needed; however, you should inform your healthcare provider about any medicines or supplements that you are taking.
You may feel a little sting when the needle is inserted and extracted but otherwise is a quick procedure. You may also experience bruising as well as mild soreness for a short amount of time after the blood extraction.
Since this test is mostly indicated in people with bleeding problems, the risk of bleeding might be slightly increased than it is for people without bleeding disorders.
Normal factor V activity results are:
In adults: from 70 to 130 %
In newborns up to 21 days of age: equal to or above 30% to 35%, then it reaches adult levels.
Reference ranges may vary based on the laboratory and the method used.
Decreased levels may be due to:
Liver disease
Disseminated intravascular coagulation (excessive activity of the proteins that control blood clotting)
Treatment with certain antibiotics following a surgical procedure
Low level of vitamin K
Intake of blood thinners, such as warfarin
Certain types of cancer
A rare condition that is known as congenital (born with it) factor V deficiency, also called parahemophilia or Owren's disease
Ask your healthcare provider what your test results mean in your specific case.
Increased levels may be due to:
Acute illness
Stress
Inflammation
Even though this condition is rare, a high factor V activity has been associated with an increased risk of thrombosis (formation of a blood clot inside a blood vessel).
This is not the same test as factor V Leiden, and therefore their results should not be interchanged.
Factor V assay: MedlinePlus Medical Encyclopedia [accessed on Oct 03, 2018]
URMC / Encyclopedia / Factor V [accessed on Oct 03, 2018]
FACTV - Clinical: Coagulation Factor V Activity Assay, Plasma [accessed on Oct 03, 2018]
Coagulation Factors [accessed on Oct 03, 2018]
086249: Factor V Activity | LabCorp [accessed on Oct 03, 2018]
Pathology Outlines - Elevated coagulation factor levels in plasma [accessed on Oct 03, 2018]
Factor V - Wikipedia [accessed on Oct 03, 2018]
Factor V deficiency - Genetics Home Reference - NIH [accessed on Oct 03, 2018]
Normal reference ranges can vary depending on the laboratory and the method used for testing. You must use the range supplied by the laboratory that performed your test to evaluate whether your results are "within normal limits."
Additional Materials (2)
5 facts about Factor V Leiden
Video by Comprehensive Bleeding Disorders Center/YouTube
Protein F5
Structure of the F5 protein.
Image by Emw
2:32
5 facts about Factor V Leiden
Comprehensive Bleeding Disorders Center/YouTube
Protein F5
Emw
Factor VII Test
Factor VII Test
Also called: Coagulation Factor VII, Stable Factor, Proconvertin, Autoprothrombin, Factor VII Activity
When a wound occurs in any part of the body, several factors (proteins) which are involved in the normal blood clotting process become active to stop the bleeding. A factor VII (pronounced factor seven) test is used to measure the activity of the coagulation factor VII, which is one of the proteins that help your blood to clot.
Factor VII Test
Also called: Coagulation Factor VII, Stable Factor, Proconvertin, Autoprothrombin, Factor VII Activity
When a wound occurs in any part of the body, several factors (proteins) which are involved in the normal blood clotting process become active to stop the bleeding. A factor VII (pronounced factor seven) test is used to measure the activity of the coagulation factor VII, which is one of the proteins that help your blood to clot.
{"label":"Factor VII Reference Range","scale":"lin","step":0.1,"hideunits":false,"units":[{"printSymbol":"%","code":"%","name":"percent"}],"items":[{"flag":"abnormal","label":{"short":"Low","long":"Low","orientation":"horizontal"},"values":{"min":0,"max":60},"text":"You have a decreased coagulation factor VII. Therefore, your bleeding risk is increased.","conditions":["Liver disease","Vitamin K deficiency","Intake of blood thinners","Homocystinuria","Aplastic anemia"]},{"flag":"normal","label":{"short":"Normal","long":"Normal","orientation":"horizontal"},"values":{"min":60,"max":140},"text":"Normal results vary based on the laboratory and the method used.","conditions":[]},{"flag":"abnormal","label":{"short":"High","long":"High","orientation":"horizontal"},"values":{"min":140,"max":200},"text":"You have an increased coagulation factor VII. Therefore, you might have an increased risk of developing blood clots.","conditions":["Ischemic heart disease","Thrombosis","Blood clots"]}],"value":100}[{"abnormal":0},{"normal":0},{"abnormal":0}]
Use the slider below to see how your results affect your
health.
%
60
140
Your result is Normal.
Normal results vary based on the laboratory and the method used.
Related conditions
When bleeding occurs, a sequence of actions involving several proteins called coagulation factors take place in the body to form blood clots; this process is known as the coagulation cascade.
A factor VII test measures the activity of the coagulation factor VII, which is one of the proteins involved in the coagulation cascade.
Your doctor may order this test in the following situations:
If you have bleeding or coagulation disorders
To help diagnose a deficiency of coagulation factor VII
To monitor the factor deficiency and to evaluate the effectiveness of treatment
You should visit your doctor if you experience any of the following signs and symptoms:
Bruises of unknown origin
Nosebleeds
Heavy menstrual bleeding
Bleeding gums or rectum
A skin rash with small red or purple dots
Blood in the stools or urine
Wounds that do not stop bleeding on its own, or that take too much time to heal
Frequent headaches
Chest pain
Temporary vision changes
A healthcare professional takes a blood sample from a vein, generally in your arm, using a needle. A small amount of blood is collected into a test tube or vial. You may feel a little sting when the needle goes in or out.
No fasting or special preparations are needed; however, you should inform your healthcare provider about any medicines or supplements that you are taking.
You may feel a little sting when the needle is inserted and extracted but otherwise is a quick procedure. You may also experience bruising as well as mild soreness for a short amount of time after the blood extraction.
Since this test is mostly indicated in people with bleeding problems, the risk of bleeding might be slightly increased than it is for people without bleeding disorders.
In adults, normal results for factor VII activity are 60 to 140%. However, reference ranges can slightly vary depending on the laboratory and the method used for testing.
Normal, full-term newborn infants or healthy premature infants may have decreased levels (> or =20%) which increase within the first postnatal week but may not reach adult levels for > or =180 days postnatal.
Decreased levels may be related to:
Liver disease
Vitamin K deficiency
Intake of blood thinners, such as warfarin
Homocystinuria
Aplastic anemia
Factor VII is the most sensitive vitamin k-dependent factor that can change its value with anticoagulation therapy.
800599: Factor VII Activity | LabCorp [accessed on Nov 22, 2018]
Fontanarosa, P., & Christiansen, S. (2009, April 01). Laboratory Values. AMA Manual of Style. Ed. [accessed on Nov 22, 2018]
Normal reference ranges can vary depending on the laboratory and the method used for testing. You must use the range supplied by the laboratory that performed your test to evaluate whether your results are "within normal limits."
Additional Materials (5)
Factors V, VII, KIF6
Genetic biomarkers test for variation in specific genes. Because genes direct the production of proteins, variation in the genes can alter the proteins produced. K1F6 produces a protein that is involved in the transport of materials within cells; abnormalities in the protein can significantly increase the risk of heart disease. Factors V and VII are proteins produced by the liver that are involved in blood clotting. Abnormalities in the genes that produce these proteins can result in abnormal clotting, which can in turn increase the risk of venous thrombosis. Other symptoms include prolonged menstrual bleeding, nosebleeds, excessive bruising and gum bleeding.
Image by TheVisualMD
Basics of Factor 7 Deficiency
Video by National Hemophilia Foundation/YouTube
Coagulation Factors | Hemostasis | Hematology
Video by Medicosis Perfectionalis/YouTube
Clotting Factors - Coagulation Cascade
Video by MEDSimplified/YouTube
Hematology | Hemostasis: Coagulation Cascade
Video by Ninja Nerd/YouTube
Factors V, VII, KIF6
TheVisualMD
25:56
Basics of Factor 7 Deficiency
National Hemophilia Foundation/YouTube
17:40
Coagulation Factors | Hemostasis | Hematology
Medicosis Perfectionalis/YouTube
5:44
Clotting Factors - Coagulation Cascade
MEDSimplified/YouTube
43:13
Hematology | Hemostasis: Coagulation Cascade
Ninja Nerd/YouTube
Factor VIII Test
Factor VIII Test
Also called: Antihemophilia Factor A, Hemophilic factor A, Coagulation factor VIII
When a wound occurs in any part of the body, several factors (proteins) which are involved in the normal blood clotting process become active to stop the bleeding. This test is used to measure the activity of the coagulation factor VIII, which is one of the proteins that help your blood to clot. This is useful to diagnose a condition known as hemophilia A.
Factor VIII Test
Also called: Antihemophilia Factor A, Hemophilic factor A, Coagulation factor VIII
When a wound occurs in any part of the body, several factors (proteins) which are involved in the normal blood clotting process become active to stop the bleeding. This test is used to measure the activity of the coagulation factor VIII, which is one of the proteins that help your blood to clot. This is useful to diagnose a condition known as hemophilia A.
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Use the slider below to see how your results affect your
health.
%
1
5
50
150
Your result is Normal.
Normal results vary based on the laboratory and the method used.
Related conditions
When bleeding occurs, a sequence of actions involving several proteins called coagulation factors take place in the body to form blood clots; this process is known as the coagulation cascade.
A factor VIII test measures the activity of the coagulation factor VIII, which is one of the proteins involved in the coagulation cascade.
Your doctor may want to order this test to diagnose a condition known as hemophilia A, also called coagulation factor VIII deficiency, in the following situations:
When previous test results, such as prothrombin time (PT) and/or partial thromboplastin time (PTT), have shown that your blood is not clotting properly.
As part of an evaluation for a bleeding disorder called von Willebrand disease.
When one of your family members is known to have hemophilia A.
To assess the response to hemophilia A treatment.
Hemophilia A is a condition that causes the blood to not clot properly, which puts the affected person at risk of uncontrolled bleeding.
Hemophilia A is usually hereditary, but can also appear spontaneously. Since the condition is inherited in an X-gene related manner, the majority of affected people are male.
Women are usually carriers of the faulty gene, which means that they don’t develop Hemophilia A, but have a 50% chance of passing it on to their children. Nevertheless, it's still possible for females to develop the disorder.
You should visit your doctor if you experience any of the following signs and symptoms:
Bruises of unknown origin
Nosebleeds
Heavy menstrual bleeding
Bleeding gums or rectum
A skin rash with small red or purple dots
Blood in the stools or urine
Wounds that do not stop bleeding on its own, or that take too much time to heal
Frequent headaches
Chest pain
Temporary vision changes
A needle will be used to extract a small quantity of blood from a vein in your arm.
No fasting or special preparations are needed; however, you should inform your healthcare provider about any medicines or supplements that you are taking.
You may feel a little sting when the needle is inserted and extracted but otherwise is a quick procedure. You may also experience bruising as well as mild soreness for a short amount of time after the blood extraction.
Since this test is mostly indicated in people with bleeding problems, the risk of bleeding might be slightly increased than it is for people without bleeding disorders.
Normal factor VIII activity results are 50% to 150%. However, this test results can vary depending on your gender, age, clinical history, other test results, and the method used for testing.
Factor VIII results below 50% are highly indicative of hemophilia A.
A result between 5% to 50% indicates mild hemophilia A; while a result from 1% to 5% suggests moderate hemophilia A. People who have less than 1% usually suffer from severe hemophilia A.
Decreased factor VIII activity may be due to:
Hemophilia A
Von Willebrand disease (another type of bleeding disorder)
Disseminated intravascular coagulation (excessive activity of the proteins that control blood clotting)
Presence of a Factor VIII inhibitor (antibody)
Increased factor VIII activity may be due to:
Liver disease
Inflammation
Diabetes
Pregnancy
Obesity
Older age
Ask your doctor what your test results mean in your specific case.
Your doctor may also order another test known as the factor VIII antigen assay, to find out the actual amount of factor VIII in your blood, not its clotting activity.
The factor VIII circulates in the blood attached to another clotting factor called von Willebrand factor (vWF); therefore, a decreased amount of the factor VIII can also mean a decreased amount of the vWF.
Factor VIII assay: MedlinePlus Medical Encyclopedia [accessed on Oct 02, 2018]
Blood Test: Factor VIII Activity (for Parents) [accessed on Oct 02, 2018]
086264: Factor VIII Activity | LabCorp [accessed on Oct 02, 2018]
Factor VIII (Antihemophilic Factor A) - Health Encyclopedia - University of Rochester Medical Center [accessed on Oct 02, 2018]
F8A - Clinical: Coagulation Factor VIII Activity Assay, Plasma [accessed on Oct 30, 2018]
Coagulation Factors [accessed on Oct 30, 2018]
Normal reference ranges can vary depending on the laboratory and the method used for testing. You must use the range supplied by the laboratory that performed your test to evaluate whether your results are "within normal limits."
Additional Materials (17)
Beyond Diagnosis: Treatment Options and Resources for People with Inhibitors
This fact sheet contains information about treatment options for inhibitors and provides resources for people have been diagnosed with an inhibitor or would like to learn more on the subject.
Document by Centers for Disease Control and Prevention (CDC)
Platelet Development
Illustration of Platelet Development
Image by OpenStax College
Sensitive content
This media may include sensitive content
Bleeding
Bleeding, technically known as hemorrhaging or hemorrhaging - Bleeding wound on finger
Image by Crystal (Crystl) from Bloomington, USA
Factors V and VII, Cutting of Skin
When the skin is cut, a cascade of reactions takes place almost immediately in order to stanch the flow of blood and lay the groundwork for healing. Platelets are cell fragments produced in the bone marrow that essential to the process of blood clotting. In addition to platelets, there are more than a dozen different blood-clotting factors that interact in the process of blood clotting; even the absence or malfunction of just one of these factors, can disrupt this process and lead to serious illness, such as hemophilia.
Image by TheVisualMD
Hemophilia
Hemophilia is an inherited disease, most commonly affecting males, that is characterized by a deficiency in blood clotting.
Image by National Human Genome Research Institute (NHGRI)
The image shows one example of how the hemophilia gene is inherited.
In this example, the father doesn't have hemophilia (that is, he has two normal chromosomes-X and Y). The mother is a carrier of hemophilia (that is, she has one faulty X chromosome and one normal X chromosome). Each daughter has a 50 percent chance of inheriting the faulty gene from her mother and being a carrier. Each son has a 50 percent chance of inheriting the faulty gene from his mother and having hemophilia.
Image by National Heart Lung and Blood Institute (NIH)
Inheritance pattern for hemophilia in which the mother is a carrier
In this example, the father does not have hemophilia. He has two normal chromosomes, X and Y. The mother is a carrier of hemophilia, because she has one hemophilia gene on one X chromosome and one normal X chromosome. Each daughter has a 50% chance of inheriting the hemophilia gene from her mother and being a carrier. Each son has a 50% chance of having hemophilia.
Image by National Heart, Lung, and Blood Institute (NHLBI)
Hemophilia - blood clotting factors
Drawing the mixed Antihemophilic Factor / Sterile Saline into syringes for injection. Jacob recieves 7 syringes each Friday.
What is Hemophilia? Blood clotting, or coagulation, is the process that controls bleeding. It changes blood from a liquid to a solid. It's a complex process involving as many as 20 different plasma proteins, or blood clotting factors. Normally, a complex chemical process occurs using these clotting factors to form a substance called fibrin that stops bleeding. When certain coagulation factors are deficient or missing, the process doesn't occur normally.
In people with bleeding disorders, clotting factors are missing or don't work as they should. This causes them to bleed for a longer time, bruise easier and have greater joint pain than those whose blood factor levels are normal.
Image by Jkgroove
Desmopressin, sold under the trade name DDAVP among others, is a medication used to treat diabetes insipidus, bedwetting, hemophilia A, von Willebrand disease, and high blood urea levels.
Desmopressin, sold under the trade name DDAVP among others, is a medication used to treat diabetes insipidus, bedwetting, hemophilia A, von Willebrand disease, and high blood urea levels. In hemophilia A and von Willebrand disease, it should only be used for mild to moderate cases. It may be given in the nose, by injection into a vein, by mouth, or under the tongue. - Wikipedia
Image by MarinaVladivostok
3d ribbon/surface model of the human factor VIII
"Crystal structure of human factor VIII: implications for the formation of the factor IXa-factor VIIIa complex"
Image by Ayacop
Hemarthrosis
Lipohemarthrosis (blood and fat in the joint space) seen in a person with a subtle tibial plateau fracture. The arrow indicates a fluid level between the upper fat component and the lower blood component.
Image by James Heilman, MD
Inheritance pattern for hemophilia in which the father has hemophilia
In this example, the mother is not a hemophilia carrier and has two normal X chromosomes. None of the children will have hemophilia. Each daughter will inherit the hemophilia gene from her father and be a carrier.
Image by National Heart, Lung, and Blood Institute (NHLBI)
Hemarthrosis - Bleeding into the joints. It may arise from trauma or spontaneously in patients with hemophilia.
Hemarthrosis Medical X-rays.
Image by Nevit Dilmen (talk)
Hemarthrosis
Hemarthrosis Medical X-rays.
Image by Nevit Dilmen (talk)
Scheme of a blood sample after centrifugation
scheme of a blood sample after centrifugation
Image by KnuteKnudsen (talk)
Platelet Disorders
Platelets by budding off from megakaryocytes
Blood fractionation
Vial of separated blood. The middle layer is a type of sterile goo which separates the blood from the rest of what's drawn.
Image by Wheeler Cowperthwaite from Reno, USA
Beyond Diagnosis: Treatment Options and Resources for People with Inhibitors
Centers for Disease Control and Prevention (CDC)
Platelet Development
OpenStax College
Sensitive content
This media may include sensitive content
Bleeding
Crystal (Crystl) from Bloomington, USA
Factors V and VII, Cutting of Skin
TheVisualMD
Hemophilia
National Human Genome Research Institute (NHGRI)
The image shows one example of how the hemophilia gene is inherited.
National Heart Lung and Blood Institute (NIH)
Inheritance pattern for hemophilia in which the mother is a carrier
National Heart, Lung, and Blood Institute (NHLBI)
Hemophilia - blood clotting factors
Jkgroove
Desmopressin, sold under the trade name DDAVP among others, is a medication used to treat diabetes insipidus, bedwetting, hemophilia A, von Willebrand disease, and high blood urea levels.
MarinaVladivostok
3d ribbon/surface model of the human factor VIII
Ayacop
Hemarthrosis
James Heilman, MD
Inheritance pattern for hemophilia in which the father has hemophilia
National Heart, Lung, and Blood Institute (NHLBI)
Hemarthrosis - Bleeding into the joints. It may arise from trauma or spontaneously in patients with hemophilia.
Nevit Dilmen (talk)
Hemarthrosis
Nevit Dilmen (talk)
Scheme of a blood sample after centrifugation
KnuteKnudsen (talk)
Platelet Disorders
Blood fractionation
Wheeler Cowperthwaite from Reno, USA
Factor IX Test
Factor IX Test
Also called: Christmas factor assay, Hemophilic factor B, Coagulation factor IX, factor IX hemophilia, FIX, factor IX deficiency test
When a wound occurs in any part of the body, several factors (proteins) which are involved in the normal blood clotting process become active to stop the bleeding. A factor IX (pronounced factor nine) test is used to measure the activity of the coagulation factor IX, which is one of the proteins that help your blood to clot. If you are lacking this...
Factor IX Test
Also called: Christmas factor assay, Hemophilic factor B, Coagulation factor IX, factor IX hemophilia, FIX, factor IX deficiency test
When a wound occurs in any part of the body, several factors (proteins) which are involved in the normal blood clotting process become active to stop the bleeding. A factor IX (pronounced factor nine) test is used to measure the activity of the coagulation factor IX, which is one of the proteins that help your blood to clot. If you are lacking this...
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Use the slider below to see how your results affect your
health.
%
70
130
Your result is Normal.
Normal results vary based on the laboratory and the method used.
Related conditions
When bleeding occurs, a sequence of actions involving several proteins called coagulation factors take place in the body to form blood clots; this process is known as the coagulation cascade.
A factor IX test measures the activity of the coagulation factor IX, which is one of the proteins involved in the coagulation cascade.
Your doctor may want to order this test in the following situations:
If you have bleeding disorders
To help diagnose a deficiency of coagulation factor IX
If you have a family member who was diagnosed with a disorder known as hemophilia B
To monitor the factor deficiency and to evaluate the effectiveness of treatment
You should visit your doctor if you experience any of the following signs and symptoms:
Bruises of unknown origin
Nosebleeds
Heavy menstrual bleeding
Bleeding gums or rectum
A skin rash with small red or purple dots
Blood in the stools or urine
Wounds that do not stop bleeding on its own, or that take too much time to heal
Frequent headaches
Chest pain
Temporary vision changes
A healthcare professional takes a blood sample from a vein generally in your arm, using a needle. A small amount of blood is collected into a test tube or vial. You may feel a little sting when the needle goes in or out.
No fasting or special preparations are needed; however, you should inform your healthcare provider about any medicines or supplements that you are taking.
You may feel a little sting when the needle is inserted and extracted but otherwise is a quick procedure. You may also experience bruising as well as mild soreness for a short amount of time after the blood extraction.
Since this test is mostly indicated in people with bleeding problems, the risk of bleeding might be slightly increased than it is for people without bleeding disorders.
In adults, normal results for factor IX activity are 70 to 130%. However, reference ranges can slightly vary depending on the laboratory and the method used for testing.
Normal, full-term newborn infants or healthy premature infants may have decreased levels (> or =20%) which increase within the first postnatal week but may not reach adult levels for > or =180 days postnatal.
Decreased levels may be related to:
Hemophilia B
Disseminated intravascular coagulation (excessive activity of the proteins that control blood clotting)
Fat malabsorption
Liver disease
Low level of vitamin K
Intake of blood thinners, such as warfarin
Factor IX assay: MedlinePlus Medical Encyclopedia [accessed on Oct 02, 2018]
086298: Factor IX Activity | LabCorp [accessed on Oct 02, 2018]
Fontanarosa, P., & Christiansen, S. (2009, April 01). Laboratory Values. AMA Manual of Style. Ed. [accessed on Nov 22, 2018]
Normal reference ranges can vary depending on the laboratory and the method used for testing. You must use the range supplied by the laboratory that performed your test to evaluate whether your results are "within normal limits."
Additional Materials (1)
The image shows one example of how the hemophilia gene is inherited.
The image shows one example of how the hemophilia gene is inherited. In this example, the father has hemophilia (that is, his X chromosome is faulty). The mother isn't a hemophilia carrier (that is, she has two normal X chromosomes). Each daughter will inherit the faulty gene from her father and be a carrier. None of the sons will inherit the faulty gene from their father; thus, none will have hemophilia.
Image by National Heart Lung and Blood Institute (NIH)
The image shows one example of how the hemophilia gene is inherited.
National Heart Lung and Blood Institute (NIH)
Factor X Test
Factor X Test
Also called: Factor X Assay, Factor X Activity, Stuart Prower Factor, Coagulation Factor X
When a wound occurs in any part of the body, several factors (proteins) which are involved in the normal blood clotting process become active to stop the bleeding. A factor X (pronounced factor ten) test is used to measure the activity of the coagulation factor X, which is one of the proteins that help your blood to clot.
Factor X Test
Also called: Factor X Assay, Factor X Activity, Stuart Prower Factor, Coagulation Factor X
When a wound occurs in any part of the body, several factors (proteins) which are involved in the normal blood clotting process become active to stop the bleeding. A factor X (pronounced factor ten) test is used to measure the activity of the coagulation factor X, which is one of the proteins that help your blood to clot.
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Use the slider below to see how your results affect your
health.
%
70
130
Your result is Normal.
Normal results vary based on the laboratory and the method used.
Related conditions
When bleeding occurs, a sequence of actions involving several proteins called coagulation factors take place in the body to form blood clots; this process is known as the coagulation cascade.
A factor X test measures the activity of the coagulation factor X, which is one of the proteins involved in the coagulation cascade.
Your doctor may want to order this test in the following situations:
When previous test results, such as prothrombin time (PT) and/or partial thromboplastin time (PTT), have shown that your blood is not clotting properly.
To help diagnose a deficiency of coagulation factor X.
You should visit your doctor if you experience any of the following signs and symptoms:
Bruises of unknown origin
Nosebleeds
Heavy menstrual bleeding
Bleeding gums or rectum
A skin rash with small red or purple dots
Blood in the stools or urine
Wounds that do not stop bleeding on its own, or that take too much time to heal
Frequent headaches
Chest pain
Temporary vision changes
A needle will be used to extract a small quantity of blood from a vein in your arm.
No fasting or special preparations are needed; however, you should inform your healthcare provider about any medicines or supplements that you are taking.
You may feel a little sting when the needle is inserted and extracted but otherwise is a quick procedure. You may also experience bruising as well as mild soreness for a short amount of time after the blood extraction.
Since this test is mostly indicated in people with bleeding problems, the risk of bleeding might be slightly increased than it is for people without bleeding disorders.
Normal factor X activity results are 70 to 130 %. However, reference ranges can slightly vary depending on the laboratory and the method used for testing.
Low
Decreased levels may be due to:
Amyloidosis (a disorder in which there is an abnormal build-up of proteins in the tissues and organs of the body)
Disseminated intravascular coagulation (excessive activity of the proteins that control blood clotting)
Fat malabsorption
Liver disease
Respiratory infections
Low level of vitamin K
Intake of blood thinners, such as warfarin
Certain types of cancer
A rare condition that is known as congenital (born with it) factor X deficiency
High
Increased levels may be due to:
Pregnancy
Intake of oral contraceptives
Even though this condition is rare, a high factor X activity has been associated with an increased risk of thrombosis (formation of a blood clot inside a blood vessel)
Ask your healthcare provider what your test results mean in your specific case.
Factor X assay: MedlinePlus Medical Encyclopedia [accessed on Aug 24, 2018]
086306: Factor X Activity | LabCorp [accessed on Nov 21, 2018]
Factor X - Health Encyclopedia - University of Rochester Medical Center [accessed on Nov 21, 2018]
Factor X Activity, Clotting [accessed on Nov 21, 2018]
Factor X Assay: Reference Range, Interpretation, Collection and Panels [accessed on Nov 21, 2018]
Fontanarosa, P., & Christiansen, S. (2009, April 01). Laboratory Values. AMA Manual of Style. Ed. [accessed on Nov 21, 2018]
Normal reference ranges can vary depending on the laboratory and the method used for testing. You must use the range supplied by the laboratory that performed your test to evaluate whether your results are "within normal limits."
Additional Materials (18)
Blood draw
An Airman gets blood drawn for a pre-deployment screening Feb. 17, 2010, at Eielson Air Force Base, Alaska. This test can screen different things depending on what public health deems necessary. Blood is also drawn post deployment. (U.S. Air Force photo by Airman 1st Class Willard E. Grande II)
Image by U.S. Air Force photo by Airman 1st Class Willard E. Grande II
Phlebotomy
This 2004 photograph is the twelfth in a series of eighteen images depicting the paraphernalia, and steps to be followed, when a trained phlebotomist obtains a blood sample, by way of a venipuncture, using the contents of a Vacutainer® kit. - The phlebotomist was now in the process of removing the tourniquet from the patient’s arm, just proximal to the venipuncture site. Note that the first Vacutainer® had been loaded with blood, and had been laid on a clean surface adjacent to the patient’s arm. The technician should always observe universal safety precautions, including the use of appropriate personal protective equipment (PPE). Keep the work areas clean, and well organized.
Image by CDC/ Jim Gathany
Tray of test tubes with a collection catheter
This image depicts a test tube tray containing a number of purple tipped vacutainer blood-collection tubes, and a needle-tipped blood collection catheter, the end of which was attached to the vacutainer collection tube adapter.
Image by CDC/ Amanda Mills
Complete blood count and differential
Illustration of complete blood count and differential (hemogram, full blood exam, leukogram etc.) test results with blood specimen in EDTA tube. N.B. these are my own CBC and diff results so no patient confidentiality issues. Symbol key: CBC, complete blood cell count; WBC, white blood cell count (leukocyte count); RBC, red blood cell count (erythrocyte count); HGB, hemoglobin level; HCT, hematocrit; MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin (per erythrocyte); MCHC, mean corpuscular hemoglobin concentration; RDW-CV, red blood cell distribution width–coefficient of variation; PLT, platelet count (thrombocyte count); MPV, mean platelet volume; NEUT, neutrophil count; LYMPH, lymphocyte count; MONO, monocyte count; EO, eosinophil count; BASO, basophil count; IG, immature granulocyte count; NRBC, nucleated red blood cell count; EDTA, ethylenediaminetetraacetic acid, a preservative that makes the blood sample last long enough to be processed (it inhibits coagulation by chelating calcium ions).
Image by SpicyMilkBoy/Wikimedia
Blood Vials Representing Hydrated and Dehydrated Blood Volumes
This image features two test tubes filled with centrifuged blood samples. The sample of the left represents healthy blood volume in a hydrated person; the sample on the right represents low blood volume from a dehydrated person. Because water is a major component of blood, lack of water decreases overall blood volume. It also destabilizes the body's balance between water and salt. The measurement of blood currently within the circulatory system is referred to as intravascular volume. The status of your intravascular volume is constantly in flux. The two basic components of blood, in nearly even proportions, are red blood cells and plasma. Plasma is primarily made up of water, so plasma volume fluctuates depending on your state of hydration and the water forever being exchanged between the bloodstream and tissues. In a healthy adult, blood plasma volume can swing by as much as 10% or 20%. Thirst is triggered when plasma volume drops by 8% - 10%.
Image by TheVisualMD
Sensitive content
This media may include sensitive content
Giving blood serves vital need
Blood components are loaded into the centrifuge for blood and plasma separation Aug. 6, 2013, at the blood donor center, Keesler Air Force Base, Miss. Keesler’s donor center is part of the Armed Services Blood Program which shares the joint mission of collecting, processing and distributing thousands of blood products for military medical centers at home and in-theater overseas. These units play a key role in the direct medical care of wounded Airmen, Soldiers, Sailors and Marines involved in worldwide contingency operations. (U.S. Air Force photo by Kemberly Groue)
Image by U.S. Air Force photo by Kemberly Groue
Blood Vials
A medical laboratory technician organizes vials at the 59th Medical Wing Armed Services Blood Donor Center at Joint Base San Antonio-Lackland, Texas, Jan. 30, 2021. Vials are taken before blood donations to ensure blood products are safe for transfusion. The blood donation center is seeking volunteers to donate COVID-19 convalescent plasma, which is collected from individuals whose plasma contains anti-SARS-CoV-2 antibodies.
Image by Air Force Staff Sgt. Amanda Stanford
Fats Within the Bloodstream
Bloodstream is the blood flowing through the circulatory system. Blood is watery, and cholesterol is fatty. Just like oil and water, the two do not mix. To travel in the bloodstream, cholesterol is carried in small packages called lipoproteins. Too much cholesterol in the blood, or high blood cholesterol, can be serious. People with high blood cholesterol have a greater chance of getting heart disease. High blood cholesterol on its own does not cause symptoms, so many people are unaware that their cholesterol level is too high.
Image by TheVisualMD
Red Blood Cell (RBC)
There are 20-30 trillion red blood cells (RBCs) in an adult's body. The life span of RBCs, which are produced in bone marrow, is about 100 days, which means that 2 million die (and are replaced) each second. In their short lifetimes, however, red blood cells can make 75,000 round trips between lungs, heart and tissues in the body.
Image by TheVisualMD
Red Blood Cell in Capillary
Red blood cells in capillaries carry oxygen to muscle and other tissues.
Image by TheVisualMD
Bone Marrow Smear Displaying Developing Blood Cell
A bone marrow smear displaying the variety of developing blood cells.
Image by TheVisualMD
River of Life: Blood Sustains & Protects
Image by TheVisualMD
Rapid Blood Flow Through a Vessel
The circulatory system is composed of the heart and blood vessels, including arteries, veins, and capillaries. Our bodies actually have two circulatory systems: the pulmonary circulation is a short loop from the heart to the lungs and back again, and the systemic circulation which sends blood from the heart to all the other parts of our bodies and back again. Everyday, approximately 10 pints of blood travel many times through the body's 100,000 miles of blood vessels.
Image by TheVisualMD
Blood Components
This image highlights the vital components of blood: 55% plasma Plasma is the liquid river that transports every blood cell to its destination. Oxygen-carrying RBCs couldn't move through arteries, veins and capillaries without it. Even though it is a watery, almost clear fluid, plasma contains many important substances, including blood-clotting agents called platelets and protective proteins called antibodies which help us fight infection. When the clotting agents are removed from blood plasma, it is called serum, which is essential in many life-saving medical situations such as transplant surgery and trauma. <1% white blood cells (wbcs or leukocytes) Some leukocytes are produced in the bone marrow, while others are generated in lymph nodes scattered throughout the body. They are far less numerous than their sister RBCs, but leukocytes are the bedrock of the immune system and are the body's front line of defense. Different types of leukocytes fight infections in different ways. Some target bacterial or fungal infections, while others respond to parasitic threats or allergic reactions. <1% platelets Platelets perform the vital function of clotting blood at wound sites. They are small, even in comparison to the other cells of your blood, but they pack a wallop when it comes to healing a scrape or staunching a more serious wound. When you cut yourself shaving, platelets arrive on the scene like your personal emergency medical team, creating a natural bandage of clotted blood, which eventually forms a scab. 45% red blood cells rbcs or erythrocytes) RBCs are produced in the bone marrow and perform the fundamental task of delivering oxygen to all of the body's cells. The vial is an example of the hematocrit, one of many tests that make up the complete blood count (CBC). Hematocrit measures the volume of RBCs in your blood. A normal hematocrit reading for women is between 36 to 44 percent; for men it's 41 to 50 percent.
Image by TheVisualMD
Hematocrit, Anemia
Blood is composed of cells (primarily red blood cells, but also white blood cells and cell fragments called platelets) along with a liquid portion known as plasma. The ratio of the volume of red blood cells to the volume of plasma is an important health indicator and is known as the hematocrit. A low hematocrit usually indicates anemia, which occurs when red blood cells are being either destroyed too quickly or produced too slowly; with fewer red blood cells, less oxygen is delivered to body tissues.
Image by TheVisualMD
Skeletal Muscle Cross-Section with Visible Fibers
This image features a cross-section of skeletal muscle with visible epimysium, endomysium, perimysium, fascicle, muscle fibers (cells), and blood vessels. In order for a muscle to contract, adenosine triphosphate (ATP) is needed. When you consume carbohydrates, they are broken down and absorbed into the blood stream as simple sugars. The liver converts digestible carbohydrates into glucose as needed so that they can be easily used by the cells of the body. The pancreas, a banana-sized gland within the abdomen, produces insulin which simulates the cells of the body to absorb glucose. Once glucose (blood sugar) is inside a cell, it enters the many small mitochondria which use it to produce adenosine triphosphate (ATP). ATP is used to power the cell's function, such as muscle contraction.
Image by TheVisualMD
Skin Cross-Section with Normal, Healing Blood Clot
This image features a skin cross-section. A healthy blood clot has formed to promote healing and prevent farther complications. Vitamin K (phylloquinone) plays an essential role in this normal blood clotting process. This is different from the dangerous blood clotting that can occur inside arteries and lead to heart attacks or stroke.
Image by TheVisualMD
Nicotine Particles in Blood
A close-up view of nicotine particles, indicated in white, after they enter the bloodstream. The visualization accompanies an explanation of the transfer of airborne substances, such as nicotine, through the tiny alveoli in the lungs to the bloodstream.
Image by TheVisualMD
Blood draw
U.S. Air Force photo by Airman 1st Class Willard E. Grande II
Phlebotomy
CDC/ Jim Gathany
Tray of test tubes with a collection catheter
CDC/ Amanda Mills
Complete blood count and differential
SpicyMilkBoy/Wikimedia
Blood Vials Representing Hydrated and Dehydrated Blood Volumes
TheVisualMD
Sensitive content
This media may include sensitive content
Giving blood serves vital need
U.S. Air Force photo by Kemberly Groue
Blood Vials
Air Force Staff Sgt. Amanda Stanford
Fats Within the Bloodstream
TheVisualMD
Red Blood Cell (RBC)
TheVisualMD
Red Blood Cell in Capillary
TheVisualMD
Bone Marrow Smear Displaying Developing Blood Cell
TheVisualMD
River of Life: Blood Sustains & Protects
TheVisualMD
Rapid Blood Flow Through a Vessel
TheVisualMD
Blood Components
TheVisualMD
Hematocrit, Anemia
TheVisualMD
Skeletal Muscle Cross-Section with Visible Fibers
TheVisualMD
Skin Cross-Section with Normal, Healing Blood Clot
TheVisualMD
Nicotine Particles in Blood
TheVisualMD
Factor XI Test
Factor XI Test
Also called: Coagulation Factor XI
When a wound occurs in any part of the body, several factors (proteins) which are involved in the normal blood clotting process become active to stop the bleeding. A factor XI (pronounced factor eleven) test is used to measure the activity of the coagulation factor XI, which is one of the proteins that help your blood to clot.
Factor XI Test
Also called: Coagulation Factor XI
When a wound occurs in any part of the body, several factors (proteins) which are involved in the normal blood clotting process become active to stop the bleeding. A factor XI (pronounced factor eleven) test is used to measure the activity of the coagulation factor XI, which is one of the proteins that help your blood to clot.
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Use the slider below to see how your results affect your
health.
%
70
130
Your result is Normal.
Normal results vary based on the laboratory and the method used.
Related conditions
When bleeding occurs, a sequence of actions involving several proteins called coagulation factors take place in the body to form blood clots; this process is known as the coagulation cascade.
A factor XI test measures the activity of the coagulation factor XI, which is one of the proteins involved in the coagulation cascade.
Your doctor may want to order this test in the following situations:
If you have bleeding disorders
To help diagnose a deficiency of coagulation factor XI
If you have a family member who was diagnosed with a disorder known as hemophilia C
To monitor the factor deficiency and to evaluate the effectiveness of treatment
You should visit your doctor if you experience any of the following signs and symptoms:
Bruises of unknown origin
Nosebleeds
Heavy menstrual bleeding
Bleeding gums or rectum
A skin rash with small red or purple dots
Blood in the stools or urine
Wounds that do not stop bleeding on its own, or that take too much time to heal
Frequent headaches
Chest pain
Temporary vision changes
A healthcare professional takes a blood sample from a vein generally in your arm, using a needle. A small amount of blood is collected into a test tube or vial. You may feel a little sting when the needle goes in or out.
No fasting or special preparations are needed; however, you should inform your healthcare provider about any medicines or supplements that you are taking.
You may feel a little sting when the needle is inserted and extracted but otherwise is a quick procedure. You may also experience bruising as well as mild soreness for a short amount of time after the blood extraction.
Since this test is mostly indicated in people with bleeding problems, the risk of bleeding might be slightly increased than it is for people without bleeding disorders.
In adults, normal results for factor XI activity are 70 to 130%. However, reference ranges can slightly vary depending on the laboratory and the method used for testing.
Normal, full-term newborn infants or healthy premature infants may have decreased levels (> or =10%) which increase within the first postnatal week but may not reach adult levels for > or =180 days postnatal.
Decreased levels may be related to:
Hemophilia C
Liver disease
Autoimmune disorders
Treatment with chlorpromazine
086314: Factor XI Activity | LabCorp [accessed on Nov 22, 2018]
Fontanarosa, P., & Christiansen, S. (2009, April 01). Laboratory Values. AMA Manual of Style. Ed. [accessed on Nov 22, 2018]
Normal reference ranges can vary depending on the laboratory and the method used for testing. You must use the range supplied by the laboratory that performed your test to evaluate whether your results are "within normal limits."
Additional Materials (2)
Factors V and VII, Cutting of Skin
When the skin is cut, a cascade of reactions takes place almost immediately in order to stanch the flow of blood and lay the groundwork for healing. Platelets are cell fragments produced in the bone marrow that essential to the process of blood clotting. In addition to platelets, there are more than a dozen different blood-clotting factors that interact in the process of blood clotting; even the absence or malfunction of just one of these factors, can disrupt this process and lead to serious illness, such as hemophilia.
Image by TheVisualMD
Structure of the F11 protein.
Structure of the F11 protein.
Image by Emw
Factors V and VII, Cutting of Skin
TheVisualMD
Structure of the F11 protein.
Emw
Factor XII Test
Factor XII Test
Also called: Coagulation factor XII, Factor XII Assay, Factor XII Activity, Hageman Factor, Surface Factor
When a wound occurs in any part of the body, several factors (proteins) which are involved in the normal blood clotting process become active to stop the bleeding. A factor XII (pronounced factor twelve) test is used to measure the activity of the coagulation factor XII, which is one of the proteins that help your blood to clot.
Factor XII Test
Also called: Coagulation factor XII, Factor XII Assay, Factor XII Activity, Hageman Factor, Surface Factor
When a wound occurs in any part of the body, several factors (proteins) which are involved in the normal blood clotting process become active to stop the bleeding. A factor XII (pronounced factor twelve) test is used to measure the activity of the coagulation factor XII, which is one of the proteins that help your blood to clot.
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Use the slider below to see how your results affect your
health.
%
70
130
Your result is Normal.
Normal results vary based on the laboratory and the method used.
Related conditions
When bleeding occurs, a sequence of actions involving several proteins called coagulation factors take place in the body to form blood clots; this process is known as the coagulation cascade.
A factor XII test measures the activity of the coagulation factor XII, which is one of the proteins involved in the coagulation cascade.
Your doctor may want to order this test in the following situations:
When you’ve had an abnormal activated partial thromboplastin time (aPTT) result, with no history of abnormal bleeding
To help diagnose a deficiency of coagulation factor XII.
A needle will be used to extract a small quantity of blood from a vein in your arm.
No fasting or special preparations are needed; however, you should inform your healthcare provider about any medicines or supplements that you are taking.
You may feel a little sting when the needle is inserted and extracted but otherwise is a quick procedure. You may also experience bruising as well as mild soreness for a short amount of time after the blood extraction.
Normal factor XII activity results are 70 to 130%. However, reference ranges can slightly vary depending on the laboratory and the method used for testing.
Low
Decreased levels may be due to:
Liver disease
Kidney disease
Certain types of cancer
Congenital factor XII deficiency
Having a low coagulation factor XII hasn’t been related to any known bleeding disorder.
High
Increased levels may be related to:
Hereditary Angioedema Type III
Even though it’s not proven, a high factor XII activity could be associated with an increased risk of thrombosis (formation of a blood clot inside a blood vessel).
Ask your healthcare provider what your test results mean in your specific case.
Factor XII assay: MedlinePlus Medical Encyclopedia [accessed on Aug 24, 2018]
F_12 - Clinical: Coagulation Factor XII Activity Assay, Plasma [accessed on Nov 21, 2018]
086322: Factor XII Activity | LabCorp [accessed on Nov 21, 2018]
Factor XII Activity, Clotting [accessed on Nov 21, 2018]
Increased Activity of Coagulation Factor XII (Hageman Factor) Causes Hereditary Angioedema Type III [accessed on Nov 21, 2018]
Fontanarosa, P., & Christiansen, S. (2009, April 01). Laboratory Values. AMA Manual of Style. Ed. [accessed on Nov 21, 2018]
Normal reference ranges can vary depending on the laboratory and the method used for testing. You must use the range supplied by the laboratory that performed your test to evaluate whether your results are "within normal limits."
Factor XIII Test
Factor XIII Test
Also called: Factor XIII Assay, Factor XIII Activity, Fibrin-stabilizing factor, Coagulation Factor XIII
When a wound occurs in any part of the body, several factors (proteins) which are involved in the normal blood clotting process become active to stop the bleeding. A factor XIII (pronounced factor thirteen) test is used to measure the activity of the coagulation factor XIII, which is one of the proteins that help your blood to clot.
Factor XIII Test
Also called: Factor XIII Assay, Factor XIII Activity, Fibrin-stabilizing factor, Coagulation Factor XIII
When a wound occurs in any part of the body, several factors (proteins) which are involved in the normal blood clotting process become active to stop the bleeding. A factor XIII (pronounced factor thirteen) test is used to measure the activity of the coagulation factor XIII, which is one of the proteins that help your blood to clot.
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Use the slider below to see how your results affect your
health.
%
57
192
Your result is Normal.
Normal results vary based on the laboratory and the method used.
Related conditions
When bleeding occurs, a sequence of actions involving several proteins called coagulation factors take place in the body to form blood clots; this process is known as the coagulation cascade.
A factor XIII test measures the activity of the coagulation factor XIII, which is one of the proteins involved in the coagulation cascade. The primary function of this factor is to stabilize the blood clot.
A doctor may want to order this test in the following situations:
When a person has excessive bleeding of unknown cause, along with normal prothrombin time (PT) and/or partial thromboplastin time (PTT) results.
When a woman has recurrent spontaneous abortions.
To help diagnose a deficiency of coagulation factor XIII.
You should visit your doctor if you experience any of the following signs and symptoms:
Bruises of unknown origin
Nosebleeds
Heavy menstrual bleeding
Bleeding gums or rectum
A skin rash with small red or purple dots
Blood in the stools or urine
Wounds that do not stop bleeding on its own, or that take too much time to heal
Frequent headaches
Chest pain
Temporary vision changes
A needle will be used to extract a small quantity of blood from a vein in your arm.
No fasting or special preparations are needed; however, you should inform your healthcare provider about any medicines or supplements that you are taking.
You may feel a little sting when the needle is inserted and extracted but otherwise is a quick procedure. You may also experience bruising as well as mild soreness for a short amount of time after the blood extraction.
Since this test is mostly indicated in people with bleeding problems, the risk of bleeding might be slightly increased than it is for people without bleeding disorders.
Normal factor XIII activity results are 57% to 192%. However, reference ranges can vary depending on the laboratory and the method used for testing.
Decreased levels may be due to:
Disseminated intravascular coagulation (excessive activity of the proteins that control blood clotting)
Liver disease
Certain types of cancer
Henoch-Schönlein purpura
Crohn's disease
Ulcerative colitis
Intake of certain drugs, such as penicillin or phenytoin
A rare condition that is known as congenital (born with it) factor XIII deficiency
Even though having a high factor XIII activity is rare, this condition has been associated with an increased risk of thrombosis (formation of a blood clot inside a blood vessel).
Ask your healthcare provider what your test results mean in your specific case.
Factor XIII deficiency - Genetics Home Reference - NIH [accessed on Nov 21, 2018]
500185: Factor XIII Activity | LabCorp [accessed on Nov 21, 2018]
086330: Factor XIII | LabCorp [accessed on Nov 21, 2018]
Factor XIII, Functional [accessed on Nov 21, 2018]
Newly-Recognized Roles of Factor XIII in Thrombosis. - PubMed - NCBI [accessed on Nov 21, 2018]
Normal reference ranges can vary depending on the laboratory and the method used for testing. You must use the range supplied by the laboratory that performed your test to evaluate whether your results are "within normal limits."
Additional Materials (13)
Human blood clot formed
This is an image of a blood clot taken using an inverted fluorescent confocal microscope (Zeiss LSM710).
3D render of a human blood clot formed in vitro under flow. Blood clots are made up of blood cells called platelets and a protein called fibrin which adheres to platelets and forms long strands which eventually join together in the form of a mesh in order to limit blood loss from wound sites. The green fluorescent staining represents the blood platelets which form the initial ‘plug’ at the site of injury. The red fluorescent staining represents Dylight647 labelled fibrin which has polymerised and formed a mesh around the platelets to form a blood clot. This 3D image shows that the fibrin has surrounded and encased the platelet aggregates in certain areas to form dense clots which mimic the 'platelet plug'.
Image by Joanne Mitchell
Blood clots
Red blood cells trapped in a fibrin network in a blood clot.
Image by Fuzis
Blood clots
This medical illustration reveals how the SHELTERTM device traps and removes blood clots in the brain.
Image by Zina Deretsky, NSF
Blood clots
Blood clot diagram (Thrombus)
Image by en:User:Persian Poet Gal
Thromboembolism in Blood Vessel
Blood clots can develop anywhere in the cardiovascular system: in the arteries, veins, even inside the heart. A thrombus is a blood clot that adheres to place where it first formed. Thromboembolisms are blood clots that break off and travel through the circulatory system until they become lodged in a blood vessel. Both thrombi and thromboembolisms may be large enough to block blood flow through a vessel, and the result can be tissue death.
Image by TheVisualMD
Plaque, Thrombus & Embolus
Blood clots normally form in response to an injury to a blood vessel, and they can develop in any part of the cardiovascular system. Blood clots are composed primarily of platelets (cell fragments in the blood that assist in clotting) and fibrin (an insoluble protein fiber formed as part of the clotting process). They may contain red blood cells as well.
Image by TheVisualMD
Prothrombin Time (PT): Pulmonary Embolism
The most dangerous complication of deep vein thrombosis (DVT) is pulmonary embolism, which occurs when an embolism travels through the heart and into the lungs. There it lodges in an artery, typically where the artery forks, and blocks blood flow. During an episode of pulmonary embolism, the lungs may be showered with blood clots. The lungs are particularly vulnerable to embolisms because all the blood in the body passes through the lungs every time it circulates.
Image by TheVisualMD
Blood clots
Normal vs. Diseased Vessel Blood clot diagram (Thrombus)
Image by Blausen.com staff. "Blausen gallery 2014"
Thrombus & Embolus
Blood clots normally form in response to an injury to a blood vessel, and they can develop in any part of the cardiovascular system. Blood clots are composed primarily of platelets (cell fragments in the blood that assist in clotting) and fibrin (an insoluble protein fiber formed as part of the clotting process). They may contain red blood cells as well.
Image by TheVisualMD
Injection of Medication
Blood clots may be treated with a variety of medications. These include aspirin, an antiplatelet medication that decreases blood clot formation by preventing platelets from sticking together; heparin and warfarin, anticoagulants that help prevent clots from forming; and tissue plasminogen activator (TPA), a potent clot-busting drug.
Image by TheVisualMD
Blood clots
Image by Blausen.com staff. "Blausen gallery 2014
Symptoms & Risk Factors
Symptoms & Risk Factors for thrombosis and embolism
Image by TheVisualMD
Scanning electron micrograph of a fragment of a fibrin clot in whole blood
Scanning electron micrograph of a fragment of a fibrin clot in whole blood
Image by Сергей Обыденный
Human blood clot formed
Joanne Mitchell
Blood clots
Fuzis
Blood clots
Zina Deretsky, NSF
Blood clots
en:User:Persian Poet Gal
Thromboembolism in Blood Vessel
TheVisualMD
Plaque, Thrombus & Embolus
TheVisualMD
Prothrombin Time (PT): Pulmonary Embolism
TheVisualMD
Blood clots
Blausen.com staff. "Blausen gallery 2014"
Thrombus & Embolus
TheVisualMD
Injection of Medication
TheVisualMD
Blood clots
Blausen.com staff. "Blausen gallery 2014
Symptoms & Risk Factors
TheVisualMD
Scanning electron micrograph of a fragment of a fibrin clot in whole blood
Сергей Обыденный
Electrolyte Panel
Electrolyte Panel
Also called: Electrolytes, Lytes
An electrolyte panel measures the level of the body's main electrolytes. Electrolytes are electrically charged minerals that help control many important functions in the body. Levels that are too high or too low can indicate a serious health problem.
Electrolyte Panel
Also called: Electrolytes, Lytes
An electrolyte panel measures the level of the body's main electrolytes. Electrolytes are electrically charged minerals that help control many important functions in the body. Levels that are too high or too low can indicate a serious health problem.
Electrolytes are electrically charged minerals that help control the amount of fluids and the balance of acids and bases in your body. They also help control muscle and nerve activity, heart rhythm, and other important functions. An electrolyte panel, also known as a serum electrolyte test, is a blood test that measures levels of the body's main electrolytes:
Sodium, which helps control the amount of fluid in the body. It also helps your nerves and muscles work properly.
Chloride, which also helps control the amount of fluid in the body. In addition, it helps maintain healthy blood volume and blood pressure.
Potassium, which helps your heart and muscles work properly.
Bicarbonate, which helps maintain the body's acid and base balance. It also plays an important role in moving carbon dioxide through the bloodstream.
Abnormal levels of any of these electrolytes can be a sign of a serious health problem, including kidney disease, high blood pressure, and a life-threatening irregularity in heart rhythm.
An electrolyte panel is often part of a routine blood screening or a comprehensive metabolic panel. The test may also be used to find out if your body has a fluid imbalance or an imbalance in acid and base levels.
Electrolytes are usually measured together. But sometimes they are tested individually. Separate testing may be done if a provider suspects a problem with a specific electrolyte.
You may need this test if you have symptoms indicating that your body's electrolytes may be out of balance. These include:
Nausea and/or vomiting
Confusion
Weakness
Irregular heartbeat (arrhythmia)
A health care professional will take a blood sample from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial. You may feel a little sting when the needle goes in or out. This usually takes less than five minutes.
You don't any special preparations for an electrolyte panel.
There is very little risk to having a blood test. You may have slight pain or bruising at the spot where the needle was put in, but most symptoms go away quickly.
Your results will include measurements for each electrolyte. Abnormal electrolyte levels can be caused by several different conditions, including:
Dehydration
Kidney disease
Heart disease
Diabetes
Acidosis, a condition in which you have too much acid in your blood. It can cause nausea, vomiting, and fatigue.
Alkalosis, a condition in which you have too much base in your blood. It can cause irritability, muscle twitching, and tingling in the fingers and toes.
Your specific results will depend on which electrolyte is affected and whether levels are too low or too high. If your electrolyte levels were not in the normal range, it doesn't necessarily mean you have a medical problem needing treatment. Many factors can affect electrolyte levels. These include taking in too much fluid or losing fluid because of vomiting or diarrhea. Also, certain medicines such as antacids and blood pressure medicines may cause abnormal results.
If you have questions about your results, talk to your health care provider.
Your health care provider may order another test, called an anion gap, along with your electrolyte panel. Some electrolytes have a positive electric charge. Others have a negative electric charge. The anion gap is a measurement of the difference between the negatively charged and positively charged electrolytes. If the anion gap is either too high or too low, it may be a sign of a serious health problem.
Electrolyte Panel: MedlinePlus Medical Test [accessed on Dec 20, 2023]
Additional Materials (10)
Overview of Fluid and Electrolyte Physiology (Fluid Compartment)
Video by Armando Hasudungan/YouTube
Electrolytes - What Are Electrolytes - Functions Of Electrolytes
Video by Whats Up Dude/YouTube
What Do Electrolytes Actually Do?
Video by Reactions/YouTube
Why You Need Electrolytes - Can It Help With Getting Stronger?
Video by PictureFit/YouTube
Fluid and Electrolytes: Chloride
Video by EmpoweRN/YouTube
Fluid and Electrolytes: Sodium
Video by EmpoweRN/YouTube
Fluid and Electrolytes: Magnesium
Video by EmpoweRN/YouTube
Fluid & Electrolytes: Potassium
Video by EmpoweRN/YouTube
Fluid & Electrolytes: Phosphate
Video by EmpoweRN/YouTube
Fluids and Electrolytes Sodium
Video by DrBruce Forciea/YouTube
8:05
Overview of Fluid and Electrolyte Physiology (Fluid Compartment)
Armando Hasudungan/YouTube
1:12
Electrolytes - What Are Electrolytes - Functions Of Electrolytes
Whats Up Dude/YouTube
2:42
What Do Electrolytes Actually Do?
Reactions/YouTube
1:47
Why You Need Electrolytes - Can It Help With Getting Stronger?
PictureFit/YouTube
3:26
Fluid and Electrolytes: Chloride
EmpoweRN/YouTube
9:43
Fluid and Electrolytes: Sodium
EmpoweRN/YouTube
4:19
Fluid and Electrolytes: Magnesium
EmpoweRN/YouTube
8:19
Fluid & Electrolytes: Potassium
EmpoweRN/YouTube
6:36
Fluid & Electrolytes: Phosphate
EmpoweRN/YouTube
3:04
Fluids and Electrolytes Sodium
DrBruce Forciea/YouTube
Sodium
Sodium Blood Test
Also called: Sodium, Hyponatremia Test, Hypernatremia Test
A sodium blood test measures the amount of sodium in your blood. If your sodium blood levels are too high or too low, it may mean that you have a problem with your kidneys, dehydration, or another medical condition.
Sodium Blood Test
Also called: Sodium, Hyponatremia Test, Hypernatremia Test
A sodium blood test measures the amount of sodium in your blood. If your sodium blood levels are too high or too low, it may mean that you have a problem with your kidneys, dehydration, or another medical condition.
{"label":"Sodium reference range","scale":"lin","step":0.1,"hideunits":false,"items":[{"flag":"abnormal","label":{"short":"Low","long":"Low","orientation":"horizontal"},"values":{"min":60,"max":134},"text":"Low sodium levels most often occur as a result of disease or a side effect of medicines; they are rarely due to too little sodium in the diet.","conditions":["Hyponatremia","Addison's disease","Diarrhea","Diuretics","Kidney disease","Heart failure","Cirrhosis"]},{"flag":"normal","label":{"short":"Normal","long":"Normal","orientation":"horizontal"},"values":{"min":134,"max":144},"text":"Sodium is a mineral that is used in regulating the amount of water in the body. Sodium also plays important roles, along with potassium, in muscle contraction, the beating of the heart, and the sending of nerve impulses.","conditions":[]},{"flag":"abnormal","label":{"short":"High","long":"High","orientation":"horizontal"},"values":{"min":144,"max":200},"text":"High sodium levels can be caused by high dietary intake of salt, diabetes, hormone deficiency or fluid imbalance caused by excessive sweating, diarrhea or burns.","conditions":["Hypernatremia","Kidney dysfunction","Dehydration","Cushing's syndrome"]}],"units":[{"printSymbol":"meq\/L","code":"meq\/L","name":"milliequivalent per liter"}],"value":139,"disclaimer":"Normal reference ranges can vary depending on the laboratory and the method used for testing. You must use the range supplied by the laboratory that performed your test to evaluate whether your results are \"within normal limits.\""}[{"abnormal":0},{"normal":0},{"abnormal":0}]
Use the slider below to see how your results affect your
health.
meq/L
134
144
Your result is Normal.
Sodium is a mineral that is used in regulating the amount of water in the body. Sodium also plays important roles, along with potassium, in muscle contraction, the beating of the heart, and the sending of nerve impulses.
Related conditions
A sodium blood test measures the amount of sodium in your blood. Sodium is a type of electrolyte. Electrolytes are electrically charged minerals. They help control the amount of fluid and the balance of acids and bases (pH balance) in your body. Sodium also helps your nerves and muscles work properly.
You get most of the sodium you need in your diet. If you take in too much, your kidneys get rid of the extra sodium in your urine. Normally, your body keeps your sodium levels in a very narrow range. If your sodium blood levels are too high or too low, it may mean that you have a kidney problem, dehydration, or another type of medical condition.
A sodium blood test is a routine test that may be used to check your general health. It may be used to help find and monitor conditions that affect the balance of fluids, electrolytes, and acidity in your body.
The test is often done as part of a group of tests called an electrolyte panel. It may also be part of two other groups of tests called a basic metabolic panel (BMP) and a comprehensive metabolic panel (CMP)
Your health care provider may order a sodium blood test as part of your regular checkup or if you take medicine that can affect your fluid balance. You may also have this test if you have symptoms of too much sodium or too little sodium in your blood.
Symptoms of high sodium levels (hypernatremia) include:
Thirst
Urinating (peeing) very little
Vomiting
Diarrhea
Confusion
Muscle twitching
Seizures
Without treatment, extremely high levels of sodium may lead to a coma and become life threatening.
Symptoms of low sodium levels (hyponatremia) include:
Weakness
Fatigue
Confusion
Muscle twitching
Seizures
Without treatment, extremely low levels of sodium may lead to a coma and become life threatening.
A health care professional will take a blood sample from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial. You may feel a little sting when the needle goes in or out. This usually takes less than five minutes.
Your provider will let you know exactly how to prepare for a sodium blood test. On the day of the test, you may need to skip or delay certain medicines. Be sure to tell your provider about any medicines, herbs, or supplements that you take. But don't stop any medicines without talking with your provider first.
You may also need to fast (not eat or drink) for several hours before the test. Ask your provider if you have any questions.
There is very little risk to having a blood test. You may have slight pain or bruising at the spot where the needle was put in, but most symptoms go away quickly.
Blood sodium levels that are too high or too low can be a sign of many different types of conditions. To make a diagnosis, your provider will usually look at the results of your sodium blood test with the results of other tests, such as measurements of other electrolytes.
Sodium blood test results that are higher than normal may be a sign of a condition, such as:
Dehydration, which may be caused by not drinking enough, diarrhea, or certain medicines called diuretics (water pills)
A disorder of the adrenal glands
A kidney disease
Diabetes insipidus (uncommon).
Sodium blood test results that are lower than normal may be a sign of a condition, such as:
A loss of sodium from diarrhea or vomiting
A condition that may cause the body to hold onto extra fluid (which dilutes sodium), including:
Kidney diseases
Cirrhosis of the liver
Heart failure
Certain brain and lung diseases
Certain types of cancer
Certain medicines, including many over-the-counter pain relievers and some antidepressants
Addison disease
Malnutrition
If your results are not in the normal range, it doesn't always mean that you have a medical condition that need treatment. Certain medicines can increase or decrease your sodium levels. If you have questions about your results, talk with your provider.
Sodium levels are often measured with other electrolytes in another test called the anion gap. An anion gap test looks at the difference between negatively charged and positively charged electrolytes. The test checks for acid imbalances and other conditions.
Sodium Blood Test: MedlinePlus Medical Test [accessed on Dec 19, 2023]
Additional Materials (16)
Hyponatremia SALT LOSS Nursing Mnemonics, Nursing School Study Tips
Video by NURSINGcom/YouTube
Hypernatremia FRIED, SWINE, SALT, MODEL Nursing Mnemonics, Nursing School Study Tips
Video by NURSINGcom/YouTube
You're Probably not Dehydrated: The Eight Glasses of Water a Day Myth
Video by Healthcare Triage/YouTube
Electrolytes - What Are Electrolytes - Functions Of Electrolytes
Video by Whats Up Dude/YouTube
Why You Need Electrolytes - Can It Help With Getting Stronger?
Video by PictureFit/YouTube
What Do Electrolytes Actually Do?
Video by Reactions/YouTube
Dietary Salt Recommendations Don't Line Up with Recent Evidence
Video by Healthcare Triage/YouTube
Fluids and Electrolytes Sodium
Video by DrBruce Forciea/YouTube
Aldosterone raises blood pressure and lowers potassium | NCLEX-RN | Khan Academy
Video by khanacademymedicine/YouTube
Plate of High Sodium Food
Salt is essential to life, but because our bodies are built to crave salt, modern diets often include too much. The kidneys balance the amount of salt and fluid in the body in order to maintain proper blood pressure. When healthy people eat too much salt, their bodies adjust and the kidneys excrete more sodium. But when the kidneys are damaged, they are less able to excrete sodium so that even normal salt intake can result in an increase in the fluid retained by the body, which causes blood pressure to rise. Controlling salt is key to controlling hypertension. High sodium foods to avoid: table salt, potato chips, bacon, pickles, olives hot dogs, pastrami, cheese.
Image by TheVisualMD
Living With the DASH Eating Plan
A glass salt shaker with a metal top photographed on a white background. Reduction of salt intake is important in reducing blood pressure.
Image by Dubravko Soric SoraZG on Flickr
Salt
Image by Sam Bald
Man with Visible Musculature Lifting Weights (sodium)
Sodium is an electrolyte that plays key roles in nerve transmission and muscle contraction, as well as helps balance bodily fluids and facilitate the movement of materials across cell membranes. Abnormal sodium levels can be caused by many conditions; either too much or too little sodium can be dangerous. The body maintains sodium blood levels in a narrow range; urine is the primary way in which the body balances sodium levels. Normal sweating is one of the ways the nervous system regulates body temperature; excessive sweating can lead to low sodium, particularly when only water is used to replace lost fluids.
Image by TheVisualMD
Fluid Regulation
The body's fluid balance is kept within a narrow range by the kidneys, which constantly monitor and adjust blood levels of electrolytes (sodium, calcium, potassium, bicarbonate, and chloride) as well as blood proteins such as albumin. If the body is unable to self-regulate, however, treatment may involve dietary changes (lower salt intake or increased fluid intake, for example), diuretics or treatment of the underlying disease causing the fluid imbalance.
Image by TheVisualMD
Sodium: Blood Vessels
A test for sodium, along with other electrolytes, is routinely included in the basic metabolic panel (BMP). If blood levels are abnormal, urine levels are also tested in order to help determine whether the problem is excessive intake of sodium or excessive loss.
Image by TheVisualMD
U.S. Army Sergeant Kornelia Rachwal gives a young Pakistani girl a drink of water as they are airlifted
U.S. Army Sergeant Kornelia Rachwal gives a young Pakistani girl a drink of water as they are airlifted from Muzaffarabad to Islamabad, Pakistan, aboard a U.S. Army CH-47 Chinook helicopter
Image by Technical Sergeant Mike Buytas of the United States Air Force
3:07
Hyponatremia SALT LOSS Nursing Mnemonics, Nursing School Study Tips
NURSINGcom/YouTube
3:33
Hypernatremia FRIED, SWINE, SALT, MODEL Nursing Mnemonics, Nursing School Study Tips
NURSINGcom/YouTube
6:46
You're Probably not Dehydrated: The Eight Glasses of Water a Day Myth
Healthcare Triage/YouTube
1:12
Electrolytes - What Are Electrolytes - Functions Of Electrolytes
Whats Up Dude/YouTube
1:47
Why You Need Electrolytes - Can It Help With Getting Stronger?
PictureFit/YouTube
2:42
What Do Electrolytes Actually Do?
Reactions/YouTube
4:42
Dietary Salt Recommendations Don't Line Up with Recent Evidence
Healthcare Triage/YouTube
3:04
Fluids and Electrolytes Sodium
DrBruce Forciea/YouTube
13:18
Aldosterone raises blood pressure and lowers potassium | NCLEX-RN | Khan Academy
khanacademymedicine/YouTube
Plate of High Sodium Food
TheVisualMD
Living With the DASH Eating Plan
Dubravko Soric SoraZG on Flickr
Salt
Sam Bald
Man with Visible Musculature Lifting Weights (sodium)
TheVisualMD
Fluid Regulation
TheVisualMD
Sodium: Blood Vessels
TheVisualMD
U.S. Army Sergeant Kornelia Rachwal gives a young Pakistani girl a drink of water as they are airlifted
Technical Sergeant Mike Buytas of the United States Air Force
Chloride
Chloride Blood Test
Also called: Chloride, Hypochloremia Test, Hyperchloremia Test
A chloride test measures the chloride in your blood. Chloride is a mineral that helps maintain the acid-base balance in your body. The test is usually part of a routine blood screening or to help determine if there is a problem with your body's electrolyte or acid-base (pH) balance.
Chloride Blood Test
Also called: Chloride, Hypochloremia Test, Hyperchloremia Test
A chloride test measures the chloride in your blood. Chloride is a mineral that helps maintain the acid-base balance in your body. The test is usually part of a routine blood screening or to help determine if there is a problem with your body's electrolyte or acid-base (pH) balance.
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Use the slider below to see how your results affect your
health.
meq/L
96
106
Your result is Normal.
You get most of your chloride in the form of sodium chloride, or salt, in the food you eat. In healthy people, chloride is usually absorbed in the gut, then it’s transported through your blood and distributed to your tissues.
Related conditions
A chloride blood test measures the amount of chloride in your blood. Chloride is a type of electrolyte. Electrolytes are electrically charged minerals that help control the amount of fluids and the balance of acids and bases (pH balance) in your body. Chloride is often measured with other electrolytes to diagnose or monitor conditions, such as kidney disease, heart failure, liver disease, and high blood pressure.
You usually get a chloride test as part of a routine blood screening to check your general health. It's also used to help diagnose conditions related to an imbalance of acids or fluids in your body.
Your health care provider may have ordered a chloride blood test as part of an electrolyte panel, which is a routine blood test. An electrolyte panel is a test that measures chloride and other electrolytes, such as potassium, sodium, and bicarbonate. You may also need a chloride blood test if you have symptoms of an acid or fluid imbalance, including:
Vomiting over a long period of time
Diarrhea
Fatigue
Weakness
Dehydration
Trouble breathing
A health care professional will take a blood sample from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial. You may feel a little sting when the needle goes in or out. This usually takes less than five minutes.
You don't need any special preparations for a chloride blood test or an electrolyte panel. If your provider has ordered other blood tests, you may need to fast (not eat or drink) for several hours before the test. Your provider will let you know if there are any special instructions to follow.
There is very little risk to having a blood test. You may have slight pain or bruising at the spot where the needle was put in, but most symptoms go away quickly.
There are many reasons why your chloride levels may not be in the normal range.
High levels of chloride may be a sign of:
Dehydration
Kidney disease
Metabolic acidosis, a condition in which you have too much acid in your blood. It can cause nausea, vomiting, and fatigue.
Low levels of chloride may be a sign of:
Heart failure
Lung disease
Addison disease, a condition in which your body's adrenal glands don't produce enough of certain types of hormones. It can cause a variety of symptoms, including weakness, dizziness, weight loss, and dehydration.
Metabolic alkalosis, a condition in which you have too much base in your blood. It can cause irritability, muscle twitching, and tingling in the fingers and toes.
If your chloride levels are not in the normal range, it doesn't always mean you have a medical problem that needs treatment. Many things can affect your chloride levels, such as drinking too much fluid or losing fluid because of vomiting or diarrhea. Also, certain medicines such as antacids can cause abnormal results. To learn what your results mean, talk with your provider.
Urine also contains some chloride. Your provider may also recommend a urine chloride test to get more information about your chloride levels.
Chloride Blood Test: MedlinePlus Medical Test [accessed on Dec 20, 2023]
Chloride test - blood: MedlinePlus Medical Encyclopedia [accessed on Dec 20, 2023]
Chloride - Health Encyclopedia - University of Rochester Medical Center [accessed on Dec 20, 2023]
Berend K, van Hulsteijn LH et al. Chloride: the queen of electrolytes?. European journal of internal medicine. Apr 1, 2012. doi:10.1016/j.ejim.2011.11.013 [accessed on Dec 20, 2023]
Additional Materials (12)
Fluid Regulation
The body's fluid balance is kept within a narrow range by the kidneys, which constantly monitor and adjust blood levels of electrolytes (sodium, calcium, potassium, bicarbonate, and chloride) as well as blood proteins such as albumin. If the body is unable to self-regulate, however, treatment may involve dietary changes (lower salt intake or increased fluid intake, for example), diuretics or treatment of the underlying disease causing the fluid imbalance.
Image by TheVisualMD
Chloride: Stomach Wall Lining Close Up
Cells in the lining of the stomach use chloride to produce hydrochloric acid, a powerful acid that aids digestion. Other cells in the stomach lining produce biocarbonate to buffer the acid and mucus to prevent the acid from damaging the stomach lining.
Image by TheVisualMD
Chloride: Stomach
Cells in the lining of the stomach use chloride to produce hydrochloric acid, a powerful acid that aids digestion. Other cells in the stomach lining produce biocarbonate to buffer the acid and mucus to prevent the acid from damaging the stomach lining.
Image by TheVisualMD
Fluid and Electrolytes: Chloride
Video by EmpoweRN/YouTube
What Do Electrolytes Actually Do?
Video by Reactions/YouTube
Why You Need Electrolytes - Can It Help With Getting Stronger?
Video by PictureFit/YouTube
Electrolytes - What Are Electrolytes - Functions Of Electrolytes
Video by Whats Up Dude/YouTube
What would happen if you didn’t drink water? - Mia Nacamulli
Video by TED-Ed/YouTube
Chloride Nursing Considerations, Normal Range, Nursing Care, Lab Values Nursing
Video by NURSINGcom/YouTube
Calcium chloride
Calcium chloride
Image by Firetwister _ Markus Brunner
Cross section Human Stomach
Cross section Human Stomach
Image by TheVisualMD
gastric acid in stomach hydrochloric acid, potassium chloride and sodium chloride
gastric acid in stomach hydrochloric acid, potassium chloride and sodium chloride
Image by TheVisualMD
Fluid Regulation
TheVisualMD
Chloride: Stomach Wall Lining Close Up
TheVisualMD
Chloride: Stomach
TheVisualMD
3:26
Fluid and Electrolytes: Chloride
EmpoweRN/YouTube
2:42
What Do Electrolytes Actually Do?
Reactions/YouTube
1:47
Why You Need Electrolytes - Can It Help With Getting Stronger?
PictureFit/YouTube
1:12
Electrolytes - What Are Electrolytes - Functions Of Electrolytes
Whats Up Dude/YouTube
4:52
What would happen if you didn’t drink water? - Mia Nacamulli
TED-Ed/YouTube
4:07
Chloride Nursing Considerations, Normal Range, Nursing Care, Lab Values Nursing
NURSINGcom/YouTube
Calcium chloride
Firetwister _ Markus Brunner
Cross section Human Stomach
TheVisualMD
gastric acid in stomach hydrochloric acid, potassium chloride and sodium chloride
TheVisualMD
Potassium
Potassium Blood Test
Also called: Potassium, Hypokalemia Test, Hyperkalemia Test
A potassium blood test measures the potassium levels in your blood. It is often included in a series of routine blood tests called an electrolyte panel. Too much or too little potassium may indicate a serious medical problem.
Potassium Blood Test
Also called: Potassium, Hypokalemia Test, Hyperkalemia Test
A potassium blood test measures the potassium levels in your blood. It is often included in a series of routine blood tests called an electrolyte panel. Too much or too little potassium may indicate a serious medical problem.
{"label":"Potassium reference range","scale":"lin","step":0.1,"hideunits":false,"items":[{"flag":"abnormal","label":{"short":"Hypokalemia","long":"Hypokalemia","orientation":"horizontal"},"values":{"min":1,"max":3.5},"text":"Low levels of potassium (hypokalemia) can be caused by vomiting and diarrhea, or the side effects of drugs including, mostly commonly, diuretics.","conditions":["Acute or chronic diarrhea","Cushing syndrome (rare)","Diuretics","Hyperaldosteronism","Hypokalemic periodic paralysis","Not enough potassium in the diet","Renal artery stenosis","Renal tubular acidosis (rare)","Vomiting"]},{"flag":"normal","label":{"short":"Normal","long":"Normal","orientation":"horizontal"},"values":{"min":3.5,"max":5},"text":"Potassium is a mineral that your cells, nerves, and muscles need to function properly. It helps your body regulate your blood pressure, heart rhythm and the water content in cells. It also helps with digestion.","conditions":[]},{"flag":"abnormal","label":{"short":"Hyperkalemia","long":"Hyperkalemia","orientation":"horizontal"},"values":{"min":5,"max":7},"text":"Too much potassium in the blood is known as hyperkalemia, which is most commonly caused by reduced kidney function, particularly in dialysis patients.","conditions":["Addison disease (rare)","Blood transfusion","Certain medicines","Crushed tissue injury","Hyperkalemic periodic paralysis","Hypoaldosteronism (very rare)","Kidney insufficiency or failure","Metabolic or respiratory acidosis","Red blood cell destruction","Too much potassium in your diet"]}],"units":[{"printSymbol":"meq\/L","code":"meq\/L","name":"milliequivalent per liter"}],"value":4.3,"disclaimer":"Normal reference ranges can vary depending on the laboratory and the method used for testing. You must use the range supplied by the laboratory that performed your test to evaluate whether your results are \"within normal limits.\""}[{"abnormal":0},{"normal":0},{"abnormal":0}]
Use the slider below to see how your results affect your
health.
meq/L
3.5
5
Your result is Normal.
Potassium is a mineral that your cells, nerves, and muscles need to function properly. It helps your body regulate your blood pressure, heart rhythm and the water content in cells. It also helps with digestion.
Related conditions
A potassium blood test measures the amount of potassium in your blood. Potassium is a type of electrolyte. Electrolytes are electrically charged minerals that help control fluid levels and the balance of acids and bases (pH balance) in your body. They also help control muscle and nerve activity and perform other important functions.
Your cells, nerves, heart, and muscles need potassium to work properly. Potassium levels that are too high or too low may be a sign of a medical problem.
Other names: potassium serum, serum potassium, serum electrolytes, K
A potassium blood test measures how much potassium is in your blood. The test is often part of a group of routine blood tests called an electrolyte panel. It may be used to monitor or diagnose conditions related to abnormal potassium levels. These conditions include kidney disease, high blood pressure, and heart disease.
Your health care provider may order a potassium blood test as part of your regular checkup or to monitor an existing condition, such as diabetes, kidney disease, or adrenal gland disorders. You may also need this test if you take medicines that could affect your potassium levels or if you have symptoms of having too much or too little potassium.
If your potassium levels are too high (hyperkalemia), your symptoms may include:
Arrhythmia (a problem with the rate or rhythm of your heartbeat)
Fatigue
Muscle weakness
Nausea
Numbness or tingling
If your potassium levels are too low (hypokalemia), your symptoms may include:
Irregular heartbeat
Muscle cramps
Weak or twitching muscles
Fatigue
Nausea
Constipation
A health care professional will take a blood sample from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial. You may feel a little sting when the needle goes in or out. This usually takes less than five minutes.
You don't need any special preparations for a potassium blood test or an electrolyte panel. If your provider has ordered more tests on your blood sample, you may need to fast (not eat or drink) for several hours before the test. Your provider will let you know if there are any special instructions to follow.
There is very little risk to having a blood test. You may have slight pain or bruising at the spot where the needle was put in, but most symptoms go away quickly.
Too much potassium in the blood (hyperkalemia). It's often the result of two or more causes. High potassium levels may be a sign of:
Kidney disease. Your kidneys remove extra potassium from your body. Too much potassium may mean your kidneys aren't working well.
Addison disease, a disorder of the adrenal glands
Injuries, burns, or surgery that can cause your cells to release extra potassium into your blood
Type 1 diabetes that is not well controlled
The side effects of certain medicines, such as diuretics ("water pills") or antibiotics
A diet too high in potassium (not common). Bananas, apricots, green leafy vegetables, avocados and many other foods are good sources of potassium that are part of a healthy diet. But eating very large amounts of potassium-rich foods or taking potassium supplements can lead to health problems.
Too little potassium in the blood (hypokalemia) may be a sign of:
Use of prescription diuretics
Fluid loss from diarrhea, vomiting, or heavy sweating
Using too many laxatives
Adrenal gland disorders, including Cushing's syndrome and aldosteronism
Kidney disease
Alcohol use disorder (AUD)
A diet too low in potassium (not common)
If your test results are not in the normal range, it doesn't always mean that you have a medical condition that needs treatment. Certain prescription and over-the-counter medicines and supplements may raise your potassium levels. And eating a lot of licorice may lower your levels. But only real licorice, which comes from licorice plants, has this effect. Most licorice products sold in the U.S. don't contain any real licorice. Check the package ingredient label to be sure.
To learn what your results mean, talk with your provider.
Repeated clenching and relaxing of your fist just before or during your blood test may temporarily increase the potassium levels in your blood. This may lead to an incorrect result.
Potassium Blood Test: MedlinePlus Medical Test [accessed on Dec 19, 2023]
Additional Materials (16)
Fluid & Electrolytes: Potassium
Video by EmpoweRN/YouTube
Electrolytes - What Are Electrolytes - Functions Of Electrolytes
Video by Whats Up Dude/YouTube
Why You Need Electrolytes - Can It Help With Getting Stronger?
Video by PictureFit/YouTube
What Do Electrolytes Actually Do?
Video by Reactions/YouTube
What would happen if you didn’t drink water? - Mia Nacamulli
Video by TED-Ed/YouTube
3 Signs You're Not Getting Enough Potassium
Video by DoctorOz/YouTube
Muscle Cramps & Spasms – Dr.Berg On Charley Horses
Video by Dr. Eric Berg DC/YouTube
What Causes Cramps?
Video by Life Noggin/YouTube
Charley Horse Causes, Relief
Video by Wendy Westwood/YouTube
High potassium levels: Should I Worry?
Video by Fox News/YouTube
Aldosterone raises blood pressure and lowers potassium | NCLEX-RN | Khan Academy
Video by khanacademymedicine/YouTube
Plate of High Potassium Food
Clockwise from top left: tomato, orange, broccoli, carrot, butternut squash, beets, banana, spinach, almonds, avocado
Image by TheVisualMD
Potassium Ion
Potassium is an electrolyte; that is, a substance that conducts electricity in the body. Potassium is critical for the proper function of all cells, tissues, and organs in the body. It is essential to heart function, and plays a major role in smooth muscle contraction, making it important for normal digestive and muscle function. The mineral also plays a role in decreasing high blood pressure, as it attenuates the water-gathering effects of sodium. Many foods contain potassium, including all meats, some types of fish (salmon, cod, flounder), and many fruits, vegetables, and legumes. Dairy products are also good sources. If you eat a variety of foods, you'll likely meet the daily requirement. Maintaining the proper balance of sodium and potassium can be difficult; E209most Americans take in far more sodium than potassium. As a rule, five times more potassium than sodium should be consumed.
Image by TheVisualMD
Potassium: Muscle Spasm
Muscles contract in response to nerve impulses. Electrolytes such as potassium establish an electric potential between the inside and outside of cell membranes, which enables the transmission of these nerve impulses. Too little potassium can result in muscle weakness or spasms.
Image by TheVisualMD
Potassium: Heart Rate
Potassium plays an important role in maintaining cardiac electrical activity. A potassium imbalance can result in a slow or irregular heart beat, or even cardiac arrest.
Image by TheVisualMD
Potassium: Neural Conduction
Electrolytes can be either negatively and positively charged (potassium has a positive charge); they establish an electric potential between the inside and outside of cell membranes, which makes possible the transmission of nerve impulses.
Image by TheVisualMD
8:19
Fluid & Electrolytes: Potassium
EmpoweRN/YouTube
1:12
Electrolytes - What Are Electrolytes - Functions Of Electrolytes
Whats Up Dude/YouTube
1:47
Why You Need Electrolytes - Can It Help With Getting Stronger?
PictureFit/YouTube
2:42
What Do Electrolytes Actually Do?
Reactions/YouTube
4:52
What would happen if you didn’t drink water? - Mia Nacamulli
TED-Ed/YouTube
5:18
3 Signs You're Not Getting Enough Potassium
DoctorOz/YouTube
4:03
Muscle Cramps & Spasms – Dr.Berg On Charley Horses
Dr. Eric Berg DC/YouTube
1:46
What Causes Cramps?
Life Noggin/YouTube
3:26
Charley Horse Causes, Relief
Wendy Westwood/YouTube
3:35
High potassium levels: Should I Worry?
Fox News/YouTube
13:18
Aldosterone raises blood pressure and lowers potassium | NCLEX-RN | Khan Academy
khanacademymedicine/YouTube
Plate of High Potassium Food
TheVisualMD
Potassium Ion
TheVisualMD
Potassium: Muscle Spasm
TheVisualMD
Potassium: Heart Rate
TheVisualMD
Potassium: Neural Conduction
TheVisualMD
Bicarbonate
Carbon Dioxide Blood Test
Also called: Carbon Dioxide, CO2, Bicarbonate, Metabolic Alkalosis Test, Metabolic Acidosis Test
A carbon dioxide (CO2) blood test measures the amount of carbon dioxide is in the blood in your veins. Too much or too little CO2 in the blood can indicate a health problem. The test is most often done as part of an electrolyte or metabolic panel.
Carbon Dioxide Blood Test
Also called: Carbon Dioxide, CO2, Bicarbonate, Metabolic Alkalosis Test, Metabolic Acidosis Test
A carbon dioxide (CO2) blood test measures the amount of carbon dioxide is in the blood in your veins. Too much or too little CO2 in the blood can indicate a health problem. The test is most often done as part of an electrolyte or metabolic panel.
{"label":"Carbon dioxide reference range","scale":"lin","step":0.1,"hideunits":false,"items":[{"flag":"abnormal","label":{"short":"Low","long":"Low","orientation":"horizontal"},"values":{"min":0,"max":22},"text":"Low results may indicate a wide range of conditions, such as electrolyte imbalance. ","conditions":["Hypocapnia","Addison's disease","Acidosis","Ketoacidosis","Shock","Kidney disorders"]},{"flag":"normal","label":{"short":"Normal","long":"Normal","orientation":"horizontal"},"values":{"min":22,"max":28},"text":"Changes in your CO2 level may suggest that you are losing or retaining acidic fluid. This may cause an imbalance in your body's acid-base balance (pH balance).","conditions":[]},{"flag":"abnormal","label":{"short":"High","long":"High","orientation":"horizontal"},"values":{"min":28,"max":60},"text":"High results may indicate that your body has an electrolyte imbalance, or that there is a problem removing carbon dioxide through your lungs.","conditions":["Hypercapnia","Lung diseases","Disorders of the adrenal glands","Hormonal disorders","Kidney disorders","Alkalosis"]}],"units":[{"printSymbol":"meq\/L","code":"meq\/L","name":"milliequivalent per liter"}],"value":25,"disclaimer":"Normal reference ranges can vary depending on the laboratory and the method used for testing. You must use the range supplied by the laboratory that performed your test to evaluate whether your results are \"within normal limits.\""}[{"abnormal":0},{"normal":0},{"abnormal":0}]
Use the slider below to see how your results affect your
health.
meq/L
22
28
Your result is Normal.
Changes in your CO2 level may suggest that you are losing or retaining acidic fluid. This may cause an imbalance in your body's acid-base balance (pH balance).
Related conditions
{"label":"pCO2 reference range","scale":"lin","step":0.1,"hideunits":false,"items":[{"flag":"abnormal","label":{"short":"Hypocapnia","long":"Hypocapnia","orientation":"horizontal"},"values":{"min":10,"max":35},"text":"A pCO2 value below 35 mm Hg is called hypocapnia, or hypocarbia. When the levels are low, the body naturally tries to produce more CO2 by joining bicarbonate (HCO3-) and hydrogen ions to create more CO2 molecules. However, hydrogen ions determine blood pH; by using up hydrogen ions to create CO2, the pH of the blood increases and becomes basic.","conditions":["Addison disease","CNS tumors","Dyspnea","Heart failure","Hyperventilation","Fatigue","Infections","Intracranial pressure","Ketoacidosis","Kidney disorders","Medications (aspirin, progesterone)","Metabolic acidosis","Pulmonary edema","Pulmonary embolism","Respiratory alkalosis","Shock"]},{"flag":"normal","label":{"short":"Normal","long":"Normal","orientation":"horizontal"},"values":{"min":35,"max":45},"text":"A partial pressure of carbon dioxide (pCO2) normally is maintained between 35 and 45 mm Hg. Carbon dioxide is a waste product that your body gets rid of when you exhale. It helps regulate your breathing rate and the acid-base balance in your blood.","conditions":[]},{"flag":"abnormal","label":{"short":"Hypercapnia","long":"Hypercapnia","orientation":"horizontal"},"values":{"min":45,"max":100},"text":"A pCO2 value above 45 mm Hg is called hypercapnia, or hypercarbia. This result may indicate that your body has an electrolyte imbalance, or that there is a problem removing carbon dioxide through your lungs.","conditions":["Adrenal glands disorders","Hormonal disorders","Hyperthyroidism","Hypoventilation","Fever","Kidney diseases","Lung diseases","Respiratory acidosis","Respiratory failure"]}],"units":[{"printSymbol":"mm\u00a0Hg","code":"mm[Hg]","name":"millimeter of mercury"}],"value":40,"disclaimer":"Normal reference ranges can vary depending on the laboratory and the method used for testing. You must use the range supplied by the laboratory that performed your test to evaluate whether your results are \"within normal limits.\""}[{"abnormal":0},{"normal":0},{"abnormal":0}]
Use the slider below to see how your results affect your
health.
mm Hg
35
45
Your result is Normal.
A partial pressure of carbon dioxide (pCO2) normally is maintained between 35 and 45 mm Hg. Carbon dioxide is a waste product that your body gets rid of when you exhale. It helps regulate your breathing rate and the acid-base balance in your blood.
Related conditions
A carbon dioxide (CO2) blood test measures the amount of carbon dioxide in your blood. Carbon dioxide is an odorless, colorless gas. It is a waste product that your body makes when it uses food for energy.
Your blood carries carbon dioxide to your lungs. When you exhale, you breathe out carbon dioxide. Having too much or too little carbon dioxide in your blood can be a sign of a health problem.
Most of the carbon dioxide in your body is in the form of bicarbonate, which is a type of electrolyte. Electrolytes are electrically charged minerals that help control the amount of fluid and the balance of acids and bases (pH balance) in your body. A CO2 blood test is often part of a group of tests called an electrolyte panel.
An electrolyte panel may be part of a regular check-up. The test may also help diagnose or monitor conditions related to an electrolyte imbalance. These include high blood pressure and diseases of the kidneys, lungs, or liver.
Your health care provider may order a CO2 blood test as part of your regular checkup or if you have symptoms of an electrolyte imbalance. These symptoms may include:
Trouble breathing
Confusion
Weakness
Fatigue
Vomiting and/or diarrhea over a long period of time
Your provider may also order a CO2 blood test to check for side effects of certain medicines that can cause electrolyte imbalances.
A health care professional will take a blood sample from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial. You may feel a little sting when the needle goes in or out. This usually takes less than five minutes.
You don't need any special preparations for a CO2 blood test or an electrolyte panel. If your provider has ordered more tests on your blood sample, you may need to fast (not eat or drink) for several hours before the test. Your provider will let you know if there are any special instructions to follow.
There is very little risk to having a blood test. You may have slight pain or bruising at the spot where the needle was put in, but most symptoms go away quickly.
Abnormal test results may be a sign that your body is having a hard time keeping the right acid-base balance (pH balance). This may be because your lungs or kidneys are having a problem removing carbon dioxide or because you have an electrolyte imbalance. Many different types of conditions can cause these problems.
Too much CO2 in the blood can be a sign of many conditions, including:
Lung diseases
Cushing's syndrome
Kidney failure
Metabolic alkalosis, a condition in which your blood is not acidic enough. You may lose acid from conditions such as vomiting, dehydration, and anorexia.
Too little CO2 in the blood may be a sign of:
Addison disease, a complication of type 1 and type 2 diabetes
Diabetic ketoacidosis
Shock
Metabolic acidosis, a condition in which your blood is too acidic. It may be caused by many things, including kidney or liver disease, or long-lasting diarrhea.
Respiratory alkalosis, a condition in which your blood is not acidic enough because of lung or breathing disorders, including hyperventilation (rapid, deep breathing).
If your test results are not in the normal range, it doesn't necessarily mean you have a medical condition that needs treatment. Other factors, including certain medicines, can affect the level of CO2 in your blood. To learn what your results mean, talk with your provider.
Some prescription and over-the-counter medicines can increase or decrease the amount of carbon dioxide in your blood. Be sure to tell your provider about any medicines you are taking.
Carbon Dioxide (CO2) in Blood: MedlinePlus Medical Test [accessed on Dec 20, 2023]
CO2 blood test: MedlinePlus Medical Encyclopedia [accessed on Dec 20, 2023]
Carbon Dioxide (Blood) - Health Encyclopedia - University of Rochester Medical Center [accessed on Dec 20, 2023]
Lipid Tests
Lipid Tests
Also called: Lipid Panel, Lipid Profile, Lipid Testing, Lipoprotein Profile
Lipid tests measure triglycerides, a type of fat found in the bloodstream, and cholesterol, a waxy, fat-like substance found in your blood and every cell of your body. High levels of triglycerides and/or a type of cholesterol, called LDL can put you at risk for heart disease.
Lipid Tests
Also called: Lipid Panel, Lipid Profile, Lipid Testing, Lipoprotein Profile
Lipid tests measure triglycerides, a type of fat found in the bloodstream, and cholesterol, a waxy, fat-like substance found in your blood and every cell of your body. High levels of triglycerides and/or a type of cholesterol, called LDL can put you at risk for heart disease.
https://www.nhlbi.nih.gov/health-topics/high-blood-cholesterol [accessed on Sep 29, 2019]
https://www.ncbi.nlm.nih.gov/books/NBK351/ [accessed on Sep 29, 2019]
Additional Materials (12)
Lipid Panel Interpretation
Video by FatIsNotYourFault/YouTube
WellnessFX Biomarker Series: Apolipoprotein B
Video by WellnessFX/YouTube
Cholesterol - what is it and how can you prevent high cholesterol?
Video by Healthchanneltv / cherishyourhealthtv/YouTube
Cholesterol Good and Bad
Video by The National Library of Medicine/YouTube
Cholesterol Blood Test
Video by Baptist Health Physician Partners/YouTube
Cholesterol Isn't Quite as Bad as You've Been Told
Video by Healthcare Triage/YouTube
This browser does not support the video element.
Cholesterol & Atherosclerosis
While the term technically refers to any disease that affects the cardiovascular system (as used in MeSH), it is usually used to refer to those related to atherosclerosis (arterial disease). Everyone talks about high cholesterol and how bad it is for you. But why is it bad for you? Where does it come from? What's the difference between "good" and "bad" cholesterol? Take a journey inside the body and explore its vessels, as world-renowned doctors explain what cholesterol is all about and how it contributes to hardening of the arteries, a dangerous condition also known as atherosclerosis.
Video by TheVisualMD
What cholesterol is and what cholesterol blood tests show
Video by Bupa Health UK/YouTube
This browser does not support the video element.
What Is HDL and LDL Cholesterol?
This video explains the difference between HDL and LDL cholesterol. It also reveals what may occur when there are high levels of LDL in the body.LDL may stick to an artery's inner wall causing the build up of plaque, affecting blood flow. When an artery stiffens and constricts, aneurysm, heart attack, and stroke can occur.
Video by TheVisualMD
This browser does not support the video element.
Fiber and Lowering Cholesterol
Take steps towards better health exploring why a diet rich in soluble fiber is a great way to help lower "bad" LDL cholesterol. Soluble fiber (found in oats, apples, beans, barley) acts like a cholesterol sponge, soaking up "bad" LDL cholesterol in the small intestine and lowering the risk of cardiovascular disease. It can also help regulate blood sugar and reduce the risk of type 2 diabetes.
Video by TheVisualMD
Fasting for a Blood Test | WebMD
Video by WebMD/YouTube
Fasting Plasma Glucose
Fasting Plasma Glucose - The fasting plasma glucose (FPG) test, also known as the fasting blood sugar test, measures blood sugar levels and is used to diagnose diabetes.
Image by TheVisualMD
1:16:38
Lipid Panel Interpretation
FatIsNotYourFault/YouTube
1:13
WellnessFX Biomarker Series: Apolipoprotein B
WellnessFX/YouTube
2:42
Cholesterol - what is it and how can you prevent high cholesterol?
Healthchanneltv / cherishyourhealthtv/YouTube
3:01
Cholesterol Good and Bad
The National Library of Medicine/YouTube
3:06
Cholesterol Blood Test
Baptist Health Physician Partners/YouTube
5:09
Cholesterol Isn't Quite as Bad as You've Been Told
Healthcare Triage/YouTube
3:08
Cholesterol & Atherosclerosis
TheVisualMD
3:53
What cholesterol is and what cholesterol blood tests show
Bupa Health UK/YouTube
0:45
What Is HDL and LDL Cholesterol?
TheVisualMD
1:07
Fiber and Lowering Cholesterol
TheVisualMD
0:50
Fasting for a Blood Test | WebMD
WebMD/YouTube
Fasting Plasma Glucose
TheVisualMD
Triglycerides Test
Triglycerides Test
Also called: TRIG
A triglycerides test measures the amount of triglycerides in your blood. High triglyceride levels may put you at risk for heart disease. The test is usually part of a lipid profile.
Triglycerides Test
Also called: TRIG
A triglycerides test measures the amount of triglycerides in your blood. High triglyceride levels may put you at risk for heart disease. The test is usually part of a lipid profile.
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Use the slider below to see how your results affect your
health.
mg/dL
150
200
500
Your result is Optimal.
For adults, triglyceride levels less than 150 mg/dL (milligrams per deciliter) are considered optimal.
Related conditions
A triglycerides test measures the amount of triglycerides in your blood. Triglycerides are a type of fat in your body. If you eat more calories than you need, the extra calories are changed into triglycerides. These triglycerides are stored in your fat cells for later use. When your body needs energy, triglycerides are released into your bloodstream to provide fuel for your muscles to work. If you eat more calories than you burn off, especially calories from carbohydrates and fats, you may get high triglyceride levels in your blood. High triglycerides may put you at greater risk for a heart attack or stroke.
A triglycerides test is usually part of a lipid profile. Lipid is another word for fat. A lipid profile is a test that measures the level of fats in your blood, including triglycerides and cholesterol, a waxy, fatty substance found in every cell of your body. If you have high levels of both LDL (bad) cholesterol and triglycerides, you may be at an increased risk for a heart attack or stroke.
Your health care provider may order a lipid profile as part of a routine exam or to diagnose or monitor heart conditions.
Healthy adults should get a lipid profile, which includes a triglycerides test, every four to six years. You may need to be tested more often if you have certain risk factors for heart disease. These include:
Family history of heart disease
Smoking
Being overweight
Unhealthy eating habits
Lack of exercise
Diabetes
High blood pressure
Age. Men 45 years or older and women 50 years or older are at a higher risk for heart disease
A triglycerides test is a blood test. During the test, a health care professional will take a blood sample from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial. You may feel a little sting when the needle goes in or out. This usually takes less than five minutes.
You may need to fast (not food or drink) for 9 to 12 hours before your blood is drawn. Your health care provider will let you know if you need to fast and if there are any special instructions to follow.
There is very little risk to having a blood test. You may have slight pain or bruising at the spot where the needle was put in, but most symptoms go away quickly.
Triglycerides are usually measured in milligrams (mg) of triglycerides per deciliter (dL) of blood. For adults, results are usually categorized as:
Normal/desirable triglyceride range: less than 150mg/dL
Borderline high triglyceride range: 150 to 199 mg/dL
High triglyceride range: 200 to 499 mg/dL
Very high triglyceride range: 500 mg/dL and above
Higher than normal triglyceride levels may put you at risk for heart disease. To reduce your levels and lower your risk, your health care provider may recommend lifestyle changes and/or prescribe medicines.
If your results were borderline high, your provider may recommend that you:
Lose weight
Eat a healthier diet
Get more exercise
Reduce alcohol intake
Take a cholesterol lowering medicine
If your results were high or very high, your provider may recommend the same lifestyle changes as above and also that you:
Follow a very low-fat diet
Lose a significant amount of weight
Take medicine or medicines designed to lower triglycerides
Be sure to talk to your health care provider before making any major changes to your diet or exercise routine.
Triglycerides Test: MedlinePlus Medical Test [accessed on May 17, 2022]
Normal reference ranges can vary depending on the laboratory and the method used for testing. You must use the range supplied by the laboratory that performed your test to evaluate whether your results are "within normal limits."
Additional Materials (39)
Triglycerides
A Triglyceride model showing the positions of Sn1, Sn2 and Sn3, fatty acids, and the glycerol backbone
Image by Roger Daniels, Bunge Oils Director of Research & Development
Excess fat cells growing on top of the muscle tissue
Triglycerides are a large and varied category of fats found in both plants and animals. Because fats and blood, like oil and water, do not mix, triglycerides (as well as cholesterol) circulate through the body in special parcels called lipoproteins, which are fat-and-protein packages that enable fats to move freely within the bloodstream. Proteins and other components make up the outer shell; fats, in the form of triglycerides and cholesterol, are packed together inside.
Image by TheVisualMD
Lipids and Lipoproteins
Lipids and Lipoproteins
Image by TheVisualMD
This browser does not support the video element.
Lipids, Heart Health and Baselining Your Health
Your blood "knows" what you eat, meaning that the cardiovascular system is a sensitive barometer of a person's health, including diet. What individuals eat is reflected in their blood chemistry and the health of their heart, arteries and vessels. Fats (also known as lipids), for example, are vital to health and wellbeing throughout our lives and yet they are mostly associated with obesity and cardiovascular disease. The problem is that not all fats (or cholesterol) are equal. They share basic chemical similarities, but they also have important differences, which, in turn, result in different roles and effects in the body. Tests that offer information on diet and heart health include total cholesterol, low-density lipoprotein (LDL or "bad" cholesterol), high-density lipoprotein (HDL or "good" cholesterol), and triglycerides.
Video by TheVisualMD
Thoracic Duct
The lymphatic system consists of a network of vessels and nodes that collect and carry a clear fluid called lymph that plays roles in immune function as well as the transport of nutrients. The thoracic duct, which is the largest vessel in the lymphatic system, delivers lymph into the bloodstream, including lymph from the intestinal system, called chyle, which is milky rich in fats.
Image by TheVisualMD
Triglyceride Molecule
Triglycerides are the body's primary form of stored fat. When you consume excess calories, your body converts them right away into triglycerides. In the liver, triglycerides are packaged up with cholesterol and with proteins in carriers called lipoproteins, which are transported through the blood to various sites of the body to be stored in fat cells. Luckily for anyone with a high triglyceride reading in their lipid profile, levels can often be lowered by making smart changes to the diet. Even if you are prescribed medication to lower triglyceride levels, your physician will also recommend improving food choices. In this model, carbon atoms are dark gray, hydrogen atoms are white, and oxygen atoms are red.
Image by TheVisualMD
Triglyceride Molecule
Triglycerides are the body's primary form of stored fat. When you consume excess calories, your body converts them right away into triglycerides. In the liver, triglycerides are packaged up with cholesterol and with proteins in carriers called lipoproteins, which are transported through the blood to various sites of the body to be stored in fat cells. Luckily for anyone with a high triglyceride reading in their lipid profile, levels can often be lowered by making smart changes to the diet. Even if you are prescribed medication to lower triglyceride levels, your physician will also recommend improving food choices. In this model, carbon atoms are dark gray, hydrogen atoms are white, and oxygen atoms are red.
Image by TheVisualMD
Lowering Triglycerides - Mayo Clinic
Video by Mayo Clinic/YouTube
Tri HDL
Video by ACAP Health/YouTube
Triglycerides: Liver and Intestines
The liver is the body's central chemical plant, removing toxins, storing sugars and lipids and producing a wide range of proteins that play key roles as enzymes. The liver also produces packages cholesterol and triglycerides, along with special proteins, into lipoproteins.
Image by TheVisualMD
Triglycerides: Triglyceride
Triglycerides are a large and varied category of fats found in both plants and animals. When we eat our bodies convert excess calories into triglycerides, which can be stored in fat cells and then released as needed into the bloodstream for energy between meals.
Image by TheVisualMD
LDL-Particles: Triglycerides
One factor that may contribute to a high LDL particle count is raised levels of triglycerides. Elevated triglyceride levels in the blood start a chain of biochemical reactions that eventually leads to a reduction in the size of LDL particles. The smaller LDL particles can't carry as much cholesterol as larger LDL particles, so a greater number of them is needed to carry a given amount of cholesterol.
Image by TheVisualMD
Triglycerides and HDL
Video by Joslin Diabetes Center/YouTube
Asian Heart Hospital - What is Triglycerides?
Video by Asian Heart Institute/YouTube
What is Plaque?
Video by CardioTabs/YouTube
Lipid Absorption
Lipid Absorption
Image by OpenStax College
lipid vesicles in these adipocytes
The preadipocyte cell line PA6 fully differentiated into adipocytes. The lipid vesicles in these adipocytes are stained using oil-red-O staining.
Image by M. Oktar Guloglu
Anatomy of a Lipoprotein
Lipoproteins transport cholesterol, triglycerides, or other lipids through the bloodstream. Lipoproteins are protein spheres that consist of a core of triglycerides and cholesterol esters, surrounded by a shell made up of water-soluble phospholipids with embedded proteins and cholesterol. The lipid-laden core of the lipoprotein is insoluble in aqueous (water-based) blood, so the phospholipid-protein shell is necessary to allow the lipoprotein to float freely in the bloodstream.
Image by TheVisualMD
Anatomy of a Lipoprotein
Lipoproteins transport cholesterol, triglycerides, or other lipids through the bloodstream. Lipoproteins are protein spheres that consist of a core of triglycerides and cholesterol esters, surrounded by a shell made up of water-soluble phospholipids with embedded proteins and cholesterol. The lipid-laden core of the lipoprotein is insoluble in aqueous (water-based) blood, so the phospholipid-protein shell is necessary to allow the lipoprotein to float freely in the bloodstream.
Image by TheVisualMD
Anatomy of a Lipoprotein
Lipoproteins transport cholesterol, triglycerides, or other lipids through the bloodstream. Lipoproteins are protein spheres that consist of a core of triglycerides and cholesterol esters, surrounded by a shell made up of water-soluble phospholipids with embedded proteins and cholesterol. The lipid-laden core of the lipoprotein is insoluble in aqueous (water-based) blood, so the phospholipid-protein shell is necessary to allow the lipoprotein to float freely in the bloodstream.
Image by TheVisualMD
Anatomy of a Lipoprotein
Lipoproteins transport cholesterol, triglycerides, or other lipids through the bloodstream. Lipoproteins are protein spheres that consist of a core of triglycerides and cholesterol esters, surrounded by a shell made up of water-soluble phospholipids with embedded proteins and cholesterol. The lipid-laden core of the lipoprotein is insoluble in aqueous (water-based) blood, so the phospholipid-protein shell is necessary to allow the lipoprotein to float freely in the bloodstream.
Image by TheVisualMD
Breast Milk Component Pathway
The components of breast milk are brought together in the alveoli via different routes. Breast milk constituents are either absorbed from the bloodstream from nutrients in the mother's diet or synthesized in special milk-producing cells called lactocytes. These constituents are brought together in the alveoli via different routes. Some components pass through or between the lactocytes, while others are assembled within the lactocytes.
Image by TheVisualMD
Maintaining Cardiovascular Health
This series of images illustrates diet and lifestyle changes that help maintain cardiovascular health, and which may actually help improve existing damage. From left to right: 1) A woman eats an apple, with visible cardiovascular system and digestive system. 2) Fresh vegetables, including tomatoes, peppers, broccoli, cauliflower and carrots, are high in fiber which helps keep blood lipid levels healthy. 3) Monounsaturated and polyunsaturated fats are better for heart health than trans fats and saturated fats. Good sources include those shown: nuts, seeds, olive oil and omega-3 fatty acids like those found in salmon. 4) A woman takes a vigorous walk with muscles, skeletal bones and heart visible. Regular exercise in combination with a heart-healthy diet helps keep your heart and blood vessels in top condition.
Image by TheVisualMD
Fat Cells Growing on the Surface of a Blood Vessel
This image shows mature fat cells growing on the surface of a blood vessel. The image is from an animation that shows how fat cells, or adipocytes, expand and contribute to obesity. Some tissue is also visible in the image.
Image by TheVisualMD
Healthy Cell Membrane
This image shows the healthy membrane of an endothelial cell in a blood vessel wall. You can see the semi-permeable double layer of phospholipids that allows lipids to move across the membrane. The cholesterol molecules (yellow) maintain permeability by keeping the phospholipid tails from sticking together.
Managing Atherosclerosis Risk : Certain lifestyle habits, traits, and conditions may increase the probability that you'll develop atherosclerosis. These conditions are known as risk factors. The more risk factors you have, the greater your chances of developing atherosclerosis. Fortunately, most of these risk factors are within your control.
Image by TheVisualMD
Abnormal blood lipid levels and hypertension both increase the risk of atherosclerosis
Message From The Heart : Abnormal blood lipid levels and hypertension both increase the risk of atherosclerosis. In atherosclerosis, cholesterol and other substances create hard, waxy plaques inside your arteries, narrowing them and making it more difficult for blood to get through.
Image by TheVisualMD
Fat: What Is It Good For?
Adipose tissue (fat tissue) is a type of connective tissue. The two main types of adipose tissue in humans are subcutaneous (under the skin) and visceral (inside the abdomen). Adipose tissue performs many functions in your body. Its main job is to store energy in the form of lipids (triglycerides and cholesterol). When you eat fatty foods, often there are more lipids than you need for energy at that time. The excess lipids are stored in your adipose tissue. The same holds true for proteins and carbohydrates—when you eat more of them than you need immediately, excess amounts are converted to lipids and stored in adipose tissue for future use.
Image by TheVisualMD
Coronary Artery Disease - Risk Factors Of Atherosclerosis
Risk Factors Of Atherosclerosis : Scientists think that immune system cells may gather at injures areas of the lining of the arteries in an attempt to "heal" the damage. Lipids like cholesterol adhere as well, together with other substances in the blood like calcium and fibrin (connective tissue). Together they form the hard, fatty deposit called plaques.
Image by TheVisualMD
Getting to the Heart of Things
The cardiovascular system consists of the heart, the blood vessels, and the blood itself. Blood is mostly made up of plasma and red and white blood cells. But it contains many other substances as well, like platelets, hormones, and nutrients such as glucose. The cardiovascular system distributes these substances throughout the body as needed and collects waste products from your cells for elimination.
Image by TheVisualMD
Obese Child Showing Cardiovascular System and Visceral Fat
Most of the kids diagnosed with type 2 diabetes are obese. Normally, insulin in the blood binds with an insulin receptor on a cell surface to allow glucose (blood sugar) to enter the cell. In type 2 diabetes, insulin doesn't work to allow glucose into the cell. Obesity and its related conditions, such as high blood pressure, abnormal glucose tolerance, and high lipid levels, are major risk factors for cardiovascular disease (CVD), diseases of the heart and blood vessels. Most of us think of CVD, the leading cause of death in the US, as an adult disease. But CVD can begin early on, even in childhood, and get progressively worse. Obese children and children with abnormally high blood cholesterol and triglyceride levels can develop fatty streaks in their arteries, the first steps in the formation of plaques. Some may even develop plaques. CVD has become a pediatric disease.
Image by TheVisualMD
Obese Young Child Showing Cardiovascular System and Visceral Fat
Most of the kids diagnosed with type 2 diabetes are obese. Normally, insulin in the blood binds with an insulin receptor on a cell surface to allow glucose (blood sugar) to enter the cell. In type 2 diabetes, insulin doesn't work to allow glucose into the cell. Obesity and its related conditions, such as high blood pressure, abnormal glucose tolerance, and high lipid levels, are major risk factors for cardiovascular disease (CVD), diseases of the heart and blood vessels. Most of us think of CVD, the leading cause of death in the US, as an adult disease. But CVD can begin early on, even in childhood, and get progressively worse. Obese children and children with abnormally high blood cholesterol and triglyceride levels can develop fatty streaks in their arteries, the first steps in the formation of plaques. Some may even develop plaques. CVD has become a pediatric disease.
Image by TheVisualMD
Lipoproteins
Lipoproteins are protein spheres that transport lipids through your bloodstream.
Image by TheVisualMD
Bile Acids
Digestion of Fats : You need cholesterol in order to digest food. One of the other major uses of cholesterol is the production of bile acids (also known as bile salts) in the liver. Bile contains a number of ingredients, including water, cholesterol, and bile acids. Bile is necessary for the absorption of fats from fecal matter passing through the intestine.
Image by TheVisualMD
Statins Lowering Cholesterol
Statins lower cholesterol levels by reducing the production of cholesterol by the liver. They also increase the capacity of the liver to remove cholesterol from the blood. When less produced and more gets removed from the bloodstream, the level of cholesterol can drop significantly.
Image by TheVisualMD
Cardiovascular disease
Atherosclerosis Risk Factors, Major Risk Factors You Can Control:
Image by TheVisualMD
Triglyceride Molecule
Triglycerides are the body's primary form of stored fat. When you consume excess calories, your body converts them right away into triglycerides. In the liver, triglycerides are packaged up with cholesterol and with proteins in carriers called lipoproteins, which are transported through the blood to various sites of the body to be stored in fat cells. Luckily for anyone with a high triglyceride reading in their lipid profile, levels can often be lowered by making smart changes to the diet. Even if you are prescribed medication to lower triglyceride levels, your physician will also recommend improving food choices. In this model, carbon atoms are dark gray, hydrogen atoms are white, and oxygen atoms are red
Image by TheVisualMD
The ABC's of Vitamins
Image by TheVisualMD
Triglycerides
Roger Daniels, Bunge Oils Director of Research & Development
Excess fat cells growing on top of the muscle tissue
TheVisualMD
Lipids and Lipoproteins
TheVisualMD
2:46
Lipids, Heart Health and Baselining Your Health
TheVisualMD
Thoracic Duct
TheVisualMD
Triglyceride Molecule
TheVisualMD
Triglyceride Molecule
TheVisualMD
2:46
Lowering Triglycerides - Mayo Clinic
Mayo Clinic/YouTube
2:17
Tri HDL
ACAP Health/YouTube
Triglycerides: Liver and Intestines
TheVisualMD
Triglycerides: Triglyceride
TheVisualMD
LDL-Particles: Triglycerides
TheVisualMD
3:25
Triglycerides and HDL
Joslin Diabetes Center/YouTube
3:11
Asian Heart Hospital - What is Triglycerides?
Asian Heart Institute/YouTube
2:19
What is Plaque?
CardioTabs/YouTube
Lipid Absorption
OpenStax College
lipid vesicles in these adipocytes
M. Oktar Guloglu
Anatomy of a Lipoprotein
TheVisualMD
Anatomy of a Lipoprotein
TheVisualMD
Anatomy of a Lipoprotein
TheVisualMD
Anatomy of a Lipoprotein
TheVisualMD
Breast Milk Component Pathway
TheVisualMD
Maintaining Cardiovascular Health
TheVisualMD
Fat Cells Growing on the Surface of a Blood Vessel
Abnormal blood lipid levels and hypertension both increase the risk of atherosclerosis
TheVisualMD
Fat: What Is It Good For?
TheVisualMD
Coronary Artery Disease - Risk Factors Of Atherosclerosis
TheVisualMD
Getting to the Heart of Things
TheVisualMD
Obese Child Showing Cardiovascular System and Visceral Fat
TheVisualMD
Obese Young Child Showing Cardiovascular System and Visceral Fat
TheVisualMD
Lipoproteins
TheVisualMD
Bile Acids
TheVisualMD
Statins Lowering Cholesterol
TheVisualMD
Cardiovascular disease
TheVisualMD
Triglyceride Molecule
TheVisualMD
The ABC's of Vitamins
TheVisualMD
Cholesterol Test
Cholesterol Test
Also called: Cholesterol Levels, Blood Cholesterol, Total Cholesterol
A cholesterol test is a blood test that measures the amount of each type of cholesterol and certain fats in your blood. Cholesterol is needed to carry out functions such as hormone and vitamin production. High cholesterol can put you at risk for heart disease.
Cholesterol Test
Also called: Cholesterol Levels, Blood Cholesterol, Total Cholesterol
A cholesterol test is a blood test that measures the amount of each type of cholesterol and certain fats in your blood. Cholesterol is needed to carry out functions such as hormone and vitamin production. High cholesterol can put you at risk for heart disease.
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Use the slider below to see how your results affect your
health.
mg/dL
200
240
Your result is Desirable.
While cholesterol levels can vary widely among healthy individuals, total cholesterol levels below 200 milligrams per deciliter (mg/dL) are considered most desirable.
Related conditions
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Use the slider below to see how your results affect your
health.
mg/dL
40
60
Your result is Desirable.
HDL levels between 40-50 mg/dL for men, and 50-60 mg/dl for women, are associated with average risk of heart disease. The higher HDL levels, the better.
Related conditions
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Use the slider below to see how your results affect your
health.
mg/dL
100
130
160
190
Your result is Optimal.
The optimal level of LDL has changed over time and depends on the number of risk factors you have for heart disease and stroke. Generally, you want your LDL to be low. It's possible to have extremely low levels of LDL, but this is rare.
Related conditions
A cholesterol test is a blood test that measures the amount of cholesterol and certain fats in your blood. Cholesterol is a waxy, fat-like substance that's found in your blood and every cell of your body. You need some cholesterol to keep your cells and organs healthy.
Your liver makes all the cholesterol your body needs. But you can also get cholesterol from the foods you eat, especially meat, eggs, poultry, and dairy products. Foods that are high in dietary fat can also make your liver produce more cholesterol.
There are two main types of cholesterol: low-density lipoprotein (LDL), or "bad" cholesterol, and high-density lipoprotein (HDL), or "good" cholesterol.
Too much LDL cholesterol in your blood increases your risk for coronary artery disease and other heart diseases. High LDL levels can cause the buildup of a sticky substance called plaque in your arteries. Over time, plaque can narrow your arteries or fully block them. When this happens, parts of your body don't get enough blood:
If the blood flow to the heart is blocked, it can cause a heart attack.
If the blood flow to the brain is blocked, it can cause a stroke.
If the blood flow to the arms or legs is blocked, it can cause peripheral artery disease.
Other names for a cholesterol test: Lipid profile, Lipid panel
A cholesterol test gives you and your health care provider important information about your risk of developing heart disease. If your test shows you have high cholesterol, you can take steps to lower it. This may decrease your risk of developing heart problems in the future. A cholesterol test measures:
LDL levels. Also known as the "bad" cholesterol, LDL is the main source of blockages in the arteries.
HDL levels. Considered the "good" cholesterol, HDL helps get rid of "bad" LDL cholesterol.
Total cholesterol. The combined amount of LDL cholesterol and HDL cholesterol in your blood.
Triglyceride levels. Triglycerides are a type of fat found in your blood. Some studies show that high levels of triglycerides may increase the risk of heart disease, especially in women.
VLDL levels. Very low-density lipoprotein (VLDL) is another type of "bad" cholesterol. High VLDL levels have been linked to plaque buildup in the arteries. VLDL isn't usually included in routine cholesterol tests because it's difficult to measure. About half of VLDL is triglycerides, so your VLDL level can be estimated as a percentage of your triglyceride level.
Your provider may order a cholesterol test as part of a routine exam. You may also have a cholesterol test if you have a family history of heart disease or if your risk for heart problems is high because of:
High blood pressure
Type 2 diabetes
Smoking
Excess weight or obesity
Lack of physical activity
A diet high in saturated fat
Your age may also be a factor, because your risk for heart disease increases as you get older.
A health care professional will take a blood sample from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial. You may feel a little sting when the needle goes in or out. This usually takes less than five minutes.
You may be able to use an at-home kit to check your cholesterol levels. Your kit will include a device to prick your finger to collect a drop of blood for testing. Be sure to follow the kit instructions carefully. Also, be sure to tell your provider if your at-home test shows that your total cholesterol level is higher than 200 mg/dl.
You may need to fast (not eat or drink) for 9 to 12 hours before your blood cholesterol test. That's why the tests are often done in the morning. Your provider will let you know if you need to fast and if there are any other special instructions.
There is very little risk to having a blood test. You may experience slight pain or bruising at the spot where the needle was put in, but most symptoms go away quickly.
Cholesterol is usually measured in milligrams (mg) of cholesterol per deciliter (dL) of blood. The information below will help you understand what your test results mean. In general, low LDL levels and high HDL cholesterol levels are good for heart health.
Total cholesterol
Total Cholesterol Level
Category
Less than 200mg/dL
Desirable
200-239 mg/dL
Borderline high
240mg/dL and above
High
LDL (bad) cholesterol
LDL (Bad) Cholesterol Level
LDL Cholesterol Category
Less than 100mg/dL
Optimal (best for your health)
100-129mg/dL
Near optimal
130-159 mg/dL
Borderline high
160-189 mg/dL
High
190 mg/dL and above
Very High
HDL (good) cholesterol
HDL (Good) Cholesterol Level
HDL Cholesterol Category
60 mg/dL and higher
Considered protective against heart disease
40-59 mg/dL
The higher, the better
Less than 40 mg/dL
A major risk factor for heart disease
The LDL listed on your results may say "calculated." This means that your LDL level is an estimate based on your total cholesterol, HDL, and triglycerides. Your LDL level may also be measured "directly" from your blood sample. Either way, you want your LDL number to be low.
A healthy cholesterol level for you may depend on your age, family history, lifestyle, and other risk factors for heart disease, such as high triglyceride levels. Your provider can explain what's right for you.
High cholesterol can lead to heart disease, the number one cause of death in the United States. You can't change some risk factors for high cholesterol, such as age and your genes. But there are actions you can take to lower your LDL levels and reduce your risk, including:
Eating a healthy diet. Reducing or avoiding foods high in saturated fat and cholesterol can help reduce the cholesterol levels in your blood.
Losing weight. Being overweight can increase your cholesterol and risk for heart disease.
Staying active. Regular exercise may help lower your LDL (bad) cholesterol levels and raise your HDL (good) cholesterol levels. It may also help you lose weight.
Talk to your provider before making any major change in your diet or exercise routine.
Normal reference ranges can vary depending on the laboratory and the method used for testing. You must use the range supplied by the laboratory that performed your test to evaluate whether your results are "within normal limits."
Additional Materials (12)
Total Cholesterol: Heart
The heart beats about 100,000 times a day, pumping blood through a vast system of arteries, veins and microscopic capillaries. While many risk factors for cardiovascular disease, including cholesterol levels, are related to lifestyle, others are largely genetic.
Image by TheVisualMD
Total Cholesterol: Heart and Liver
The liver produces most of the body's cholesterol in order to package fats in the form of lipoproteins. HDL is referred to as \"good\" cholesterol because it picks up excess cholesterol in the bloodstream and carries it back to the liver for disposal.
Image by TheVisualMD
Total Cholesterol: Thrombus
Thrombosis is the formation of a blood clot (thrombus) inside a blood vessel. If the clot is large or persistent enough, it can obstruct blood flow, which can starve tissue of oxygen-carrying blood. Most strokes are the result of thrombosis.
Image by TheVisualMD
This browser does not support the video element.
Lipids, Heart Health and Baselining Your Health
Your blood "knows" what you eat, meaning that the cardiovascular system is a sensitive barometer of a person's health, including diet. What individuals eat is reflected in their blood chemistry and the health of their heart, arteries and vessels. Fats (also known as lipids), for example, are vital to health and wellbeing throughout our lives and yet they are mostly associated with obesity and cardiovascular disease. The problem is that not all fats (or cholesterol) are equal. They share basic chemical similarities, but they also have important differences, which, in turn, result in different roles and effects in the body. Tests that offer information on diet and heart health include total cholesterol, low-density lipoprotein (LDL or "bad" cholesterol), high-density lipoprotein (HDL or "good" cholesterol), and triglycerides.
Video by TheVisualMD
This browser does not support the video element.
What Is Atherosclerosis?
Voyage inside your body to see where cholesterol is made and how plaques form inside your arteries. Witness the inner workings of your own personal cholesterol factory: your liver. Dr. Mehmet Oz, Dr. Peter Fail, and other top experts talk about cholesterol-how it accumulates with other substances in your arteries as plaque, and what happens when plaques rupture. See exactly how tiny stents are inserted in blocked vessels, and view footage of actual bypass surgery. Discover how you can keep your arteries clear and flexible through lifestyle changes and medications.
Video by TheVisualMD
What cholesterol is and what cholesterol blood tests show
Video by Bupa Health UK/YouTube
Cholesterol Blood Test
Video by Baptist Health Physician Partners/YouTube
Cholesterol - what is it and how can you prevent high cholesterol?
Video by Healthchanneltv / cherishyourhealthtv/YouTube
Cholesterol Good and Bad
Video by The National Library of Medicine/YouTube
This browser does not support the video element.
What Is HDL and LDL Cholesterol?
This video explains the difference between HDL and LDL cholesterol. It also reveals what may occur when there are high levels of LDL in the body.LDL may stick to an artery's inner wall causing the build up of plaque, affecting blood flow. When an artery stiffens and constricts, aneurysm, heart attack, and stroke can occur.
Video by TheVisualMD
This browser does not support the video element.
Refined Carbohydrates and Atherosclerosis
Refined Carbohydrates and Atherosclerosis : In atherosclerosis, hard, fatty deposits called plaque build up inside your arteries. For decades it was thought that eating too many fatty foods, especially foods rich in cholesterol, was to blame for plaque accumulation.
Video by TheVisualMD
This browser does not support the video element.
Cardiovascular Inflammation
Heart disease is the number one killer of men and women in the U.S. The most common cause of heart attack, stroke, and cardiovascular death is atherosclerosis. Atherosclerosis is a chronic inflammatory response in the walls of arteries that leads to the hardening of arterial walls and the buildup of fatty deposits called plaques, or atheromas. Although the process of inflammation can be beneficial in other parts of the body, chronic inflammation within arterial walls is problematic as it seems to promote this underlying growth of plaque. The combination of arterial inflammation and the growth of plaque can lead to the rupture of the plaque, and result in a blood clot. Blood clots can lead to dangerous conditions such as heart attack or stroke.
Video by TheVisualMD
Total Cholesterol: Heart
TheVisualMD
Total Cholesterol: Heart and Liver
TheVisualMD
Total Cholesterol: Thrombus
TheVisualMD
2:46
Lipids, Heart Health and Baselining Your Health
TheVisualMD
3:10
What Is Atherosclerosis?
TheVisualMD
3:53
What cholesterol is and what cholesterol blood tests show
Bupa Health UK/YouTube
3:06
Cholesterol Blood Test
Baptist Health Physician Partners/YouTube
2:42
Cholesterol - what is it and how can you prevent high cholesterol?
Healthchanneltv / cherishyourhealthtv/YouTube
3:01
Cholesterol Good and Bad
The National Library of Medicine/YouTube
0:45
What Is HDL and LDL Cholesterol?
TheVisualMD
2:21
Refined Carbohydrates and Atherosclerosis
TheVisualMD
4:26
Cardiovascular Inflammation
TheVisualMD
High-Density Lipoprotein Test
High-Density Lipoprotein Test
Also called: HDL, HDL-C, HDL Cholesterol, High-Density Lipoprotein Cholesterol
HDL, or high-density lipoprotein, is the "good" cholesterol. It helps to remove bad cholesterol from your arteries, so a higher HDL level is better.
High-Density Lipoprotein Test
Also called: HDL, HDL-C, HDL Cholesterol, High-Density Lipoprotein Cholesterol
HDL, or high-density lipoprotein, is the "good" cholesterol. It helps to remove bad cholesterol from your arteries, so a higher HDL level is better.
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Use the slider below to see how your results affect your
health.
mg/dL
40
60
Your result is Desirable.
HDL levels between 40-50 mg/dL for men, and 50-60 mg/dl for women, are associated with average risk of heart disease. The higher HDL levels, the better.
Related conditions
Cholesterol is a waxy, fat-like substance that's found in all the cells in your body. Your liver makes cholesterol, and it is also in some foods, such as meat and dairy products. Your body needs some cholesterol to work properly. But having too much cholesterol in your blood raises your risk of coronary artery disease.
HDL and LDL are two types of lipoproteins.They are a combination of fat (lipid) and protein. The lipids need to be attached to the proteins so they can move through the blood. HDL and LDL have different purposes:
HDL stands for high-density lipoproteins. It is sometimes called the "good" cholesterol because it carries cholesterol from other parts of your body back to your liver. Your liver then removes the cholesterol from your body.
LDL stands for low-density lipoproteins. It is sometimes called the "bad" cholesterol because a high LDL level leads to a buildup of cholesterol in your arteries.
A blood test can measure your cholesterol levels, including HDL. When and how often you should get this test depends on your age, risk factors, and family history. The general recommendations are:
For people who are age 19 or younger:
The first test should be between ages 9 to 11
Children should have the test again every 5 years
Some children may have this test starting at age 2 if there is a family history of high blood cholesterol, heart attack, or stroke
For people who are age 20 or older:
Younger adults should have the test every 5 years
Men ages 45 to 65 and women ages 55 to 65 should have it every 1 to 2 years
With HDL cholesterol, higher numbers are better, because a high HDL level can lower your risk for coronary artery disease and stroke. How high your HDL should be depends on your age and sex:
Group
Healthy HDL Level
Age 19 or younger
More than 45mg/dl
Men age 20 or older
More than 40mg/dl
Women age 20 or older
More than 50mg/dl
If your HDL level is too low, lifestyle changes may help. These changes may also help prevent other diseases, and make you feel better overall:
Eat a healthy diet. To raise your HDL level, you need to eat good fats instead of bad fats. This means limiting saturated fats, which include full-fat milk and cheese, high-fat meats like sausage and bacon, and foods made with butter, lard, and shortening. You should also avoid trans fats, which may be in some margarines, fried foods, and processed foods like baked goods. Instead, eat unsaturated fats, which are found in avocado, vegetable oils like olive oil, and nuts. Limit carbohydrates, especially sugar. Also try to eat more foods naturally high in fiber, such as oatmeal and beans.
Stay at a healthy weight. You can boost your HDL level by losing weight, especially if you have lots of fat around your waist.
Exercise. Getting regular exercise can raise your HDL level, as well as lower your LDL. You should try to do 30 minutes of moderate to vigorous aerobic exercise on most, if not all, days.
Avoid cigarettes. Smoking and exposure to secondhand smoke can lower your HDL level. If you are a smoker, ask your health care provider for help in finding the best way for you to quit. You should also try to avoid secondhand smoke.
Limit alcohol. Moderate alcohol may lower your HDL level, although more studies are needed to confirm that. What we do know is that too much alcohol can make you gain weight, and that lowers your HDL level.
Some cholesterol medicines, including certain statins, can raise your HDL level, in addition to lowering your LDL level. Health care providers don't usually prescribe medicines only to raise HDL. But if you have a low HDL and high LDL level, you might need medicine.
Taking certain medicines can lower HDL levels in some people. They include
Beta blockers, a type of blood pressure medicine
Anabolic steroids, including testosterone, a male hormone
Progestins, which are female hormones that are in some birth control pills and hormone replacement therapy
Benzodiazepines, sedatives that are often used for anxiety and insomnia
If you are taking one of these and you have a very low HDL level, ask your provider if you should continue to take them.
Diabetes can also lower your HDL level, so that gives you another reason to manage your diabetes.
HDL: The "Good" Cholesterol: MedlinePlus [accessed on Oct 08, 2018]
Cholesterol Levels: What You Need to Know: MedlinePlus [accessed on Oct 08, 2018]
High blood cholesterol levels: MedlinePlus Medical Encyclopedia [accessed on Oct 08, 2018]
Normal reference ranges can vary depending on the laboratory and the method used for testing. You must use the range supplied by the laboratory that performed your test to evaluate whether your results are "within normal limits."
Additional Materials (21)
HDL and LDL Molecules Subfractionization
The standard lipid profile, which measures the quantity of LDL and HDL cholesterol in the blood stream, has proven itself to be very useful in identifying many people who are risk for heart disease. But it doesn't catch everyone at risk. A more detailed lipid profile, called lipoprotein subfraction testing, divides the basic cholesterol groups into finer categories, which makes possible more accurate risk assessment. This interactive features all of the different tests involved in a lipid panel- HDL, LDL and VLDL, and the different subclasses for each.
Image by TheVisualMD
LDL particle
LDL (low-density lipoprotein or \"bad cholesterol\") along with HDL (high-density lipoprotein or \"good cholesterol\") are the two main types of cholesterol particles in the bloodstream. LDL is referred to as \"bad\" cholesterol because it forms deposits (plaque) in the lining of blood vessels. The size and density of the lipoprotein determines whether its cholesterol is classified as \"good: or \"bad\". Low-density lipoproteins (LDL) are larger, lighter, and fluffier; high-density lipoproteins (HDL) are small and dense. An LDL test is part of a lipid panel that measures total cholesterol, LDL, HDL, and triglycerides. Cholesterol tests do not diagnose heart disease; instead, they are used to estimate risk. And while cholesterol levels can vary widely among healthy individuals, the evidence suggests that low levels of LDL cholesterol decrease the risk of heart disease and stroke, while high levels of LDL increase that risk.
Image by TheVisualMD
Cholesterol, Healthy Heart
A heart-healthy lifestyle includes a diet based on the principles of balance, variety and moderation in the consumption of fats. Fats are essential nutrients and critical building blocks. The type of fat in a diet, however, turns out to be even more important than the total amount; there are \"good\" fats and \"bad\" dietary fats, just as there are \"good\" and \"bad\" types of cholesterol in our bloodstream. Other keys to cardiovascular health and wellbeing: get aerobic exercise, don't smoke, and drink alcohol only in moderation.
Image by TheVisualMD
Aerobic athletes in general, particularly lean ones, have lower LDL (or "bad" cholesterol) levels
There are many factors that can potentially influence cholesterol levels. Exercise may be an important one, though evidence is not definitive; studies have shown that endurance athletes have higher HDL (or \"good\" cholesterol) levels, and aerobic athletes in general, particularly lean ones, have lower LDL (or \"bad\" cholesterol) levels.
Image by TheVisualMD
Cross-Section View of HDL Lipoprotein
This image shows a cross-section of a globule of High Density-Lipoprotein (HDL). HDL has a large amount of protein, which makes it denser than other lipoproteins. The purple area shows protein content (33-57%), the off-white shell shows phospholipids (26-43%), and the yellow and red interior shows cholesterol (17-40%) and triglycerides (3-15%). HDL supplies two other lipoproteins-chylomicrons and VLDLs-with proteins that signal the liver to trap and extract their fat. HDL also sponges up excess cholesterol from blood vessel linings and carries it to the liver for removal. This reduces the risk of plaque build-up in the arteries and gives HDL its nickname \"good\" cholesterol.
Image by TheVisualMD
Cholesterol, Atherosclerotic Heart Disease
Atherosclerosis is a disease in which fatty deposits called plaque build up inside arteries; one of the components of plaque is LDL or \"bad\" cholesterol. Over time, plaque narrows the arteries, which limits the flow of oxygen-rich blood to the body; plaque in coronary arteries restricts blood supply to the heart. Plaque also makes the arterial walls stiff and less elastic, which is why a common term for artherosclerosis is \"hardening\" of the arteries. To try to clean up the mess, the endothelial cells that make up the inner lining send out chemical signals that summon inflammatory cells. These cells invade the area and engulf the fatty molecules, leaving behind the fatty streaks. If the levels of cholesterol don't drop, the buildup continues. The fats start to accumulate faster than the cleanup process can remove them and develop into noticeable deposits known as plaque. As the plaques grow, so do the problems. The bulging plaque reduces the diameter of the arteries, which decreases blood flow and increases blood pressure. As a defense, the arteries start shoring up, making more support cells to cope with the rising blood pressure. The arteries become less flexible; hence the description of the condition as hardening of the arteries.
Image by TheVisualMD
Cholesterol pathway
Cholesterol is essential for the maintenance of cell membranes, production of sex hormones, and absorption of key vitamins. We get cholesterol from the foods we eat (particularly red meat, dairy and eggs), but our livers produce most of it in a multi-step process (drugs like statins interrupt this process). Cholesterol is carried in the bloodstream in specialized packages called lipoproteins.
Image by TheVisualMD
Cholesterol Traveling Through Cell Membrane to HDL
This image shows the healthy membrane of an endothelial cell in a blood vessel wall. You can see the semi-permeable double layer of phospholipids that allows lipids to move across the membrane. The cholesterol molecules (yellow) maintain permeability by keeping the phospholipid tails from sticking together. Excess cholesterol molecules are passing through the phospholipid bilayer through passive, aqueous diffusion to a mature high-denisty lipoprotein (HDL) molecule. HDL is considered \"good\" cholesterol. The cell membrane benefits from this interaction with HDL and now has less cholesterol in the membrane. The HDL molecule carries the cholesterol away and back to the liver for recycling or degradation.
Image by TheVisualMD
High-Density Lipoprotein (HDL) Molecule
High-density lipoproteins, abbreviated HDL, are small and dense protein spheres that transport cholesterol, triglyceride, and other lipids through the bloodstream. Because the density of a protein bundle is associated with its ability to gather cholesterol from cells and transport it to the liver for eventual elimination, high-density lipoproteins are commonly referred to as the \"good\" cholesterol. A heart-healthy diet is rich in HDL sources. Wholesome foods that deliver Omega-3 fatty acids, antioxidants, and soluble fibers can raise HDL levels and provide numerous health benefits, including the warding off of life-threatening diseases.
Image by TheVisualMD
This browser does not support the video element.
What Is HDL and LDL Cholesterol?
This video explains the difference between HDL and LDL cholesterol. It also reveals what may occur when there are high levels of LDL in the body.LDL may stick to an artery's inner wall causing the build up of plaque, affecting blood flow. When an artery stiffens and constricts, aneurysm, heart attack, and stroke can occur.
Video by TheVisualMD
This browser does not support the video element.
Cardiovascular Inflammation
Heart disease is the number one killer of men and women in the U.S. The most common cause of heart attack, stroke, and cardiovascular death is atherosclerosis. Atherosclerosis is a chronic inflammatory response in the walls of arteries that leads to the hardening of arterial walls and the buildup of fatty deposits called plaques, or atheromas. Although the process of inflammation can be beneficial in other parts of the body, chronic inflammation within arterial walls is problematic as it seems to promote this underlying growth of plaque. The combination of arterial inflammation and the growth of plaque can lead to the rupture of the plaque, and result in a blood clot. Blood clots can lead to dangerous conditions such as heart attack or stroke.
Video by TheVisualMD
This browser does not support the video element.
Lipids, Heart Health and Baselining Your Health
Your blood "knows" what you eat, meaning that the cardiovascular system is a sensitive barometer of a person's health, including diet. What individuals eat is reflected in their blood chemistry and the health of their heart, arteries and vessels. Fats (also known as lipids), for example, are vital to health and wellbeing throughout our lives and yet they are mostly associated with obesity and cardiovascular disease. The problem is that not all fats (or cholesterol) are equal. They share basic chemical similarities, but they also have important differences, which, in turn, result in different roles and effects in the body. Tests that offer information on diet and heart health include total cholesterol, low-density lipoprotein (LDL or "bad" cholesterol), high-density lipoprotein (HDL or "good" cholesterol), and triglycerides.
Video by TheVisualMD
The 5 Most Important Molecules in Your Body
Video by SciShow/YouTube
Cholesterol Blood Test
Video by Baptist Health Physician Partners/YouTube
High Cholesterol Medical Animation (Hyperlipidemia)
Video by Silverback Video/YouTube
British Heart Foundation - Cholesterol and heart disease
Video by British Heart Foundation/YouTube
HDL: When Good Cholesterol Goes Bad
Video by UW Video/YouTube
Lipid Panel Interpretation
Video by FatIsNotYourFault/YouTube
Triglycerides and HDL
Video by Joslin Diabetes Center/YouTube
Tri HDL
Video by ACAP Health/YouTube
HDL Molecule
HDL Molecule
Image by TheVisualMD
HDL and LDL Molecules Subfractionization
TheVisualMD
LDL particle
TheVisualMD
Cholesterol, Healthy Heart
TheVisualMD
Aerobic athletes in general, particularly lean ones, have lower LDL (or "bad" cholesterol) levels
TheVisualMD
Cross-Section View of HDL Lipoprotein
TheVisualMD
Cholesterol, Atherosclerotic Heart Disease
TheVisualMD
Cholesterol pathway
TheVisualMD
Cholesterol Traveling Through Cell Membrane to HDL
TheVisualMD
High-Density Lipoprotein (HDL) Molecule
TheVisualMD
0:45
What Is HDL and LDL Cholesterol?
TheVisualMD
4:26
Cardiovascular Inflammation
TheVisualMD
2:46
Lipids, Heart Health and Baselining Your Health
TheVisualMD
7:55
The 5 Most Important Molecules in Your Body
SciShow/YouTube
3:06
Cholesterol Blood Test
Baptist Health Physician Partners/YouTube
1:19
High Cholesterol Medical Animation (Hyperlipidemia)
Silverback Video/YouTube
6:23
British Heart Foundation - Cholesterol and heart disease
British Heart Foundation/YouTube
54:59
HDL: When Good Cholesterol Goes Bad
UW Video/YouTube
1:16:38
Lipid Panel Interpretation
FatIsNotYourFault/YouTube
3:25
Triglycerides and HDL
Joslin Diabetes Center/YouTube
2:17
Tri HDL
ACAP Health/YouTube
HDL Molecule
TheVisualMD
Low Density Lipoprotein Test
Low Density Lipoprotein Test
Also called: LDL, LDL-C, LDL Cholesterol, Low-Density Lipoprotein Cholesterol
LDL, or low-density lipoprotein, is the "bad" cholesterol. A high LDL level can lead to a buildup of cholesterol in your arteries. Too much LDL is linked to heart disease and stroke.
Low Density Lipoprotein Test
Also called: LDL, LDL-C, LDL Cholesterol, Low-Density Lipoprotein Cholesterol
LDL, or low-density lipoprotein, is the "bad" cholesterol. A high LDL level can lead to a buildup of cholesterol in your arteries. Too much LDL is linked to heart disease and stroke.
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Use the slider below to see how your results affect your
health.
mg/dL
100
130
160
190
Your result is Optimal.
The optimal level of LDL has changed over time and depends on the number of risk factors you have for heart disease and stroke. Generally, you want your LDL to be low. It's possible to have extremely low levels of LDL, but this is rare.
Related conditions
Cholesterol is a waxy, fat-like substance that's found in all the cells in your body. Your liver makes cholesterol, and it is also in some foods, such as meat and dairy products. Your body needs some cholesterol to work properly. But having too much cholesterol in your blood raises your risk of coronary artery disease.
LDL and HDL are two types of lipoproteins. They are a combination of fat (lipid) and protein. The lipids need to be attached to the proteins so they can move through the blood. LDL and HDL have different purposes:
LDL stands for low-density lipoproteins. It is sometimes called the "bad" cholesterol because a high LDL level leads to a buildup of cholesterol in your arteries.
HDL stands for high-density lipoproteins. It is sometimes called the "good" cholesterol because it carries cholesterol from other parts of your body back to your liver. Your liver then removes the cholesterol from your body.
If you have a high LDL level, this means that you have too much LDL cholesterol in your blood. This extra LDL, along with other substances, forms plaque. The plaque builds up in your arteries; this is a condition called atherosclerosis.
Coronary artery disease happens when the plaque buildup is in the arteries of your heart. It causes the arteries to become hardened and narrowed, which slows down or blocks the blood flow to your heart. Since your blood carries oxygen to your heart, this means that your heart may not be able to get enough oxygen. This can cause angina (chest pain), or if the blood flow is completely blocked, a heart attack.
A blood test can measure your cholesterol levels, including LDL. When and how often you should get this test depends on your age, risk factors, and family history. The general recommendations are:
For people who are age 19 or younger:
The first test should be between ages 9 to 11
Children should have the test again every 5 years
Some children may have this test starting at age 2 if there is a family history of high blood cholesterol, heart attack, or stroke
For people who are age 20 or older:
Younger adults should have the test every 5 years
Men ages 45 to 65 and women ages 55 to 65 should have it every 1 to 2 years
Things that can affect your LDL level include
Diet. Saturated fat and cholesterol in the food you eat make your blood cholesterol level rise
Weight. Being overweight tends to raise your LDL level, lower your HDL level, and increase your total cholesterol level
Physical Activity. A lack of physical activity can lead to weight gain, which can raise your LDL level
Smoking. Cigarette smoking lowers your HDL cholesterol. Since HDL helps to remove LDL from your arteries, if you have less HDL, that can contribute to you having a higher LDL level.
Age and Gender. As women and men get older, their cholesterol levels rise. Before the age of menopause, women have lower total cholesterol levels than men of the same age. After the age of menopause, women's LDL levels tend to rise.
Genetics. Your genes partly determine how much cholesterol your body makes. High cholesterol can run in families. For example, familial hypercholesterolemia (FH) is an inherited form of high blood cholesterol.
Medicines. Certain medicines, including steroids, some blood pressure medicines, and HIV/AIDS medicines, can raise your LDL level.
Other medical conditions. Diseases such as chronic kidney disease, diabetes, and HIV/AIDS can cause a higher LDL level.
Race. Certain races may have an increased risk of high blood cholesterol. For example, African Americans typically have higher HDL and LDL cholesterol levels than whites.
With LDL cholesterol, lower numbers are better, because a high LDL level can raise your risk for coronary artery disease and related problems:
LDL (Bad) Cholesterol Level
LDL Cholesterol Category
Less than 100mg/dL
Optimal
100-129mg/dL
Near optimal/above optimal
130-159 mg/dL
Borderline high
160-189 mg/dL
High
190 mg/dL and above
Very High
There are two main ways to lower your LDL cholesterol:
Therapeutic lifestyle changes (TLC). TLC includes three parts:
Heart-healthy eating. A heart-healthy eating plan limits the amount of saturated and trans fats that you eat. Examples of eating plans that can lower your cholesterol include the Therapeutic Lifestyle Changes diet and the DASH eating plan.
Weight Management. If you are overweight, losing weight can help lower your LDL cholesterol.
Physical Activity. Everyone should get regular physical activity (30 minutes on most, if not all, days).
Drug Treatment. If lifestyle changes alone do not lower your cholesterol enough, you may also need to take medicines. There are several types of cholesterol-lowering drugs available, including statins. The medicines work in different ways and can have different side effects. Talk to your health care provider about which one is right for you. While you are taking medicines to lower your cholesterol, you still should continue with the lifestyle changes.
Some people with familial hypercholesterolemia (FH) may receive a treatment called lipoprotein apheresis. This treatment uses a filtering machine to remove LDL cholesterol from the blood. Then the machine returns the rest of the blood back to the person.
https://medlineplus.gov/ldlthebadcholesterol.html [accessed on Mar 01, 2019]
https://medlineplus.gov/ency/patientinstructions/000386.htm [accessed on Mar 01, 2019]
https://labtestsonline.org/tests/ldl-cholesterol [accessed on Mar 01, 2019]
https://my.clevelandclinic.org/health/articles/11920-cholesterol-numbers-what-do-they-mean [accessed on Mar 01, 2019]
Normal reference ranges can vary depending on the laboratory and the method used for testing. You must use the range supplied by the laboratory that performed your test to evaluate whether your results are "within normal limits."
Additional Materials (19)
Lipids and Lipoproteins
Lipids and Lipoproteins
Image by TheVisualMD
Lipid Absorption
Lipid Absorption
Image by OpenStax College
Cholesterol
Cholesterol is a soft, waxy, fatty substance that's found naturally in every cell in your body. It's categorized as a lipid-that is, a fat, oil, or wax that won't dissolve in water. Cholesterol is necessary for your body's health because it helps to make cell membranes, digest fats, and produce vitamin D and various steroid hormones. Your bloodstream transports cholesterol throughout your body bound to water-soluble particles called lipoproteins.
Image by TheVisualMD
Lipids & Fats
Image by TheVisualMD
Lipids & Fats
Lipids & Fats
Image by TheVisualMD
Anatomy of a Lipoprotein
Lipoproteins transport cholesterol, triglycerides, or other lipids through the bloodstream. Lipoproteins are protein spheres that consist of a core of triglycerides and cholesterol esters, surrounded by a shell made up of water-soluble phospholipids with embedded proteins and cholesterol. The lipid-laden core of the lipoprotein is insoluble in aqueous (water-based) blood, so the phospholipid-protein shell is necessary to allow the lipoprotein to float freely in the bloodstream.
Image by TheVisualMD
Anatomy of a Lipoprotein
Lipoproteins transport cholesterol, triglycerides, or other lipids through the bloodstream. Lipoproteins are protein spheres that consist of a core of triglycerides and cholesterol esters, surrounded by a shell made up of water-soluble phospholipids with embedded proteins and cholesterol. The lipid-laden core of the lipoprotein is insoluble in aqueous (water-based) blood, so the phospholipid-protein shell is necessary to allow the lipoprotein to float freely in the bloodstream.
Image by TheVisualMD
Dr. Tara Dall discusses LDL, LDL Cholesterol (LDL-C) & LDL Particles (LDL-P)
Video by AdvLip/YouTube
What Is HDL and LDL Cholesterol?
This video explains the difference between HDL and LDL cholesterol. It also reveals what may occur when there are high levels of LDL in the body.LDL may stick to an artery's inner wall causing the build up of plaque, affecting blood flow. When an artery stiffens and constricts, aneurysm, heart attack, and stroke can occur.
Image by TheVisualMD
The New Marker for Heart Disease that is BETTER than LDL Cholesterol
Video by Dr. Adrian Chavez/YouTube
% Small Dense LDL Cholesterol
The predominance of small, dense low-density lipoprotein (LDL) is now recognized as a serious cardiovascular risk factor by the National Cholesterol Education Program Adult Treatment Panel. Research showed that the predominance of small, dense LDL is associated with an increased risk of coronary artery disease (CAD).
Image by TheVisualMD
This browser does not support the video element.
What Is HDL and LDL Cholesterol?
This video explains the difference between HDL and LDL cholesterol. It also reveals what may occur when there are high levels of LDL in the body.LDL may stick to an artery's inner wall causing the build up of plaque, affecting blood flow. When an artery stiffens and constricts, aneurysm, heart attack, and stroke can occur.
Video by TheVisualMD
HDL and LDL Cholesterol Sub-fraction, Heart Disease
The standard lipid profile, which measures the quantity of LDL (\"bad\") and HDL (\"good\") cholesterol in the bloodstream, has proven itself to be useful in identifying many people who are at risk for heart disease. But it doesn't catch everyone at risk. A more detailed lipid profile, called lipoprotein sub-fraction testing, categorizes cholesterol particles according to their size and density. Such testing is more sensitive and is especially useful for people who have a strong family history of heart disease. Heart attack (myocardial infarction) is a condition when blood flow to the heart is reduced or blocked. Heart cells die when the blood supply is cut off; the longer the blood supply is cut off, the greater the area of heart damage.
Image by TheVisualMD
Low Density Lipoprotein: Arterial Wall
It's estimated that there are nearly 100,000 miles of arteries in an adult body. The walls of these arteries are composed of fibroblasts, smooth muscle cells, elastica interna, and an endothelial cell layer.
Image by TheVisualMD
Constantly High Levels Of Insulin Causes Weight Gain
Tap each number for a closer look at the process of fat storage and usage.
Interactive by TheVisualMD
Low Density Lipoprotein: Clogged Arteries (Atherosclerosis) / Plaque in Coronary Artery, close up
Plaque in Coronary Artery / Leading to a Heart Attack
1) Plaque in Coronary Artery - In this image, a tiny coronary artery has been cross-sectioned to reveal a stenosis, or narrowing, caused by fatty deposits in the blood stream. Plaque in a coronary artery may break apart, and the resulting release of platelet adhesion-enhancing substances encourages clots to form on the plaque surface. The clot may then block the flow of blood through the already narrowed artery. Having this condition present in the coronary arteries is particularly dangerous because these are the arteries that wrap around the surface of the heart and supply the organ itself with oxygen and nutrients needed to pump blood to the entire body.
2) Leading to a Heart Attack - In this image, a tiny coronary artery has been cross-sectioned to reveal a stenosis, or narrowing, caused by fatty deposits in the blood stream. It is evident that this stenosis has advanced such that tissue necrosis, or death, has occurred in the area upstream from the blockage. Plaque in a coronary artery may break apart, and the resulting release of platelet adhesion-enhancing substances encourages clots to form on the plaque surface. The clot may then block the flow of blood through the already narrowed artery. Having this condition present in the coronary arteries is particularly dangerous because these are the arteries that wrap around the surface of the heart and supply the organ itself with oxygen and nutrients needed to pump blood to the entire body. This heart has been severely injured and the individual is at a high risk for heart attack.
Lp-PLA2 (or lipoprotein-associated phospholipase A2) is an enzyme produced by specialized immune cells called macrophages that engulf and destroy pathogens, foreign particles, aging cells and biological debris. Most of the Lp-PLA2 in the body is bound to LDL (or `bad` cholesterol) and the enzyme, like LDL, is linked to inflammation and the formation of plaques on blood vessel walls. Because Lp-PLA2 is very specifically linked to inflammation of blood vessels rather than inflammation that is systemic (throughout the body), it is a particularly good biomarker for vessel health.
Image by TheVisualMD
Oleic Acid Molecule
Oleic acid is a monounsaturated Omega-9 fatty acid found in animal and vegetable fats. Monounsaturated fats have one double bond between carbon atoms in the chain and polyunsaturated fats have more than one double bond. These fats lower the risk of heart disease by reducing levels of low-density lipoprotein (LDL, or "bad" cholesterol) in the blood. In this model, carbon atoms are dark gray, hydrogen atoms are white, and oxygen atoms are red. Interactive also available on white background.
Image by TheVisualMD
Lipoprotein(a) Molecule
The test for Lipoprotein(a) is used to help assess an individual's risk of developing cardiovascular disease. Unlike other risk factors for heart disease, however, Lp(a) levels are largely genetically determined and remain fairly stable over a person's life; they are also relatively resistant to treatment by either lifestyle changes or drugs. So why test for it? Because it is additional risk factor that can flag patients and their doctors to take an aggressive approach towards other, more treatable risk factors.
Image by TheVisualMD
Lipids and Lipoproteins
TheVisualMD
Lipid Absorption
OpenStax College
Cholesterol
TheVisualMD
Lipids & Fats
TheVisualMD
Lipids & Fats
TheVisualMD
Anatomy of a Lipoprotein
TheVisualMD
Anatomy of a Lipoprotein
TheVisualMD
8:37
Dr. Tara Dall discusses LDL, LDL Cholesterol (LDL-C) & LDL Particles (LDL-P)
AdvLip/YouTube
What Is HDL and LDL Cholesterol?
TheVisualMD
5:19
The New Marker for Heart Disease that is BETTER than LDL Cholesterol
Dr. Adrian Chavez/YouTube
% Small Dense LDL Cholesterol
TheVisualMD
0:45
What Is HDL and LDL Cholesterol?
TheVisualMD
HDL and LDL Cholesterol Sub-fraction, Heart Disease
TheVisualMD
Low Density Lipoprotein: Arterial Wall
TheVisualMD
Constantly High Levels Of Insulin Causes Weight Gain
TheVisualMD
Plaque in Coronary Artery / Leading to a Heart Attack
Also called: VLDL-C, VLDL, Very Low Density Lipoprotein
VLDL stands for very low-density lipoprotein. Lipoproteins are particles that carry fat in the bloodstream. Like LDL cholesterol, VLDL cholesterol is considered a type of "bad" cholesterol. Testing for VLDL cholesterol can be used to assess a person's cardiovascular risk.
VLDL Cholesterol Test
Also called: VLDL-C, VLDL, Very Low Density Lipoprotein
VLDL stands for very low-density lipoprotein. Lipoproteins are particles that carry fat in the bloodstream. Like LDL cholesterol, VLDL cholesterol is considered a type of "bad" cholesterol. Testing for VLDL cholesterol can be used to assess a person's cardiovascular risk.
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Use the slider below to see how your results affect your
health.
mg/dL
30
Your result is Normal.
Normal results may vary based on the laboratory and the method used.
Related conditions
Lipoproteins are the particles that transport fat and lipids (cholesterol and triglycerides) in the bloodstream.VLDL-cholesterol is produced in the liver, and from there it gets released into the blood to provide the body tissues with triglycerides.
Since about half of VLDL particles consist of triglycerides, this kind of structure makes VLDL particles very easy to anchor to the walls of arteries and eventually block the blood flow. These blockages may lead to atherosclerosis and heart disease. Therefore, VLDL-cholesterol is considered to be “bad” cholesterol.
The VLDL-cholesterol (very low-density lipoprotein cholesterol) test is part of a lipid (fats) profile to assess a person's risk for heart disease.
The values of VLDL cholesterol are usually estimated based on the triglyceride values. The calculation to estimate the values are as follows:
Divide the triglyceride value by 5 in case the result is given in mg/dL
Divide the triglyceride value by 2.2 in case the result is given in mmol/L.
Testing for VLDL is mainly done to assess a person's risk of developing atherosclerosis (decreased blood flow through the arteries due to a build-up of cholesterol and lipids) and heart disease.
A VLDL test is not normally used as a screening test; therefore, is not indicated in all cases. However, if you happen to have normal or slightly elevated LDL-C (low-density lipoprotein cholesterol) levels, and you have a personal or family history of heart disease at a young age, your doctor may want to use this test to assess your risk of cardiovascular disease (CVD).
Similarly, if you have certain chronic conditions such as high blood pressure or type 2 diabetes, your doctor may also want to measure your VLDL levels to help determine your CVD risk.
Please note that VLDL is always ordered together with other lipid analysis (total cholesterol, HDL, LDL, and triglycerides).
A needle will be used to draw a small amount of blood from a vein in your arm; this usually takes only a few seconds to be done.
You will need to fast for at least 9 to 12 hours and avoid consuming alcohol for at least 24 hours before the test. Usually, no other special preparations are needed.
The risks are related only to the blood extraction procedure, including a little bleeding, temporary pain or discomfort, bruising, or local infection.
A normal VLDL value is considered to be up to 30 mg/dL or 0.77 mmol/L.
An increased VLDL value indicates that you have an increased risk of developing coronary heart disease (stroke, heart attack). Therefore, you need to change some lifestyle habits to lower your blood lipid levels.
If a person's triglyceride value is higher than 40 mg/dL (4.5 mmol/L), the VLDL calculation does not apply because other lipids can interfere with the result.
There is a possibility to measure VLDL levels directly, but these techniques are expensive and difficult to perform. Therefore, they are mostly used for research purposes.
Doing regular exercise and maintaining a healthy diet normally helps in decreasing the levels of lipids (fats) in the blood.
VLDL Cholesterol. MedlinePlus. [accessed on Oct 31, 2018]
VLDL Cholesterol - Health Encyclopedia - University of Rochester Medical Center [accessed on Oct 31, 2018]
VLDL Cholesterol. Lab Tests Online. [accessed on Oct 31, 2018]
VLDL cholesterol: Is it harmful? Mayo Clinic. [accessed on Oct 31, 2018]
Normal reference ranges can vary depending on the laboratory and the method used for testing. You must use the range supplied by the laboratory that performed your test to evaluate whether your results are "within normal limits."
Additional Materials (17)
What Is HDL and LDL Cholesterol?
This video explains the difference between HDL and LDL cholesterol. It also reveals what may occur when there are high levels of LDL in the body.LDL may stick to an artery's inner wall causing the build up of plaque, affecting blood flow. When an artery stiffens and constricts, aneurysm, heart attack, and stroke can occur.
Image by TheVisualMD
This browser does not support the video element.
Cholesterol & Atherosclerosis
While the term technically refers to any disease that affects the cardiovascular system (as used in MeSH), it is usually used to refer to those related to atherosclerosis (arterial disease). Everyone talks about high cholesterol and how bad it is for you. But why is it bad for you? Where does it come from? What's the difference between "good" and "bad" cholesterol? Take a journey inside the body and explore its vessels, as world-renowned doctors explain what cholesterol is all about and how it contributes to hardening of the arteries, a dangerous condition also known as atherosclerosis.
Video by TheVisualMD
Lipoprotein in the Blood Stream
Lipoprotein in the Blood Stream
Image by TheVisualMD
Lipids
Cross section of the different structures that phospholipids can take in a aqueous solution. The circles are the hydrophilic heads and the wavy lines are the fatty acyl side chains.
Image by Mariana Ruiz Villarreal , LadyofHats
Lipids and Lipoproteins
Lipids and Lipoproteins
Image by TheVisualMD
Chylomicron structure - ApoA, ApoB, ApoC, ApoE (apolipoproteins); T (triacylglycerol); C (cholesterol); green (phospholipids)
Chylomicron structure - ApoA, ApoB, ApoC, ApoE (apolipoproteins); T (triacylglycerol); C (cholesterol); green (phospholipids)
Image by Xvazquez
Total Cholesterol Rotation (HDL, LDL, and VLDL Molecules)
A test for total cholesterol is an overall measure of “good” as well as “bad” cholesterol. A lipoprotein (from the Greek lipos, for fat) is a fat-and-protein package that enables fats and cholesterol to move freely within the bloodstream (fats and blood, like oil and water, do not mix). Proteins and other components make up the outer shell of the lipoprotein; cholesterol and other fats are packed together inside. The size and density of the lipoprotein determines whether its cholesterol is classified as “good” or “bad.” This interactive features 3 lipoproteins: very high density lipoprotein (VLDL) which is the largest molecule, low-density lipoproteins (LDL) which is the medium-sized molecule, and high-density lipoproteins (HDL), which are the smallest and most dense.
Image by TheVisualMD
Controlling Cholesterol
Controlling Cholesterol with Medicine
Image by TheVisualMD
Controlling Cholesterol
Controlling Cholesterol with Medicine
Image by TheVisualMD
Lipid Absorption
Lipid Absorption
Image by OpenStax College
Lipids
The membrane that surrounds a cell is made up of proteins and lipids. Depending on the membrane's location and role in the body, lipids can make up anywhere from 20 to 80 percent of the membrane, with the remainder being proteins. Cholesterol (green), which is not found in plant cells, is a type of lipid that helps stiffen the membrane.
Image by Judith Stoffer - NIH National Institute of General Medical Sciences
Cholesterol pathway
Cholesterol pathway
Image by TheVisualMD
Liver and Lipoproteins
Liver and Lipoproteins
Image by TheVisualMD
Liver and Lipoproteins
Liver and Lipoproteins
Image by TheVisualMD
VLDL
VLDL 1
Image by Servier Medical Art
Dimensions of lipoproteins
Dimensions of lipoproteins
Image by Peter Forster
Lipid Metabolism
Lipid logistics: transport of triglycerides and cholesterol in organisms in form of lipoproteins as chylomicrons, VLDL, LDL, IDL, HDL.
Image by Peter Forster
What Is HDL and LDL Cholesterol?
TheVisualMD
3:08
Cholesterol & Atherosclerosis
TheVisualMD
Lipoprotein in the Blood Stream
TheVisualMD
Lipids
Mariana Ruiz Villarreal , LadyofHats
Lipids and Lipoproteins
TheVisualMD
Chylomicron structure - ApoA, ApoB, ApoC, ApoE (apolipoproteins); T (triacylglycerol); C (cholesterol); green (phospholipids)
Xvazquez
Total Cholesterol Rotation (HDL, LDL, and VLDL Molecules)
TheVisualMD
Controlling Cholesterol
TheVisualMD
Controlling Cholesterol
TheVisualMD
Lipid Absorption
OpenStax College
Lipids
Judith Stoffer - NIH National Institute of General Medical Sciences
Cholesterol pathway
TheVisualMD
Liver and Lipoproteins
TheVisualMD
Liver and Lipoproteins
TheVisualMD
VLDL
Servier Medical Art
Dimensions of lipoproteins
Peter Forster
Lipid Metabolism
Peter Forster
Non-HDL Cholesterol Test
Non-HDL Cholesterol Test
Also called: Non-HDL-C, Non-High Density Lipoprotein Cholesterol
Under certain conditions, the risk of developing coronary heart disease (strokes, heart attack) cannot be properly assessed only by looking at the lipids test results. In these cases, the non-HDL cholesterol can be used to assess of how high a person's cardiovascular risk is.
Non-HDL Cholesterol Test
Also called: Non-HDL-C, Non-High Density Lipoprotein Cholesterol
Under certain conditions, the risk of developing coronary heart disease (strokes, heart attack) cannot be properly assessed only by looking at the lipids test results. In these cases, the non-HDL cholesterol can be used to assess of how high a person's cardiovascular risk is.
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Use the slider below to see how your results affect your
health.
mg/dL
130
159
189
219
Your result is Desirable.
You have optimal levels of non-HDL cholesterol; therefore, your cardiovascular risk is considered to be low.
Related conditions
Cholesterol is a type of fat (lipid) that is necessary for the maintenance of some body functions, like for instance the production of hormones. Cholesterol travels through the blood attached to certain proteins called lipoproteins.
There are two main types of lipoproteins, which are low-density lipoprotein cholesterol (LDL-C) also known as “bad cholesterol,” and high-density lipoprotein cholesterol (HDL-C) also known as “good cholesterol.”
LDL-C moves cholesterol into your arteries, hence increasing your risk of developing coronary heart disease (CHD); while HDL-C carries away excess cholesterol out of your arteries, therefore decreasing your risk for CHD.
Nevertheless, there are other minor lipoproteins that are also involved in the development of CHD, such as very low-density lipoprotein (VLDL) and intermediate-density lipoprotein (IDL). This is the reason why the non-cholesterol levels reflect better the risk of developing CHD.
Non-HDL cholesterol is calculated by subtracting your levels of HDL cholesterol from your total cholesterol levels.
Total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides are usually part of a lipid profile test, which is used to monitor and screen for unhealthy levels of fats in the blood.
If you have borderline results or imbalanced lipid levels, your doctor may want to know what your non-HDL cholesterol is, since it can provide more information about your overall CHD risk.
Every person with no risk factors for heart disease should get tested at least every five years as part of a routine check-up. When one or more risk factors for heart disease are associated, the test should be done more frequently.
Risk factors for cardiovascular disease include:
Unbalanced diet
Physical inactivity (sedentarism)
Being overweight or obese
More than 50 years of age in women
More than 45 years of age in men
Cigarette smoking
Diabetes
High blood pressure
Family history of early heart disease
Previously diagnosed heart disease
A small amount of blood will be drawn from a vein in your arm by using a needle.
You will need to fast for at least 9 to 12 hours before the test. Usually, no other special preparations are needed.
Only the risks related to blood extraction, which are temporary discomfort, bruising, little bleeding, and risk of infection in the place where the needle was inserted.
Optimal non-HDL cholesterol levels are 130 mg/dL (3.37 mmol/L) for adults and 120 mg/dL (3.11 mmol/L) for children and teenagers.
Test results may vary depending on several factors, such as the method used by the laboratory, your age, gender, and medical history. Ask your healthcare provider what your test results mean in your specific case.
High levels of non-HDL-C are related to an increased risk of developing coronary heart disease (CHD), which includes heart attack and stroke.
This test is not diagnostic, but it’s rather used to evaluate a person’s risk to develop CVD.
Doc's Opinion: Non-HDL Cholesterol (Non-HDL-C) [accessed on Oct 03, 2018]
URMC / Encyclopedia / Lipid Panel with Non-HDL Cholesterol [accessed on Oct 03, 2018]
LPNF1 - Clinical: Lipid Panel, Non-Fasting, Serum [accessed on Oct 03, 2018]
Non-High Density Lipoprotein Cholesterol | Lab Tests Online [accessed on Oct 03, 2018]
344265: Non-HDL Cholesterol Profile | LabCorp [accessed on Oct 03, 2018]
Normal reference ranges can vary depending on the laboratory and the method used for testing. You must use the range supplied by the laboratory that performed your test to evaluate whether your results are "within normal limits."
Additional Materials (30)
Cholesterol Numbers - Mayo Clinic
Video by Mayo Clinic/YouTube
What is Cholesterol?
Video by American Heart Association/YouTube
How to Read and Understand Your Cholesterol Levels – Dr.Berg
Video by Dr. Eric Berg DC/YouTube
What Does My Non HDL Score Mean
Video by PreDiabetes Centers/YouTube
Recommended Cholesterol Levels
Video by AllHealthGo/YouTube
Supersize sperm from the past
Video by nature video/YouTube
A Return to Specific LDL-Cholesterol Goals
Video by Mayo Clinic/YouTube
At a Glance: What You Need To Know About High Blood Cholesterol
High blood cholesterol is one of the major risk factors for heart disease. In fact, the higher your blood
cholesterol, the greater your risk of developing heart
disease or having a heart attack. Heart disease is the
#1 killer of men and women in the United States.
Each year, more than a million Americans have a
heart attack, and about half a million people die of
heart disease.
Document by National Heart, Lung, and Blood Institute (NHLBI)
Your Guide to A Healthy Heart
Document by www.nhlbi.nih.gov
Nutrition Facts Label: Cholesterol
Cholesterol is a nutrient to get less of.
Document by Food and Drug Administration (FDA)
High Blood Cholesterol: What you need to know
Your blood cholesterol level has a lot to do with
your chances of getting heart disease.
Document by National Heart, Lung, and Blood Institute
On the Move to Better Heart Health for African Americans
Learn how to reduce your chances of having a heart attack or stroke by reducing your sodium intake. Includes healthy food choices, cooking ideas, information on shopping and reading food labels.
Document by www.nhlbi.nih.gov
Cholesterol Conversation Starters
Cholesterol can be a confusing health topic for a lot of people, but understanding and managing high blood cholesterol is an important step in taking control of heart health.
Document by Centers for Disease Control and Prevention (CDC)
Depression--Medicines To Help You
Do you feel depressed? Do not feel ashamed. Women are more likely than men to feel depressed. About 1 woman in 5 has depression in the U.S.
Document by FDA
What Is HDL and LDL Cholesterol?
This video explains the difference between HDL and LDL cholesterol. It also reveals what may occur when there are high levels of LDL in the body.LDL may stick to an artery's inner wall causing the build up of plaque, affecting blood flow. When an artery stiffens and constricts, aneurysm, heart attack, and stroke can occur.
Image by TheVisualMD
Cholesterol, Heart and Liver
Cholesterol is essential for the maintenance of cell membranes, production of sex hormones, and absorption of key vitamins. We get cholesterol from the foods we eat, but our livers produce most of it. There are two main types of cholesterol particles found in the bloodstream: HDL (high-density lipoprotein, or \"good\" cholesterol); and LDL (low-density lipoprotein, or \"bad\" cholesterol). LDL is referred to as bad cholesterol because it leads to the formation of plaque deposits that can clog arteries and increase the risk of heart disease.
Image by TheVisualMD
Bile Acid Sequestrant
Bile-acid sequestrants, also known as bile-acid resins, bind in the intestines with bile acids, which are produced by converting cholesterol. Bile acids are then eliminated in the stool, stimulating the liver to convert more cholesterol into bile acids, thereby lowering LDL-cholesterol levels. This is one mechanism of action that can be effective in lowering one's cholesterol and reducing one's risk of atherosclerosis and cardiovascular disease.
Image by TheVisualMD
Cholesterol Sources with Anatomy
Cholesterol is made by your own body. It is also found in food products derived from animals. Cholesterol is used to make bile acids in the liver, necessary for fat digestion. Cholesterol is constantly transported in the bloodstream between the liver and all the body's tissues. HDL-cholesterol helps clear excess cholesterol from your body. LDL-cholesterol is ingested by cells in need of cholesterol. LDL particles of the Pattern A type are larger and less dense and may be harmless. LDL particles of the Pattern B type, however, are smaller and more dense and can penetrate through the lining of an artery and into its interior. Oxidized LDL particles (oxLDL) can cause major damage.
Image by TheVisualMD
Cholesterol and Statins Infographic
Cholesterol and Statins Infographic
Image by FDA
Vessel Plaque Caused by Cholesterol
HDL, high density lipoprotein, is known as the body's \"good cholesterol\". It is a protein secreted by the liver that travels through the blood stream, picking up up excess cholesterol in the blood and transporting it to the liver for elimination from the body. It is favorable to have a high HDL count, as these are the molecules responsible for eliminating cholesterol from the blood, thereby preventing the fat from building up and causing complications such as atherosclerosis. LDL on the other hand, is the protein that transport cholesterol TO cells. Having a high LDL signifies that too much cholesterol is being delivered to cells, and the HDL may not be able to keep up with it. In this image, a flap of an artery in the body is cut open to reveal fatty deposits of cholesterol in the artery wall.
Image by TheVisualMD
Statin's effect on Cholesterol
Statin's effect on Cholesterol
Image by TheVisualMD
Fibrate Molecule
Fibrates lower triglyceride and modestly increase HDL levels by reducing the liver's VLDL production. VLDL is a type of \"bad cholesterol\", and stands for \"very low-density lipoprotein\". These molecules transport cholesterol to body cells and are what become dangerous to the body in excess. Fibrate plays a role in production of LDL that has a higher than usual affinity for LDL-receptors, gateways into cells from the blood stream. This means that LDL's are removed from the blood stream more frequently, thereby decreasing the risk of cholesterol buildup in the walls of arteries.
Image by TheVisualMD
Cholesterol Molecule
Cholesterol is a fatlike substance produced naturally by your body and is necessary for its health. Cholesterol is transported in your bloodstream throughout your system, bound to water-soluble particles called lipoproteins. LDL (low-density lipoproteins) transport cholesterol from the liver to body cells, while HDL (high-density lipoproteins) transport cholesterol from cells back to the liver. Cholesterol is used by cells to contribute to the structure of plasma membranes and is a precursor to many steroid hormones, bile acids, and vitamin D. It is important to have healthy levels of cholesterol, however, as the blood vessels through which the molecule travels around the body are suseptible to buildup of fat. This can lead to hardening of the arteries, or atherosclerosis.
Image by TheVisualMD
Cholesterol in the Bloodstream
Cholesterol is a fat-like substance that is transported through the bloodstream throughout the entire circulatory system. It is bound to water-soluble particles called liproproteins. Plaque buildup is characteristic of atherosclerosis, and can happen as a result of fatty materials such as cholesterol in the blood. As the cholesterol travels through the blood stream, it sticks to the artery walls and accumulates over time. It becomes hard and calcified, leading to detrimental results. Cholesterol builds up in the walls of the arteries around the body, often blocking blood supply to the vital areas. Seen in this image is a cut-away into an artery in the body where the hardened, fatty material has accumulated in the lumen, or opening. This plaque impedes on the necessary tube structure of the artery, preventing blood from flowing through. As a result, one can experience poor circulation or tissue death in the part of the body where that artery's destination lies.
Image by TheVisualMD
Anatomy of a Lipoprotein
Lipoproteins transport cholesterol, triglycerides, or other lipids through the bloodstream. Lipoproteins are protein spheres that consist of a core of triglycerides and cholesterol esters, surrounded by a shell made up of water-soluble phospholipids with embedded proteins and cholesterol. The lipid-laden core of the lipoprotein is insoluble in aqueous (water-based) blood, so the phospholipid-protein shell is necessary to allow the lipoprotein to float freely in the bloodstream.
Image by TheVisualMD
Anatomy of a Lipoprotein
Lipoproteins transport cholesterol, triglycerides, or other lipids through the bloodstream. Lipoproteins are protein spheres that consist of a core of triglycerides and cholesterol esters, surrounded by a shell made up of water-soluble phospholipids with embedded proteins and cholesterol. The lipid-laden core of the lipoprotein is insoluble in aqueous (water-based) blood, so the phospholipid-protein shell is necessary to allow the lipoprotein to float freely in the bloodstream.
Image by TheVisualMD
Anatomy of a Lipoprotein
Lipoproteins transport cholesterol, triglycerides, or other lipids through the bloodstream. Lipoproteins are protein spheres that consist of a core of triglycerides and cholesterol esters, surrounded by a shell made up of water-soluble phospholipids with embedded proteins and cholesterol. The lipid-laden core of the lipoprotein is insoluble in aqueous (water-based) blood, so the phospholipid-protein shell is necessary to allow the lipoprotein to float freely in the bloodstream.
Image by TheVisualMD
Anatomy of a Lipoprotein
Lipoproteins transport cholesterol, triglycerides, or other lipids through the bloodstream. Lipoproteins are protein spheres that consist of a core of triglycerides and cholesterol esters, surrounded by a shell made up of water-soluble phospholipids with embedded proteins and cholesterol. The lipid-laden core of the lipoprotein is insoluble in aqueous (water-based) blood, so the phospholipid-protein shell is necessary to allow the lipoprotein to float freely in the bloodstream.
Image by TheVisualMD
Cholesterol is Everywhere
The human body contains about 100-150 g of cholesterol, most of it incorporated into cell membranes. One of the other major uses of cholesterol is the production of bile acids (also known as bile salts) in the liver. Bile contains a number of ingredients, including water, cholesterol, and bile acids. Bile is necessary for the absorption of fats from fecal matter passing through the intestine.
Image by TheVisualMD
Controlling Cholesterol
Doctors generally recommend lifestyle changes as the first line of defense against cholesterol levels and atherosclerosis. In addition, one or more of the following drugs may be prescribed:
Image by TheVisualMD
2:16
Cholesterol Numbers - Mayo Clinic
Mayo Clinic/YouTube
2:54
What is Cholesterol?
American Heart Association/YouTube
8:15
How to Read and Understand Your Cholesterol Levels – Dr.Berg
Dr. Eric Berg DC/YouTube
0:51
What Does My Non HDL Score Mean
PreDiabetes Centers/YouTube
2:12
Recommended Cholesterol Levels
AllHealthGo/YouTube
1:58
Supersize sperm from the past
nature video/YouTube
10:36
A Return to Specific LDL-Cholesterol Goals
Mayo Clinic/YouTube
At a Glance: What You Need To Know About High Blood Cholesterol
National Heart, Lung, and Blood Institute (NHLBI)
Your Guide to A Healthy Heart
www.nhlbi.nih.gov
Nutrition Facts Label: Cholesterol
Food and Drug Administration (FDA)
High Blood Cholesterol: What you need to know
National Heart, Lung, and Blood Institute
On the Move to Better Heart Health for African Americans
www.nhlbi.nih.gov
Cholesterol Conversation Starters
Centers for Disease Control and Prevention (CDC)
Depression--Medicines To Help You
FDA
What Is HDL and LDL Cholesterol?
TheVisualMD
Cholesterol, Heart and Liver
TheVisualMD
Bile Acid Sequestrant
TheVisualMD
Cholesterol Sources with Anatomy
TheVisualMD
Cholesterol and Statins Infographic
FDA
Vessel Plaque Caused by Cholesterol
TheVisualMD
Statin's effect on Cholesterol
TheVisualMD
Fibrate Molecule
TheVisualMD
Cholesterol Molecule
TheVisualMD
Cholesterol in the Bloodstream
TheVisualMD
Anatomy of a Lipoprotein
TheVisualMD
Anatomy of a Lipoprotein
TheVisualMD
Anatomy of a Lipoprotein
TheVisualMD
Anatomy of a Lipoprotein
TheVisualMD
Cholesterol is Everywhere
TheVisualMD
Controlling Cholesterol
TheVisualMD
Total Cholesterol/HDL Ratio
Total Cholesterol/HDL Ratio
Also called: TC/HDL ratio, Cholesterol ratio
The total cholesterol to HDL cholesterol ratio is a number that is helpful in predicting atherosclerosis, the process of fatty buildup in the walls of the arteries. The number is obtained by dividing total cholesterol by HDL (good) cholesterol.
Total Cholesterol/HDL Ratio
Also called: TC/HDL ratio, Cholesterol ratio
The total cholesterol to HDL cholesterol ratio is a number that is helpful in predicting atherosclerosis, the process of fatty buildup in the walls of the arteries. The number is obtained by dividing total cholesterol by HDL (good) cholesterol.
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Use the slider below to see how your results affect your
health.
{ratio}
3.5
5
Your result is Normal.
The optimum ratio is 3.5.
Related conditions
Cholesterol is a type of fat (lipid) that is necessary for the maintenance of some body functions, like for instance the production of hormones. Cholesterol travels through the blood attached to certain proteins called lipoproteins.
There are two main types of lipoproteins, which are low-density lipoprotein cholesterol (LDL-C) also known as “bad cholesterol,” and high-density lipoprotein cholesterol (HDL-C) also known as “good cholesterol.”
LDL-C moves cholesterol into your arteries, hence increasing your risk of developing coronary heart disease (CHD); while HDL-C carries away excess cholesterol out of your arteries, therefore decreasing your risk for CHD.
To calculate your cholesterol ratio, divide your total cholesterol number by your HDL cholesterol number.
Total cholesterol, HDL-C, LDL-C, and triglycerides are usually part of a lipid profile test, which is used to monitor and screen for unhealthy levels of fats in the blood.
If you have borderline results or very imbalance lipid levels, your doctor may want to know what your total cholesterol to HDL ratio is, since it can provide more information about your overall CHD risk.
Every person with no risk factors for heart disease should get tested at least every five years as part of a routine check-up. When one or more risk factors for heart disease are associated, the test should be done more frequently.
Cardiovascular disease risk factors include:
Unbalanced diet
Being overweight or obese
Physical inactivity (sedentarism)
More than 50 years of age in women
More than 45 years of age in men
Cigarette smoking
Diabetes
High blood pressure
Family history of early heart disease
Already diagnosed heart disease
A small amount of blood will be drawn from a vein in your arm by using a needle.
In some cases,fasting for at least 9 to 12 hours is necessary. Follow your healthcare provider instructions.
Only the risks related to blood extraction, which are temporary discomfort, bruising, little bleeding, and risk of infection in the place where the needle was inserted.
Total cholesterol ranges in adults are:
Normal: less than 200 mg/dL.
Borderline high: from 200 to 239 mg/dL.
High: equal or greater than 240 mg/dL.
HDL levels in adults are:
Low: less than 40 mg/dL in men, and less than 50 mg/dL in women.
Acceptable: from 40 to 50 mg/dL in men, and from 50 to 59 mg/dL in women.
Optimal: equal or greater than 60 mg/dL.
An acceptable cholesterol ratio in adults is considered to be below 5 to 1 (5:1). While an optimal ratio is below 3.5 to 1 (3.5:1). The higher the ratio, the higher is the risk of developing CHD.
For example, if a person has a total cholesterol level of 230 mg/dL and an HDL level of 40 mg/dL (total cholesterol to HDL ratio: 230/40), the resulting ratio would be of 5.7 (or 5.7:1). This person does not have an acceptable ratio and therefore has an increased risk of developing CHD.
Lipid Panel with Total Cholesterol: HDL Ratio - Health Encyclopedia - University of Rochester Medical Center [accessed on Oct 08, 2018]
Normal reference ranges can vary depending on the laboratory and the method used for testing. You must use the range supplied by the laboratory that performed your test to evaluate whether your results are "within normal limits."
Additional Materials (9)
This browser does not support the video element.
What Is HDL and LDL Cholesterol?
This video explains the difference between HDL and LDL cholesterol. It also reveals what may occur when there are high levels of LDL in the body.LDL may stick to an artery's inner wall causing the build up of plaque, affecting blood flow. When an artery stiffens and constricts, aneurysm, heart attack, and stroke can occur.
Video by TheVisualMD
Triglycerides and HDL
Video by Joslin Diabetes Center/YouTube
The 5 Most Important Molecules in Your Body
Video by SciShow/YouTube
British Heart Foundation - Cholesterol and heart disease
Video by British Heart Foundation/YouTube
HDL: When Good Cholesterol Goes Bad
Video by UW Video/YouTube
Tri HDL
Video by ACAP Health/YouTube
High Density Lipoprotein: Cholesterol pathway
We get cholesterol from foods like red meat, dairy and eggs, but our livers produce most of our cholesterol in a multi-step process (drugs like statins interrupt this process). Cholesterol is carried in the bloodstream in specialized packages called lipoproteins.
Image by TheVisualMD
High Density Lipoprotein: Arterial Wall
It's estimated that there are nearly 100,000 miles of arteries in an adult body. The walls of these arteries are composed of fibroblasts, smooth muscle cells, elastica interna, and an endothelial cell layer.
Image by TheVisualMD
High Density Lipoprotein: Aerobic exercise
There are many factors that can potentially influence cholesterol levels. Exercise is an important one. Studies have shown that endurance athletes have higher HDL levels, and aerobic athletes in general, particularly lean ones, have lower LDL levels.
Image by TheVisualMD
0:45
What Is HDL and LDL Cholesterol?
TheVisualMD
3:25
Triglycerides and HDL
Joslin Diabetes Center/YouTube
7:55
The 5 Most Important Molecules in Your Body
SciShow/YouTube
6:23
British Heart Foundation - Cholesterol and heart disease
British Heart Foundation/YouTube
54:59
HDL: When Good Cholesterol Goes Bad
UW Video/YouTube
2:17
Tri HDL
ACAP Health/YouTube
High Density Lipoprotein: Cholesterol pathway
TheVisualMD
High Density Lipoprotein: Arterial Wall
TheVisualMD
High Density Lipoprotein: Aerobic exercise
TheVisualMD
Glucose Test
Blood Glucose Test
Also called: Blood Sugar Level, Glucose Test, Random Plasma Glucose, Random Glucose, Random Blood Glucose (RPG)
A blood glucose test measures the amount of glucose (sugar) in your blood. It may be used to help diagnose or monitor diabetes. The test can involve a finger prick or a blood draw from your vein.
Blood Glucose Test
Also called: Blood Sugar Level, Glucose Test, Random Plasma Glucose, Random Glucose, Random Blood Glucose (RPG)
A blood glucose test measures the amount of glucose (sugar) in your blood. It may be used to help diagnose or monitor diabetes. The test can involve a finger prick or a blood draw from your vein.
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Use the slider below to see how your results affect your
health.
mg/dL
70
100
125
Your result is Normal.
A healthy (normal) fasting blood glucose level for someone without diabetes is 70 to 99 mg/dL (3.9 to 5.5 mmol/L). Values between 50 and 70 mg/dL (2.8 to 3.9 mmol/L) for people without diabetes can be "normal" too.
Related conditions
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Use the slider below to see how your results affect your
health.
mg/dL
80
140
200
Your result is Normal.
In a random blood glucose test, a normal result depends on when you last ate. You may start your day at below 100 mg/dL in the morning before breakfast and your blood glucose may rise as high as 140 mg/dL about 2 hours after meals during the day. Most of the time, the blood glucose level will be below 125 mg/dL (6.9 mmol/L).
Related conditions
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Use the slider below to see how your results affect your
health.
mg/dL
140
Your result is Normal.
Within 2 hours of eating, your insulin and blood glucose levels should return to normal. Normal blood glucose values in people who don't have diabetes are less than 140 mg/dL, and in people with diabetes are less than 180 mg/dL.
Related conditions
A blood glucose test measures the glucose levels in your blood. Glucose is a type of sugar. It is your body's main source of energy. A hormone called insulin helps move glucose from your bloodstream into your cells.
Too much or too little glucose in the blood can be a sign of a serious medical condition. High blood glucose levels (hyperglycemia) may be a sign of diabetes, a disorder that can cause serious, long-term health conditions.
High blood sugar may also be caused by other conditions that can affect insulin or glucose levels in your blood, such as problems with your pancreas or adrenal glands.
Low blood glucose levels (hypoglycemia) are common among people with type 1 diabetes and people with type 2 diabetes who take certain diabetes medicines. Certain conditions, such as liver disease, may cause low levels of blood glucose in people without diabetes, but this is uncommon. Without treatment, severe low blood sugar can lead to major health problems, including seizures and brain damage.
Other names: blood sugar, self-monitoring of blood glucose (SMBG), fasting plasma glucose (FPG), fasting blood sugar (FBS), fasting blood glucose (FBG), random blood sugar, glucose challenge test, oral glucose tolerance test (OGTT)
A blood glucose test is used to find out if your blood sugar levels are in a healthy range. It is often used to help diagnose and monitor diabetes.
Your health care provider may order a blood glucose test if you have symptoms of high glucose levels or low glucose levels.
Symptoms of high blood glucose levels include:
Increased thirst and urination (peeing)
Blurred vision
Fatigue
Sores that don't heal
Weight loss when you're not trying to lose weight
Numbness or tingling in your feet or hands
Symptoms of low blood glucose levels include:
Feeling shaky or jittery
Hunger
Fatigue
Feeling dizzy, confused, or irritable
Headache
A fast heartbeat or arrhythmia (a problem with the rate or rhythm of your heartbeat)
Having trouble seeing or speaking clearly
Fainting or seizures
You may also need a blood glucose test if you have a high risk for developing type 2 diabetes. You're more likely to develop diabetes if you:
Are overweight or have obesity
Are age 45 or older
Have a family history of diabetes
Have high blood pressure
Don't exercise enough
Have a history of heart disease or stroke
Have had gestational diabetes (diabetes that happens only during pregnancy)
If you are pregnant, you will likely get a blood glucose test between the 24th and 28th week of your pregnancy to check for gestational diabetes.
A health care professional will take a blood sample from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial. You may feel a little sting when the needle goes in or out.
For some types of glucose blood tests, you will drink a sugary liquid and wait for an hour before your blood sample is taken:
A glucose challenge test is used to test for gestational diabetes in pregnancy. If your blood glucose level is higher than normal, you may have gestational diabetes. You'll need an oral glucose tolerance test (OGTT) to get a diagnosis.
An oral glucose tolerance test (OGTT) is used to diagnose gestational diabetes, and type 2 diabetes and prediabetes in people who aren't pregnant. A blood sample will be taken before you have a sugary drink and then again, every hour for the next 2 or 3 hours.
If your provider orders a fasting blood glucose test or an oral glucose tolerance test, you will need to fast (not eat or drink) for at least eight hours before the test. Other blood glucose tests don't require any special preparations. Ask your provider whether you need to fast before your glucose test.
There is very little risk to having a blood test. You may have slight pain or bruising at the spot where the needle was put in, but most symptoms go away quickly. After an oral glucose tolerance test, you may feel light-headed. Your provider may suggest that you plan to have someone take you home.
If your results show higher than normal glucose levels, it may mean you have or are at risk for getting diabetes. High glucose levels may also be a sign of:
Hyperthyroidism
Pancreas disorders
Stress from surgery, very serious illness, or trauma
If you have diabetes, lower than normal glucose levels may be caused by:
Side effects from certain diabetes medicines
Not eating enough, especially after taking diabetes medicine
Being more physically active than usual
If you don't have diabetes, low blood glucose levels may be a sign of:
Liver disease
Kidney disease
Underactive adrenal, pituitary, or thyroid gland (hypothyroidism)
Alcohol use disorder (AUD)
If your glucose results are not normal, it doesn't always mean you have a medical condition that needs treatment. Certain medicines and stress can affect glucose levels. To learn what your test results mean, talk with your health care provider.
If you have diabetes, you may need to do blood sugar testing at home every day to help manage your blood glucose levels. There are two ways to do this:
Blood glucose meters require you to prick your finger with a small device called a lancet. You apply a drop of blood to a test strip and insert it into a small, electronic glucose meter, which measures the glucose is in your blood.
Continuous glucose monitors (CGM) use a tiny sensor that you insert under your skin. Every few minutes, the sensor measures glucose levels in fluids between your cells. If your glucose is too high or too low, you use a blood glucose meter to check your blood levels before making changes to raise or lower your glucose level.
Blood sugar test: Health Article | MedlinePlus - NIH [accessed on Sep 07, 2018]
Random glucose test - Wikipedia [accessed on Sep 07, 2018]
001032: Glucose | LabCorp [accessed on Sep 07, 2018]
001818: Glucose, Plasma | LabCorp [accessed on Sep 07, 2018]
Glucose (Blood) - Health Encyclopedia - University of Rochester Medical Center [accessed on Sep 07, 2018]
Blood Glucose Test: MedlinePlus Medical Test [accessed on Dec 12, 2022]
Normal reference ranges can vary depending on the laboratory and the method used for testing. You must use the range supplied by the laboratory that performed your test to evaluate whether your results are "within normal limits."
Additional Materials (12)
Glucose: Pancreas
The pancreas is a large gland (located behind the stomach) that secretes digestive enzymes into the duodenum (small intestine), which then combine with bile, produced in the liver. The pancreas also produces the hormone insulin, which helps control blood sugar levels.
Image by TheVisualMD
Glucose: Neurons (Utilize Glucose)
Our brains need a continuous supply of fuel in the form of glucose because they can't store energy as fat or glycogen. Though the brain represents only about 2% of the body's mass, it consumes 60% of the sugar coursing through our bloodstreams.
Image by TheVisualMD
Glucose: Insulin & Glucose
The body's ability to use glucose depends on the hormone insulin, produced by the pancreas. Blood levels of glucose rise after meals, but insulin keeps glucose levels within a narrow range; excess glucose is stored in the liver as glycogen.
Image by TheVisualMD
Molecular structure of glucose | Macromolecules | Biology | Khan Academy
Video by Khan Academy/YouTube
Glucose Insulin and Diabetes
Video by Khan Academy/YouTube
How do carbohydrates impact your health? - Richard J. Wood
Video by TED-Ed/YouTube
Diabetes and insulin injection
There are 3 main types of diabetes. Type 1 diabetes develops when the body's immune system destroys the pancreatic cells that produce the hormone insulin. Type 2 diabetes develops when cells can no longer use insulin effectively, which can result in the pancreas gradually losing its ability to produce insulin. Both types of diabetes can require insulin injections to compensate for this deficiency. A third type, gestational diabetes, is a form of glucose intolerance that appears in some women during pregnancy.
Image by TheVisualMD
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Blood Glucose and Baselining Your Health
Our bodies and brains run on glucose, a simple sugar produced by the digestion of carbohydrates. The body's ability to use glucose depends on the hormone insulin, which is produced by the pancreas. Blood sugar levels naturally rise after meals, but insulin from a healthy pancreas keeps these levels within a narrow range. In diabetes, however, this balance is disrupted because either the body loses its ability to respond to insulin or the pancreas loses its ability to produce insulin. Too much or too little glucose in the bloodstream can damage blood vessels in the kidneys and eyes, as well as nerve cells; acute disruptions of the insulin/glucose balance can be life threatening. Blood and urine tests can determine whether someone is diabetic or pre-diabetic. Diabetes is looming as a major public health concern; an estimated 25 million people in the U.S. have diabetes, with more than a quarter of them undiagnosed.
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Fasting Plasma Glucose
The fasting plasma glucose (FPG) test, also known as the fasting blood sugar test, measures blood sugar levels and is used to diagnose diabetes.
Video by TheVisualMD
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What Is Type 2 Diabetes?
Go deep inside your body to see how type 2 diabetes happens, what it does to your body-and what you can do about it. Diabetes expert Dr. David Katz of the Yale Prevention Research Center talks about the frightening future of diabetes: in just a few decades, one third of all Americans may have diabetes. See the pancreas, where insulin is produced. Real imaging data reveals the body's inner anatomy slice by slice, from brain to base of spine. Dr. Cynthia Geyer of Canyon Ranch talks about how insulin resistance develops. View its results, as visceral abdominal fat builds up and chokes the vital organs. Discover the symptoms of type 2 diabetes and find out if you should be tested. See the complications of diabetes, including cardiovascular disease, hypertension, vision damage, kidney disease, and gangrene. The good news? Diabetes is a highly manageable disease. Dr. Mark Liponis of Canyon Ranch talks about controlling your risk for type 2 diabetes and, by managing it, reversing its symptoms and literally slowing the aging process.
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What are Carbohydrates?
Most of the foods we consume, including fruits and vegetables, contain carbohydrates. Once metabolized, these macronutrients become the body's primary source of energy, providing food to cells. And while nature never produced any "good" or "bad" carbs, it's also true that excessive carbohydrate consumption can lead to unwanted weight gain. Before you strike carbs from your diet, though, learn more about how this important nutrient supports your good health.
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Simple Carbohydrates
Because only the smallest molecules of sugar can pass through the intestinal walls and into the blood stream, foods ingested as simple carbohydrates (single- and double-molecule sugars) can be used immediately while complex carbohydrates (three or more molecules) require more time and action to break down and be absorbed. Some simple sugars occur naturally in vegetables, milk, honey, and other unprocessed foods. Synthetic sweeteners such as corn syrup and high fructose are simple sugars as well. Simple carbs cause a rapid rise and fall in glucose, leaving you feeling hungry faster.
Video by TheVisualMD
Glucose: Pancreas
TheVisualMD
Glucose: Neurons (Utilize Glucose)
TheVisualMD
Glucose: Insulin & Glucose
TheVisualMD
9:19
Molecular structure of glucose | Macromolecules | Biology | Khan Academy
Khan Academy/YouTube
7:24
Glucose Insulin and Diabetes
Khan Academy/YouTube
5:11
How do carbohydrates impact your health? - Richard J. Wood
TED-Ed/YouTube
Diabetes and insulin injection
TheVisualMD
1:36
Blood Glucose and Baselining Your Health
TheVisualMD
0:23
Fasting Plasma Glucose
TheVisualMD
4:22
What Is Type 2 Diabetes?
TheVisualMD
1:11
What are Carbohydrates?
TheVisualMD
1:09
Simple Carbohydrates
TheVisualMD
Cerebrospinal Fluid Analysis
Cerebrospinal Fluid Analysis
Also called: CSF Analysis, Spinal Fluid Analysis
A cerebrospinal fluid (CSF) analysis is a group of tests that help diagnose diseases and conditions affecting the brain and spinal cord.
Cerebrospinal Fluid Analysis
Also called: CSF Analysis, Spinal Fluid Analysis
A cerebrospinal fluid (CSF) analysis is a group of tests that help diagnose diseases and conditions affecting the brain and spinal cord.
Cerebrospinal fluid (CSF) is a clear, colorless liquid found in your brain and spinal cord. The brain and spinal cord make up your central nervous system. Your central nervous system controls and coordinates everything you do including, muscle movement, organ function, and even complex thinking and planning. CSF helps protect this system by acting like a cushion against sudden impact or injury to the brain or spinal cord. CSF also removes waste products from the brain and helps your central nervous system work properly.
A CSF analysis is a group of tests that look at your cerebrospinal fluid to help diagnose diseases and conditions that affect the brain and spinal cord.
A CSF analysis may include tests to diagnose:
Infectious diseases of the brain and spinal cord, including meningitis and encephalitis. CSF tests for infections look at white blood cells, bacteria, and other substances in the cerebrospinal fluid
Autoimmune disorders, such as Guillain-Barré Syndrome and multiple sclerosis (MS). CSF tests for these disorders look for high levels of certain proteins in the cerebrospinal fluid. These tests are called albumin protein and igG/albumin.
Bleeding in the brain
Brain tumors
You may need a CSF analysis if you have symptoms of an infection of the brain or spinal cord, or of an autoimmune disorder, such as multiple sclerosis (MS).
Symptoms of a brain or spinal cord infection include:
Fever
Severe headache
Seizures
Stiff neck
Nausea and vomiting
Sensitivity to light
Double vision
Changes in behavior
Confusion
Symptoms of MS include:
Blurred or double vision
Tingling in the arms, legs, or face
Muscle spasms
Weak muscles
Dizziness
Bladder control problems
Symptoms of Guillain-Barré syndrome include weakness and tingling in the legs, arms, and upper body.
You may also need a CSF analysis if you've had an injury to your brain or spinal cord, or have been diagnosed with cancer that has spread to the brain or spinal cord.
Your cerebrospinal fluid will be collected through a procedure called a spinal tap, also known as a lumbar puncture. A spinal tap is usually done in a hospital. During the procedure:
You will lie on your side or sit on an exam table.
A health care provider will clean your back and inject an anesthetic into your skin, so you won't feel pain during the procedure. Your provider may put a numbing cream on your back before this injection.
Once the area on your back is completely numb, your provider will insert a thin, hollow needle between two vertebrae in your lower spine. Vertebrae are the small backbones that make up your spine.
Your provider will withdraw a small amount of cerebrospinal fluid for testing. This will take about five minutes.
You'll need to stay very still while the fluid is being withdrawn.
Your provider may ask you to lie on your back for an hour or two after the procedure. This may prevent you from getting a headache afterward.
You don't need any special preparations for a CSF analysis, but you may be asked to empty your bladder and bowels before the test.
There is very little risk to having a spinal tap. You may feel a little pinch or pressure when the needle is inserted. After the test, you may get a headache, called a post-lumbar headache. About one in 10 people will get a post-lumbar headache. This can last for several hours or up to a week or more. If you have a headache that lasts longer than several hours, talk to your health care provider. He or she may be able to provide treatment to relieve the pain.
You may feel some pain or tenderness in your back at the site where the needle was inserted. You may also have some bleeding at the site.
Your CSF analysis results may indicate that you have an infection, an autoimmune disorder, such as multiple sclerosis, or another disease of the brain or spinal cord. Your provider will likely order more tests to confirm your diagnosis.
Some infections, such as meningitis caused by bacteria, are life-threatening emergencies. If your provider suspects you have bacterial meningitis or another serious infection, he or she may give you medicine before your diagnosis is confirmed.
005256: Cell Count, Cerebrospinal Fluid | LabCorp [accessed on Oct 01, 2018]
CSF Analysis [accessed on Oct 01, 2018]
Cerebrospinal Fluid Analysis - - American Family Physician [accessed on Oct 01, 2018]
Cerebrospinal Fluid | Lab Tests | GLOWM [accessed on Oct 01, 2018]
CSF Analysis - Neurology - Michigan Medicine Confluence [accessed on Oct 01, 2018]
Additional Materials (17)
Ventricular system
The Human en:Ventricular system colored and animated
Image by en:Anatomography
Lumbar puncture
Image by BruceBlaus
What is hydrocephalus and what are the different types?
Illustration showing different effects of hydrocephalus on the brain and cranium.
Image by Centers for Disease Control and Prevention
Hydrocephalus - Who gets it and what causes it?
Image by Vimont, Engelmann /Scan by NLM
Cerebrospinal fluid and System
Cerebrospinal fluid and System
Image by Blausen.com staff (2014). "Medical gallery of Blausen Medical 2014"
Diagram showing how you have a lumbar puncture.
Diagram showing how you have a lumbar puncture.
Image by Cancer Research UK / Wikimedia Commons
Normal Pressure Hydrocephalus
Images from a patient with normal pressure hydrocephalus (NPH)
Image by Nevit Dilmen
Normal Pressure Hydrocephalus
Hydrocephalus _ Animated MRI Images from a patient with normal pressure hydrocephalus
Image by Nevit Dilmen
4 vials of human cerebrospinal fluid
4 vials of human cerebral spinal fluid of normal appearance, collected via lumbar puncture from the L3/L4 disk space.
Image by James Heilman, MD
Epidural blood patch
Illustration of Epidural blood patch
Image by Gurch
Lumbar puncture
Lumbar puncture procedure in a new born infant in a Neonatal Medium Care Unit, Maracay, Venezuela.
Image by Bobjgalindo
Spinal Cord Cross Section
Spinal Cord Cross Section
Image by OpenStax College
Lumbar Vertebrae
3D visualization based on scanned human data of lumbar vertebrae. Strong and wide lumbar vertebrae bear weight of the body and provide stability.
Image by TheVisualMD
Lumbar Puncture
Video by DrER.tv/YouTube
Lumbar Spine Anatomy
Video by Randale Sechrest/YouTube
Lumbar Puncture
Lumbar Puncture
Image by Blausen.com staff (2014). "Medical gallery of Blausen Medical 2014"
Healthy Brain cross section
Brain with Ischemic Stroke cross section
Brain with Hemorrhagic Stroke, cross section
1
2
3
Types of Stroke
Cross Section
1) Healthy Brain - This cross-sectional image through the frontal plane of the head of a healthy individual reveals the temporal and frontal lobes of the brain, along with some major structures visible at this level. The vertebral arteries enter the skull through the foramen magnum. They meet to form the basilar artery, then ultimately branch into the posterior cerebral arteries. The Circle of Willis is a pattern of arteries in the center of the brain, surrounding the pituitary gland. The ventricles are fluid-filled cavities in the brain continuous with the central canal of the spinal cord, housing cells that produce and secrete cerebrospinal fluid. This fluid lubricates and has an immunological function.
2) Ischemic Stroke - This cross-sectional image through the frontal plane of the head of a healthy individual reveals the temporal and frontal lobes of the brain, along with some major structures visible at this level. A portion of dead brain tissue can be seen on the individual's left side of the brain near the surface. The dead tissue is due to an ischemic stroke, most likely a result of blockage in an artery to the brain. The blockage can also occur elsewhere in the body, but break apart and travel through the bloodstream, getting caught in the smaller arteries in the brain. Blood is unable to reach the tissue destination, and therefore that tissue becomes necrotic. The cause of blockage in the first place is likely due to fatty deposits in arterial walls, or atherosclerosis.
3) Hemorrhagic Stroke - This cross-sectional image through the frontal plane of the head of a healthy individual reveals the temporal and frontal lobes of the brain, along with some major structures visible at this level. A hemorrhagic stroke has occurred, as indicated by the area of bleeding on the individual's left side of the brain. A hemorrhagic stroke can occur when a vessel weakened by conditions such as an aneurysm or arteriovenous malformation (AVM) ruptures, allowing blood to leak out into the surrounding tissues. These conditions can be congenital, but risks may increase due to high blood pressure, high cholesterol, smoking, and atherosclerosis.
Interactive by TheVisualMD
Ventricular system
en:Anatomography
Lumbar puncture
BruceBlaus
What is hydrocephalus and what are the different types?
Centers for Disease Control and Prevention
Hydrocephalus - Who gets it and what causes it?
Vimont, Engelmann /Scan by NLM
Cerebrospinal fluid and System
Blausen.com staff (2014). "Medical gallery of Blausen Medical 2014"
Diagram showing how you have a lumbar puncture.
Cancer Research UK / Wikimedia Commons
Normal Pressure Hydrocephalus
Nevit Dilmen
Normal Pressure Hydrocephalus
Nevit Dilmen
4 vials of human cerebrospinal fluid
James Heilman, MD
Epidural blood patch
Gurch
Lumbar puncture
Bobjgalindo
Spinal Cord Cross Section
OpenStax College
Lumbar Vertebrae
TheVisualMD
4:06
Lumbar Puncture
DrER.tv/YouTube
5:32
Lumbar Spine Anatomy
Randale Sechrest/YouTube
Lumbar Puncture
Blausen.com staff (2014). "Medical gallery of Blausen Medical 2014"
A platelet count test measures the number of platelets in your blood. Platelets, also known as thrombocytes, are small blood cells that are essential for blood clotting. Platelets may be counted to monitor or diagnose diseases, or to look for the cause of too much bleeding or clotting.
A platelet count test measures the number of platelets in your blood. Platelets, also known as thrombocytes, are small blood cells that are essential for blood clotting. Platelets may be counted to monitor or diagnose diseases, or to look for the cause of too much bleeding or clotting.
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Use the slider below to see how your results affect your
health.
(10³)/μL
50
150
450
Your result is Normal.
A normal platelet count ranges from 150,000 to 450,000 platelets per microliter of blood. Platelets are tiny blood cells that are made in the bone marrow from larger cells. When you are injured, platelets stick together to form a plug to seal your wound. This plug is called a blood clot.
Related conditions
Platelets, also known as thrombocytes, are small blood cells that are essential for blood clotting. Clotting is the process that helps you stop bleeding after an injury. There are two types of platelet tests: a platelet count test and platelet function tests.
A platelet count test measures the number of platelets in your blood. A lower than normal platelet count is called thrombocytopenia. This condition can cause you to bleed too much after a cut or other injury that causes bleeding. A higher than normal platelet count is called thrombocytosis. This can make your blood clot more than you need it to. Blood clots can be dangerous because they can block blood flow.
Other names: platelet count, thrombocyte count
A platelet count is most often used to monitor or diagnose conditions that cause too much bleeding or too much clotting. A platelet count may be included in a complete blood count, a test that is often done as part of a regular checkup.
You may need platelet count testing if you have symptoms of having too few or too many platelets.
Symptoms of too few platelets include:
Prolonged bleeding after a minor cut or injury
Nosebleeds
Unexplained bruising
Pinpoint sized red spots on the skin, known as petechiae
Purplish spots on the skin, known as purpura. These may be caused by bleeding under the skin.
Heavy and/or prolonged menstrual periods
Symptoms of too many platelets include:
Numbness of hands and feet
Headache
Dizziness
Weakness
Most platelet tests are done on a blood sample.
During the test, a health care professional will take a blood sample from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial. You may feel a little sting when the needle goes in or out. This usually takes less than five minutes.
You don't need any special preparations for a platelet count test.
There is very little risk to having a blood test. You may have slight pain or bruising at the spot where the needle was put in, but most symptoms go away quickly.
If your results show a lower than normal platelet count (thrombocytopenia), it may indicate:
A cancer that affects the blood, such as leukemia or lymphoma
A viral infection, such as mononucleosis, hepatitis, or measles
An autoimmune disease. This is a disorder that causes the body to attack its own healthy tissues, which can include platelets.
Infection or damage to the bone marrow
Cirrhosis
Vitamin B12 deficiency
Gestational thrombocytopenia, a common, but mild, low-platelet condition affecting pregnant women. It is not known to cause any harm to a mother or her unborn baby. It usually gets better on its own during pregnancy or after birth.
If your results show a higher than normal platelet count (thrombocytosis), it may indicate:
Certain types of cancer, such as lung cancer or breast cancer
Anemia
Inflammatory bowel disease
Rheumatoid arthritis
A viral or bacterial infection
Platelet Tests: MedlinePlus Medical Test [accessed on Jan 20, 2024]
Platelet Count (PLT) Blood Test - Testing.com. Dec 19, 2023 [accessed on Jan 20, 2024]
Platelet count: MedlinePlus Medical Encyclopedia [accessed on Jan 20, 2024]
Normal reference ranges can vary depending on the laboratory and the method used for testing. You must use the range supplied by the laboratory that performed your test to evaluate whether your results are "within normal limits."
Additional Materials (8)
Platelet Development
Illustration of Platelet Development
Image by OpenStax College
Sensitive content
This media may include sensitive content
Platelet Disorders
From left to right: erythrocyte, thrombocyte, leukocyte
Image by Electron Microscopy Facility at The National Cancer Institute at Frederick (NCI-Frederick)
Scheme of a blood sample after centrifugation
scheme of a blood sample after centrifugation
Image by KnuteKnudsen (talk)
Decode Your Blood Test: Platelets 💉 | Merck Manual Consumer Version
Video by Merck Manuals/YouTube
This browser does not support the video element.
Complete Blood Count, and Baselining Your Health
Video Topics : Our lifeblood consists of many components and a complete blood count (CBC) includes measurements of the fundamental elements. The largest categories are red and white blood cells (RBCs and WBCs) and cell fragments called platelets, which play roles in blood clotting. There are 20-30 trillion red blood cells in the body of an adult, each with a lifespan of about 100 days (RBCs contain an iron-containing protein called hemoglobin that enables them to carry oxygen to tissues throughout the body and then return carbon dioxide to the lungs). WBCs are in the front lines in the body's ongoing fight against harmful viruses, bacteria and even fungus; when a pathogen enters the body, WBCs mobilize in a coordinated defense response to eliminate, neutralize or mark the invader for destruction. The liquid portion of blood is called plasma and it carries nutrients, electrolytes, waste products, and hormones.
Video by TheVisualMD
Platelets Nursing Considerations, Normal Range, Nursing Care, Lab Values Nursing
Video by NURSINGcom/YouTube
Platelets Explained in Two Minutes
Video by American Red Cross/YouTube
The life and times of RBCs and platelets
Video by khanacademymedicine/YouTube
Platelet Development
OpenStax College
Sensitive content
This media may include sensitive content
Platelet Disorders
Electron Microscopy Facility at The National Cancer Institute at Frederick (NCI-Frederick)
Scheme of a blood sample after centrifugation
KnuteKnudsen (talk)
0:48
Decode Your Blood Test: Platelets 💉 | Merck Manual Consumer Version
Merck Manuals/YouTube
2:12
Complete Blood Count, and Baselining Your Health
TheVisualMD
3:54
Platelets Nursing Considerations, Normal Range, Nursing Care, Lab Values Nursing
NURSINGcom/YouTube
1:47
Platelets Explained in Two Minutes
American Red Cross/YouTube
10:35
The life and times of RBCs and platelets
khanacademymedicine/YouTube
Complete Blood Count
Complete Blood Count
Also called: CBC, Full Blood Count, Blood Cell Count, Hemotology Panel
A complete blood count (CBC) is often part of a routine exam. It is used to measure different parts and features of your blood. A CBC can help detect a variety of disorders including infections, anemia, diseases of the immune system, and blood cancers.
Complete Blood Count
Also called: CBC, Full Blood Count, Blood Cell Count, Hemotology Panel
A complete blood count (CBC) is often part of a routine exam. It is used to measure different parts and features of your blood. A CBC can help detect a variety of disorders including infections, anemia, diseases of the immune system, and blood cancers.
A complete blood count, or CBC, is a blood test that measures many different parts and features of your blood, including:
Red blood cells, which carry oxygen from your lungs to the rest of your body.
White blood cells, which fight infections and other diseases. There are five major types of white blood cells. A CBC test measures the total number of white cells in your blood. A different test called a CBC with differential measures the number of each type of these white blood cells.
Platelets, which stop bleeding by helping your blood to clot.
Hemoglobin, a protein in red blood cells that carries oxygen from your lungs to the rest of your body.
Hematocrit, a measurement of how much of your blood is made up of red blood cells.
Mean corpuscular volume (MCV), a measure of the average size of your red blood cells.
Other names for a complete blood count: CBC, full blood count, blood cell count
A complete blood count is a common blood test that is often part of a routine checkup. Complete blood counts can help detect a variety of disorders including infections, anemia, diseases of the immune system, and blood cancers.
Your health care provider may have ordered a complete blood count as part of your checkup or to monitor your overall health. The test may also be used to:
Help diagnose blood diseases, infection, immune system disorders, or other medical conditions
Check for changes in an existing blood disorder
A health care professional will take a blood sample from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial. You may feel a little sting when the needle goes in or out. This usually takes less than five minutes.
Usually there is no special preparation necessary for a complete blood count. But if your provider ordered other tests on your blood sample, you may need to fast (not eat or drink) for several hours before the test. Your provider will let you know if there are any special instructions to follow.
There is very little risk to having a blood test. You may experience slight pain or bruising at the spot where the needle went in, but most symptoms go away quickly.
A CBC counts the cells in your blood. There are many reasons your levels may not be in the normal range. For example:
Abnormal levels of red blood cells, hemoglobin, or hematocrit may be a sign of anemia, heart disease, or too little iron in your body.
Low white cell count may be a sign of an autoimmune disorder, bone marrow disorder, or cancer.
High white cell count may be a sign of an infection or a reaction to medicine.
If any of your levels are abnormal, it doesn't always mean you have a medical condition that needs treatment. Diet, activity level, medicines, a menstrual period, not drinking enough water, and other factors can affect the results. Talk with your provider to learn what your results mean.
A complete blood count is only one tool your health care provider uses to learn about your health. Your provider will consider your medical history, symptoms, and other factors to make a diagnosis. You may also need additional tests.
Complete Blood Count (CBC): MedlinePlus Medical Test [accessed on Jan 20, 2024]
Blood Tests - Blood Tests | NHLBI, NIH. Mar 24, 2022 [accessed on Jan 20, 2024]
Additional Materials (25)
Reticulocyte Count, Hemorrhage/Chronic Blood Loss
Reticulocytes are immature red blood cells (RBCs) released into the bloodstream from the bone marrow in which they developed. Normally, only a tiny percentage red blood cells circulating in the bloodstream are reticulocytes. The reticulocyte count rises, however, when bone marrow is called upon to produce more RBCs, in conditions such as heavy bleeding or certain types of anemia.
Image by TheVisualMD
Blood sample
During the blood collection process, medical personnel gather additional blood samples to test for an array of blood disorders and communicable diseases. Every unit of blood is rigorously tested before approved for transfusion into a patient.
Image by United States Marine Corps
Phlebotomy
Venipuncture (blood draw / collection) in the left arm of a male.
Image by MatthewLammers
Blood and Related Conditions
Blood and Related Conditions : Anemia results when there are too few red blood cells circulating in the bloodstream to deliver adequate oxygen to body tissues. There are different types and causes of anemia, including malnutrition, chronic bleeding, and diseases that result in red blood cells either being destroyed too quickly or produced too slowly.
Image by TheVisualMD
Components of Blood
Components of Blood : Our blood is composed of many different components, the largest categories being red and white blood cells (blood-clotting platelets are another key component) and the liquid portion known as blood plasma. A Complete Blood Count (CBC) includes several of the most basic, yet important, measurements of these components.
Image by TheVisualMD
Blood fractionation
Vial of separated blood. The middle layer is a type of sterile goo which separates the blood from the rest of what's drawn.
Image by Wheeler Cowperthwaite from Reno, USA
Whole Blood
A Red Cross whole blood donation before any separation
Image by Whoisjohngalt
White Blood Cells Rotation
This rotational interactive features five white blood cells. At the top left is a neutrophil (purple nucleus); center is a Monocyte-macrophage (orange nucleus); top right is a Lymphocyte (red nucleus); bottom left a Basophil (green nucleus); and bottom right an Eosinophil (yellow nucleus). These molecules are all part of a white blood cell count test. A white blood cell count is an important measure of this key component of the immune system; when the body is under attack, more WBCs are produced. White blood cells (also called leukocytes or WBCs) are in the front lines in the fight against harmful viruses, bacteria and even fungus. A white blood cell count is an important measure of this key component of the immune system; when the body is under attack, more WBCs are produced. Other factors, however, may also affect WBC counts, including allergies, chemotherapy, and other drugs, as well as leukemia.
Image by TheVisualMD
Medical Checkups
Image by TheVisualMD
Medical Checkups
Most doctors believe that people should have regular checkups as a part of preventive treatment. Regular health exams can help find problems before they begin, or in their early stages, when the chances of successful treatment are best.
Blood Pressure Reading: Photo Copyright 2005, James Gathany
Image by TheVisualMD
This browser does not support the video element.
Complete Blood Count, and Baselining Your Health
Video Topics : Our lifeblood consists of many components and a complete blood count (CBC) includes measurements of the fundamental elements. The largest categories are red and white blood cells (RBCs and WBCs) and cell fragments called platelets, which play roles in blood clotting. There are 20-30 trillion red blood cells in the body of an adult, each with a lifespan of about 100 days (RBCs contain an iron-containing protein called hemoglobin that enables them to carry oxygen to tissues throughout the body and then return carbon dioxide to the lungs). WBCs are in the front lines in the body's ongoing fight against harmful viruses, bacteria and even fungus; when a pathogen enters the body, WBCs mobilize in a coordinated defense response to eliminate, neutralize or mark the invader for destruction. The liquid portion of blood is called plasma and it carries nutrients, electrolytes, waste products, and hormones.
Video by TheVisualMD
Full Blood Count – what it tells your doctor about your health
Video by Pathology Tests Explained/YouTube
Complete Blood Count (CBC)
Video by Medicosis Perfectionalis/YouTube
Complete Blood Count
Video by Tom Wade MD/YouTube
high white blood cell count Video
Video by itbestshop/YouTube
Complete Blood Count pt1
Video by Med Immersion/YouTube
Complete Blood Count pt2
Video by Med Immersion/YouTube
This browser does not support the video element.
Normal Red Blood Cell (RBC) Count
An animation simulating a view of a healthy count of red blood cells as viewed in a slide projector or under a microscope. Initially, the screen in white with a circular black vignette along its borders. Then a still showing red blood cells slides up from the bottom left filling the screen and then comes into focus. The red blood cells resemble those taken from an scanning electron micrograph (SEM) and fill up the given space on the screen.
Video by TheVisualMD
This browser does not support the video element.
Anemic Blood Flow
Camera is stationary as it focuses on a capillary in a cell bed demonstrating anemic blood flow and it's lower red blood cell count.
Video by TheVisualMD
This browser does not support the video element.
Anemic Red Blood Cell (RBC) Count
An animation simulating a view of an unhealthy count of red blood cells as viewed in a slide projector or under a microscope. Initially, the screen in white with a circular black vignette along its borders. Then a still showing red blood cells on a light red background slides up from the bottom left filling the screen and then comes into focus. The red blood cells resemble those taken from an scanning electron micrograph (SEM). There are only a few red blood cells in this slide indicative of the low amount typical of some one who is anemic.
Video by TheVisualMD
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Anemic Red Blood Cell (RBC) Count
An animation simulating a close-up of an unhealthy count of red blood cells as viewed in a slide projector or under a microscope. Initially, the screen in white with a circular black vignette along its borders. Then a still showing red blood cells on a light red background slides up from the bottom left filling the screen and then comes into focus. Throughout the animation, the slide jitters a little. The red blood cells resemble those taken from an scanning electron micrograph (SEM). In this close up there are a few red blood cells along with a few white blood cells.
Video by TheVisualMD
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Red Blood Cells
Red Blood Cell (RBC) Count
Also called: Erythrocyte Count, RBC Count, Red Blood Count, Red Blood Cell Count, Red Count
A red blood cell (RBC) count is a blood test that measures the number of red blood cells in your blood. Red blood cells carry oxygen from your lungs to the rest of your body. An abnormal RBC count can be a sign of a serious health problem.
Red Blood Cell (RBC) Count
Also called: Erythrocyte Count, RBC Count, Red Blood Count, Red Blood Cell Count, Red Count
A red blood cell (RBC) count is a blood test that measures the number of red blood cells in your blood. Red blood cells carry oxygen from your lungs to the rest of your body. An abnormal RBC count can be a sign of a serious health problem.
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Use the slider below to see how your results affect your
health.
(10<sup>6</sup>)/μL
3.9
5.5
Your result is Normal.
Red blood cells (RBC) are made in the bone marrow and contain hemoglobin, a protein that carries oxygen to the tissues in the body. RBCs make up approximately 44% of the total blood volume.
Related conditions
A red blood cell (RBC) count measures the number of red blood cells, also known as erythrocytes, in your blood. Red blood cells carry oxygen from your lungs to every cell in your body. Your cells need oxygen to grow, reproduce, and stay healthy. An RBC count that is higher or lower than normal is often the first sign of an illness. So the test may allow you to get treatment even before you have symptoms.
Other names: erythrocyte count, red count
A red blood cell (RBC) count is almost always part of a complete blood count, a group of tests that measure many different parts and features of your blood. The RBC measurement is used to help diagnose red blood cell disorders, such as anemia, a condition in which your body does not make enough healthy red blood cells.
You may get this test as part of a complete blood count, which is often included in a routine checkup. You may also need this test if you have symptoms of a low or high red blood cell count.
Symptoms of a low red blood cell count include:
Weakness
Fatigue
Pale skin
Rapid heartbeat
Symptoms of a high red blood cell count include:
Headache
Dizziness
Vision problems
A health care professional will take a blood sample from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial. You may feel a little sting when the needle goes in or out. This usually takes less than five minutes.
You don't need any special preparations for a red blood cell (RBC) count.
There is very little risk to having a blood test. There may be slight pain or bruising at the spot where the needle was put in, but most symptoms go away quickly.
Your results will show whether you have a normal red blood cell count or a count that is too low or too high.
A low red blood cell count can be a sign of:
Anemia
Leukemia, a type of blood cancer
Malnutrition, a condition in which your body does not get the calories, vitamins, and/or minerals needed for good health
Multiple myeloma, a cancer of the bone marrow
Kidney failure
It may also be a sign of pregnancy.
A high red blood cell count can be a sign of:
Dehydration
Heart disease
Polycythemia vera, a bone marrow disease that causes too many red blood cells to be made
Scarring of the lungs, often due to cigarette smoking
Lung disease
Kidney cancer
If you have questions about your results, talk to your health care provider.
If results showed you had a low or a high red blood cell count, you may need more tests to help make a diagnosis. These include:
Reticulocyte count, a test that counts the number of reticulocytes in the blood. Reticulocytes are red blood cells that are still developing. These are also known as immature red blood cells.
Iron tests, which measure iron levels in the blood. Iron is essential for making red blood cells.
Vitamin B test, which measures the amount of one or more B vitamins in the blood. B vitamins are important for making red blood cells.
Red Blood Cell (RBC) Count: MedlinePlus Medical Test [accessed on Jan 20, 2024]
RBC count: MedlinePlus Medical Encyclopedia [accessed on Jan 20, 2024]
Red Blood Cell Count (RBC) Test - Testing.com. Sep 27, 2022 [accessed on Jan 20, 2024]
Normal reference ranges can vary depending on the laboratory and the method used for testing. You must use the range supplied by the laboratory that performed your test to evaluate whether your results are "within normal limits."
Additional Materials (19)
Red blood cells
Red blood cells
Image by John Kalekos of Massachusetts image distribution for Science and Learning
Red Blood Cell
This image shows two red blood cells. The red blood cell is also called an erythrocyte: erythro is Greek for \"red,\" cyte is Latin for \"cell.\" The disc-shaped RBCs have the critical job of transporting oxygen from the lungs to the body's cells and bringing carbon dioxide from the cells back to the lungs to be expelled.
Image by TheVisualMD
Red Blood Cell in Capillary
The cardiovascular system is vast network of arteries, veins and vessels that would extend 60,000 miles if stretched end-to-end. All but a tiny fraction of this vessel network is invisible to the naked eye. The smallest capillaries (from latin "hairlike") are so narrow that red blood cells must pass through in single file. Higher than normal blood iron levels have been linked to heart disease and the reason is believed to be the oxidative stress the excess iron places on the walls of the blood vessels. It is the biological counterpart of rust. There are 20-30 trillion red blood cells (RBCs) in an adult's body. The life span of RBCs, which are produced in bone marrow, is about 100 days, which means that 2 million die (and are replaced) each second, but in that short lifetime they can make 75,000 round trips between lungs, heart and tissues in the body.
Image by TheVisualMD
Blood Smear Showing Reduced Red Blood Cell Count
Individual blood cells were first detected and described in the 17th century. Later, red blood cells (RBCs) were counted manually from a blood smear, a thin film of blood prepared on a glass slide and examined under a microscope (blood analysis is now automated, though smears are still used to detect visible abnormalities and to check or confirm the results of other tests). Anemia results when there are too few RBCs in circulation because they are being destroyed too quickly or produced too slowly. Anemia can be temporary or long term and range from mild to severe. Folate (also known as vitamin B9) is necessary for red blood cell production and the prevention of anemia, as well as the metabolism of carbohydrates. But folate also plays key roles in the synthesis and maintenance of DNA and is especially important in cell division and growth in fetal development (deficiencies of the vitamin in pregnancy is a common cause of birth defects). Pernicious anemia is a disorder in which the body's loses its ability to utilize folate and vitamin B12.
Image by TheVisualMD
Red Blood Cell (RBC)
There are 20-30 trillion red blood cells (RBCs) in an adult's body. The life span of RBCs, which are produced in bone marrow, is about 100 days, which means that 2 million die (and are replaced) each second. In their short lifetimes, however, red blood cells can make 75,000 round trips between lungs, heart and tissues in the body.
Image by TheVisualMD
Red Blood Cell
The RBC is disc-shaped and concave on both sides. The concave shape increases the cells' surface area, which allows them to distribute more oxygen to the body's cells. The shape also enables the cells to bunch together more compactly, helping them travel through the bloodstream more efficiently. Some RBCs are a bit thicker or thinner, wider or longer than others, but can change their shape to suit the demands of their environment. The cell membranes of the RBCs are protein meshes that give them flexibility, allowing them to navigate the twists and turns of the blood vessel network. The nearly 300 million hemoglobin molecules contained within each RBC easily move and slide past each other within the cell, adjusting their positions to conform to the RBC's shifting shape. Diameter : 7 μm
Image by TheVisualMD
Capillary Revealing Red Blood Cell
A portion of a capillary wall has been cut away to reveal the red blood cells flowing within.
Image by TheVisualMD
Red Blood Cell and White Blood Cell
Medical visualization of red blood cells and leukocytes.
Image by TheVisualMD
Blood Smear Showing Normal Red Blood Cell Count
Individual blood cells were first detected and described in the 17th century. Later, red blood cells were counted manually from a blood smear, a thin film of blood prepared on a glass slide and examined under a microscope. Blood analysis is now automated, though blood smears are still used to detect visible abnormalities and to check or confirm the results of other tests. There are normally between 4.2-5.8 million red blood cells per microliter (about a drop), which means there are 20-30 trillion red blood cells circulating through the body of an adult.
Image by TheVisualMD
Tubule of Nephron Revealing Many Red Blood Cell
This image shows the cut distal convoluted tubule of nephron with surrounding capillaries cut to reveal many red blood cells and healthy amounts of Erythopoeitin, EPO, (yellow particles). Erythropoeitin, EPO, is produced by the endothelial cells of the capillaries and the fibroblasts in the interstitial tissue surrounding the distal tubules. Normally, the kidneys produce EPO in response to low oxygen levels in order to stimulate red blood cell production in the bone marrow. A normal amount of red blood cells allows for the delivery of an adequate supply of oxygen.
Image by TheVisualMD
Red Blood Cell in Capillary
This image shows red blood cells traveling through capillaries, the smallest blood vessels in the body.
Image by TheVisualMD
Tubule of Nephron Revealing Few Red Blood Cell
Our kidneys are remarkable filters. Each day, they filter about 200 quarts of blood to extract about 2 quarts of wastes, which is then eliminated as urine. The kidneys' delicate filtration units are called nephrons; each kidney has about a million nephrons, and within each nephron are dense forests of tiny capillaries called glomeruli, which remove waste products from the blood while preventing the loss of other components, including proteins, electrolytes and blood cells. The glomerular filtration rate is the amount of blood that is filtered by the glomeruli per minute.
Image by TheVisualMD
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Complete Blood Count, and Baselining Your Health
Video Topics : Our lifeblood consists of many components and a complete blood count (CBC) includes measurements of the fundamental elements. The largest categories are red and white blood cells (RBCs and WBCs) and cell fragments called platelets, which play roles in blood clotting. There are 20-30 trillion red blood cells in the body of an adult, each with a lifespan of about 100 days (RBCs contain an iron-containing protein called hemoglobin that enables them to carry oxygen to tissues throughout the body and then return carbon dioxide to the lungs). WBCs are in the front lines in the body's ongoing fight against harmful viruses, bacteria and even fungus; when a pathogen enters the body, WBCs mobilize in a coordinated defense response to eliminate, neutralize or mark the invader for destruction. The liquid portion of blood is called plasma and it carries nutrients, electrolytes, waste products, and hormones.
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Flowing Red Blood Cell (RBC)
Animation of red blood cells flowoing quicly through a blood vessel. The camera is positioned in the lumen of the vessel and the rbc's are flowing towards the viewer. The rbc and and lumen are rendered with muted colors to give it a softer look.
Video by TheVisualMD
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Red Blood Cell Development
This video explains red blood cell development, following a pluripotent stem cell to red blood cell.
Video by TheVisualMD
Red blood cells
John Kalekos of Massachusetts image distribution for Science and Learning
Red Blood Cell
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Red Blood Cell in Capillary
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Blood Smear Showing Reduced Red Blood Cell Count
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Red Blood Cell (RBC)
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Red Blood Cell
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Capillary Revealing Red Blood Cell
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Red Blood Cell and White Blood Cell
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Blood Smear Showing Normal Red Blood Cell Count
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Tubule of Nephron Revealing Many Red Blood Cell
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White Blood Cells
White Blood Count (WBC)
Also called: WBC, WBC Blood Test, White Blood Count, White Blood Cell Count, Leukocyte Count, Leukopenia Test, Leukocytosis Test
A white blood count measures the number of white cells in your blood. White blood cells are part of the immune system. A count that is too high or too low can indicate an infection, immune system disorder, or another health problem.
White Blood Count (WBC)
Also called: WBC, WBC Blood Test, White Blood Count, White Blood Cell Count, Leukocyte Count, Leukopenia Test, Leukocytosis Test
A white blood count measures the number of white cells in your blood. White blood cells are part of the immune system. A count that is too high or too low can indicate an infection, immune system disorder, or another health problem.
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Use the slider below to see how your results affect your
health.
4500
11000
Your result is Normal.
Normally, people produce about 100 billion white blood cells (WBCs) a day. The total white blood cell count normally ranges between 4,500 and 11,000 WBCs per microliter.
Related conditions
A white blood count measures the number of white cells in your blood. White blood cells are part of the immune system. They help your body fight off infections and other diseases.
When you get sick, your body makes more white blood cells to fight the bacteria, viruses, or other foreign substances causing your illness. This increases your white blood count.
Other diseases can cause your body to make fewer white blood cells than you need. This lowers your white blood count. Diseases that can lower your white blood count include some types of cancer and HIV/AIDS, a viral disease that attacks white blood cells. Certain medicines, including chemotherapy, may also lower the number of your white blood cells.
There are five major types of white blood cells:
Neutrophils
Lymphocytes
Monocytes
Eosinophils
Basophils
A white blood count measures the total number of these cells in your blood. Another test, called a blood differential, measures the amount of each type of white blood cell.
Other names: WBC count, white cell count, white blood cell count
A white blood count is most often used to help diagnose disorders related to having a high white blood cell count or low white blood cell count.
Disorders related to having a high white blood count include:
Autoimmune and inflammatory diseases, conditions that cause the immune system to attack healthy tissues
Bacterial or viral infections
Cancers such as leukemia and Hodgkin disease
Allergic reactions
Disorders related to having a low white blood count include:
Diseases of the immune system, such as HIV/AIDS
Lymphoma, a cancer of the bone marrow
Diseases of the liver or spleen
A white blood count can show if the number of your white blood cells is too high or too low, but it can't confirm a diagnosis. So it is usually done along with other tests, such as a complete blood count, blood differential, blood smear, and/or bone marrow test.
You may need this test if you have signs of an infection, inflammation, or autoimmune disease. Symptoms of infection include:
Fever
Chills
Body aches
Headache
Symptoms of inflammation and autoimmune diseases will be different, depending on the area of inflammation and type of disease.
You may also need this test if you have a disease that weakens your immune system or are taking medicine that lowers your immune response. If the test shows your white blood count is getting too low, your provider may be able to adjust your treatment.
Your newborn or older child may also be tested as part of a routine screening, or if they have symptoms of a white blood cell disorder.
A health care professional will take a blood sample from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial. You may feel a little sting when the needle goes in or out.
To test children, a health care provider will take a sample from the heel (newborns and young babies) or the fingertip (older babies and children). The provider will clean the heel or fingertip with alcohol and poke the site with a small needle. The provider will collect a few drops of blood and put a bandage on the site.
You don't need any special preparations for a white blood count.
After a blood test, you may have slight pain or bruising at the spot where the needle was put in, but most symptoms go away quickly.
There is very little risk to your baby or child with a needle stick test. Your child may feel a little pinch when the site is poked, and a small bruise may form at the site. This should go away quickly.
A high white blood count may mean you have one of the following conditions:
A bacterial or viral infection
An inflammatory disease such as rheumatoid arthritis
An allergy
Leukemia or Hodgkin disease
Tissue damage from a burn injury or surgery
A low white blood count may mean you have one of the following conditions:
Bone marrow damage. This may be caused by infection, disease, or treatments such as chemotherapy.
Cancers that affect the bone marrow
An autoimmune disorder, such as lupus (or SLE)
HIV/AIDS
If you are already being treated for a white blood cell disorder, your results may show if your treatment is working or whether your condition has improved.
If you have questions about your results, talk to your health care provider.
White blood count results are often compared with results of other blood tests, including a blood differential. A blood differential test shows the amount of each type of white blood cell, such as neutrophils or lymphocytes. Neutrophils mostly target bacterial infections. Lymphocytes mostly target viral infections.
A higher than normal amount of neutrophils is known as neutrophilia.
A lower than normal amount is known as neutropenia.
A higher than normal amount of lymphocytes is known as lymphocytosis.
A lower normal amount is known as lymphopenia.
White Blood Count (WBC): MedlinePlus Medical Test [accessed on Jan 20, 2024]
WBC count: MedlinePlus Medical Encyclopedia [accessed on Jan 20, 2024]
White Blood Cell Count (WBC Blood Test) - Testing.com. Sep 28, 2022 [accessed on Jan 20, 2024]
Normal reference ranges can vary depending on the laboratory and the method used for testing. You must use the range supplied by the laboratory that performed your test to evaluate whether your results are "within normal limits."
Additional Materials (37)
White Blood Cell Count: Bone Marrow
Disease or damage to the bone marrow, caused by infection, cancer, radiation treatment, or chemotherapy can lower white blood cell count by impairing the marrow's ability to produce new white blood cells.
Image by TheVisualMD
White Blood Cells, Bone Marrow
Bone marrow is constantly producing blood cells, including white blood cells and red blood cells as well platelets, which are cell fragments important for blood clotting. Disease and disorders of the bone marrow can, in turn, affect the production of blood cells. Both cancer and cancer treatment (chemotherapy and radiation) can also have an impact on the bone marrow's ability to produce blood cells.
Image by TheVisualMD
This browser does not support the video element.
Complete Blood Count, and Baselining Your Health
Video Topics : Our lifeblood consists of many components and a complete blood count (CBC) includes measurements of the fundamental elements. The largest categories are red and white blood cells (RBCs and WBCs) and cell fragments called platelets, which play roles in blood clotting. There are 20-30 trillion red blood cells in the body of an adult, each with a lifespan of about 100 days (RBCs contain an iron-containing protein called hemoglobin that enables them to carry oxygen to tissues throughout the body and then return carbon dioxide to the lungs). WBCs are in the front lines in the body's ongoing fight against harmful viruses, bacteria and even fungus; when a pathogen enters the body, WBCs mobilize in a coordinated defense response to eliminate, neutralize or mark the invader for destruction. The liquid portion of blood is called plasma and it carries nutrients, electrolytes, waste products, and hormones.
Video by TheVisualMD
The Immune System Explained I – Bacteria Infection
Video by Kurzgesagt – In a Nutshell/YouTube
Immune Response to Bacteria
Video by NIAID/YouTube
Immunology - Adaptive Immune System
Video by Armando Hasudungan/YouTube
Immune System - Natural Killer Cell
Video by Kyle Thornthwaite/YouTube
Your Immune System: Natural Born Killer - Crash Course Biology #32
Video by CrashCourse/YouTube
White Blood Cell and Red Blood Cell
Medical visualization of blood cells. Depicted are numerous red blood cells and a single white blood cell.
Image by TheVisualMD
White Blood Cell and Red Blood Cell
Medical visualization of blood cells. Depicted are numerous red blood cells and a single white blood cell.
Image by TheVisualMD
Red Blood Cell and White Blood Cell
Visualization of red blood cells and a white blood cell
Image by TheVisualMD
Sensitive content
This media may include sensitive content
Blood cells (from left to right: erythrocyte, thrombocyte, leukocyte)
A single drop of blood contains millions of red blood cells, white blood cells, and platelets. One of each type is shown here, isolated from a scanning electron micrograph.
Image by Electron Microscopy Facility at The National Cancer Institute at Frederick (NCI-Frederick)
Bone structure
Anatomy of the bone. The bone is made up of compact bone, spongy bone, and bone marrow. Compact bone makes up the outer layer of the bone. Spongy bone is found mostly at the ends of bones and contains red marrow. Bone marrow is found in the center of most bones and has many blood vessels. There are two types of bone marrow: red and yellow. Red marrow contains blood stem cells that can become red blood cells, white blood cells, or platelets. Yellow marrow is made mostly of fat.
Image by Smart Servier website
Blood Cells
Formed Elements of Blood
Image by Blausen.com staff (2014). \"Medical gallery of Blausen Medical 2014\"
Phagocytosis - C-reactive protein (CRP) is a substance made by the liver that is released into the bloodstream by inflammation and infection as part of the body's immune response.
C-reactive protein (CRP) is a substance made by the liver that is released into the bloodstream by inflammation and infection as part of the body's immune response. White blood cells are also mobilized by the immune system and CRP is believed to enhance the activity of the white blood cells called macrophages. Each type of white blood cell has its own specialized immune functions; macrophages, for example, basically engulf and \"eat\" foreign invaders such as bacteria, viruses and fungi. Macrophages in the spleen and the liver weed out old and defective red blood cells and break them into recyclables (iron, heme, and some globin) and wastes (such as bilirubin). The bilirubin is then used by the liver to produce bile, which is stored in the gallbladder and released into the small intestine to aid digestion.
Image by TheVisualMD
White blood cells
Immune cells surrounding hair follicles in mouse skin. These hair follicles are home to a diverse array of commensal bacteria.
Image by NIAID
Neutrophil
Neutrophil function, relationship to disease, and location in the human body. Credit: NIAID
Image by NIAID
Innate immune system
Image by US Gov
Macrophage Capturing Foreign Antigen
Cell-mediated immunity is an immune response that does not involve antibodies or complement but rather involves the activation of macrophages, natural killer cells (NK), antigen-specific cytotoxic T-lymphocytes, and the release of various cytokines in response to an antigen. Macrophages are white blood cells that engulf and digest cellular debris and pathogens
Image by TheVisualMD
Mast Cell
Mast cells produce histamine. Histamine is known for its role in inflammation. It affects a variety of behavior patterns including the sleep-wake cycle and food intake. Antihistamines may work at odds with inflammation and depression.
Image by TheVisualMD
Leukocytes
Image by OpenStax College
Innate immune system
Illustration of the Innate Immune System responding to injury.
Image by OpenStax College
Eosinophilia
Drawing of an eosinophil white blood cell
Image by Iceclanl
Two neutrophils among many red blood cells. Neutrophils are one type of cell affected by chronic granulomatous disease.
Image by Uploaded by Mgiganteus
Eosinophils
Eosinophil function, relationship to disease, and location in the human body.
Image by NIAID
Sensitive content
This media may include sensitive content
Blood Cells
This is a scanning electron microscope image from normal circulating human blood. One can see red blood cells, several white blood cells including lymphocytes, amonocyte, a neutrophil, and many small disc-shaped platelets. Red cells are nonnucleated and contain hemoglobin, an important protein that contains iron and allows the cell to carry oxygen to other parts of the body. They also carry carbon dioxide away from peripheral tissue to the lungs where it can be exhaled. The infection-fighting white blood cells are classified in two main groups: granular and agranular. All blood cells are formed in the bone marrow. There are two types of agranulocytes: lymphocytes, which fight disease by producing antibodies and thus destroying foreign material, and monocytes. Platelets are tiny cells formed in bone marrow and are necessary for blood clotting.
Image by Bruce Wetzel (photographer). Harry Schaefer (photographer), National Cancer Institute
Immune System and Autoimmune Diseases
Normally, an individual's immune system learns to identify and ignore all of the distinctive little structures found on that individual's own cells. Sometimes, however, it will make a mistake and identify its own body as foreign. If that happens, the immune system produces antibodies that attempt to destroy the body's own cells in the same way it would try to destroy a foreign invader.
Image by TheVisualMD
Eosinophils
Drawing of an eosinophil white blood cell
Image by BruceBlaus
Eosinophils
On the left there is a segmented polymorphonuclear neutrophil, on the right and below is one eosinophil leucocyte. For comparison the red blood cell have a diameter of 7-8 micrometers. The picture was taken with a Nikon Eclipse 600 microscope, magnification was 1000x.
Image by Davidcsaba Dr. David Csaba L.
Neutrophil action - Inflammation
Neutrophil granulocyte migrates from the blood vessel to the matrix, secreting proteolytic enzymes, in order to dissolve intercellular connections (for improvement of its mobility) and envelop bacteria through Phagocytosis.
Image by Uwe Thormann/Wikimedia
Neutrophil
Image by BruceBlaus
White Blood Cells
A type of immune cell. Most white blood cells are made in the bone marrow and are found in the blood and lymph tissue. White blood cells help the body fight infections and other diseases. Granulocytes, monocytes, and lymphocytes are white blood cells.
Image by Blausen.com staff (2014). "Medical gallery of Blausen Medical 2014"
high white blood cell count Video
Video by itbestshop/YouTube
What Are White Blood Cells | Health | Biology | FuseSchool
Video by FuseSchool - Global Education/YouTube
Learning to Decode Your Blood Test Results for Chronic Lymphocytic Leukemia (CLL)
Video by CLL Society/YouTube
WellnessFX: White Blood Cells And Differential with Bryan Walsh
Video by WellnessFX/YouTube
White Blood Count
White Blood Count
Image by TheVisualMD
White Blood Cell Count: Bone Marrow
TheVisualMD
White Blood Cells, Bone Marrow
TheVisualMD
2:12
Complete Blood Count, and Baselining Your Health
TheVisualMD
6:49
The Immune System Explained I – Bacteria Infection
Kurzgesagt – In a Nutshell/YouTube
1:47
Immune Response to Bacteria
NIAID/YouTube
14:59
Immunology - Adaptive Immune System
Armando Hasudungan/YouTube
3:02
Immune System - Natural Killer Cell
Kyle Thornthwaite/YouTube
15:02
Your Immune System: Natural Born Killer - Crash Course Biology #32
CrashCourse/YouTube
White Blood Cell and Red Blood Cell
TheVisualMD
White Blood Cell and Red Blood Cell
TheVisualMD
Red Blood Cell and White Blood Cell
TheVisualMD
Sensitive content
This media may include sensitive content
Blood cells (from left to right: erythrocyte, thrombocyte, leukocyte)
Electron Microscopy Facility at The National Cancer Institute at Frederick (NCI-Frederick)
Bone structure
Smart Servier website
Blood Cells
Blausen.com staff (2014). \"Medical gallery of Blausen Medical 2014\"
Phagocytosis - C-reactive protein (CRP) is a substance made by the liver that is released into the bloodstream by inflammation and infection as part of the body's immune response.
TheVisualMD
White blood cells
NIAID
Neutrophil
NIAID
Innate immune system
US Gov
Macrophage Capturing Foreign Antigen
TheVisualMD
Mast Cell
TheVisualMD
Leukocytes
OpenStax College
Innate immune system
OpenStax College
Eosinophilia
Iceclanl
Two neutrophils among many red blood cells. Neutrophils are one type of cell affected by chronic granulomatous disease.
Uploaded by Mgiganteus
Eosinophils
NIAID
Sensitive content
This media may include sensitive content
Blood Cells
Bruce Wetzel (photographer). Harry Schaefer (photographer), National Cancer Institute
Immune System and Autoimmune Diseases
TheVisualMD
Eosinophils
BruceBlaus
Eosinophils
Davidcsaba Dr. David Csaba L.
Neutrophil action - Inflammation
Uwe Thormann/Wikimedia
Neutrophil
BruceBlaus
White Blood Cells
Blausen.com staff (2014). "Medical gallery of Blausen Medical 2014"
8:22
high white blood cell count Video
itbestshop/YouTube
3:12
What Are White Blood Cells | Health | Biology | FuseSchool
FuseSchool - Global Education/YouTube
1:17:17
Learning to Decode Your Blood Test Results for Chronic Lymphocytic Leukemia (CLL)
CLL Society/YouTube
16:52
WellnessFX: White Blood Cells And Differential with Bryan Walsh
WellnessFX/YouTube
White Blood Count
TheVisualMD
Hemoglobin
Hemoglobin Blood Test
Also called: Hemoglobin, Hgb
A hemoglobin test measures the levels of hemoglobin in your blood. Hemoglobin is an iron-rich protein in red blood cells that carries oxygen. Abnormal levels may mean you have anemia or another blood disorder.
Hemoglobin Blood Test
Also called: Hemoglobin, Hgb
A hemoglobin test measures the levels of hemoglobin in your blood. Hemoglobin is an iron-rich protein in red blood cells that carries oxygen. Abnormal levels may mean you have anemia or another blood disorder.
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Use the slider below to see how your results affect your
health.
g/dL
13.8
17.2
Your result is Normal.
Heme, an iron-containing molecule, combines with globin proteins to form hemoglobin, which carries oxygen in red blood cells from the lungs to the rest of the body.
Related conditions
A hemoglobin test measures the levels of hemoglobin in your blood. Hemoglobin is a protein in your red blood cells that carries oxygen from your lungs to the rest of your body. If your hemoglobin levels are abnormal, it may be a sign that you have a blood disorder.
Other names: Hb, Hgb
A hemoglobin test is often used to check for anemia, a condition in which your body has fewer red blood cells than normal. If you have anemia, the cells in your body don't get all the oxygen they need. Hemoglobin tests are measured as part of a complete blood count (CBC).
Your health care provider may order the test as part of a routine exam, or if you have:
Symptoms of anemia, which include weakness, dizziness, and cold hands and feet
A family history of thalassemia, sickle cell anemia, or other inherited blood disorder
A diet low in iron and other minerals
A long-term infection
Excessive blood loss from an injury or surgical procedure
A health care professional will take a blood sample from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial. You may feel a little sting when the needle goes in or out. This usually takes less than five minutes.
You don't need any special preparation for a hemoglobin test. If your health care provider has ordered other tests on your blood sample, you may need to fast (not eat or drink) for several hours before the test. Your health care provider will let you know if there are any special instructions to follow.
There is very little risk to having a blood test. After the test, some people experience mild pain, dizziness, or bruising. These symptoms usually go away quickly.
There are many reasons your hemoglobin levels may not be in the normal range.
Low hemoglobin levels may be a sign of:
Different types of anemia
Thalassemia
Iron deficiency
Liver disease
Cancer and other diseases
High hemoglobin levels may be a sign of:
Lung disease
Heart disease
Polycythemia vera, a disorder in which your body makes too many red blood cells. It can cause headaches, fatigue, and shortness of breath.
If any of your levels are abnormal, it doesn't always mean you have a medical condition that needs treatment. Diet, activity level, medicines, a menstrual period, and other factors can affect the results. You may also have higher than normal hemoglobin levels if you live in a high altitude area. Talk with your provider to learn what your results mean.
Some forms of anemia are mild, while other types of anemia can be serious and even life threatening if not treated. If you are diagnosed with anemia, be sure to talk to your health care provider to find out the best treatment plan for you.
Hemoglobin Test: MedlinePlus Medical Test [accessed on Jan 20, 2024]
Hemoglobin: MedlinePlus Medical Encyclopedia [accessed on Jan 20, 2024]
Hemoglobin - Health Encyclopedia - University of Rochester Medical Center [accessed on Jan 20, 2024]
Normal reference ranges can vary depending on the laboratory and the method used for testing. You must use the range supplied by the laboratory that performed your test to evaluate whether your results are "within normal limits."
Additional Materials (16)
Hemoglobin | Human anatomy and physiology | Health & Medicine | Khan Academy
Video by Khan Academy/YouTube
Blood, Part 2 - There Will Be Blood: Crash Course A&P #30
Video by CrashCourse/YouTube
Haemoglobin
Video by Wellcome Trust/YouTube
Hemoglobin A1c & Diabetes
Video by DiabeTV/YouTube
Hemoglobin Molecule
Molecule of hemoglobin.
Image by TheVisualMD
Hemoglobin A1C Molecule
Hemoglobin is a protein found inside red blood cells that carries oxygen from the lungs to cells throughout the body. Hemoglobin also binds with glucose. Diabetics have too much glucose in the bloodstream and this extra glucose binds (or glycates) with hemoglobin. Glycated hemoglobin usually stays glycated for the life of the red blood cell (about 3 months). Therefore, the percentage of hemoglobin that is glycated (measured as A1C) reflects glucose levels that have affected red blood cells up to 3 months in the past. The hemoglobin A1C test measures the percentage of hemoglobin bound to blood sugar (glucose); the test is used to diagnose type 1 and type 2 diabetes. Because the test results reflect average blood sugar levels over a period of 2-3 months (rather than daily fluctuations), the hemoglobin A1C test is also used to gauge how well patients are managing their diabetes over time.
Image by TheVisualMD
Hemoglobin A1C: Red Blood Cells
Red blood cells use the iron-rich protein hemoglobin to carry oxygen from the lungs to cells throughout the body and return carbon dioxide to the lungs. The percentage of hemoglobin bound to blood glucose (hemoglobin A1C) is used to diagnose diabetes.
Image by TheVisualMD
Hemoglobin of Red Blood Cell
Hemoglobin is an iron-containing protein found in red blood cells that binds oxygen and carbon dioxide for transport and delivery to different parts of the body.
Image by TheVisualMD
Hemoglobin Molecule
Hemoglobin is an iron-rich protein that is packed inside RBCs. It is a structurally complex molecule that can change shape to either hold or release oxygen, depending on the body's need. There are close to 300 million hemoglobin molecules within each RBC.
Image by TheVisualMD
Hemoglobin Molecule Heme Group
A heme group in a hemoglobin molecule consists of an iron atom bound equally to four nitrogen atoms, all lying in one plane. The iron atom is the site of oxygen binding.
Image by TheVisualMD
This browser does not support the video element.
Hemoglobin Within Red Blood Cell (RBC)
A red blood cell rushes toward the camera, the camera enters the cell to focus on all of the hemoglobin molecules within
Video by TheVisualMD
Hemoglobin, Carbon Monoxide
Hemoglobin is an iron-containing protein that enables red blood cells to deliver oxygen from the lungs to cells throughout the body. But the same binding site on the hemoglobin molecule has an even stronger affinity for carbon monoxide, which is why we are so susceptible to poisoning by this deadly gas; carbon monoxide grabs all the binding sites and starves the body's tissues of oxygen
Image by TheVisualMD
This browser does not support the video element.
Hemoglobin A1c
The hemoglobin A1c test measures the percentage of hemoglobin bound to blood sugar (glucose); the test is used to diagnose type 1 and type 2 diabetes. Because the test results reflect average blood sugar levels over a period of 2-3 months (rather than daily fluctuations), the hemoglobin A1C test is also used to gauge how well patients are managing their diabetes over time.
Video by TheVisualMD
Hemoglobin A1c
The hemoglobin A1c test measures the percentage of hemoglobin bound to blood sugar (glucose); the test is used to diagnose type 1 and type 2 diabetes. Because the test results reflect average blood sugar levels over a period of 2-3 months (rather than daily fluctuations), the hemoglobin A1C test is also used to gauge how well patients are managing their diabetes over time.
Image by TheVisualMD
Hemoglobin: O2 Binding Hemoglobin
Hemoglobin normally binds to life-sustaining oxygen. But the same binding site on the hemoglobin molecule has an even stronger affinity for carbon monoxide, which is why we are so susceptible to poisoning by this deadly gas.
Image by TheVisualMD
HemoglobinA1C
Hemoglobin Test for O2 Binding Hemoglobin : A hemoglobin test is a measurement of your blood's oxygen-carrying capacity. High levels of hemoglobin can be the result of dehydration, lung disease and other conditions. Low levels of hemoglobin indicate that there is a shortage of red blood cells; this can be the result of RBCs being lost or destroyed too quickly or produced too slowly. Hemoglobin is an iron-containing protein that enables red blood cells to deliver oxygen from the lungs to cells throughout the body. But the same binding site on the hemoglobin molecule has an even stronger affinity for carbon monoxide, which is why we are so susceptible to poisoning by this deadly gas; carbon monoxide grabs all the binding sites and starves the body's tissues of oxygen.
Image by TheVisualMD
14:34
Hemoglobin | Human anatomy and physiology | Health & Medicine | Khan Academy
Khan Academy/YouTube
10:01
Blood, Part 2 - There Will Be Blood: Crash Course A&P #30
CrashCourse/YouTube
5:31
Haemoglobin
Wellcome Trust/YouTube
1:43
Hemoglobin A1c & Diabetes
DiabeTV/YouTube
Hemoglobin Molecule
TheVisualMD
Hemoglobin A1C Molecule
TheVisualMD
Hemoglobin A1C: Red Blood Cells
TheVisualMD
Hemoglobin of Red Blood Cell
TheVisualMD
Hemoglobin Molecule
TheVisualMD
Hemoglobin Molecule Heme Group
TheVisualMD
0:27
Hemoglobin Within Red Blood Cell (RBC)
TheVisualMD
Hemoglobin, Carbon Monoxide
TheVisualMD
0:27
Hemoglobin A1c
TheVisualMD
Hemoglobin A1c
TheVisualMD
Hemoglobin: O2 Binding Hemoglobin
TheVisualMD
HemoglobinA1C
TheVisualMD
Hematocrit
Hematocrit Blood Test
Also called: Hematrocit, HCT, Crit, Packed Cell Volume, PCV
Hematocrit is a blood test that measures how much of a person's blood is made up of red blood cells. Hematocrit levels that are too high or too low can be a sign of a blood disorder, dehydration, or other medical conditions that affect your blood.
Hematocrit Blood Test
Also called: Hematrocit, HCT, Crit, Packed Cell Volume, PCV
Hematocrit is a blood test that measures how much of a person's blood is made up of red blood cells. Hematocrit levels that are too high or too low can be a sign of a blood disorder, dehydration, or other medical conditions that affect your blood.
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Use the slider below to see how your results affect your
health.
%
40.7
50.3
Your result is Normal.
Normal hematocrit levels vary based on age and race. In adults, normal levels for men range from 41%-50%. For women, the normal range is slightly lower: 36%-44%.
Related conditions
A hematocrit test is a blood test that measures how much of your blood is made up of red blood cells. Red blood cells carry oxygen from your lungs to the rest of your body. The other parts of your blood include white blood cells (to help fight infection), platelets (to help make blood clots to stop bleeding), and a liquid called plasma.
Hematocrit levels that are too high or too low can be a sign of a blood disorder, dehydration, or other medical conditions that affect your blood.
Other names: HCT, packed cell volume, PCV, Crit; H and H (Hemoglobin and Hematocrit)
A hematocrit test is often part of a complete blood count (CBC). A CBC is a common blood test that measures the different parts of your blood. It is used to check your general health. It may also be used to help diagnose blood disorders, including anemia, a condition in which you don't have enough red blood cells, and polycythemia, an uncommon disorder in which you have too many red blood cells and your blood becomes too thick.
Your health care provider may order a hematocrit test as part of your regular checkup or to monitor your health if you are being treated for cancer or have an ongoing health condition. Your provider may also order this test if you have symptoms of a red blood cell disorder, such as anemia or polycythemia:
Symptoms of anemia (too few red blood cells) may include:
Shortness of breath
Weakness or fatigue
Headache
Dizziness
Arrhythmia (a problem with the rate or rhythm of your heartbeat)
Symptoms of polycythemia (too many red blood cells) may include:
Headache
Feeling light-headed or dizzy
Shortness of breath
Weakness or fatigue
Skin symptoms such as itching after a shower or bath, burning, or a red face
Heavy sweating, especially during sleep
Blurred or double vision and blind spots
Bleeding gums and heavy bleeding from small cuts
A health care professional will take a blood sample from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial. You may feel a little sting when the needle goes in or out. This usually takes less than five minutes.
You don't need any special preparations for a hematocrit test. If your provider has ordered more tests on your blood sample, you may need to fast (not eat or drink) for several hours before the test. Your provider will let you know if there are any special instructions to follow.
There is very little risk to having a hematocrit test or other type of blood test. You may have slight pain or bruising at the spot where the needle was put in, but most symptoms go away quickly.
Your hematocrit test results are reported as a number. That number is the percentage of your blood that's made of red blood cells. For example, if your hematocrit test result is 42, it means that 42% of your blood is red blood cells and the rest is white blood cells, platelets, and blood plasma.
A hematocrit level that's lower than normal may be a sign that:
Your body doesn't have enough red blood cells (anemia). There are many types of anemia that can be caused by different medical conditions.
Your body is making too many white blood cells, which may be caused by:
Bone marrow disease
Certain cancers, including leukemia, lymphoma, multiple myeloma, or cancers that spread to the bone marrow from other parts of the body
A hematocrit level that's higher than normal may be a sign that:
Your body is making too many red blood cells, which may be caused by:
Lung disease
Congenital heart disease
Heart failure
Polycythemia
Your blood plasma level is too low, which may be caused by:
Dehydration, the most common cause of a high hematocrit
Shock
If your results are not in the normal range, it doesn't always mean that you have a medical condition that needs treatment. Living at high altitudes where there's less oxygen in the air may cause a high hematocrit. That's because your body responds to low oxygen levels by making more red blood cells so that you get the oxygen you need.
Pregnancy can cause a low hematocrit. That's because the body has more fluid than normal during pregnancy, which decreases the percentage that's made of red blood cells.
To learn what your test results mean, talk with your provider.
Normal hematocrit levels will be different depending on your sex, age, and the altitude where you live. Ask your provider what hematocrit level is normal for you.
Hematocrit Test: MedlinePlus Medical Test [accessed on Jan 20, 2024]
Hematocrit: MedlinePlus Medical Encyclopedia [accessed on Jan 20, 2024]
Hematrocit Blood Test - Testing.com. Sep 13, 2022 [accessed on Jan 20, 2024]
Normal reference ranges can vary depending on the laboratory and the method used for testing. You must use the range supplied by the laboratory that performed your test to evaluate whether your results are "within normal limits."
Additional Materials (30)
This browser does not support the video element.
Complete Blood Count, and Baselining Your Health
Video Topics : Our lifeblood consists of many components and a complete blood count (CBC) includes measurements of the fundamental elements. The largest categories are red and white blood cells (RBCs and WBCs) and cell fragments called platelets, which play roles in blood clotting. There are 20-30 trillion red blood cells in the body of an adult, each with a lifespan of about 100 days (RBCs contain an iron-containing protein called hemoglobin that enables them to carry oxygen to tissues throughout the body and then return carbon dioxide to the lungs). WBCs are in the front lines in the body's ongoing fight against harmful viruses, bacteria and even fungus; when a pathogen enters the body, WBCs mobilize in a coordinated defense response to eliminate, neutralize or mark the invader for destruction. The liquid portion of blood is called plasma and it carries nutrients, electrolytes, waste products, and hormones.
Video by TheVisualMD
Vial of Centrifuged Blood
Blood is made up of red and white blood cell (as well as platelets), suspended in a liquid known as blood plasma. Plasma, which makes up 55% of our blood's volume, is a clear liquid (mainly water) that transports food molecules, hormones, waste as well as a wide range of dissolved chemicals. Red cells, which normally make up 40-50% of total blood volume, are produced continuously in our bone marrow at the rate of about 2-3 million cells per second. White cells make up a very small part of blood's volume-normally only about 1% in healthy people. This image shows two vials of centrifuged blood. The left vial shows healthy amount of red blood cells in female (36-44%) ; The right vial shows healthy amount of red blood cells in male (41-50%). The hematocrit (along with the hemoglobin test) is the central test to diagnosing anemia in that it indicates the amount of RBCs in the blood.
Image by TheVisualMD
Red Blood Cells, Bone Marrow
A skeleton may have a dry and lifeless Halloween image, but bone is actually dynamic, living tissue. Bone is not uniformly solid; within its interior is a network of cavities that house blood vessels and marrow. Bone marrow, particularly in larger bones, is where stem cells give rise to red blood cells (erythrocytes) as well as white blood cells (leukocytes) and blood clotting agents (platelets). As the source of blood cells, the bone marrow is critical to health. Disease or damage to bone marrow can result in either too many or too few blood cells.
Hematocrit Nursing Considerations, Normal Range, Nursing Care, Lab Values Nursing
Video by NURSINGcom/YouTube
Hematocrit, Dehydration
Blood is composed of cells (primarily red blood cells, but also white blood cells and cell fragments called platelets) along with a liquid portion known as plasma. The ratio of the volume of red blood cells to the volume of plasma is an important health indicator and is known as the hematocrit. The most common cause of a high hematocrit is dehydration, which is usually temporary and easily remedied by increasing fluid intake, thereby restores the balance between RBCs and blood plasma volume.
Image by TheVisualMD
Hematocrit, Anemia
Blood is composed of cells (primarily red blood cells, but also white blood cells and cell fragments called platelets) along with a liquid portion known as plasma. The ratio of the volume of red blood cells to the volume of plasma is an important health indicator and is known as the hematocrit. A low hematocrit usually indicates anemia, which occurs when red blood cells are being either destroyed too quickly or produced too slowly; with fewer red blood cells, less oxygen is delivered to body tissues.
Image by TheVisualMD
Vial of Blood for Hematocrit Test
This image is a vial of blood that has been centrifuged (and thus separated) to determine hematocrit. This vial shows, from top to bottom, 55% plasma, <1% white blood cells, <1% platelets , 45% red blood cells. Hematocrit measures how much of the blood, by volume, is taken up by RBCs. A normal range for hematocrit is 41 to 50 percent in men and 36 to 44 percent in women. In many cases, a reading below the normal range for hematocrit will lead to a diagnosis of CKD-related anemia.This other diagnostic test is the hemoglobin test, which measures the amount of hemoglobin molecules in the blood and is a good indicator of the body's ability to carry oxygen throughout the body.
Image by TheVisualMD
Hematocrit: Bone Marrow
Bone marrow produces about 2 million red blood cells (RBCs) a second to maintain a healthy hematocrit. Many conditions, including kidney disease, chemotherapy, and dietary deficiencies, can reduce RBC production, while others can result in too many RBCs.
Image by TheVisualMD
Hematocrit: Blood Cells
The hematocrit is another way to look at the health of red blood cells (RBCs). Blood is composed of cells (primarily RBCs) and a liquid portion called plasma. The proportions of RBCs and plasma must be kept in balance and this is what the hematocrit measures.
Image by TheVisualMD
Blood
Components of Blood : Blood is mostly made up of plasma and red and white blood cells. But it also contains many other substances as well, like platelets, hormones, nutrients such as glucose, and fats like cholesterol. Blood is the fluid of life, transporting oxygen from the lungs to body tissue and carbon dioxide from body tissue to the lungs.
Image by TheVisualMD
Hematocrit
Hematocrit Blood Vials : If you are at risk for cardiovascular disease, your doctor may order a cholesterol and triglyceride level test as well as a complete blood count (CBC). Abnormal results may be the first clue in determining risk of and in diagnosing cardiovascular disease.
Image by TheVisualMD
Blood Smear Showing Reduced Red Blood Cell Count
Individual blood cells were first detected and described in the 17th century. Later, red blood cells (RBCs) were counted manually from a blood smear, a thin film of blood prepared on a glass slide and examined under a microscope (blood analysis is now automated, though smears are still used to detect visible abnormalities and to check or confirm the results of other tests). Anemia results when there are too few RBCs in circulation because they are being destroyed too quickly or produced too slowly. Anemia can be temporary or long term and range from mild to severe. Folate (also known as vitamin B9) is necessary for red blood cell production and the prevention of anemia, as well as the metabolism of carbohydrates. But folate also plays key roles in the synthesis and maintenance of DNA and is especially important in cell division and growth in fetal development (deficiencies of the vitamin in pregnancy is a common cause of birth defects). Pernicious anemia is a disorder in which the body's loses its ability to utilize folate and vitamin B12.
Image by TheVisualMD
Blood Smear Showing Normal Red Blood Cell Count
Individual blood cells were first detected and described in the 17th century. Later, red blood cells were counted manually from a blood smear, a thin film of blood prepared on a glass slide and examined under a microscope. Blood analysis is now automated, though blood smears are still used to detect visible abnormalities and to check or confirm the results of other tests. There are normally between 4.2-5.8 million red blood cells per microliter (about a drop), which means there are 20-30 trillion red blood cells circulating through the body of an adult.
Image by TheVisualMD
This browser does not support the video element.
Red Blood Cells Carry Oxygen
This video focuses on one of the main components of blood, the red blood cell and its function to carry oxygen. The video begins with revealing the red blood cells and the heart that pumps the oxygenated blood to the rest of the body. Hemoglobin is the protein molecule found in these red blood cells that enable blood to transport oxygen. If the blood's capacity to transport oxygen to the tissues is reduced due to a decrease in the number of red blood cells, anemia may occur.
Video by TheVisualMD
Components of Blood
Components of Blood : Our blood is composed of many different components, the largest categories being red and white blood cells (blood-clotting platelets are another key component) and the liquid portion known as blood plasma. A Complete Blood Count (CBC) includes several of the most basic, yet important, measurements of these components.
Image by TheVisualMD
Blood and Related Conditions
Blood and Related Conditions : Anemia results when there are too few red blood cells circulating in the bloodstream to deliver adequate oxygen to body tissues. There are different types and causes of anemia, including malnutrition, chronic bleeding, and diseases that result in red blood cells either being destroyed too quickly or produced too slowly.
Image by TheVisualMD
Pellet of Lymphocyte Cells Created in the Centrifuge
This photograph shows Wendy Watford, Ph.D. holding a test tube containing isolated lymphocyte cells. The cells were spun in a centrifuge to create a pellet at the bottom of the test tube. The cells will be labeled with CFSE dye, which will stain the membranes of the cells. After culturing the cells for three days she will determine the number of cell divisions that have taken place by measuring the dilution of the CFSE dye. The purpose of the work is to measure the proliferation of lymphocytes under various conditions. The principal investigator for this work is John J. O’Shea, M.D., NIAMS Scientific Director.
Image by NIAMS/Photographer: Rhoda Baer
Red Blood Cells
Digital holographic microscopy (DHM) image of red blood cells.
Image by Egelberg (talk)
Test Tube
Between 5,000 and 8,000 blood serum, fecal, urine, viral and respiratory samples arrive six days a week from U.S. Air Force hospitals and clinics worldwide, as well as some other Department of Defense facilities, for analysis at the Epidemiology Laboratory Service, also known as the "Epi Lab" at the 711th Human Performance Wing’s United States Air Force School of Aerospace Medicine and Public Health at Wright Patterson AFB, Ohio.The lab is a Department of Defense reference laboratory offering clinical diagnostic, public health, and force health screening and testing. (U.S. Air Force photo by J.M. Eddins Jr.)
Image by U.S. Air Force photo by J.M. Eddins Jr.
Phlebotomy
This image was uploaded as part of Wiki Loves e-textbooks contest in Poland.
Image by Sean Michael Ragan
Red Blood Cells Carry Oxygen
This video focuses on one of the main components of blood, the red blood cell and its function to carry oxygen. The video begins with revealing the red blood cells and the heart that pumps the oxygenated blood to the rest of the body. Hemoglobin is the protein molecule found in these red blood cells that enable blood to transport oxygen. If the blood's capacity to transport oxygen to the tissues is reduced due to a decrease in the number of red blood cells, anemia may occur.
Image by TheVisualMD
Composition of Blood
Composition of Blood
Image by OpenStax College
Hematology | Hematocrit
Video by Ninja Nerd/YouTube
Erythrocyte indices (Hemoglobin, Hematocrit, MCV, MCH & MCHC) What Do These Lab Tests Mean?
Video by Medicosis Perfectionalis/YouTube
How to Interpret RBC Indices (e.g. hemoglobin vs. hematocrit, MCV, RDW)
Video by Strong Medicine/YouTube
Haematocrit or PCV
Video by LabsforLifeProject/YouTube
Packed cell volume/ Hematocrit
Video by Pathology Simplified/YouTube
Fetal hemoglobin and hematocrit | Human anatomy and physiology | Health & Medicine | Khan Academy
Also called: MCV, MCV Blood Test, Mean Corpuscular Volume, Mean RBC Volume
A mean corpuscular volume (MCV) blood test measures the size of your red blood cells. If blood cells are too small or too large, it may indicate a blood disorder.
MCV (Mean Corpuscular Volume) Test
Also called: MCV, MCV Blood Test, Mean Corpuscular Volume, Mean RBC Volume
A mean corpuscular volume (MCV) blood test measures the size of your red blood cells. If blood cells are too small or too large, it may indicate a blood disorder.
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Use the slider below to see how your results affect your
health.
fL
76
96
Your result is Normal.
A normal MCV indicates that the red blood cells are normal average size, or normocytic. Normal results vary based on the laboratory and the method used.
Related conditions
MCV stands for mean corpuscular volume. An MCV blood test measures the average size of your red blood cells.
Red blood cells carry oxygen from your lungs to every cell in your body. Your cells need oxygen to grow, reproduce, and stay healthy. If your red blood cells are too small or too large, it could be a sign of a blood disorder such as anemia, a lack of certain vitamins, or other medical conditions.
Other names: CBC with differential
An MCV blood test is often part of a complete blood count (CBC). A CBC is a common blood test that measures many parts of your blood, including red blood cells. It is used to check your general health.
An MCV test may also be used with other tests to help diagnose or monitor certain blood disorders, including anemia. There are many types of anemia. An MCV test can help diagnose which type of anemia you have.
Your health care provider may order a complete blood count, which includes an MCV test, as part of your regular checkup. You may also have the test if you have a chronic (long-lasting) condition that could lead to anemia or if you have the symptoms of anemia:
Shortness of breath
Weakness or fatigue
Headache
Dizziness
Arrhythmia (a problem with the rate or rhythm of your heartbeat)
During the test, a health care professional will take a blood sample from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial. You may feel a little sting when the needle goes in or out. This usually takes less than five minutes.
You don't need any special preparations for an MCV blood test. If your provider has ordered more tests on your blood sample, you may need to fast (not eat or drink) for several hours before the test. Your provider will let you know if there are any special instructions to follow.
There is very little risk to having a blood test. You may have slight pain or bruising at the spot where the needle was put in, but most symptoms go away quickly.
An MCV test alone cannot diagnose any disease. Your provider will use the results of your MCV, other test results, and your medical history to make a diagnosis.
If your results show that your red blood cells are smaller than normal, it may be a sign of:
Certain types of anemia, including iron-deficiency anemia, the most common type
Thalassemia, an uncommon genetic condition
If your results show that your red blood cells are larger than normal, it may be a sign of:
Pernicious anemia, which may be caused by:
A lack of vitamin B12
A disease that affects your body's ability to use vitamin B12, such as certain autoimmune diseases, celiac disease, or Crohn's disease.
Anemia caused by a lack of folic acid
Liver disease
It's also possible to have anemia with a normal MCV. This may happen if anemia is caused by conditions, such as:
A sudden loss of blood
Kidney failure
Aplastic anemia (uncommon)
If your MCV levels are not in the normal range, it doesn't always mean that you have a medical problem that needs treatment. Diet, activity level, medicines, a menstrual period, and other conditions can affect the test results. Talk with your health care provider to learn what your results mean.
If your provider thinks you may have anemia or another blood disorder, you may have other red blood cell tests with an MCV. These tests may include a red blood cell count and measurements of hemoglobin. All together, these tests are called red blood cell indices.
MCV (Mean Corpuscular Volume): MedlinePlus Medical Test [accessed on Jan 20, 2024]
Normal reference ranges can vary depending on the laboratory and the method used for testing. You must use the range supplied by the laboratory that performed your test to evaluate whether your results are "within normal limits."
Additional Materials (22)
Microcytic, normocytic, and macrocytic anemias | NCLEX-RN | Khan Academy
Video by khanacademymedicine/YouTube
Non-megaloblastic Macrocytic Anemia
Video by Medicosis Perfectionalis/YouTube
Microcytic anemia | Hematologic System Diseases | NCLEX-RN | Khan Academy
Video by khanacademymedicine/YouTube
Living with and Managing Iron-Deficiency Anemia
Video by NHLBI/YouTube
Hemolytic Anemia
Video by DrER.tv/YouTube
Medical School - Anemia Made Easy
Video by iMedicalSchool/YouTube
Iron deficency anemia diagnosis | Hematologic System Diseases | NCLEX-RN | Khan Academy
WellnessFX: Red Blood Cell Indices Part 1 with Bryan Walsh
Video by WellnessFX/YouTube
WellnessFX: Red Blood Cell Indices Part 2 with Bryan Walsh
Video by WellnessFX/YouTube
Blood Brain Barrier Endothelium
The blood-brain barrier keeps potentially toxic substances from entering the brain. The semipermeable membrane formed by the tightly spaced cells of capillaries in this area selectively screens out large molecules, while permitting the transport of essential nutrients such as glucose. The endothelium is the cellular lining of the blood vessel and is made up of endothelial cells connected to one another by tight junctions. These are the strongest cell-to-cell adhesions in the body. Toxic materials being transported in the blood are too large to pass through these junctions and exit the blood. Therefore, the brain is protected from exposure to many harmful substances. The barrier is does not, however, prevent fat-soluble materials from entering the brain; this includes alcohol and nicotine.
Image by TheVisualMD
Normal Blood Glucose Levels in Capillary
This image depicts a healthy capillary with normal glucose (pink) and insulin (yellow) levels. Capillaries, the smallest blood vessels in your body, are where nutrients are transferred from blood to cells, and waste from cells to blood. The body's cells depend on sugar in the blood, which is derived from carbohydrates, for food and energy. Allowing for the innumerable differences among individuals, the threshold for a normal blood-sugar (glucose) level in healthy people is 100 mg/dL; that is, 100 milligrams of glucose per deciliter of blood. Lower-than-normal levels characterize hypoglycemia and higher than normal levels characterize hyperglycemia.
Image by TheVisualMD
Cross-Section of Healthy Capillary Blood Vessel with Normal Glucose and Insulin Levels
This image depicts a healthy capillary. Capillaries are the smallest blood vessels in your body and are where the transfer of nutrients from blood to cells and wastes from cells to the blood takes place.The cells of the body depend on sugar in the blood, derived from carbohydrates, for food and energy. Allowing for the innumerable differences among individuals, the threshold for a normal blood-sugar (glucose) level in healthy people is 100 mg/dL; that is, 100 milligrams of glucose per deciliter of blood. Lower-than-normal levels characterize hypoglycemia and higher than normal levels hyperglycemia.
Image by TheVisualMD
Blood Vessels in the Brain
The Blood Brain Barrier and Astrocytes type 1
Image by Ben Brahim Mohammed
Cross-Section of Damaged Capillary Blood Vessel with Very High Glucose and Insulin Levels
This image depicts an unhealthy, damaged capillary with very high levels of insulin and glucose. Capillaries, the smallest blood vessels in your body, are where nutrients are transferred from blood to cells, and waste from cells to the blood The body's cells depend on sugar (glucose) in the blood, which is derived from carbohydrates, for food and energy. Without insulin, glucose is not able to enter cells to be used as fuel. Allowing for the innumerable differences among individuals, the threshold for a normal blood-sugar (glucose) level in healthy people is 100 mg/dL; that is, 100 milligrams of glucose per deciliter of blood. Higher than normal levels lead to hyperglycemia. Hyperglycemia is the hallmark of prediabetes (between 100 and 125 mg/dL) and diabetes (126 mg/dL and higher). It is caused by either too little insulin being released by the pancreas or the body's inability to use insulin properly. Hyperglycemia leads to microangiopathy, marked by endothelial cell apoptosis (programmed cell death), accumulation of AGEs (advanced glycation end products), and thickening of the basement membrane, which can lead to development of lesions, vasoconstriction, and altered vessel function
Blood Components
This image highlights the vital components of blood: 55% plasma Plasma is the liquid river that transports every blood cell to its destination. Oxygen-carrying RBCs couldn't move through arteries, veins and capillaries without it. Even though it is a watery, almost clear fluid, plasma contains many important substances, including blood-clotting agents called platelets and protective proteins called antibodies which help us fight infection. When the clotting agents are removed from blood plasma, it is called serum, which is essential in many life-saving medical situations such as transplant surgery and trauma. <1% white blood cells (wbcs or leukocytes) Some leukocytes are produced in the bone marrow, while others are generated in lymph nodes scattered throughout the body. They are far less numerous than their sister RBCs, but leukocytes are the bedrock of the immune system and are the body's front line of defense. Different types of leukocytes fight infections in different ways. Some target bacterial or fungal infections, while others respond to parasitic threats or allergic reactions. <1% platelets Platelets perform the vital function of clotting blood at wound sites. They are small, even in comparison to the other cells of your blood, but they pack a wallop when it comes to healing a scrape or staunching a more serious wound. When you cut yourself shaving, platelets arrive on the scene like your personal emergency medical team, creating a natural bandage of clotted blood, which eventually forms a scab. 45% red blood cells rbcs or erythrocytes) RBCs are produced in the bone marrow and perform the fundamental task of delivering oxygen to all of the body's cells. The vial is an example of the hematocrit, one of many tests that make up the complete blood count (CBC). Hematocrit measures the volume of RBCs in your blood. A normal hematocrit reading for women is between 36 to 44 percent; for men it's 41 to 50 percent.
Image by TheVisualMD
Test Tube Containing Blood
Visualization of a test tube containing blood. Blood comprises of 55% plasma, 1% platelets and white blood cells, and 45% red blood cells.
Image by TheVisualMD
Blood Smear Showing Reduced Red Blood Cell Count
Individual blood cells were first detected and described in the 17th century. Later, red blood cells (RBCs) were counted manually from a blood smear, a thin film of blood prepared on a glass slide and examined under a microscope (blood analysis is now automated, though smears are still used to detect visible abnormalities and to check or confirm the results of other tests). Anemia results when there are too few RBCs in circulation because they are being destroyed too quickly or produced too slowly. Anemia can be temporary or long term and range from mild to severe. Folate (also known as vitamin B9) is necessary for red blood cell production and the prevention of anemia, as well as the metabolism of carbohydrates. But folate also plays key roles in the synthesis and maintenance of DNA and is especially important in cell division and growth in fetal development (deficiencies of the vitamin in pregnancy is a common cause of birth defects). Pernicious anemia is a disorder in which the body's loses its ability to utilize folate and vitamin B12.
Image by TheVisualMD
Red Blood Cell in Capillary
The cardiovascular system is vast network of arteries, veins and vessels that would extend 60,000 miles if stretched end-to-end. All but a tiny fraction of this vessel network is invisible to the naked eye. The smallest capillaries (from latin "hairlike") are so narrow that red blood cells must pass through in single file. Higher than normal blood iron levels have been linked to heart disease and the reason is believed to be the oxidative stress the excess iron places on the walls of the blood vessels. It is the biological counterpart of rust. There are 20-30 trillion red blood cells (RBCs) in an adult's body. The life span of RBCs, which are produced in bone marrow, is about 100 days, which means that 2 million die (and are replaced) each second, but in that short lifetime they can make 75,000 round trips between lungs, heart and tissues in the body.
Image by TheVisualMD
Kidney and Stem Cell Creating Red Blood Cell. B12 is critical for the creation of red blood cells.
We are used to thinking of our kidneys mostly as hardworking filters that rid our bodies of wastes and excess water. But the kidneys are also constantly monitoring and adjusting levels of key substances in the blood, depending on what the body needs. Specialized cells in the kidney that are very sensitive to low oxygen levels, for example, produce a hormone called erythropoietin (EPO), which in turn promotes the production of red blood cells in the bone marrow. The boost in red blood cells increases the oxygen-carrying capacity of the blood.
Image by TheVisualMD
Healthy Capillary Blood Vessel
Cross-section of Healthy Capillary Blood Vessel with Normal Glucose and Insulin Levels
Cross-Section of Damaged Capillary Blood Vessel with Very High Glucose and Insulin Levels
1
2
3
Healthy Capillary Blood Vessel and and Damaged Capillary Blood Vessel Caused by High Levels of Blood Glucose
1) Healthy Capillary Blood Vessel - This image depicts a healthy capillary. Capillaries are the smallest blood vessels in your body. They can be so thin in diameter that blood cells have to bend in order to pass through. Capillaries are where the transfer of nutrients from the blood to cells, and the transfer of waste from cells to blood, takes place. In a healthy body, the blood vessels are smooth and elastic.
2) Cross-Section of Healthy Capillary Blood Vessel with Normal Glucose and Insulin Levels - This image depicts a healthy capillary. The body's cells depend on sugar in the blood, which is derived from carbohydrates, for food and energy. Allowing for the innumerable differences among individuals, the threshold for a normal blood sugar (glucose, pink) level in healthy people is 100 mg/dL; that is, 100 milligrams of glucose per deciliter of blood. Lower-than-normal levels characterize hypoglycemia and higher-than-normal levels characterize hyperglycemia. Without insulin (yellow), glucose is not able to enter cells to be used as fuel. Because of this, healthy insulin levels are a key factor in keeping blood glucose levels normal.
3) Cross-Section of Damaged Capillary Blood Vessel with Very High Glucose and Insulin Levels - This image depicts an unhealthy, damaged capillary with very high levels of insulin and glucose. Higher than normal levels of blood glucose lead to hyperglycemia. Hyperglycemia is the hallmark of prediabetes (between 100 and 125 mg/dL) and diabetes (126 mg/dL and higher). It is caused by either too little insulin being released by the pancreas or the body's inability to use insulin properly. Hyperglycemia leads to microangiopathy, marked by endothelial cell apoptosis (programmed cell death), accumulation of AGEs (advanced glycation end products), and thickening of the basement membrane, which can lead to the development of lesions, vasoconstriction, and altered vessel function
Interactive by TheVisualMD
5:57
Microcytic, normocytic, and macrocytic anemias | NCLEX-RN | Khan Academy
khanacademymedicine/YouTube
4:39
Non-megaloblastic Macrocytic Anemia
Medicosis Perfectionalis/YouTube
9:42
Microcytic anemia | Hematologic System Diseases | NCLEX-RN | Khan Academy
khanacademymedicine/YouTube
3:56
Living with and Managing Iron-Deficiency Anemia
NHLBI/YouTube
3:24
Hemolytic Anemia
DrER.tv/YouTube
3:16
Medical School - Anemia Made Easy
iMedicalSchool/YouTube
9:54
Iron deficency anemia diagnosis | Hematologic System Diseases | NCLEX-RN | Khan Academy
WellnessFX: Red Blood Cell Indices Part 1 with Bryan Walsh
WellnessFX/YouTube
28:05
WellnessFX: Red Blood Cell Indices Part 2 with Bryan Walsh
WellnessFX/YouTube
Blood Brain Barrier Endothelium
TheVisualMD
Normal Blood Glucose Levels in Capillary
TheVisualMD
Cross-Section of Healthy Capillary Blood Vessel with Normal Glucose and Insulin Levels
TheVisualMD
Blood Vessels in the Brain
Ben Brahim Mohammed
Cross-Section of Damaged Capillary Blood Vessel with Very High Glucose and Insulin Levels
Blood Components
TheVisualMD
Test Tube Containing Blood
TheVisualMD
Blood Smear Showing Reduced Red Blood Cell Count
TheVisualMD
Red Blood Cell in Capillary
TheVisualMD
Kidney and Stem Cell Creating Red Blood Cell. B12 is critical for the creation of red blood cells.
TheVisualMD
Healthy Capillary Blood Vessel and and Damaged Capillary Blood Vessel Caused by High Levels of Blood Glucose
TheVisualMD
Electrocardiogram
Electrocardiogram
Also called: EKG, ECG
An electrocardiogram (EKG) is a test that measures electrical signals in your heart. An abnormal EKG can be a sign of heart damage or disease.
Electrocardiogram
Also called: EKG, ECG
An electrocardiogram (EKG) is a test that measures electrical signals in your heart. An abnormal EKG can be a sign of heart damage or disease.
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Use the slider below to see how your results affect your
health.
Your result is Normal.
EKG results are normal with a consistent heartbeat and rhythm.
Related conditions
An electrocardiogram (EKG) test is a simple, painless, and quick test that records your heart's electrical activity. Each time your heart beats, an electrical signal travels through your heart. The signal triggers your heart's four chambers to contract (squeeze) in the proper rhythm so that your heart can pump blood to your body.
An EKG recording of these signals looks like wavy lines. Your provider can read these lines to look for abnormal heart activity that may be a sign of heart disease or damage.
An EKG can show:
How fast your heart is beating
Whether the rhythm of your heartbeat is steady or irregular
The strength and timing of the electrical signals passing through each part of your heart
Sometimes information from an EKG can help measure the size and position of your heart's chambers.
An EKG is often the first test you'll have if you have signs of a heart condition. It may be done in your provider's office, an outpatient clinic, in a hospital before surgery, or as part of another heart test called a stress test.
An EKG test is also called an ECG. EKG is based on the German spelling, elektrokardiogramm. EKG may be preferred over ECG to avoid confusion with an EEG, a test that measures brain waves.
An EKG test is used to help diagnose and monitor many types of heart conditions and their treatment. These conditions include:
Arrhythmia
Cardiomyopathy
Coronary artery disease
Heart attack
Heart failure
Heart valve diseases
Congenital heart defects
EKG tests are mainly used for people who have symptoms of a heart condition or have already been diagnosed with a heart condition. They are not generally used to screen people who don't have symptoms unless they have an increased risk of developing heart disease. Your provider can explain your risk for heart disease and let you know if need to have an EKG test. In certain cases, your provider may have you see a cardiologist, a doctor who specializes in heart diseases.
You may need an EKG test if you have symptoms of a heart condition, including:
Chest pain
Rapid or irregular heartbeat
Shortness of breath
Dizziness
Fatigue
A decrease in your ability to exercise
You may also need an EKG to:
Find out if you had a heart attack in the past but didn't know it
Monitor your heart if you have a known heart condition
Check how well your heart treatment is working, including medicine and/or a pacemaker
Check your heart health:
Before having surgery
If you have an increased risk for developing heart disease because:
Heart disease runs in your family
You have another condition, such as diabetes, that makes your risk higher than normal
An EKG test only takes a few minutes. It generally includes these steps:
You will lie on an exam table.
A provider will place several electrodes (small sensors that stick to your skin) on your arms, legs, and chest. The provider may need to shave body hair to make sure the electrodes stay on.
The electrodes are attached by wires to a computer or a special EKG machine
You will lie very still while your heart's electrical activity is recorded on a computer or printed on paper by an EKG machine.
You don't need any special preparations for an EKG test.
There is very little risk to having an EKG. You may feel a little discomfort or skin irritation after the electrodes are removed. The EKG doesn't send any electricity to your body. It only records electrical signals from your heart, so there's no risk of electric shock.
Your provider will check your EKG results for a steady heartbeat and rhythm. If your results are not normal, it may be a sign of a heart condition. The specific condition depends on which part of your EKG wasn't normal.
You may need to have other heart health tests before your provider can make a diagnosis. Your provider can explain what your test results mean for your heart health and treatment.
An EKG is a "snapshot" of your heart's activity over a very short time. If you have heart symptoms that come and go, a regular EKG may not catch the problem. In that case, your provider may recommend that you wear a small portable EKG monitor that can record your heart for days or longer while you do your normal activities. You may also need a longer EKG recording if your provider wants to check how well your heart is working after a heart attack or to see if treatment is helping you.
There are many types of long-term EKG monitors. The two main groups are Holter monitors, which can be worn for up to two days, and event monitors, which may record your heart activity for weeks to years depending on the type.
A Holter monitor is about the size of a small camera. You usually wear it on a belt or strap around your neck for a day or two. Wires under your clothes attach to electrodes that stick to your chest. The monitor records your heart's electrical signals the whole time you're wearing it. You may be asked to keep a diary of your symptoms during the test period. After the test period, you remove the monitor and return it according to the instructions. A provider will review the recording of your heart's electrical activity from the monitor.
An event monitor records your heart's electrical activity when you press a button or when the device detects abnormal heart activity. There two main types of event monitors:
Event monitors that you wear or carry with you. You wear some monitors on your chest or wrist. Other monitors are designed to carry. If you have symptoms, you hold the monitor to your chest. These event monitors may be used for weeks to months. Some of them wirelessly transmit information about your heart to a provider. Others must be returned so a provider can examine the recorded information.
Event monitors that are inserted under the skin of your chest. These are called implantable event monitors. They are put under your skin during minor surgery that's often done in a doctor's office. These monitors can track your heart's electrical activity for years. You may need this type of EKG monitor if you had a stroke or frequent fainting, and your provider hasn't found the cause. Implantable monitors wirelessly transmit the information they record so your provider can regularly check it.
Electrocardiogram: MedlinePlus Medical Test [accessed on Mar 09, 2023]
Electrocardiogram: MedlinePlus Medical Encyclopedia [accessed on Feb 04, 2019]
Normal reference ranges can vary depending on the laboratory and the method used for testing. You must use the range supplied by the laboratory that performed your test to evaluate whether your results are "within normal limits."
Additional Materials (35)
How to Read an Electrocardiogram (ECG): Introduction – Cardiology | Lecturio
Video by Lecturio Medical/YouTube
Major Types of Heart Block
Video by Jeff Otjen/YouTube
How An ECG Works
Video by LivingHealthyChicago/YouTube
This browser does not support the video element.
What are Arrhythmias?
Your heart is electric. In this video you'll see how your heart's electrical system works, and what happens when it malfunctions. Voyage inside the human body as Dr. Mehmet Oz and others explain the dangers of heart arrhythmias, including tachycardia, bradycardia, and atrial fibrillation.
Video by TheVisualMD
12 Lead ECG Explained, Animation
Video by Alila Medical Media/YouTube
Bundle Branch Block, Animation.
Video by Alila Medical Media/YouTube
QRS Transitional Zone. See link for real voice update in description!
Video by Alila Medical Media/YouTube
ECG Interpretation Basics - ST Segment Changes. See link for real voice update in description!
Video by Alila Medical Media/YouTube
Cardiac Axis Interpretation. See link for real voice update in description!
Video by Alila Medical Media/YouTube
Electrical system of the heart | Circulatory system physiology | NCLEX-RN | Khan Academy
Video by khanacademymedicine/YouTube
Cardiovascular | EKG Basics
Video by Ninja Nerd/YouTube
Cardiovascular | EKG's
Video by Ninja Nerd/YouTube
Normal sinus rhythm on an EKG | Circulatory System and Disease | NCLEX-RN | Khan Academy
Video by khanacademymedicine/YouTube
Cardiac Conduction System and Understanding ECG, Animation.
Video by Alila Medical Media/YouTube
Willem Einthoven and the ECG - Stuff of Genius
Video by Stuff of Genius - HowStuffWorks/YouTube
Electrocardiogram (ECG)
A useful tool for determining whether a person has heart disease, an electrocardiogram (ECG) is a test that records the electrical activity of the heart. An ECG, which is painless (no electricity is sent through the body), is used to measure damage to the heart, how fast the heart is beating and whether it is beating normally, the effects of drugs or devices used to control the heart (such as a pacemaker), and the size and position of the heart chambers.
Image by TheVisualMD
Cardiac cycle
Cardiac Cycle vs Electrocardiogram
Image by OpenStax College
Medical Checkups
Image by TheVisualMD
Electrocardiogram
Electrocardiograms (EKGs) are the most commonly given test used to diagnose coronary artery disease. They record the heart's electrical activity and show evidence of angina or heart attack.
Image by TheVisualMD
electrocardiogram-illustration made up from Medications
A normal tracing shows the P wave, QRS complex, and T wave. Also indicated are the PR, QT, QRS, and ST intervals, plus the P-R and S-T segments.
Image by CNX Openstax
What To Expect After an Electrocardiogram
Normal ECG/EKG complex with labels
Image by Derivative: Hazmat2 Original: Hank van Helvete
Cardiac Stress Test
The image shows a patient having a stress test. Electrodes are attached to the patient's chest and connected to an EKG (electrocardiogram) machine. The EKG records the heart's electrical activity. A blood pressure cuff is used to record the patient's blood pressure while he walks on a treadmill.
Image by National Heart Lung and Blood Institute
Relationship between the Cardiac Cycle and ECG
Initially, both the atria and ventricles are relaxed (diastole). The P wave represents depolarization of the atria and is followed by atrial contraction (systole). Atrial systole extends until the QRS complex, at which point, the atria relax. The QRS complex represents depolarization of the ventricles and is followed by ventricular contraction. The T wave represents the repolarization of the ventricles and marks the beginning of ventricular relaxation.
Image by CNX Openstax
The Electric Heart
Image by TheVisualMD
Electrocardiogram (EKG)
Electrocardiogram (EKG) is a test used to measure the electrical activity of the heart.
Image by U.S. National Library of Medicine
Comparison of Arrhythmia and Normal ECG
As the muscle tissue in an overstressed heart expands, it tears and scars. The resulting tissue - hardened and marred - does not conduct electricity well. The result is that the system can no longer be relied on to deliver the carefully synchronized pattern of jolts needed to keep the heart pumping smoothly. Doctors call it \"arrhythmia.\" The heart is literally \"skipping a beat.\" This can be measured by an electrocardiogram (ECG). In some cases, arrhythmia can mean simply that the heartbeat is too fast or too slow - a bothersome but not necessarily life-threatening condition. In the worst cases, the arrhythmia indicates a potentially lethal instability in the heart's electric system. The signals that control the heart's contractions get crossed and the heart spasms. If not corrected immediately, this fibrillation of the heart is often fatal. In the U.S., more than 1,000 people die every day from sudden cardiac death, or cardiac arrest.
Image by TheVisualMD
Heart Revealing Chamber and Valve
Your heart beats faster or slower depending on information from your brain, which monitors your body's need for blood. However, the basic rhythm of your heart is automatic; it does not depend on signals from your brain. Your heart cells can generate their own electrical signals, which trigger the contractions and cause the entire heart to pump in synchrony. A specialized bundle of muscle and nerve cells called the sinoatrial node (SA node) sits at the top of the right atrium and is the pacemaker of the heart. It generates the signal for the atria to contract and send blood to the ventricles. A similar node - the atrioventricular or AV node - sits at the atrioventricular septum near the bottom of the right atrium and relays the signal from the SA node to the ventricles to contract and pump blood out of the heart. An electrocardiogram (ECG) measures the electrical signals given off by these two nodes and their conduction through the heart. By looking at the frequency and the height of the peaks and valleys of these signals on an ECG, healthcare professionals get a very good idea of how well the electrical system of your heart is working.
Image by TheVisualMD
Electrocardigram
An electrocardiogram (EKG) detects and records the heart's electrical activity. When the electrical impulse passes through the atria a small peak is recorded (P), followed by a steep spike as it erupts through the ventricles (R), and then another small peak (T) as the wave passes through and the heart repolarizes (recharges) itself for the next beat.
Image by TheVisualMD
Electro- cardiogram
Electrocardiograms, or EKGs, record the electrical activity of the heart. Since injured heart muscle conducts electrical impulses abnormally, the EKG shows if the patient has had or is having a heart attack. It is usually the first test performed.
Image by TheVisualMD
SinusRhythmLabels
Schematic diagram of normal sinus rhythm for a human heart as seen on ECG. In atrial fibrillation, however, the P waves, which represent depolarization of the atria, are absent.
Image by Agateller (Anthony Atkielski)
How To Use an Automated External Defibrillator
The image shows a typical setup using an automated external defibrillator (AED). The AED has step-by-step instructions and voice prompts that enable an untrained bystander to correctly use the machine.
Image by National Heart Lung and Blood Institute
Who Needs an Implantable Cardioverter Defibrillator?
Lead II (2) ECG EKG strip of an AICD ICD converting a patient back into thier baseline cardiac ryhthm. The AICD fires near the end of the strip, where the straight line is seen.
Image by Public Domain
Cardiac Cycle
CG Animated Human Heart cut section showing the atria, ventricles and valves, synced with wiggers diagram.
Image by DrJanaOfficial/Wikimedia
Mammalian Heart and Blood Vessels
The beating of the heart is regulated by an electrical impulse that causes the characteristic reading of an ECG. The signal is initiated at the sinoatrial valve. The signal then (a) spreads to the atria, causing them to contract. The signal is (b) delayed at the atrioventricular node before it is passed on to the (c) heart apex. The delay allows the atria to relax before the (d) ventricles contract. The final part of the ECG cycle prepares the heart for the next beat.
Image by CNX Openstax
9:53
How to Read an Electrocardiogram (ECG): Introduction – Cardiology | Lecturio
Lecturio Medical/YouTube
9:23
Major Types of Heart Block
Jeff Otjen/YouTube
2:45
How An ECG Works
LivingHealthyChicago/YouTube
3:27
What are Arrhythmias?
TheVisualMD
3:27
12 Lead ECG Explained, Animation
Alila Medical Media/YouTube
3:48
Bundle Branch Block, Animation.
Alila Medical Media/YouTube
3:50
QRS Transitional Zone. See link for real voice update in description!
Alila Medical Media/YouTube
1:24
ECG Interpretation Basics - ST Segment Changes. See link for real voice update in description!
Alila Medical Media/YouTube
3:32
Cardiac Axis Interpretation. See link for real voice update in description!
Alila Medical Media/YouTube
9:43
Electrical system of the heart | Circulatory system physiology | NCLEX-RN | Khan Academy
khanacademymedicine/YouTube
52:29
Cardiovascular | EKG Basics
Ninja Nerd/YouTube
20:37
Cardiovascular | EKG's
Ninja Nerd/YouTube
8:53
Normal sinus rhythm on an EKG | Circulatory System and Disease | NCLEX-RN | Khan Academy
khanacademymedicine/YouTube
3:45
Cardiac Conduction System and Understanding ECG, Animation.
Alila Medical Media/YouTube
1:46
Willem Einthoven and the ECG - Stuff of Genius
Stuff of Genius - HowStuffWorks/YouTube
Electrocardiogram (ECG)
TheVisualMD
Cardiac cycle
OpenStax College
Medical Checkups
TheVisualMD
Electrocardiogram
TheVisualMD
electrocardiogram-illustration made up from Medications
GDJ
Electrocardiogram
CNX Openstax
What To Expect After an Electrocardiogram
Derivative: Hazmat2 Original: Hank van Helvete
Cardiac Stress Test
National Heart Lung and Blood Institute
Relationship between the Cardiac Cycle and ECG
CNX Openstax
The Electric Heart
TheVisualMD
Electrocardiogram (EKG)
U.S. National Library of Medicine
Comparison of Arrhythmia and Normal ECG
TheVisualMD
Heart Revealing Chamber and Valve
TheVisualMD
Electrocardigram
TheVisualMD
Electro- cardiogram
TheVisualMD
SinusRhythmLabels
Agateller (Anthony Atkielski)
How To Use an Automated External Defibrillator
National Heart Lung and Blood Institute
Who Needs an Implantable Cardioverter Defibrillator?
Radiography of the vascular system of the brain after injection of a contrast medium.
Source: National Center for Biotechnology Information, U.S. National Library of Medicine / NIH
Additional Materials (3)
Diagnostic Cerebral Angiography
Video by Johns Hopkins Medicine/YouTube
Stroke - Carotid Artery Disease and TIA
Video by EdwardHospital/YouTube
Right Side
Back Side
Left Side
1
2
3
Brain angiography with contrast
Cerebral angiography is a procedure that uses a special dye (contrast material) and x-rays to see how blood flows through the brain. Doctors may order this test if symptoms or signs of vascular malformation (abnormal blood vessels), aneurysm (blood-filled dilation of a blood vessel), narrowing of the arteries in the brain, and vasculitis (inflammation of blood vessels) are present. Sometimes, it is also used to confirm a brain tumor, evaluate the arteries of the head and neck before surgery, and find a clot that may have caused a stroke.
Carotid ultrasound uses an ultrasound machine to detect plaque buildup in the carotid arteries in the neck and see whether the buildup is blocking blood flow to the brain. Test results help your doctor plan treatment to remove the plaque and help prevent a stroke.
Carotid ultrasound uses an ultrasound machine to detect plaque buildup in the carotid arteries in the neck and see whether the buildup is blocking blood flow to the brain. Test results help your doctor plan treatment to remove the plaque and help prevent a stroke.
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Use the slider below to see how your results affect your
health.
%
50
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Your result is Normal.
The results will tell your doctor how open or narrowed your carotid arteries are. The lower the degree of arterial stenosis the better.
Related conditions
Carotid ultrasound is a painless imaging test that uses high-frequency sound waves to create pictures of the inside of your carotid arteries.
This test uses an ultrasound machine, which includes a computer, a screen, and a transducer. The transducer is a handheld device that sends and receives sound waves.
If combined with Doppler ultrasound, this test also can show how blood is moving through your arteries.
Carotid ultrasound is done to detect plaque buildup in one or both of the carotid arteries in the neck and to see whether the buildup is narrowing your carotid arteries and blocking blood flow to the brain.
Test results will help your doctor plan treatment to remove the plaque and help prevent a stroke.
A carotid ultrasound can show whether plaque buildup has narrowed one or both of your carotid arteries. If so, you might be at risk of having a stroke. The risk depends on the extent of the blockage and how much it has reduced blood flow to your brain.
To lower your risk of stroke, your doctor may recommend medical or surgical treatments to reduce or remove plaque from your carotid arteries.
Carotid ultrasound usually is done in a doctor's office or hospital. The test is painless and often doesn't take more than 30 minutes.
The ultrasound machine includes a computer, a screen, and a transducer. The transducer is a hand-held device that sends and receives ultrasound waves.
You will lie on your back on an exam table for the test. Your technician or doctor will put gel on your neck where your carotid arteries are located. The gel helps the ultrasound waves reach the arteries.
Your technician or doctor will put the transducer against different spots on your neck and move it back and forth. The transducer gives off ultrasound waves and detects their echoes as they bounce off the artery walls and blood cells. Ultrasound waves can't be heard by the human ear.
The computer uses the echoes to create and record pictures of the insides of the carotid arteries. These pictures usually appear in black and white. The screen displays these live images for your doctor to review.
Your carotid ultrasound test might include a Doppler ultrasound. Doppler ultrasound is a special test that shows the movement of blood through your arteries. Blood flow through the arteries usually appears in color on the ultrasound pictures.
Carotid ultrasound has no risks because the test uses harmless sound waves. They are the same type of sound waves that doctors use to record pictures of fetuses in pregnant women.
https://www.nhlbi.nih.gov/health-topics/carotid-ultrasound [accessed on Aug 28, 2021]
https://medlineplus.gov/ency/article/003774.htm [accessed on Aug 28, 2021]
https://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/cardiology/peripheral-arterial-disease-carotid/ [accessed on Aug 28, 2021]
Normal reference ranges can vary depending on the laboratory and the method used for testing. You must use the range supplied by the laboratory that performed your test to evaluate whether your results are "within normal limits."
Additional Materials (32)
Carotid Artery Ultrasound
Video by ConemaughHealthSyst/YouTube
A Carotid Artery Screening - using ultrasound to detect your risk for a stroke.
Video by healthscreenings/YouTube
The Doctors TV Show-HeartSmart IMT -- The Test that could save your life
Video by ProactiveWellnessCtr/YouTube
Common Carotid Artery
3D visualization based on scanned human data of the main vasculature to the head. Since the brain uses about one fifth of the oxygen absorbed into the lungs and brain tissue is at risk of permanent damage just after 5 minutes of blood deprivation, 2 pairs of large vessels - one running through the vertebrae, the other arising from the chest - ensure a generous, constant supple of blood.
Image by TheVisualMD
What Is Carotid Artery Disease?
Carotid Artery: Figure A shows the location of the right carotid artery in the head and neck. Figure B is a cross-section of a normal carotid artery that has normal blood flow. Figure C shows a carotid artery that has plaque buildup and reduced blood flow.
Image by National Heart Lung and Blood Institute (NIH)
Cervical Spine with Carotid Artery Aneurysm
3D visualization based on scanned human data of an aneurysm in the left carotid artery. A carotid artery aneurysm can after trauma, infection or previous surgery of the carotid artery.
Image by TheVisualMD
Plaque Build Up in Carotid Artery
This 3D visualization reveals plaque buildup and atherosclerosis within the carotid artery.
Image by TheVisualMD
What To Expect During Carotid Ultrasound
Carotid ultrasound: Figure A shows how the ultrasound probe (transducer) is placed over the carotid artery. Figure B is a color ultrasound image showing blood flow (the red color in the image) in the carotid artery. Figure C is a waveform image showing the sound of flowing blood in the carotid artery.
Image by National Heart Lung and Blood Institute (NIH)
Carotid stenting
Carotid Artery Stenting: The illustration shows the process of carotid artery stenting. Figure A shows an internal carotid artery that has plaque buildup and reduced blood flow. The inset image shows a cross-section of the narrowed carotid artery. Figure B shows a stent being placed in the carotid artery to support the inner artery wall and keep the artery open. Figure C shows normal blood flow restored in the stent-widened artery. The inset image shows a cross-section of the stent-widened artery.
Image by National Heart Lung and Blood Insitute (NIH)
Carotid ultrasonography
color flow ultrasonography (Doppler) of a carotid artery - scanner and screen
Image by Etan J. Tal
Blockage in Carotid Artery of Head and Neck
An ischemic stroke happens when a blockage occurs in the arteries leading to, and within, the brain. Ischemic strokes are more common than hemorrhagic strokes and fall into different categories. A person suffers a thrombotic stroke if the blockage is a is clot or a narrowing of the artery leading to the brain. An embolic stroke happens when a clot breaks off from its original site and moves through the bloodstream to block one of the smaller arteries in the brain. Embolic strokes tend to occur very suddenly. Thrombotic strokes may occur slowly over a period of time, and may actually be preceded by transient ischemic attacks or mini-strokes.
Image by TheVisualMD
Treatment
Coronary Heart Disease and Heart Attack Treatment
Image by TheVisualMD
Living With Carotid Artery Disease
Segments of the internal carotid artery, delineated on an MRA of the head.
Image by Behrang Amini
Carotid endarterectomy
Carotid endarterectomy: The illustration shows the process of carotid endarterectomy. Figure A shows a carotid artery that has plaque buildup. The inset image shows a cross-section of the narrowed carotid artery. Figure B shows how the carotid artery is cut and the plaque removed. Figure C shows the artery stitched up and normal blood flow restored. The inset image shows a cross-section of the artery with plaque removed and normal blood flow restored.
Image by National Heart Lung and Blood Institute (NIH)
Carotid Artery
Human head anatomy with external and internal carotid arteries
Image by Patrick J. Lynch from North Haven, Connecticut, United States
Image by Ruben Sebben, MD, at Dr Jones and Partners Medical Imaging (Adelaide, Australia)
Carotid Arteries of Heart
Major vasculature is revealed in this image looking up at a man's neck and head. Visible are the common carotid arteries, a pair of blood vessels that run along both sides of the neck supplying freshly oxygenated blood to the head and neck. The right common carotid artery is a branch off the brachiocephalic trunk- the first branch of the aorta. The left common carotid artery is the second branch of the aorta. Each common carotid bifurcates in the neck into an internal and external carotid artery. The external carotid artery supplies the tissues of the face and neck, while the internal carotid artery travels straight up into the skull to deliver blood to the brain.
Image by TheVisualMD
Carotid Duplex Exam
Video by Sonographic Tendencies/YouTube
Carotid artery testing
Video by CVADOCS/YouTube
Carotid Artery Disease and Stroke: Prevention and Treatment | Q&A
Video by Johns Hopkins Medicine/YouTube
Carotid Artery Disease & Stroke Angioplasty - Dr. May Nour | UCLAMDChat
Video by UCLA Health/YouTube
Carotid arterial ultrasound
A patient has an ultrasonic transducer placed against their neck during a carotid arterial ultrasound at Yokota Air Base, Japan, May 11, 2016. The transducer works on similar principals to radar and sonar systems, converting ultrasound waves into electrical signals. (U.S. Air Force photo by Senior Airman David C. Danford/Released)
Image by U.S. Air Force photo by Senior Airman David C. Danford/Released
external and internal carotid arteries
Human head anatomy with external and internal carotid arteries
Image by Patrick J. Lynch from North Haven, Connecticut, United States
Venous Insufficiency
Video by CVADOCS/YouTube
Carotid Protocol (Esther Collado, RN, RVI)
Video by Houston Methodist DeBakey CV Education/YouTube
Identifying carotid artery disease with ultrasound
Video by Medmastery/YouTube
Who Should be Screened for Carotid Disease?
Video by SVS Vascular/YouTube
Ask ADC: Carotid Ultrasound
Video by The Austin Diagnostic Clinic (ADCHealth)/YouTube
Carotid artery ultrasound scan to detect plaque
American Screening Association’s Cardiovascular Technician Lashawn Hines performs Carotid artery ultrasound scan to detect plaque in Vascular Technician Linda Callirgosm as she demonstrate one of several types of ultrasound procedures available during the U.S. Department of Agriculture (USDA) National Work and Family Month Open House and Expo on Thursday, October 16, 2014, in the Whitten building patio and South Building cafeteria meeting rooms, in Washington, D.C. USDA
Image by U.S. Department of Agriculture Photo by Lance Cheung.
Doppler ultrasound analyzer of blood velocity
Doppler ultrasound analyzer of blood velocity produced by JSC "Bioss" (Zelenograd, Moscow, Russia).
Image by Юрий Петрович Маслобоев / Yury Petrovich Masloboev
Doppler Ultrasound, Investigation
Image by Beeki/Pixabay
Sonoline fetal doppler - Ultrasound - 5412
Sonoline B fetal doppler - 3MHz Ultrasound
Image by Amada44
8:44
Carotid Artery Ultrasound
ConemaughHealthSyst/YouTube
2:24
A Carotid Artery Screening - using ultrasound to detect your risk for a stroke.
healthscreenings/YouTube
4:42
The Doctors TV Show-HeartSmart IMT -- The Test that could save your life
ProactiveWellnessCtr/YouTube
Common Carotid Artery
TheVisualMD
What Is Carotid Artery Disease?
National Heart Lung and Blood Institute (NIH)
Cervical Spine with Carotid Artery Aneurysm
TheVisualMD
Plaque Build Up in Carotid Artery
TheVisualMD
What To Expect During Carotid Ultrasound
National Heart Lung and Blood Institute (NIH)
Carotid stenting
National Heart Lung and Blood Insitute (NIH)
Carotid ultrasonography
Etan J. Tal
Blockage in Carotid Artery of Head and Neck
TheVisualMD
Treatment
TheVisualMD
Living With Carotid Artery Disease
Behrang Amini
Carotid endarterectomy
National Heart Lung and Blood Institute (NIH)
Carotid Artery
Patrick J. Lynch from North Haven, Connecticut, United States
What To Expect After Carotid Endarterectomy
Ruben Sebben, MD, at Dr Jones and Partners Medical Imaging (Adelaide, Australia)
Carotid Arteries of Heart
TheVisualMD
12:25
Carotid Duplex Exam
Sonographic Tendencies/YouTube
2:09
Carotid artery testing
CVADOCS/YouTube
10:08
Carotid Artery Disease and Stroke: Prevention and Treatment | Q&A
Johns Hopkins Medicine/YouTube
12:49
Carotid Artery Disease & Stroke Angioplasty - Dr. May Nour | UCLAMDChat
UCLA Health/YouTube
Carotid arterial ultrasound
U.S. Air Force photo by Senior Airman David C. Danford/Released
external and internal carotid arteries
Patrick J. Lynch from North Haven, Connecticut, United States
4:07
Venous Insufficiency
CVADOCS/YouTube
7:34
Carotid Protocol (Esther Collado, RN, RVI)
Houston Methodist DeBakey CV Education/YouTube
4:18
Identifying carotid artery disease with ultrasound
Medmastery/YouTube
3:57
Who Should be Screened for Carotid Disease?
SVS Vascular/YouTube
2:33
Ask ADC: Carotid Ultrasound
The Austin Diagnostic Clinic (ADCHealth)/YouTube
Carotid artery ultrasound scan to detect plaque
U.S. Department of Agriculture Photo by Lance Cheung.
Doppler ultrasound analyzer of blood velocity
Юрий Петрович Маслобоев / Yury Petrovich Masloboev
Doppler Ultrasound, Investigation
Beeki/Pixabay
Sonoline fetal doppler - Ultrasound - 5412
Amada44
Treatment
Treating Stroke
Image by TheVisualMD
Treating Stroke
Ft Blood Thinners & Clot-busting Medication, Rt Image Thrombolytic therapy. A clot-dissolving drug is inserted into the artery at the point at which it is blocked.
Bypass surgery. The blocked artery is bypassed by creating a new artery, called a graft. The graft may be created either from another blood vessel in the body (usually from the leg) or from a synthetic tube. One end of the graft is attached above the blockage and the other is attached below, creating a new route for the blood to flow. Complications of bypass surgery can include blockage of the graft, bleeding from the incision, infection, heart attack, kidney failure, and stroke.
Image by TheVisualMD
How Is Stroke Treated?
The treatment you receive for your stroke depends upon the type of stroke you had and how quickly you receive medical care.
Treatment for ischemic stroke
The first-choice treatment for the most common type of stroke (ischemic stroke) is a clot-busting drug called tissue plasminogen activator (tPA, pronounced "T-P-A"). It is usually injected into one of your veins. This drug travels in the blood to your brain and breaks up the clot.
To work properly and safely, tPA should be given within 3 hours (but can be given up to 4 ½ hours) from the time your stroke started. In fact, the sooner tPA is given, the better it works. Before you can get tPA, you need to be tested to make sure you're not having a hemorrhagic stroke because tPA can make hemorrhagic strokes worse. This is why it is so important for a person having a stroke to call 911 quickly.
Some people with ischemic stroke can't get tPA. They might have gotten to the hospital too late or have another medical condition. These people will receive a different treatment:
Blood thinners. These medicines can improve your blood flow if you have a clot. If you have atrial fibrillation or a history of stroke, your doctor might put you on long-term blood thinner treatment to prevent another stroke in the future.
Blood clot removal. Some people do not get to the hospital in time to receive tPA, or they were given tPA, but it didn't work. The doctor may use a device to remove the clot causing the blockage.
Treatment for hemorrhagic stroke
Hemorrhagic strokes are very dangerous and have fewer treatment options. Treatment usually involves trying to control the bleeding and reduce pressure with drugs or surgery. The type of treatment you'll receive depends on what caused the bleeding and whether the bleeding is inside or outside your brain tissue. The main options are:
Drugs to lower blood pressure. High blood pressure is the most common cause of a hemorrhagic stroke. Usually, in these kinds of strokes, there are tiny leaks in blood vessels throughout the brain. Lowering your blood pressure can help heal the leaks.
Surgery to release the extra blood. A lot of bleeding in your brain can cause pressure inside your skull that can damage your brain. Doctors may make a cut in your skull to release some of the blood and lower the pressure.
Surgical clipping. This procedure is used to treat a stroke caused by an aneurysm in your brain that has burst open. Surgeons cut into your skull and use a metal clip to close the blood vessel that has burst.
Endovascular coiling. This procedure is also used to treat a burst aneurysm. It doesn't involve opening the skull, so it can be less risky than surgical clipping. It also takes less time to recover afterward. In this surgery, the surgeon puts a long, thin tube called a catheter through a small cut in an artery. He or she moves the end of it to the aneurysm and releases small metal coils into the aneurysm. A blood clot forms around the coils and stops the bleeding.
Procedures to correct abnormal blood vessels. Some hemorrhagic strokes are caused by abnormally shaped blood vessels. If the problem is close to the surface of the brain, surgery can correct it. For problems deeper in the brain, surgeons can use a catheter inserted through the groin to enter the blood vessels, block abnormal connections, and stop the bleeding.
After stroke treatment, you might also need rehabilitation to recover from the damage the stroke did to your brain.
Source: Office on Women's Health (OWH), U.S. Department of Health and Human Services
Additional Materials (4)
Treatment of stroke with interventions | Circulatory System and Disease | NCLEX-RN | Khan Academy
Video by khanacademymedicine/YouTube
Acute treatment of stroke with medications | NCLEX-RN | Khan Academy
Video by khanacademymedicine/YouTube
Advances in Stroke Treatment
Video by Michigan Medicine/YouTube
Emergency Treatment for Ischemic Stroke - Dr. Reza Jahan | UCLA Interventional Radiology
Video by UCLA Health/YouTube
7:15
Treatment of stroke with interventions | Circulatory System and Disease | NCLEX-RN | Khan Academy
khanacademymedicine/YouTube
9:18
Acute treatment of stroke with medications | NCLEX-RN | Khan Academy
khanacademymedicine/YouTube
3:56
Advances in Stroke Treatment
Michigan Medicine/YouTube
14:50
Emergency Treatment for Ischemic Stroke - Dr. Reza Jahan | UCLA Interventional Radiology
UCLA Health/YouTube
Surviving a Stroke
Ambulance
Image by Luciano de Graaf
Ambulance
Ambulance - Emergency Services
Image by Luciano de Graaf
How to Survive a Stroke
A stroke is a medical emergency. It can cause lasting brain damage, long-term disability, and even death. If you notice the symptoms of stroke, call 911 right away. The sooner you get treatment, the better your chances of surviving and making a full recovery.
Prepare for a stroke ahead of time. Learn your risk factors for stroke. All older women are at higher risk of stroke. If you are at high risk of stroke, or are a caregiver for an older person, write down the following and keep this list in your wallet or on your refrigerator:
Location of the nearest hospital with a 24-hour stroke center. Find a Primary Stroke Center or Comprehensive Stroke Center in your area on QualityCheck.org. Stroke centers are hospitals with special certifications in stroke care. In some states, if a stroke center is nearby, you or your family members can ask the ambulance to take you there.
List of medicines you take and ones you are allergic to. Include prescription and over-the-counter medicines and any vitamins and minerals or other supplements you take. Keep a copy with you at all times.
Take action. If you notice any stroke symptoms, don't wait.
Call 911 right away. The sooner you get treatment, the better your chances of surviving and making a full recovery. For many people, the best stroke treatment must be given within 3 to 4½ hours of when your symptoms start. Note the time when you first notice any symptoms.
Don't drive. Wait for the ambulance to arrive, as ambulance workers can begin lifesaving treatment on the way to the hospital.
Do not take aspirin. Aspirin can make some kinds of stroke worse.
Source: Office on Women's Health (OWH), U.S. Department of Health and Human Services
Additional Materials (4)
Ingredients for surviving a stroke: rapid response, comprehensive care
Video by UF Health/YouTube
Surviving a Stroke After a 10% Chance of Survival - Jim's Story
Video by UCHealthCincinnati/YouTube
UConn Health Minute: Surviving a Stroke
Video by UConn Health/YouTube
What happens during a stroke? - Vaibhav Goswami
Video by TED-Ed/YouTube
3:12
Ingredients for surviving a stroke: rapid response, comprehensive care
UF Health/YouTube
3:59
Surviving a Stroke After a 10% Chance of Survival - Jim's Story
UCHealthCincinnati/YouTube
1:00
UConn Health Minute: Surviving a Stroke
UConn Health/YouTube
5:00
What happens during a stroke? - Vaibhav Goswami
TED-Ed/YouTube
Control Health Conditions
Preventing a Stroke
Image by TheVisualMD
Preventing a Stroke
Preventing a Stroke
Image by TheVisualMD
Stroke Risk Factors You Can Control: Health Conditions
You can take steps to manage health problems and lower your risk of stroke.
High blood pressure
High blood pressure, also called hypertension, is the most important risk factor for stroke. Blood pressure is the force your blood makes against your artery walls when your heart beats. If this force (pressure) is too high, it can damage your arteries.
You are more likely to have high blood pressure if you have a family history of high blood pressure. Other risk factors for high blood pressure include eating unhealthy food often, not exercising, and having overweight or obesity.
In the United States, non-Hispanic black women are at the highest risk of high blood pressure. This may be because they are more likely to have obesity or diabetes, which can cause high blood pressure. Research has also found a gene common in people who are African-American that increases sensitivity to salt. In people who have this gene, just one extra half a teaspoon of salt a day could raise blood pressure. Also, studies show that blood pressure levels are higher among people who are African-American even after controlling for other factors, and some of this difference may be due to the effects of discrimination in the United States.
High blood pressure usually shows no symptoms. The only way to know you have it is to get your blood pressure measured. Measure your blood pressure to find out your numbers:
Systolic (the top number) is the pressure as your heart beats or pumps blood into your arteries.
Diastolic (the bottom number) is the pressure when your heart is at rest.
To lower your risk of stroke, try to lower your blood pressure to less than 120 systolic/80 diastolic.
Many women — more than men — get "white coat hypertension." This means that your anxiety or stress level goes up when you are at the doctor's office, and this can make your blood pressure go up. If medical visits increase your stress level, ask your doctor for a monitor to wear at home to get a more accurate blood pressure reading.
Heart disease
Having other types of heart disease is a major risk factor for stroke. This is because heart disease, which can include blood vessel diseases, affects all the vessels in your body. Some conditions also make blood clots more likely.
Common heart problems that increase your risk of stroke include:
Atherosclerosis. This condition happens when plaque builds up on artery walls, making them stiff and hard. Atherosclerosis can affect the arteries supplying blood to the heart (coronary artery disease), legs and arms (peripheral artery disease), and brain (carotid artery disease).
Atrial fibrillation (AF or Afib).Afib is a type of arrhythmia, or irregular heartbeat. Afib symptoms include heart flutters, a fast heartbeat, dizziness, and shortness of breath. Afib makes it easier for your blood to clot because your heart cannot pump as well as it should. Women are more likely than men to have a stroke caused by Afib, especially women older than 75.If you have Afib, your doctor may give you medicine to prevent clots.
Heart failure. This happens when the heart is not able to pump blood through the body as well as it should. In heart failure your blood is more likely to form a clot that can cause a stroke. Heart failure symptoms include:
Shortness of breath
Swelling in feet, ankles, and legs
Extreme fatigue (tiredness)
Heart valve disease. Heart valve disease affects the valves that control blood flow in and out of different parts of the heart. A birth defect, older age, or an infection can cause your heart valves to not open fully or close completely. This causes the heart to work harder to pump blood. Heart valve disease can lead to stroke as well as heart failure, blood clots, or sudden cardiac arrest. Heart valve disease can cause problems during pregnancy, when your heart already has to work harder than usual to supply blood to your unborn baby. Your doctor can help you prevent problems during pregnancy if you know you have heart valve disease. But, some women do not find out that they have a heart valve problem until they get pregnant.
High cholesterol and triglycerides
Cholesterol is a waxy, fat-like substance that is found in all cells of your body. Your body makes all the cholesterol you need. You also get cholesterol and saturated fat in foods such as meat and dairy products. Fruits and vegetables do not have any cholesterol or saturated fat.
The extra fat from the foods you eat can clog your arteries. A blood test can measure your levels of:
Low-density lipoprotein (LDL) or "bad" cholesterol. High LDL levels lead to cholesterol buildup in arteries, which can raise your risk of stroke.
High-density lipoprotein (HDL) or "good" cholesterol. High HDL levels are actually good. HDL cholesterol helps lower the total cholesterol level in your body.
Total cholesterol. This is the total amount of cholesterol in your blood, including LDL cholesterol and HDL cholesterol.
Triglycerides. Triglycerides are another type of fat in your blood. High triglycerides may raise your risk of stroke and heart attack.
There are no symptoms of high cholesterol. The only way to know whether you have high cholesterol is to talk to your doctor about a blood test. Your doctor can prescribe medicines and talk with you about other changes, like getting more physical activity and making heart-healthy eating choices, to help lower your cholesterol and triglyceride levels and your risk of stroke.
Overweight and obesity
Having overweight or obesity raises your chance of stroke, especially when you carry extra body fat around your waist (apple-shaped body) rather than around your hips and thighs (pear-shaped body).
Women with an apple-shaped body may have a higher risk of stroke than women with a pear-shaped body.
Postmenopausal women with a high blood triglyceride level and a waist size larger than 35 inches are more likely to have a stroke than postmenopausal women with normal cholesterol levels and a waist size of 35 inches or less.
To lower your risk of stroke, your body mass index (BMI) should be between 18.5 and 24.9. A BMI between 25 and 29.9 is considered overweight. A BMI of 30 or higher is considered obese. Find your BMI using this BMI calculator from the Centers for Disease Control and Prevention.
Losing weight lowers your risk of stroke because your risk of high blood pressure, diabetes, high cholesterol, and metabolic syndrome goes down.
Diabetes
Women with diabetes are more likely to die after a stroke than men with diabetes. If they do survive, their risk of future health problems may be higher.
Uncontrolled diabetes can damage your arteries. Diabetes also makes you more likely to get high blood pressure and get blood clots that can cause a stroke.
Slightly more than 1 in 4 people with diabetes did not know they had it when they were diagnosed. The only way to know for sure whether you have diabetes is to get a blood test.
Metabolic syndrome
Metabolic syndrome is the name for a group of risk factors that happen together and are related to your metabolism. Metabolism is the process your body uses to convert food into energy. Having metabolic syndrome doubles your risk of heart disease. Metabolic syndrome is more common in women than men.
Having metabolic syndrome raises your risk of stroke. You have metabolic syndrome if you have any 3 of these 5 risk factors:
Waist measurement of more than 35 inches
Triglyceride level greater than 150 mg/dL (milligrams per deciliter)
HDL cholesterol less than 50 mg/dL
Blood pressure of 130/85 mm Hg (millimeters of mercury) or higher
Blood glucose greater than 110 mg/dL after fasting for at least eight hours
If you have metabolic syndrome, you can take steps to control your risk factors. Your doctor will check your cholesterol, blood pressure, and blood glucose regularly to find out your risk of metabolic syndrome.
Excessive blood clotting
Excessive, or extra, blood clotting is when blood clots form too easily or break apart too slowly. Blood clots can narrow arteries and veins or block blood flow completely. This can lead to stroke, heart attack, or damage to the kidneys, lungs, or other parts of the body.
Women are at higher risk of blood clots in the years they can have children (ages 15 to 44) than men of the same age.Some women also have gene mutations (changes in the genes you are born with) that make their blood more likely to clot and put them at higher risk of stroke.
Your family health history, pregnancy, and certain medicines can cause excessive blood clotting. Medicines with the hormone estrogen, such as hormonal birth control or menopausal hormone therapy, can also raise your risk of blood clots. Everyday habits like healthy eating and physical activity can make clots less likely to form. Some people with this condition might also need medicine to prevent clots.
Lupus and rheumatoid arthritis
Lupus and rheumatoid arthritis are health problems that affect more women than men. Lupus and rheumatoid arthritis are autoimmune disorders. This means they cause your immune system to attack the tissues and organs in your body, rather than just fighting off infections. Sometimes your heart and blood vessels are the tissues and organs that are attacked.
Because of this damage, you're more likely to have a stroke. If you have lupus or rheumatoid arthritis, treatment can also lower your risk of stroke.
C-reactive protein
C-reactive protein (CRP) is made by the body and released into the blood in response to swelling. Swelling (or inflammation) is how your body reacts to heal infections or cuts. Swelling can also happen over time in response to high stress levels or poor eating habits. Swelling for infections or cuts will raise your CRP levels for a short time, but swelling that continues for a long time can mean your arteries are damaged, which puts you at risk of stroke.
Women usually have higher CRP levels than men. Also, Hispanic and African-American women have the highest CRP levels.
If you are at borderline risk of stroke, your doctor might test your CRP levels to use as a "tiebreaker." The test will help your doctor decide whether you need to take steps to lower your CRP levels and help prevent stroke. This may include changing your eating habits, getting more physical activity, or taking medicine to treat high blood pressure or high cholesterol.
Source: Office on Women's Health (OWH), U.S. Department of Health and Human Services
Additional Materials (4)
Stroke Risk Factors
Video by Barnes-Jewish Hospital/YouTube
#InaMinute – Stroke Risk Factors
Video by Sutter Health/YouTube
Reduce Your Risk of Stroke
Video by Mayfield Brain & Spine/YouTube
Stroke risk factors
Video by Cleveland Clinic Martin Health/YouTube
5:25
Stroke Risk Factors
Barnes-Jewish Hospital/YouTube
1:25
#InaMinute – Stroke Risk Factors
Sutter Health/YouTube
5:38
Reduce Your Risk of Stroke
Mayfield Brain & Spine/YouTube
2:14
Stroke risk factors
Cleveland Clinic Martin Health/YouTube
Factors You Can't Control
Head & Neck Aneurysms
Image by TheVisualMD
Head & Neck Aneurysms
Image by TheVisualMD
Stroke Risk Factors You Can't Control
Factors outside your control can raise your risk of stroke. Learn what you can do to offset that risk.
Age and menopause
As a woman ages, her risk of stroke goes up each year by 10%.
When you are younger, your arteries have smooth linings and flexible walls that allow blood to flow freely. As you age, the linings get stiff and the walls thicken, which can make it harder for blood to flow. This is mainly caused by plaque buildup in your arteries, a process called atherosclerosis. Atherosclerosis begins in childhood. The older you are, the more likely your arteries will be narrowed or blocked enough to cause problems.
Your chance of surviving a stroke also goes down as you get older. This is usually because you are more likely to have other health problems when you are older, such as high blood pressure, high cholesterol, or diabetes. These health conditions make it harder for your body to recover from stroke.
Menopause raises your risk of stroke because your ovaries stop making estrogen. Estrogen is a hormone that may help keep blood vessels relaxed and open and help the body maintain a healthy balance of good and bad cholesterol. Without estrogen, cholesterol may start building up on artery walls. This can lead to stroke and other types of heart disease.
Menopausal hormone therapy
Many women take menopausal hormone therapy to help relieve menopause symptoms such as hot flashes. Results from a large study called the Women's Health Initiative showed that women taking menopausal hormone therapy with estrogen plus progesterone had a higher risk of stroke, serious blood clots, heart attacks, and other serious health problems. The risks were found to be much higher for women 60 years and older.
If you decide to use menopausal hormone therapy, talk to your doctor. The Food and Drug Administration advises women who want to try menopausal hormone therapy to use the lowest dose that works for the shortest time needed.
Personal and family health history
Having already had a stroke is the biggest risk factor for having another stroke.
Your family history also puts you at risk of a stroke. Your risk of stroke is higher if one of your parents, especially your mother, had a stroke.
If stroke runs in your family, it may be because your family carries genes that raise your risk. An example would be a gene that makes your blood more likely to clot. Talk to your doctor about your family health history.
Race and ethnicity
Women who are black and non-Hispanic are more likely to have a stroke and die from stroke than white women. The reason for this is not totally clear. It is partly because many of the other risk factors for stroke are more common in black women than white women, including diabetes, obesity, high blood pressure, and high cholesterol. Black women are also less likely to get to the hospital in time for treatment with tPA, a clot-busting drug that must be given within 3 to 4½ hours of symptoms starting. Black women are also less likely to be treated with tPA if they do get to the hospital in time.
Some of these risk factors are also more common among women who are American Indian/Alaska Native and Hispanic. No matter your racial or ethnic group, you can take the same steps as any other woman to control your risk factors for stroke.
Pregnancy
During and soon after pregnancy, your risk of stroke is higher. Although pregnancy-related stroke is not common, the number of women who have a stroke during or soon after pregnancy is going up. This is likely because more women have other risk factors for stroke, including heart disease, overweight and obesity, and high blood pressure, during pregnancy.
The increased risk of stroke during pregnancy comes from several changes that happen to your body during pregnancy, such as increased blood clotting. Your body also makes more blood during pregnancy. After birth, these changes reverse rapidly, and this can trigger a stroke.
Some women are more at risk of pregnancy-related stroke. You may be more at risk if you already have risk factors for stroke, such as high blood pressure, and you:
Are African-American
Are older than 35
Have lupus
Have migraine headaches
The best way to lower the risk of stroke during pregnancy is to control your stroke risk factors before you get pregnant.
Pregnancy history
Some health problems can happen during pregnancy and raise your risk of stroke later in life:
Preeclampsia. Preeclampsia is a health problem that can happen during pregnancy. It is unexpected high blood pressure and problems with your kidneys (called "protein in the urine"). If you have ever had preeclampsia, you are at a higher risk of stroke even decades later. Having preeclampsia before 32 weeks of pregnancy is especially risky. This may be because women who get preeclampsia have other problems with their blood vessels that can also lead to stroke. Another reason could be that preeclampsia causes long-term changes in the blood vessels. If you've had preeclampsia, you are more likely to develop high blood pressure later in life, the number one stroke risk factor.
Gestational high blood pressure (sometimes called gestational hypertension). High blood pressure during pregnancy can happen in some women who do not normally have high blood pressure. Gestational high blood pressure goes away after birth but raises your risk of stroke later in life, after pregnancy is over. Gestational high blood pressure can also lead to preeclampsia.
Gestational diabetes. Having gestational diabetes (diabetes during pregnancy) puts you at higher risk of having type 2 diabetes later in life, after pregnancy is over. Diabetes is a major risk factor for stroke.
Migraine headaches
Having a migraine with aura (seeing bright flashing lights or spots that aren't real) raises your risk of stroke, especially if you are younger than 55 or if you smoke. Women on hormonal birth control pills who have migraine with aura are also at risk of stroke. Researchers are studying whether migraine raises stroke risk for women on other forms of hormonal birth control, like the patch or ring.
However, the overall risk of stroke for otherwise healthy women who get migraine is still low. The type of stroke that happens most often in women with migraine is also less serious. If you have migraine, talk to your doctor about your stroke risk.
Source: Office on Women's Health (OWH), U.S. Department of Health and Human Services
Sex Differences: Improving Stroke Recovery in Women
Johns Hopkins University/YouTube
11:41
Risk factors for stroke | Circulatory System and Disease | NCLEX-RN | Khan Academy
khanacademymedicine/YouTube
1:42
Risk Factors of Stroke - Mayo Clinic
Mayo Clinic/YouTube
Prevention
9 Years - Aging Vessel
25 Years - Aging Vessel
50 Years - Aging Vessel
75 Years - Aging Vessel
1
2
3
4
Women's Aging Arteries
Interactive by TheVisualMD
9 Years - Aging Vessel
25 Years - Aging Vessel
50 Years - Aging Vessel
75 Years - Aging Vessel
1
2
3
4
Women's Aging Arteries
Top half of artery reflect aging well / Bottom half reflects poor life-style and accelerated plaque build-up leading to chronic diseases and early death - Image 1) 9 Years, Image 2) 25 Years, Image 3) 50 Years, Image 4) 75 Years
Over the years, if we don't take care of our bodies, our blood vessels can start to lose their resiliency and plaque can start to build up in our arteries. Plaque is composed of cholesterol, inflammatory (immune) cells, calcium, and other substances that flow through our bloodstreams. Plaque buildup occurs if we eat high-fat diets, don't get enough exercise, are overweight, smoke, or have other unhealthy habits.
Interactive by TheVisualMD
Stroke Prevention
You don't need to become a super athlete or go on a very strict diet to protect your heart and lower your risk of heart disease and stroke. Every woman can take steps every day toward a more heart-healthy lifestyle. And the best part is that being more heart-healthy also lowers your risk of other diseases like cancer and diabetes.
Get moving
For the most health benefits, you need to get enough aerobic activity to get your heart pumping and do muscle-strengthening activities every week. (Always check with your doctor before starting any regular exercise you are not used to doing.)
You should get at least 30 minutes a day of moderate-intensity aerobic activity, like brisk walking, on most days of the week. The 30 minutes of heart-pumping activity don't have to be all at one time. You can break it up into 10-minute activities throughout the day.
The Physical Activity Guidelines suggest that each week, women get at least:
2 hours and 30 minutes (150 minutes) of moderate-intensity aerobic physical activity, such as a brisk walk
OR
1 hour and 15 minutes (75 minutes) of vigorous-intensity aerobic physical activity, such as running
OR
A combination of moderate and vigorous-intensity aerobic physical activity
AND
Muscle-strengthening activities on 2 or more days
Eat healthy foods
Making unhealthy food choices can lead to weight gain. But that is not the only risk. Unhealthy eating affects your arteries, blood pressure, glucose level, and many other parts of your heart health. Talk to your doctor or nurse about a heart-healthy eating plan that lowers your risk of heart attack and stroke.
Keep a healthy weight
Reaching and staying at a healthy weight will lower your risk of heart disease and stroke. If you already have heart disease, a healthy weight will help you control your disease and prevent heart attack. A slow and steady weight loss is the best way to lose weight and keep it off. Talk to your doctor about how much weight you need to lose and the best ways to do it.
Know your heart disease numbers
Ask your doctor to check your blood pressure, cholesterol (total, HDL, LDL, and triglycerides) and blood sugar levels. Most insurance plans must cover these tests at no cost to you. These tests will give you important information about your heart health. Your doctor can tell you what your numbers mean and what you need to do to protect your heart.
Know the symptoms of heart attack and stroke
All women need to know the symptoms of heart attack and stroke and what to do. Make sure your friends and loved ones know how to recognize the symptoms too. If you think you are having a heart attack or stroke, call 911.
Knowing the symptoms and getting help quickly can help you survive a heart attack or stroke and make a full recovery.
Don't smoke
If you smoke, get the help you need to quit.
Limit your alcohol use
If you drink alcohol, do so in moderation. For women, this means no more than one drink per day.
"One drink" is:
A glass of wine (5 ounces)
A can of beer (12 ounces)
A shot of liquor (1.5 ounces of 80-proof liquor)
If you don't already drink, don't start drinking for any reason. Moderate drinking is also linked to breast cancer, violence, and injuries. No amount of alcohol is safe during pregnancy.
Take care of yourself
Stress, anxiety, depression, and lack of sleep can raise your risk of heart disease. Take care of yourself with these steps:
Get enough sleep. Most adults need seven to nine hours of sleep each night.
Don't stress. Keep stress in check by taking time each day to relax and unwind.
Treat mental health problems. Get help if you have trouble coping because of depression, anxiety, or other health problems.
Make a well-woman visit. Make an appointment with your doctor for an annual well-woman visit.
Source: Office on Women's Health (OWH), U.S. Department of Health and Human Services
Million Hearts: Preventing Heart Attacks and Strokes
Centers for Disease Control and Prevention (CDC)/YouTube
Recovery Steps
Walking with an orthosis after a stroke
Image by Orthokin
Walking with an orthosis after a stroke
Walking with an orthosis after a stroke
Image by Orthokin
Stroke Recovery Steps
Stroke is a life-changing event. How long it takes you to recover depends on many factors, including the type of stroke you had, the area of your brain affected, and the amount of brain injury. The recovery process begins at the hospital as soon as you are medically stable. Often, this is within a day of having the stroke. Your doctor will talk to you about next steps. This will involve changes in your everyday habits, medicines, rehabilitation, or surgeries to lower the risk of another stroke.
Step 1. Educate yourself about stroke recovery.
The first step is to learn all you can about your condition and what to expect during recovery.
Ask your doctor, nurses, or physical or occupational therapist questions about your treatment and rehabilitation. Other stroke survivors can also help with practical tips. You can use the stroke resources on this website.
Step 2. Take steps to prevent another stroke.
If you've had a stroke, you're at high risk of having another. As you recover from your stroke, take steps to prevent a second one:
Identify and control your stroke risk factors.
Continue with your treatment plan. After a stroke, your doctor will work with you on a treatment plan. Your plan is designed to help you recover from your stroke and prevent another stroke. Even if you feel better, do not stop taking a medicine without talking to your doctor first.
Step 3. Figure out what rehabilitation services you will need.
Stroke rehabilitation is a program to help you recover from stroke. Almost all stroke survivors benefit from rehabilitation. However, many women do not join a rehabilitation program for reasons that are not clear. Many women are older at the time of their stroke and often go to assisted-living facilities or hospice after a stroke rather than to a rehabilitation program.1
Most insurance plans must cover stroke rehabilitation, although you may need to pay a copayment, coinsurance, and meet your deductible first. Find out what your insurance will cover, and what benefits you can receive from government programs or from your employer.
After a stroke, you will often recover some function in the first few months. This is part of the body's natural healing process. Women who get stroke rehabilitation:
Relearn skills and abilities that were damaged or lost
Regain as much independence as possible
Learn to cope with any remaining limitations
Also, think about what, if anything, you will need from caregivers at home and what they are able to provide. Who is available to help with your care? How much time can they spend taking care of you? Can they provide financial support?
Step 4. Set goals for your recovery.
Set realistic, measureable goals for recovery in each area of your life your stroke affected. Keep in mind that stroke recovery is usually fast in the first few months. Then it may slow down. Having goals will help to motivate you to keep making progress.
Write down your long-term goals and create a timeline for achieving them. Break each one down into steps to make short-term goals.
Step 5. Follow through on your plan.
A stroke can often make you feel powerless. Part of recovery is figuring out how to live as independently as possible. Know that you are likely to face challenges as you adjust to the differences in how your body works.
The road to stroke recovery is often a long one, but focusing on your progress can help you reach your goals.
Source: Office on Women's Health (OWH), U.S. Department of Health and Human Services
Additional Materials (7)
Stroke Rehab
Stroke Rehab
Image by TheVisualMD
7 Steps to Stroke Recovery
Video by After Stroke BC/YouTube
7 Steps to Stroke Recovery - Step #1 - Exercise and Mobility
Video by After Stroke BC/YouTube
7 Steps to Stroke Recovery - Step 2: Communication and Language
Video by After Stroke BC/YouTube
7 Steps to Stroke Recovery Step 3 Social Interaction & Recreation MASTER
Video by After Stroke BC/YouTube
Stroke Recovery Rehabilitation
Video by Cleveland Clinic/YouTube
Deep Brain Stimulation for Stroke Recovery Animation
Video by Cleveland Clinic/YouTube
Stroke Rehab
TheVisualMD
12:11
7 Steps to Stroke Recovery
After Stroke BC/YouTube
10:45
7 Steps to Stroke Recovery - Step #1 - Exercise and Mobility
After Stroke BC/YouTube
11:11
7 Steps to Stroke Recovery - Step 2: Communication and Language
After Stroke BC/YouTube
9:02
7 Steps to Stroke Recovery Step 3 Social Interaction & Recreation MASTER
After Stroke BC/YouTube
2:34
Stroke Recovery Rehabilitation
Cleveland Clinic/YouTube
0:12
Deep Brain Stimulation for Stroke Recovery Animation
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Stroke and Women
Stroke is a leading cause of death for women. Stroke also kills more women than men each year. Get the facts about how stroke affects women and how to know if it's happening to you.