Colorectal cancer is a disease in which malignant (cancer) cells form in the tissues of the colon or the rectum.
Walking Infant with Visible Skeletal, Cardiovascular, Muscular, and Digestive Systems
Image by TheVisualMD
Childhood Colorectal Cancer
The lower GI tract (child)
Image by NIDDK Image Library
The lower GI tract (child)
Drawing of the lower gastrointestinal tract inside the outline of a man’s torso with an inset that includes labels for cecum, ascending colon, transverse colon, descending colon, sigmoid colon, rectum, and anus.
Image by NIDDK Image Library
Childhood Colorectal Cancer
General Information About Childhood Colorectal Cancer
KEY POINTS
Colorectal cancer is a disease in which malignant (cancer) cells form in the tissues of the colon or the rectum.
Having certain inherited syndromes increases the risk of colorectal cancer.
Signs and symptoms of colorectal cancer include pain in the abdomen, constipation, and diarrhea.
Tests that examine the colon and rectum are used to diagnose colorectal cancer.
Certain factors affect prognosis (chance of recovery).
Colorectal cancer is a disease in which malignant (cancer) cells form in the tissues of the colon or the rectum.
The colon is part of the body's digestive system. The digestive system removes and processes nutrients (vitamins, minerals, carbohydrates, fats, proteins, and water) from foods and helps pass waste material out of the body. The digestive system is made up of the mouth, throat, esophagus, stomach, and the small and large intestines. In an adult, the colon (large bowel) is the first part of the large intestine and is about 5 feet long. Together, the rectum and anal canal make up the last part of the large intestine and are 6 to 8 inches long. The anal canal ends at the anus (the opening of the large intestine to the outside of the body).
Having certain inherited syndromes increases the risk of colorectal cancer.
Anything that increases your chance of getting a disease is called a risk factor. Having a risk factor does not mean that you will get cancer; not having risk factors doesn't mean that you will not get cancer. Talk with your child's doctor if you think your child may be at risk.
Childhood colorectal cancer may be part of an inherited syndrome. Some colorectal cancers in young people are linked to a gene mutation that causes polyps (growths in the mucous membrane that lines the colon) to form that may turn into cancer later. The risk of colorectal cancer is increased by having inherited conditions, such as the following:
Familial adenomatous polyposis (FAP).
Attenuated FAP.
MUTYH-associated polyposis.
Oligopolyposis.
Change in the NTHL1 gene.
Juvenile polyposis syndrome.
Cowden syndrome.
Peutz-Jeghers syndrome.
Neurofibromatosis type 1 (NF1).
Polyps that form in the colon of children who do not have an inherited syndrome are not linked to an increased risk of cancer.
Source: National Cancer Institute (NCI)
Additional Materials (9)
Child Digestive system
An illustration of the digestive system in a child.
Image by BruceBlaus
Drawing of a child's digestive system with the larger intestine labeled and shaded
Drawing of a child's digestive system with the larger intestine labeled and shaded
Image by NIDDK
Drawing of the digestive tract within an outline of the top half of a child’s body. The large intestine, colon, rectum, and anus are labeled
The lower GI tract.
Image by NIDDK Image Library
Drawing of a child’s gastrointestinal tract
Drawing of a child’s gastrointestinal tract with labels pointing to the liver, esophagus, stomach, large intestine, small intestine, colon, rectum, and anus. Hirschsprung disease (HD) is a disease of the large intestine that causes severe constipation or intestinal obstruction.
Image by NIDDK Image Library
Walking Infant with Visible Skeletal, Cardiovascular, Muscular, and Digestive Systems
This image features a male toddler walking with a cross-section that reveals his skeletal, cardiovascular, muscular, and digestive systems. The instructions for making proteins are contained within our DNA. When protein is needed, the process of protein synthesis is turned on. The instructions are used to initiate production of the required protein. Protein synthesis occurs continuously inside your body's cardiac, skeletal, skin, fat and smooth muscle cells.
Image by TheVisualMD
Who's at risk for colon cancer? - Amit H. Sachdev and Frank G. Gress
Video by TED-Ed/YouTube
The Colorectal Center | Cincinnati Children's
Video by Cincinnati Children's/YouTube
Colorectal Cancer Prevention Can Start in Childhood
Video by Ohio State University Comprehensive Cancer Center-James Cancer Hospital & Solove Research Institute/YouTube
Colon Cancer in Younger People
Video by Sentara Healthcare/YouTube
Child Digestive system
BruceBlaus
Drawing of a child's digestive system with the larger intestine labeled and shaded
NIDDK
Drawing of the digestive tract within an outline of the top half of a child’s body. The large intestine, colon, rectum, and anus are labeled
NIDDK Image Library
Drawing of a child’s gastrointestinal tract
NIDDK Image Library
Walking Infant with Visible Skeletal, Cardiovascular, Muscular, and Digestive Systems
TheVisualMD
4:44
Who's at risk for colon cancer? - Amit H. Sachdev and Frank G. Gress
TED-Ed/YouTube
4:17
The Colorectal Center | Cincinnati Children's
Cincinnati Children's/YouTube
1:01
Colorectal Cancer Prevention Can Start in Childhood
Ohio State University Comprehensive Cancer Center-James Cancer Hospital & Solove Research Institute/YouTube
3:11
Colon Cancer in Younger People
Sentara Healthcare/YouTube
Signs and Symptoms
Constipation in a young child as seen on X-ray
Image by Jafarpulpally at Malayalam Wikipedia
Constipation in a young child as seen on X-ray
Constipation in a young child as seen on X-ray
Image by Jafarpulpally at Malayalam Wikipedia
Signs and Symptoms of Colorectal Cancer Include Pain in the Abdomen, Constipation, and Diarrhea
Signs and symptoms of childhood colorectal cancer usually depend on where the tumor forms. These and other signs and symptoms may be caused by colorectal cancer or by other conditions.
Check with your child's doctor if your child has any of the following:
Tumors of the rectum or lower colon may cause pain in the abdomen, constipation, or diarrhea.
Tumors in the part of the colon on the left side of the body may cause:
A lump in the abdomen.
Weight loss for no known reason.
Nausea and vomiting.
Loss of appetite.
Blood in the stool.
Anemia (tiredness, dizziness, fast or irregular heartbeat, shortness of breath, pale skin).
Tumors in the part of the colon on the right side of the body may cause:
Pain in the abdomen.
Blood in the stool.
Constipation or diarrhea.
Nausea and vomiting.
Weight loss for no known reason.
Source: National Cancer Institute (NCI)
Test
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Virtual Colonoscopy
Interactive by TheVisualMD
All Views
Inside
Outside
Unfurled
1
2
3
4
Virtual Colonoscopy
Virtual colonoscopy is a new technology that uses computerized tomography (CT) images to look for polyps and cancer in the colon. The result is a computer-generated, animated, three-dimensional view of the interior of the colon. The preparation for the procedure is similar to that for a colonoscopy, but the procedure itself takes only about 10 minutes, and no sedation is required. If abnormalities are found, a conventional colonoscopy is performed for removal or biopsy of the growth.
Interactive by TheVisualMD
Tests That Examine the Colon and Rectum Are Used to Diagnose Colorectal Cancer
The following tests and procedures may be used:
Physical exam and health history: An exam of the body to check general signs of health, including checking for signs of disease, such as lumps or anything else that seems unusual. A history of the patient’s health habits and past illnesses and treatments will also be taken.
Colonoscopy: A procedure to look inside the rectum and colon for polyps, abnormal areas, or cancer. A colonoscope is inserted through the rectum into the colon. A colonoscope is a thin, tube-like instrument with a light and a lens for viewing. It also has a tool to remove polyps or tissue samples, which are checked under a microscope for signs of cancer.
Barium enema: A series of x-rays of the lower gastrointestinal tract. A liquid that contains barium (a silver-white metallic compound) is put into the rectum. The barium coats the lower gastrointestinal tract and x-rays are taken. This procedure is also called a lower GI series.
Fecal occult blood test: A test to check stool (solid waste) for blood that can only be seen with a microscope. Small samples of stool are placed on special cards and returned to the doctor or laboratory for testing.
Complete blood count (CBC): A procedure in which a sample of blood is drawn and checked for the following:
The number of red blood cells, white blood cells, and platelets.
The amount of hemoglobin (the protein that carries oxygen) in the red blood cells.
The portion of the blood sample made up of red blood cells.
Carcinoembryonic antigen (CEA) assay: A test that measures the level of CEA in the blood. CEA is released into the bloodstream from both cancer cells and normal cells. When found in higher than normal amounts, it can be a sign of colorectal cancer or other conditions.
Certain factors affect prognosis (chance of recovery).
Prognosis depends on the following:
Whether the tumor was completely removed by surgery.
Whether the cancer has spread to other parts of the body, such as the lymph nodes, lung, liver, pelvis, ovaries, or bone.
Whether the cancer has just been diagnosed or has recurred (come back).
Source: National Cancer Institute (NCI)
Additional Materials (1)
Testing for bowel cancer
Video by Cancer Research UK/YouTube
1:37
Testing for bowel cancer
Cancer Research UK/YouTube
Virtual Colonoscopy
Virtual Colonoscopy
Also called: Computed Tomographic Colonography, CT Colonography
Virtual colonoscopy is a non-invasive imaging method that uses computed tomographic data combined with specialized imaging software to examine the colon. It produces three-dimensional images of the colon which are examined for colorectal cancer and precancerous polyps.
Virtual Colonoscopy
Also called: Computed Tomographic Colonography, CT Colonography
Virtual colonoscopy is a non-invasive imaging method that uses computed tomographic data combined with specialized imaging software to examine the colon. It produces three-dimensional images of the colon which are examined for colorectal cancer and precancerous polyps.
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Use the slider below to see how your results affect your
health.
Your result is Negative.
No abnormalities were detected in the colon. If you're at average risk of colon cancer, meaning you have no colon cancer risk factors other than age, your doctor may recommend repeating the exam in five years.
Related conditions
A method to examine the inside of the colon by taking a series of x-rays. A computer is used to make 2-dimensional (2-D) and 3-D pictures of the colon from these x-rays. The pictures can be saved, changed to give better viewing angles, and reviewed after the procedure, even years later.
Also called computed tomographic colonography, computed tomography colonography, CT colonography, and CTC.
You may need a virtual colonoscopy to find the cause of unexplained symptoms such as:
Bleeding from your anus (the opening of the rectum through which stool passes out of your body)
Changes in your bowel activity, such as diarrhea
Pain in your abdomen (belly)
Unexplained weight loss
Doctors also use the procedure to screen for colon polyps and cancer. Screening is testing for diseases when you have no symptoms. It may find diseases at an early stage, when they are easier to treat. If aren't at higher risk for colorectal cancer, your health care provider will likely recommend you start getting screenings at age 45. If you at higher risk, you may need to start getting screened for colorectal cancer earlier.
There are also other tests to screen for colorectal cancer, including stool tests. Talk with your provider about which test is right for you and when and how often you should get it.
This is a type of x-ray that uses a CT scan (computed tomography) to take detailed, 3-dimensional pictures of the entire colon and rectum. It is usually done in a radiology department of a hospital or medical center. This procedure also requires bowel prep beforehand. During the test:
You will lie on a narrow table.
You may be asked to drink a liquid containing contrast dye. Contrast dye is a substance that makes parts of your body show up more clearly on an x-ray.
A provider will insert a small tube into the rectum.
Air will be pumped through the tube to make the colon bigger and easier to see.
The table will slide into the CT machine.
A series of images will be taken.
For a virtual colonoscopy, you will need to do a bowel prep. Your provider will give you specific instructions on how to do your bowel prep, but steps for bowel prep may include:
Following a liquid diet for one to three days before the test.
Drinking plenty of clear liquids one to three days before the test. Clear liquids include water, black coffee or tea, fat-free broth, and sports drinks without added color.
Drinking a strong liquid laxative and/or using an enema on the evening before your test.
The laxative or enema will help you empty your bowels. You should prepare to spend a lot of time in the bathroom. Bowel prep can be inconvenient and uncomfortable, but if the colon is not thoroughly cleaned out, your provider may not be able to get a full picture of your colon and rectum. Polyps and other abnormal areas may not be seen.
In a virtual colonoscopy, risks include:
Exposure to a small dose of radiation from the scan.
Rarely, a tear in the colon or rectum can happen when it is inflated with air.
Normal findings are healthy intestinal tissues. Abnormal results may include the following:
Colorectal polyps or abnormal tissue were seen on the CT scan.
You will probably need a traditional colonoscopy so your provider can get a tissue sample. Sometimes this procedure can be done on the same day as your virtual colonoscopy.
If you have questions about your results, talk to your health care provider.
Colorectal Cancer Screening Tests: MedlinePlus Medical Test [accessed on Feb 12, 2024]
Colonoscopy | MedlinePlus. National Library of Medicine. Dec 5, 2022 [accessed on Feb 12, 2024]
Virtual Colonoscopy | NIDDK [accessed on Dec 28, 2018]
Tests to Detect Colorectal Cancer and Polyps - National Cancer Institute [accessed on Dec 28, 2018]
Colorectal Cancer Screening | Cancer Trends Progress Report [accessed on Dec 28, 2018]
CT Colonography [accessed on Dec 28, 2018]
Virtual colonoscopy - Mayo Clinic [accessed on Dec 28, 2018]
Normal reference ranges can vary depending on the laboratory and the method used for testing. You must use the range supplied by the laboratory that performed your test to evaluate whether your results are "within normal limits."
Additional Materials (14)
Virtual Colonoscopy 3D Model
With virtual colonoscopy, a computed tomography scanner takes cross-sectional images of the patient's colon, after the colon has been inflated with gas. A three-dimensional model is then created from the CT slices and evaluated by a radiologist for abnormalities.
Image by TheVisualMD
Virtual Colonoscopy open colon section view
After the image-taking procedure is complete, the cross-sectional pictures are processed by the computer to create animated, three-dimensional images of the large intestine. They are examined by a radiologist to identify any abnormal growths. If abnormalities are found, a conventional colonoscopy will be performed so that the abnormal growths can be removed or biopsied.
Image by TheVisualMD
A Less Invasive Look
Virtual colonoscopy is a new technology that uses computed tomography (CT), or, less often, magnetic resonance imaging (MRI) images to look for polyps, cancer, or other diseases of the colon when an abnormality is suspected. A computer program assembles the images to create an animated, three-dimensional view of the interior of the colon. The preparation for the procedure is similar to that for a colonoscopy, but the procedure itself takes only about 10 minutes, and no sedation is required. If abnormalities are found, a conventional colonoscopy will need to be performed for removal or biopsy of the growth.
Image by TheVisualMD
This browser does not support the video element.
Colon unfurling
Virtual colonoscopy is a new technology that uses computed tomography (CT), or, less often, magnetic resonance imaging (MRI) images to look for polyps, cancer, or other diseases of the colon when an abnormality is suspected. A computer program assembles the images to create an animated, three-dimensional view of the interior of the colon. The preparation for the procedure is similar to that for a colonoscopy, but the procedure itself takes only about 10 minutes, and no sedation is required. If abnormalities are found, a conventional colonoscopy will need to be performed for removal or biopsy of the growth.
Video by TheVisualMD
This browser does not support the video element.
Colorectal Cancer Clip 3
Colorectal Cancer Clip 3
Video by TheVisualMD
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Colorectal Cancer Clip 4
Colorectal Cancer Clip 4
Video by TheVisualMD
Spectrum of Medical Imaging
This composite image was created in recognition of The Society of Photo-Optical Instrumentation Engineers (SPIE) designation of 2015 as the “International Year of Light.” Medical imaging scientists and engineers contribute to the quest for the improved human condition by providing imaging that spans the entire usable electro-magnetic spectrum (seen at bottom). From the humblest of beginnings with simple magnification of objects and focusing with lenses, to the biological observation of cells with rudimentary microscopes in the visible spectrum, medical imaging today has both extended away from the visible spectrum towards longer and shorter wavelengths (low and high energies) and exploited the hyperspectral nature of the visible which was once considered “commonplace” or rudimentary. Considering yet a different cross-section through the various imaging modalities across the spectrum, the medically useful information gained spans anatomic, physiologic, and molecular regimes. Systems and algorithms have been developed as single-modality acquisition systems, and also as multiple-modalities with conjoint reconstruction, each informing the other in the quest to optimize image quality and information content. In addition, the role of light-based technologies in enabling advanced computations in tomographic reconstructions, computer-aided diagnosis, machine learning (neural networks, deep learning, etc.) , and 3D visualizations as well as in data-enriched storage of medical images has further extended the potential knowledge “seen” through imaging. The breadth of the electromagnetic spectrum offers limitless opportunities for improvement and inquiry, in our quest to answer human life’s difficult questions. This montage was first published on the cover of the SPIE’s Journal of Medical Imaging (July-Sept. 2015, vol. 3, no. 3) and is but a small tribute to the multitude of medical imaging scientists who have contributed to the wealth of new knowledge as we interrogate the human condition. The gray-scale whole body images (from Left to Right) are acquired from longer wavelength modalities to shorter wavelength modalities spanning the (currently) usable electromagnetic spectrum. The background images include: a coronal Magnetic Resonance Image (MRI) T2 weighted image slice, a posterior surface Infra Red (IR) heat map, a coronal non-contrast Computed Tomography (CT) slice, and a coronal 18F-fluoro-deoxyglucose Positron Emission Tomography (FDG-PET) slice. The selection of color inset images includes (from Top-to-Bottom, then Left to Right): [1] diffusion tensor magnetic resonance imaging (MRI) used to image long white matter tracts within and around the human brain illustrating neuronal connectivity (coloring refers to bluish=vertical direction; green=horizontal A-P direction; red=horizontal lateral direction) (courtesy of Arthur Toga, PhD); [2] registered and superimposed coronal proton-MRI (gray-scale) and a hyper polarized 129Xe ventilation MRI scan (color scale) within the same patient’s lungs, prior to their receiving a bronchial stent (courtesy of Bastiaan Driehuys, PhD); [3] coronal slice through a microwave-based image reconstruction of the Debye parameter ε (epsilon) in a heterogeneously dense human breast phantom (courtesy of Susan Hagness, PhD); [4] juxtaposed optical image of the retina and vertical and horizontal Optical Coherence Tomograph (OCT) slices showing pigmentosa retinopathy (courtesy of Jean-Michel Muratet, MD); [5] functional 3-D photoacoustic imaging of melanoma (gray scale) in vivo, surrounded by highly optically absorptive blood vessels (red) (courtesy of Lihong Wang, PhD); [6] optical micrograph of HeLa cells stained for microtubules (blue) and co-stained with DAPI for actin visualization (red); HeLa cells are the world's first stem cell line, originally derived from the aggressive cervical cancer cells of Henrietta Lacks (courtesy Tom Deerinck/NCMIR); [7] visualization of the pelvis highlighting the colon, which is imaged with contrast x-ray computed tomography (CT), and after digital surface rendering can be used in virtual colonoscopy, thus avoiding a physical visible light-based colonoscopy; [8] registered and fused sagittal 99mTc-sestamibi dedicated molecular single photon emission computed tomography (SPECT, heat color scale) and low-dose CT slice (gray scale) of a patient’s uncompressed, pendant breast containing two surgically confirmed DCIS loci in the posterior breast (courtesy of Martin Tornai, PhD); [9] classic, early x-radiograph of Wilhelm Röntgen’s wife’s hand (adapted from http://en.wikipedia.org/wiki/100_Photographs_that_Changed_the_World); [10] transverse pelvic CT (gray scale) with multiple superimposed simulated x-ray photon radiotherapy beams, and their cumulative 20Gy (red) deposited dose isocontours at the focus of a tumor (courtesy of Paul Read, MD, PhD); [11] false-colored scanning electron micrograph of human immunodeficiency virus (HIV) particles (yellow) infecting a human H9 T-cell (turquoise) (adapted from http://biosingularity.com/category/infection/); [12] transverse 18F-dopa positron emission tomography (PET) slice through a Parkinson patient’s brain showing decreased in vivo quantitative uptake in the right caudate and putamen (courtesy of Christaan Schiepers, MD, PhD); [13] registered and fused transverse head CT (gray scale) and registered superimposed PET image (color) of a patient immediately after radio-therapeutic proton irradiation showing endogenously created 15O-positron emitter (2 min half-life) within the nasopharyngeal tumor focus (courtesy of Kira Grogg, PhD). [14] transverse (long axis) cardiac 99mTc-sestamibi SPECT slice illustrating thinned myocardial apical wall in a procedure performed thousands of times daily around the world (adapted from www.medscape.com). These images are but a small sampling of the breadth of the spectrum of light that is currently being investigated the world over by passionate scientists and engineers on a quest for the betterment of the human condition. All contributors for these images used herein have given their permission for their use, and are graciously thanked.
Image by Martin Tornai
Virtual Colonoscopy: A Kinder Gentler Way to Prevent Colon Cancer
Video by University of California Television (UCTV)/YouTube
Virtual Colonoscopy Q&A | Dr. Karen Horton
Video by Johns Hopkins Medicine/YouTube
All Views
Inside
Outside
Unfurled
1
2
3
4
Virtual Colonoscopy
Virtual colonoscopy is a new technology that uses computerized tomography (CT) images to look for polyps and cancer in the colon. The result is a computer-generated, animated, three-dimensional view of the interior of the colon. The preparation for the procedure is similar to that for a colonoscopy, but the procedure itself takes only about 10 minutes, and no sedation is required. If abnormalities are found, a conventional colonoscopy is performed for removal or biopsy of the growth.
Interactive by TheVisualMD
UCSF Radiology: How is Virtual Colonoscopy Performed?
Video by UCSF Imaging/YouTube
Virtual Colonoscopy - Lexington Diagnostic Center
Video by Lexington Diagnostic Center/YouTube
Virtual Colonoscopy-Mayo Clinic
Video by Mayo Clinic/YouTube
3D Visualization of Colon and Virtual Colonoscopy
3D Visualization of Colon and Virtual Colonoscopy
Image by TheVisualMD
Virtual Colonoscopy 3D Model
TheVisualMD
Virtual Colonoscopy open colon section view
TheVisualMD
A Less Invasive Look
TheVisualMD
0:13
Colon unfurling
TheVisualMD
0:49
Colorectal Cancer Clip 3
TheVisualMD
0:15
Colorectal Cancer Clip 4
TheVisualMD
Spectrum of Medical Imaging
Martin Tornai
1:26:06
Virtual Colonoscopy: A Kinder Gentler Way to Prevent Colon Cancer
University of California Television (UCTV)/YouTube
8:26
Virtual Colonoscopy Q&A | Dr. Karen Horton
Johns Hopkins Medicine/YouTube
Virtual Colonoscopy
TheVisualMD
2:33
UCSF Radiology: How is Virtual Colonoscopy Performed?
UCSF Imaging/YouTube
2:24
Virtual Colonoscopy - Lexington Diagnostic Center
Lexington Diagnostic Center/YouTube
2:19
Virtual Colonoscopy-Mayo Clinic
Mayo Clinic/YouTube
3D Visualization of Colon and Virtual Colonoscopy
TheVisualMD
Colonoscopy
Colonoscopy
Also called: Coloscopy
Colonoscopy is an exam in which a doctor uses a colonoscope, to look inside your rectum and colon. Colonoscopy can show irritated and swollen tissue, ulcers, polyps, and cancer.
Colonoscopy
Also called: Coloscopy
Colonoscopy is an exam in which a doctor uses a colonoscope, to look inside your rectum and colon. Colonoscopy can show irritated and swollen tissue, ulcers, polyps, and cancer.
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Use the slider below to see how your results affect your
health.
Your result is Negative.
Normal findings are healthy intestinal tissues. If no abnormalities are discovered, an adult at average risk of colon cancer is generally advised to have a repeat colonoscopy 10 years until age 75.
Related conditions
Colonoscopy is a exam in which a doctor uses a flexible tube with a camera on one end, called a colonoscope or scope, to look inside your rectum and colon. The rectum and colon make up most of your large intestine.
Colonoscopy can show irritated and swollen tissue, ulcers, polyps, and cancer.
A colonoscopy is used:
to look for early signs of cancer in the colon and rectum. It may be part of a routine screening, which usually starts at age 45.
to look for causes of unexplained changes in bowel habits
to evaluate symptoms like abdominal pain, rectal bleeding, and weight loss
Your doctor can also remove polyps from your colon during the procedure.
You may need a colonoscopy to find the cause of unexplained symptoms such as:
Bleeding from your anus (the opening of the rectum through which stool passes out of your body)
Changes in your bowel activity, such as diarrhea
Pain in your abdomen (belly)
Unexplained weight loss
Doctors also use the procedure to screen for colon polyps and cancer. Screening is testing for diseases when you have no symptoms. It may find diseases at an early stage, when they are easier to treat. If aren't at higher risk for colorectal cancer, your health care provider will likely recommend you start getting screenings at age 45. If you at higher risk, you may need to start getting screened for colorectal cancer earlier.
There are also other tests to screen for colorectal cancer, including stool tests. Talk with your provider about which test is right for you and when and how often you should get it.
This test allows a provider to view your entire colon and rectum. It is often done in an outpatient department of a hospital or medical center. Before the test, you will need to empty out your colon (large bowel) in a procedure called bowel prep. During the test:
You will lie on an exam table.
You will be given medicine called a sedative to help you relax. It also prevents you from feeling pain during the procedure. You may be awake for the test, but you probably won't remember anything.
A colonoscope, a thin, lighted tube with a camera attached, will be inserted into your rectum and up into your colon.
Your provider will look for colorectal polyps or other abnormal areas.
Your provider may remove polyps or tissue samples using special tools inserted through the scope.
Polyps or samples may be sent to a lab for testing.
The sedative you are given may make you drowsy for several hours. You should arrange for someone to drive you home.
For a colonoscopy, you will need to do a bowel prep. Your provider will give you specific instructions on how to do your bowel prep, but steps for bowel prep may include:
Following a liquid diet for one to three days before the test.
Drinking plenty of clear liquids one to three days before the test. Clear liquids include water, black coffee or tea, fat-free broth, and sports drinks without added color.
Drinking a strong liquid laxative and/or using an enema on the evening before your test.
The laxative or enema will help you empty your bowels. You should prepare to spend a lot of time in the bathroom. Bowel prep can be inconvenient and uncomfortable, but if the colon is not thoroughly cleaned out, your provider may not be able to get a full picture of your colon and rectum. Polyps and other abnormal areas may not be seen.
Serious risks of colonoscopy are rare but can include:
Tears in the colon or rectum wall
Bleeding
Reaction to the sedative
Normal findings are healthy intestinal tissues. Abnormal results may include the following:
Colorectal polyps or abnormal tissue were found and removed.
Samples were sent to a lab for testing.
Most polyps aren't cancerous but can turn into cancer if not removed. Depending on the size and number of polyps, your provider may recommend more frequent colonoscopies.
If you have questions about your results, talk to your health care provider.
You may feel cramping in your abdomen or bloating during the first hour after the colonoscopy. If the doctor removed polyps or performed a biopsy, you may have light bleeding from your anus. This bleeding is normal.
Colorectal Cancer Screening Tests: MedlinePlus Medical Test [accessed on Feb 10, 2024]
Colonoscopy - NIDDK. National Institute of Diabetes and Digestive and Kidney Diseases. Feb 10, 2024 [accessed on Feb 10, 2024]
Colonoscopy | MedlinePlus. National Library of Medicine. Dec 5, 2022 [accessed on Feb 10, 2024]
Colonoscopy: MedlinePlus Medical Encyclopedia [accessed on Feb 10, 2024]
Robert H. Shmerling, MD. Understanding the results of your colonoscopy - Harvard Health. Oct 14, 2020 [accessed on Feb 10, 2024]
Normal reference ranges can vary depending on the laboratory and the method used for testing. You must use the range supplied by the laboratory that performed your test to evaluate whether your results are "within normal limits."
Additional Materials (40)
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Colorectal Cancer Clip 6
Colorectal Cancer Clip 6
Video by TheVisualMD
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Colorectal Cancer Clip 4
Colorectal Cancer Clip 4
Video by TheVisualMD
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Colorectal Cancer Clip 3
Colorectal Cancer Clip 3
Video by TheVisualMD
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Colorectal Cancer Screening
Colorectal cancer is one of the few preventable forms of cancer thanks to effective screening. For many people, screening for colorectal cancer is an unpleasant thought, but knowing your options and taking a pro-active approach especially if you're over 50 can save your life. In this video, you can learn the "ins and outs" of colonoscopy, as well as learn about a new technique called virtual colonoscopy, which uses high-tech CT scans to screen the colon.
Video by TheVisualMD
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Colorectal Cancer Screening & Diagnosis
Colorectal cancer includes cancer of both the colon and rectum. It is the fourth most common cancer in the United States and the second leading cause of cancer-related deaths affecting both men and women equally. The CDC recommends that everyone age 50 or over be screened. When diagnosed early, patients have a 90% 5-year survival rate.
Video by TheVisualMD
Preparing for a Colonoscopy
Video by Dartmouth-Hitchcock/YouTube
Why No One Should Be Afraid of a Colonoscopy
Video by Stanford Health Care/YouTube
What are Colonoscopy Risks? • Risks of Colonoscopy | Colonoscopy Center of Excellence
Video by La Peer/YouTube
Having a colonoscopy
Video by Cancer Research UK/YouTube
The Importance of Good Bowel Preparation During Colonoscopy
Video by Johns Hopkins Medicine/YouTube
What is a colonoscopy and how do I prepare for it?
Video by You and Colonoscopy/YouTube
Virtual Colonoscopy Q&A | Dr. Karen Horton
Video by Johns Hopkins Medicine/YouTube
What to expect during a colonoscopy
Video by MD Anderson Cancer Center/YouTube
6 Reasons to Get a Colonoscopy
Video by Cleveland Clinic/YouTube
Colonoscopy Video Tour: Removal of a Colon Polyp (Polypectomy)
Video by AmCollege Gastro/YouTube
What happens during and after a colonoscopy?
Video by You and Colonoscopy/YouTube
How to prepare for a colonoscopy
Video by MD Anderson Cancer Center/YouTube
Colonoscopy and Flexible Sigmoidoscopy
Video by Gastro Pros/YouTube
Virtual Colonoscopy: A Kinder Gentler Way to Prevent Colon Cancer
Video by University of California Television (UCTV)/YouTube
Screening for Colorectal Cancer
Video by Dartmouth-Hitchcock/YouTube
What is Colorectal Cancer?
Video by Stanford Health Care/YouTube
Rectal Cancer | Q&A
Video by Johns Hopkins Medicine/YouTube
5 Things to Know About Colonoscopy - The Nebraska Medical Center
Video by Nebraska Medicine Nebraska Medical Center/YouTube
Video by PreOp.com Patient Engagement - Patient Education/YouTube
UCSF Radiology: How is Virtual Colonoscopy Performed?
Video by UCSF Imaging/YouTube
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Diagram showing a colonoscopy
Diagram showing a colonoscopy.
Image by Cancer Research UK / Wikimedia Commons
Virtual Colonoscopy 3D Model
With virtual colonoscopy, a computed tomography scanner takes cross-sectional images of the patient's colon, after the colon has been inflated with gas. A three-dimensional model is then created from the CT slices and evaluated by a radiologist for abnormalities.
Image by TheVisualMD
Virtual Colonoscopy Slice of CT Data
Virtual colonoscopy is a new imaging technology that uses computed tomography (CT) images to look for polyps and cancer in the colon. A computed tomography scanner takes cross-sectional images of the patient's colon, after the colon has been inflated with gas. A three-dimensional model is created from the CT slices and evaluated by a radiologist for abnormalities.
Image by TheVisualMD
Colonoscopy or sigmoidoscopy testing
Drawing of a woman being tested for colon polyps. The woman is lying on her left side with her head on a pillow. In the background is a TV screen showing images of the colon.
Image by NIDDK Image Library
Colorectal Cancer Types of Surgery
Surgery is the main treatment for colorectal cancer. Polyps and very early stage cancers (Stage 0 and some early Stage I tumors) can be removed during a colonoscopy, using a variety of techniques. In late Stage I and in Stage II and III cancer, the cancerous part of the colon is removed surgically. The surgeon may perform a resection, consisting of a partial colectomy (removing the cancer and a small amount of healthy tissue around it) and an anastomosis (sewing the parts of the colon back together). Nearby lymph nodes may also be removed and biopsied. If it isn't possible to perform a resection (for instance, if the cancer is at the outlet of the rectum), a colostomy may be performed. In a colostomy, a portion of the large intestine is brought through the abdominal wall to carry stool out of the body, where it empties into a special bag. The colostomy may be temporary in order to allow the colon or rectum time to heal after surgery, or it may be permanent.
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Capsule endoscopy
Image of the colon acquired by capsule endoscopy
Image by Dr.HH.Krause
All Views
Inside
Outside
Unfurled
1
2
3
4
Virtual Colonoscopy
Virtual colonoscopy is a new technology that uses computerized tomography (CT) images to look for polyps and cancer in the colon. The result is a computer-generated, animated, three-dimensional view of the interior of the colon. The preparation for the procedure is similar to that for a colonoscopy, but the procedure itself takes only about 10 minutes, and no sedation is required. If abnormalities are found, a conventional colonoscopy is performed for removal or biopsy of the growth.
Interactive by TheVisualMD
Virtual Colonoscopy open colon section view
After the image-taking procedure is complete, the cross-sectional pictures are processed by the computer to create animated, three-dimensional images of the large intestine. They are examined by a radiologist to identify any abnormal growths. If abnormalities are found, a conventional colonoscopy will be performed so that the abnormal growths can be removed or biopsied.
Image by TheVisualMD
Screening and Diagnosis Colonoscopy
A colonoscopy is an examination of the interior of the colon. It is often used as a screening tool for early detection of colorectal cancer. During a colonoscopy, a long flexible tube with a video camera at one end, called a colonoscope, is inserted first into the anus and then into the colon. The doctor can view the inside of the colon along its entire length on a video monitor.
Image by TheVisualMD
A Less Invasive Look
Virtual colonoscopy is a new technology that uses computed tomography (CT), or, less often, magnetic resonance imaging (MRI) images to look for polyps, cancer, or other diseases of the colon when an abnormality is suspected. A computer program assembles the images to create an animated, three-dimensional view of the interior of the colon. The preparation for the procedure is similar to that for a colonoscopy, but the procedure itself takes only about 10 minutes, and no sedation is required. If abnormalities are found, a conventional colonoscopy will need to be performed for removal or biopsy of the growth.
Image by TheVisualMD
Screening and Diagnosis Colonoscope
A colonoscopy is an examination of the interior of the colon. It is often used as a screening tool for early detection of colorectal cancer. During a colonoscopy, a long flexible tube with a video camera at one end, called a colonoscope, is inserted first into the anus and then into the colon. The doctor can view the inside of the colon along its entire length on a video monitor.
Image by TheVisualMD
Capsule endoscopy
Picture of a capsule
Image by Euchiasmus
Preparing for a colonoscopy
Video by AmerGastroAssn/YouTube
0:05
Colorectal Cancer Clip 6
TheVisualMD
0:15
Colorectal Cancer Clip 4
TheVisualMD
0:49
Colorectal Cancer Clip 3
TheVisualMD
4:13
Colorectal Cancer Screening
TheVisualMD
4:12
Colorectal Cancer Screening & Diagnosis
TheVisualMD
14:55
Preparing for a Colonoscopy
Dartmouth-Hitchcock/YouTube
3:35
Why No One Should Be Afraid of a Colonoscopy
Stanford Health Care/YouTube
2:56
What are Colonoscopy Risks? • Risks of Colonoscopy | Colonoscopy Center of Excellence
La Peer/YouTube
1:37
Having a colonoscopy
Cancer Research UK/YouTube
1:23
The Importance of Good Bowel Preparation During Colonoscopy
Johns Hopkins Medicine/YouTube
6:30
What is a colonoscopy and how do I prepare for it?
You and Colonoscopy/YouTube
8:26
Virtual Colonoscopy Q&A | Dr. Karen Horton
Johns Hopkins Medicine/YouTube
1:16
What to expect during a colonoscopy
MD Anderson Cancer Center/YouTube
3:17
6 Reasons to Get a Colonoscopy
Cleveland Clinic/YouTube
2:45
Colonoscopy Video Tour: Removal of a Colon Polyp (Polypectomy)
AmCollege Gastro/YouTube
5:15
What happens during and after a colonoscopy?
You and Colonoscopy/YouTube
8:08
How to prepare for a colonoscopy
MD Anderson Cancer Center/YouTube
2:49
Colonoscopy and Flexible Sigmoidoscopy
Gastro Pros/YouTube
1:26:06
Virtual Colonoscopy: A Kinder Gentler Way to Prevent Colon Cancer
University of California Television (UCTV)/YouTube
4:06
Screening for Colorectal Cancer
Dartmouth-Hitchcock/YouTube
3:47
What is Colorectal Cancer?
Stanford Health Care/YouTube
8:46
Rectal Cancer | Q&A
Johns Hopkins Medicine/YouTube
4:18
5 Things to Know About Colonoscopy - The Nebraska Medical Center
UCSF Radiology: How is Virtual Colonoscopy Performed?
UCSF Imaging/YouTube
Sensitive content
This media may include sensitive content
Diagram showing a colonoscopy
Cancer Research UK / Wikimedia Commons
Virtual Colonoscopy 3D Model
TheVisualMD
Virtual Colonoscopy Slice of CT Data
TheVisualMD
Colonoscopy or sigmoidoscopy testing
NIDDK Image Library
Colorectal Cancer Types of Surgery
TheVisualMD
Sensitive content
This media may include sensitive content
Capsule endoscopy
Dr.HH.Krause
Virtual Colonoscopy
TheVisualMD
Virtual Colonoscopy open colon section view
TheVisualMD
Screening and Diagnosis Colonoscopy
TheVisualMD
A Less Invasive Look
TheVisualMD
Screening and Diagnosis Colonoscope
TheVisualMD
Capsule endoscopy
Euchiasmus
1:15
Preparing for a colonoscopy
AmerGastroAssn/YouTube
Sigmoidoscopy
Sigmoidoscopy
Also called: Flexible Sigmoidoscopy, Rigid Sigmoidoscopy, Proctoscopy, Proctosigmoidoscopy
A sigmoidoscopy is a diagnostic test used to check the sigmoid colon, which is the lower part of your colon or large intestine. It is used to help diagnose bowel problems and detect colon polyps that can become colon cancer.
Sigmoidoscopy
Also called: Flexible Sigmoidoscopy, Rigid Sigmoidoscopy, Proctoscopy, Proctosigmoidoscopy
A sigmoidoscopy is a diagnostic test used to check the sigmoid colon, which is the lower part of your colon or large intestine. It is used to help diagnose bowel problems and detect colon polyps that can become colon cancer.
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Use the slider below to see how your results affect your
health.
Your result is Negative.
A negative result means that no abnormalities were found in the colon. If you're at average risk of colon cancer, meaning you have no colon cancer risk factors other than age, your doctor may recommend repeating the exam in five years.
Related conditions
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Use the slider below to see how your results affect your
health.
Your result is Normal.
The lining of the colon appears smooth and pink, with numerous folds. No abnormal growths, pouches, bleeding, or inflammation is seen.
Related conditions
Sigmoidoscopy is a test in which the rectum and sigmoid colon are examined using a sigmoidoscope, a flexible lighted tube with a lens for viewing and a tool for removing tissue. This instrument is inserted through the anus into the rectum and sigmoid colon as air is pumped into the colon to expand it so the doctor can see the colon lining more clearly.
A sigmoidoscope is of two types:
Rigid sigmoidoscope: This sigmoidoscope is 25 cm long, and it allows examination of up to about 20 cm of the rectum and colon.
Flexible sigmoidoscope: It is made of a flexible fiber-optic tube and can be up to 60 cm long. It allows examination of the descending colon.
During sigmoidoscopy, abnormal growths in the rectum and sigmoid colon can be removed for analysis (biopsied). The lower colon must be cleared of stool before sigmoidoscopy, but the preparation is not very extensive. People are usually not sedated for this test.
You may need a sigmoidoscopy to find the cause of unexplained symptoms such as:
Bleeding from your anus (the opening of the rectum through which stool passes out of your body)
Changes in your bowel activity, such as diarrhea
Pain in your abdomen (belly)
Unexplained weight loss
Doctors also use the procedure to screen for colon polyps and cancer. Screening is testing for diseases when you have no symptoms. It may find diseases at an early stage, when they are easier to treat. If aren't at higher risk for colorectal cancer, your health care provider will likely recommend you start getting screenings at age 45. If you at higher risk, you may need to start getting screened for colorectal cancer earlier.
There are also other tests to screen for colorectal cancer, including stool tests. Talk with your provider about which test is right for you and when and how often you should get it.
This test allows your provider to look at the lower part of the colon. During the test:
You will lie on an exam table with your knees drawn up to your chest.
A sigmoidoscope, a flexible, lighted tube with a camera, will be inserted into the rectum and up into the lower part of the colon.
Air will be pumped through the sigmoidoscope to make the colon bigger and easier to see.
The air may make you feel like you need to have a bowel movement or pass gas.
Your provider may remove polyps or tissue samples using special tools inserted through the scope.
Polyps or samples may be sent to a lab for testing.
For a sigmoidoscopy, before the test, you may need to:
Follow a clear liquid diet one or more days before the procedure. This isn't always required, so be sure to talk to your provider before the test.
You may be asked to fast (not eat or drink) on the morning of the procedure.
Use an enema to empty your bowels about one hour before the procedure. A second enema is sometimes needed.
There are fewer risks to sigmoidoscopy than with a colonoscopy. Tears in the colon and bleeding can happen, but they are even less common than with a colonoscopy.
Normal findings are healthy intestinal tissues. Abnormal results may include the following:
Colorectal polyps or abnormal tissue were found. They may or may not be removed depending on their location.
Whether or not your polyps were removed, you will probably need a colonoscopy so your provider can view your entire colon and rectum.
If you have questions about your results, talk to your health care provider.
Tests to Detect Colorectal Cancer and Polyps - National Cancer Institute [accessed on Dec 28, 2018]
Colorectal Cancer Screening | Cancer Trends Progress Report [accessed on Dec 28, 2018]
Colorectal Cancer Screening (PDQ®)—Patient Version - National Cancer Institute [accessed on Dec 28, 2018]
Rigid and Flexible Sigmoidoscopy. MedicineNet [accessed on Feb 09, 2024]
Colorectal Cancer Screening Tests: MedlinePlus Medical Test [accessed on Feb 10, 2024]
Normal reference ranges can vary depending on the laboratory and the method used for testing. You must use the range supplied by the laboratory that performed your test to evaluate whether your results are "within normal limits."
Additional Materials (24)
Colorectal Cancer Screening
Video by Mechanisms in Medicine/YouTube
Testing for bowel cancer
Video by Cancer Research UK/YouTube
Screening for Cancer
Common Screening Tests and American Cancer Society Recommendations
Image by TheVisualMD
Screening & Diagnosis
Image by TheVisualMD
This browser does not support the video element.
Colorectal Cancer Clip 1
Colorectal Cancer Clip 1
Video by TheVisualMD
This browser does not support the video element.
Colorectal Cancer Clip 6
Colorectal Cancer Clip 6
Video by TheVisualMD
Colonoscopy or sigmoidoscopy testing
Drawing of a woman being tested for colon polyps. The woman is lying on her left side with her head on a pillow. In the background is a TV screen showing images of the colon.
Image by NIDDK Image Library
Drawing of the digestive system with sigmoid colon, rectum, and anus highlighted and parts labeled: esophagus, stomach, liver, gallbladder, duodenum, pancreas, small intestine, colon, sigmoid colon, rectum, and anus
The digestive system focusing on the sigmoid colon, rectum, and anus.
Image by NIDDK Image Library
colonoscopy
SAN DIEGO (April 5, 2011) Hospitalman Urian D. Thompson, left, Lt. Cmdr. Eric A. Lavery and Registered Nurse Steven Cherry review the monitor while Lavery uses a colonoscope on a patient during a colonoscopy at Naval Medical Center San Diego. (U.S. Navy photo by Mass Communication Specialist 2nd Class Chad A. Bascom/Released)
Image by U.S. Navy photo by Mass Communication Specialist 2nd Class Chad A. Bascom
Sensitive content
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Diagram showing a colonoscopy
Diagram showing a colonoscopy.
Image by Cancer Research UK / Wikimedia Commons
Sensitive content
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normal rectum colonoscopy
normal rectum 70y.o. Japanese / colonoscopy
Image by melvil
Familial adenomatous polyposis as seen on sigmoidoscopy
Familial adenomatous polyposis as seen on sigmoidoscopy
Image by Samir
Proctoscopy
Two proctoscopes
Image by Ralf Lotys (Sicherlich)
An anoscope, a proctoscope and a rectoscope, with approximate lengths
An anoscope, a proctoscope and a rectoscope, with approximate lengths
Image by Mikael Häggström
This browser does not support the video element.
Sigmoidoscopy: NCI B-roll [video]
NCI B-roll of a patient receiving a sigmoidoscopy. This video is silent. A version of this video with audio can be found in the video NCI Detection B-roll. Downloadable video files are 1280x720 at 30 fps. This image is part of the NCI B-Roll Videos collection.
View video using embedded player on this page or at youtube.com.
Video by National Cancer Institute (NCI)
Lower GI Series
A lower GI series, also called a barium
enema, is an x-ray exam used to help
diagnose problems of the large intestine. An
x ray is a picture created by using radiation
and recorded on film or on a computer. To
make the large intestine more visible on x ray,
a health care provider will fill the person’s
intestine with a chalky liquid called barium.
Document by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Drawing of the digestive system with sigmoid colon, rectum, and anus highlighted
The digestive system focusing on the sigmoid colon and stomach.
Image by NIDDK Image Library
Benign Tumor
Image of en:familial adenomatous polyposis as seen on en:sigmoidoscopy.
Image by Samir at English Wikipedia
What is a flexible sigmoidoscopy?
Video by You and Colonoscopy/YouTube
Colon Cancer Screening Tests: Flexible Sigmoidoscopy
Video by American Cancer Society/YouTube
Colon cancer: Essential facts
Video by Institute for Cancer Genetics and Informatics/YouTube
Screening for Colorectal Cancer
Video by Dartmouth-Hitchcock/YouTube
What to expect during a colonoscopy
Video by MD Anderson Cancer Center/YouTube
6 Reasons to Get a Colonoscopy
Video by Cleveland Clinic/YouTube
2:42
Colorectal Cancer Screening
Mechanisms in Medicine/YouTube
1:37
Testing for bowel cancer
Cancer Research UK/YouTube
Screening for Cancer
TheVisualMD
Screening & Diagnosis
TheVisualMD
0:15
Colorectal Cancer Clip 1
TheVisualMD
0:05
Colorectal Cancer Clip 6
TheVisualMD
Colonoscopy or sigmoidoscopy testing
NIDDK Image Library
Drawing of the digestive system with sigmoid colon, rectum, and anus highlighted and parts labeled: esophagus, stomach, liver, gallbladder, duodenum, pancreas, small intestine, colon, sigmoid colon, rectum, and anus
NIDDK Image Library
colonoscopy
U.S. Navy photo by Mass Communication Specialist 2nd Class Chad A. Bascom
Sensitive content
This media may include sensitive content
Diagram showing a colonoscopy
Cancer Research UK / Wikimedia Commons
Sensitive content
This media may include sensitive content
normal rectum colonoscopy
melvil
Familial adenomatous polyposis as seen on sigmoidoscopy
Samir
Proctoscopy
Ralf Lotys (Sicherlich)
An anoscope, a proctoscope and a rectoscope, with approximate lengths
Mikael Häggström
1:17
Sigmoidoscopy: NCI B-roll [video]
National Cancer Institute (NCI)
Lower GI Series
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Drawing of the digestive system with sigmoid colon, rectum, and anus highlighted
NIDDK Image Library
Benign Tumor
Samir at English Wikipedia
1:55
What is a flexible sigmoidoscopy?
You and Colonoscopy/YouTube
2:49
Colon Cancer Screening Tests: Flexible Sigmoidoscopy
American Cancer Society/YouTube
2:49
Colon cancer: Essential facts
Institute for Cancer Genetics and Informatics/YouTube
4:06
Screening for Colorectal Cancer
Dartmouth-Hitchcock/YouTube
1:16
What to expect during a colonoscopy
MD Anderson Cancer Center/YouTube
3:17
6 Reasons to Get a Colonoscopy
Cleveland Clinic/YouTube
Barium Enema
Barium Enema
Also called: Lower GI Series
A barium enema, also called a lower GI series, is an x-ray exam used to help diagnose problems of the large intestine. To make the large intestine more visible on x-ray, the intestine is filled with a chalky liquid called barium.
Barium Enema
Also called: Lower GI Series
A barium enema, also called a lower GI series, is an x-ray exam used to help diagnose problems of the large intestine. To make the large intestine more visible on x-ray, the intestine is filled with a chalky liquid called barium.
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Use the slider below to see how your results affect your
health.
Your result is Negative.
A negative result means that there were no abnormalities found. Barium filled the colon evenly, showing normal bowel shape and position and no blockages.
Related conditions
A barium enema is an x-ray exam in which a liquid that contains barium sulfate is put through the anus into the rectum and colon. Barium sulfate is a silver-white metallic compound that helps show pictures of the colon, rectum, and anus on an x-ray.
https://www.niddk.nih.gov/health-information/diagnostic-tests/lower-gi-series [accessed on Sep 19, 2019]
https://medlineplus.gov/ency/article/003817.htm [accessed on Sep 19, 2019]
https://www.radiologyinfo.org/en/info.cfm?pg=lowergi [accessed on Sep 19, 2019]
https://www.healthline.com/health/barium-enema [accessed on Sep 19, 2019]
Normal reference ranges can vary depending on the laboratory and the method used for testing. You must use the range supplied by the laboratory that performed your test to evaluate whether your results are "within normal limits."
Additional Materials (11)
Screening and Diagnosis Barium Enema
A barium enema is an X-ray examination of the colon. To make the intestine visible on X-ray, a white liquid called barium is inserted into the colon through a tube placed in the anus. The barium blocks X-rays, causing the outline of the barium-filled colon to show up clearly on the X-ray image.
Image by TheVisualMD
Barium Enema
Double Contrast Barium Enema - Using Positive and Negative Contrast
Image by The original uploader was Glitzy queen00 at English Wikipedia
A barium swallow exam taken via fluoroscopy.
A barium swallow exam taken via fluoroscopy.
Image by Normaler_Schluck-00.jpg (and others): Hellerhoff
Upper gastrointestinal series
X-ray of the stomach with both positive (bariumsulphate) and negative (CO2)contrastmedia.
Image by Lucien Monfils
Hernia
X-rays image: Double Contrast Barium Enema depicting gas filled loop of colon trapped outside the normal peritoneal confines. This marks the entrance or exit of transdiafragmatic, colonic herniation.
Image by Nevit Dilmen (talk)
Peutz-Jeghers syndrome
Note multiple polyps (mostly pedunculated) and at least one large mass at the hepatic flexure coated with contrast.
Image by robhengxr
Upper gastrointestinal series
Barium follow though showing the small bowel.
Image by Glitzy queen00 at en.wikipedia
Diverticulosis and Diverticulitis
Representation of the rectum, colon and descending colon sigmoideums in double contrast in an X-ray contrast enema. In the distal descending colon and sigmoid, individual small protuberances indicate which are called diverticula.
Image by Bragel
Gastroesophageal reflux disease - Treatment for GER and GERD
Gastroesophageal reflux barium X-ray : X-ray of the abdomen and chest in a patient with a gastrostomy. Radio-contrast was injected into the stomach and quickly seen migrating upwards through the entire esophagus. The patient had severe reflux esophagitis.
Image by Steven Fruitsmaak
Double Contrast Barium Enema - Using Positive and Negative Contrast
Double Contrast Barium Enema - Using Positive and Negative Contrast
Image by Glitzy queen00
Lower GI Series
A lower GI series, also called a barium
enema, is an x-ray exam used to help
diagnose problems of the large intestine. An
x ray is a picture created by using radiation
and recorded on film or on a computer. To
make the large intestine more visible on x ray,
a health care provider will fill the person’s
intestine with a chalky liquid called barium.
Document by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Screening and Diagnosis Barium Enema
TheVisualMD
Barium Enema
The original uploader was Glitzy queen00 at English Wikipedia
A barium swallow exam taken via fluoroscopy.
Normaler_Schluck-00.jpg (and others): Hellerhoff
Upper gastrointestinal series
Lucien Monfils
Hernia
Nevit Dilmen (talk)
Peutz-Jeghers syndrome
robhengxr
Upper gastrointestinal series
Glitzy queen00 at en.wikipedia
Diverticulosis and Diverticulitis
Bragel
Gastroesophageal reflux disease - Treatment for GER and GERD
Steven Fruitsmaak
Double Contrast Barium Enema - Using Positive and Negative Contrast
Glitzy queen00
Lower GI Series
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Fecal Occult Blood Test
Fecal Occult Blood Test
Also called: FOBT, Stool Hemoccult, Hemoccult Test
A fecal occult blood test looks for blood in the stool. Occult blood means that you can't see it with the naked eye. And fecal means that it is in your stool. Blood in stool may indicate hemorrhoids, colorectal cancer, or another condition.
Fecal Occult Blood Test
Also called: FOBT, Stool Hemoccult, Hemoccult Test
A fecal occult blood test looks for blood in the stool. Occult blood means that you can't see it with the naked eye. And fecal means that it is in your stool. Blood in stool may indicate hemorrhoids, colorectal cancer, or another condition.
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Use the slider below to see how your results affect your
health.
Your result is Negative.
A negative test result means that there is no blood in the stool.
Related conditions
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Use the slider below to see how your results affect your
health.
Your result is Negative.
A negative or normal result means the test did not detect any blood in the stool. However, because cancers in the colon may not always bleed, you may need to do the test a few times to confirm that there is no blood in your stool.
Related conditions
A fecal occult blood test (FOBT) looks at a sample of your stool (poop) to check for blood. Occult blood means that you can't see it with the naked eye. And fecal means that it is in your stool.
Blood in your stool means there is bleeding in the digestive tract. The bleeding may be caused by a variety of conditions, including:
Polyps, abnormal growths on the lining of the colon or rectum
Hemorrhoids, swollen veins in your anus or rectum
Diverticulosis, a condition with small pouches in the inside wall of the colon
Ulcers, sores in the lining of the digestive tract
Colitis, a type of inflammatory bowel disease
Colorectal cancer, a type of cancer that starts in the colon or rectum
Colorectal cancer is one of the most common types of cancer in the United States. A fecal occult blood test can screen for colorectal cancer to help find the disease early when treatment may be most effective.
Other names: FOBT, stool occult blood, occult blood test, Hemoccult test, guaiac smear test, gFOBT, immunochemical FOBT, iFOBT; FIT
A fecal occult blood test is commonly used as a screening test to help find colorectal cancer before you have symptoms. The test also has other uses. It may be done when there is concern about bleeding in the digestive tract from other conditions.
In certain cases, the test is used to help find the cause of anemia. And it can help tell the difference between irritable bowel syndrome (IBS), which usually doesn't cause bleeding, and inflammatory bowel disease (IBD), which is likely to cause bleeding.
But a fecal occult blood test alone cannot diagnose any condition. If your test results show blood in your stool, you will likely need other tests to diagnose the exact cause.
Your health care provider may order a fecal occult blood test if you have symptoms of a condition that could involve bleeding in your digestive tract. Or you may have the test to screen for colorectal cancer when you don't have any symptoms.
Expert medical groups strongly recommend that people get regular screening tests for colorectal cancer. Most medical groups recommend that you start screening tests at age 45 or 50 if you have an average risk of developing colorectal cancer. They recommend regular testing until at least age 75. Talk with your provider about your risk for colorectal cancer and when you should get a screening test.
A fecal occult blood test is one or several types of colorectal screening tests. Other tests include:
A stool DNA test. This test checks your stool for blood and cells with genetic changes that may be a sign of cancer.
Colonoscopy or sigmoidoscopy. Both tests use a thin tube with a camera to look inside your colon. A colonoscopy allows your provider to see your entire colon. A sigmoidoscopy shows only the lower part of your colon.
CT colonography, also called "virtual colonoscopy." For this test, you usually drink a dye before having a CT scan that uses x-rays to take detailed 3-dimensional pictures of your entire colon and rectum.
There are pros and cons of each type of test. Your provider can help you figure out which test is right for you.
Usually, your provider will give you a kit to collect samples of your stool (poop) at home. The kit will include instructions on how to do the test.
There are two main types of fecal occult blood tests:
The guaiac fecal occult blood test (gFOBT) uses a chemical (guaiac) to find blood in stool. It usually requires stool samples from two or three separate bowel movements.
The fecal immunochemical test (iFOBT or FIT) uses antibodies to find blood in stool. Research shows that FIT testing is better at finding colorectal cancers than gFOBT testing. A FIT test requires stool samples from one to three separate bowel movements, depending on the brand of the test.
Different test kits have different instructions, so it's very important to follow the specific instructions that come with your kit. The typical process for gathering a stool sample usually includes these general steps:
Collecting a bowel movement. Your kit may include a special paper to place over your toilet to catch your bowel movement. Or you may use plastic wrap or a clean, dry container. If you are doing a guaiac test, be careful not to let any urine mix in with your stool.
Taking a stool sample from the bowel movement. Your kit will include a wooden stick or applicator brush for scraping the stool sample from your bowel movement. Follow the instructions for where to gather the sample from the stool.
Preparing the stool sample. You will either smear the stool on a special test card or insert the applicator with the stool sample into a tube that came with your kit.
Labeling and sealing the sample as directed.
Repeating the test on your next bowel movement as directed if more than one sample is needed.
Returning the samples as directed. This might be mailing them or taking them to your provider's office or a lab.
You do not need any special preparations for many fecal occult blood tests. But for some guaiac fecal occult blood tests (gFOBTs), certain foods, supplements, and medicines may affect the results of the test. If you are having one of these tests, your provider will tell you what you need to avoid and for how long. For example, you might need to avoid:
Nonsteroidal, anti-inflammatory drugs (NSAIDs), such as ibuprofen, naproxen, and aspirin. If you take aspirin for heart problems, talk with your provider before stopping your medicine. You may be able to take acetaminophen during this time but check with your provider before taking it.
Vitamin C in amounts over 250 mg a day. This includes vitamin C from supplements, fruit juices, or fruit.
Red meat, such as beef, lamb, and pork. Traces of blood from these meats may show up in your stool.
Certain raw fruits and vegetables.
There is no known risk to having a fecal occult blood test.
If your results from a fecal occult blood test show that you have blood in your stool, it means you likely have bleeding somewhere in your digestive tract. But that doesn't always mean you have cancer. Other conditions that may cause blood in your stool include ulcers, hemorrhoids, polyps, and benign (not cancer) tumors.
If you have blood in your stool, your provider will likely recommend more tests to figure out the exact location and cause of your bleeding. The most common follow-up test is a colonoscopy. If you have questions about your test results, talk with your provider.
Learn more about laboratory tests, reference ranges, and understanding results.
Regular colorectal cancer screenings, such as fecal occult blood tests, are an important tool in the fight against cancer. Studies show that screening tests can help find cancer early and may reduce deaths from the disease.
If you decide to use fecal occult blood testing for your colorectal cancer screening, you will need to do the test every year.
You can buy gFOBT and FIT stool collection kits without a prescription. Most of these tests require you to send a sample of your stool to a lab. But some tests can be done completely at home for quick results. If you're considering buying your own test, ask your provider which one is best for you.
Fecal Occult Blood Test (FOBT): MedlinePlus Lab Test Information [accessed on Dec 28, 2018]
Tests to Detect Colorectal Cancer and Polyps - National Cancer Institute [accessed on Dec 28, 2018]
Additional Materials (4)
Colorectal Cancer Types of Surgery
Surgery is the main treatment for colorectal cancer. Polyps and very early stage cancers (Stage 0 and some early Stage I tumors) can be removed during a colonoscopy, using a variety of techniques. In late Stage I and in Stage II and III cancer, the cancerous part of the colon is removed surgically. The surgeon may perform a resection, consisting of a partial colectomy (removing the cancer and a small amount of healthy tissue around it) and an anastomosis (sewing the parts of the colon back together). Nearby lymph nodes may also be removed and biopsied. If it isn't possible to perform a resection (for instance, if the cancer is at the outlet of the rectum), a colostomy may be performed. In a colostomy, a portion of the large intestine is brought through the abdominal wall to carry stool out of the body, where it empties into a special bag. The colostomy may be temporary in order to allow the colon or rectum time to heal after surgery, or it may be permanent.
Image by TheVisualMD
This browser does not support the video element.
Colorectal Cancer Screening & Diagnosis
Colorectal cancer includes cancer of both the colon and rectum. It is the fourth most common cancer in the United States and the second leading cause of cancer-related deaths affecting both men and women equally. The CDC recommends that everyone age 50 or over be screened. When diagnosed early, patients have a 90% 5-year survival rate.
Video by TheVisualMD
Screening and Diagnosis Fecal Occult Blood Test
A fecal occult blood test (FOBT) finds blood in the stool by placing a stool sample on a chemically treated card, pad, or cloth wipe. A fecal occult blood test may be used to check for colorectal cancer, but it is never used to diagnose the condition.
Image by TheVisualMD
Fecal impaction
Fecal impaction : Plain abdominal X-ray showing a huge fecal impaction extending from the pelvis upwards to the left subphrenic space and from the left towards the right flank, measuring over 40 cm in length and 33 cm in width.
Image by Di Saverio S, Tugnoli G, Orlandi PE, Casali M, Catena F, et al.
Colorectal Cancer Types of Surgery
TheVisualMD
4:12
Colorectal Cancer Screening & Diagnosis
TheVisualMD
Screening and Diagnosis Fecal Occult Blood Test
TheVisualMD
Fecal impaction
Di Saverio S, Tugnoli G, Orlandi PE, Casali M, Catena F, et al.
Complete Blood Count
Complete Blood Count
Also called: CBC, Full Blood Count, Blood Cell Count, Hemotology Panel
A complete blood count (CBC) is often part of a routine exam. It is used to measure different parts and features of your blood. A CBC can help detect a variety of disorders including infections, anemia, diseases of the immune system, and blood cancers.
Complete Blood Count
Also called: CBC, Full Blood Count, Blood Cell Count, Hemotology Panel
A complete blood count (CBC) is often part of a routine exam. It is used to measure different parts and features of your blood. A CBC can help detect a variety of disorders including infections, anemia, diseases of the immune system, and blood cancers.
A complete blood count, or CBC, is a blood test that measures many different parts and features of your blood, including:
Red blood cells, which carry oxygen from your lungs to the rest of your body.
White blood cells, which fight infections and other diseases. There are five major types of white blood cells. A CBC test measures the total number of white cells in your blood. A different test called a CBC with differential measures the number of each type of these white blood cells.
Platelets, which stop bleeding by helping your blood to clot.
Hemoglobin, a protein in red blood cells that carries oxygen from your lungs to the rest of your body.
Hematocrit, a measurement of how much of your blood is made up of red blood cells.
Mean corpuscular volume (MCV), a measure of the average size of your red blood cells.
Other names for a complete blood count: CBC, full blood count, blood cell count
A complete blood count is a common blood test that is often part of a routine checkup. Complete blood counts can help detect a variety of disorders including infections, anemia, diseases of the immune system, and blood cancers.
Your health care provider may have ordered a complete blood count as part of your checkup or to monitor your overall health. The test may also be used to:
Help diagnose blood diseases, infection, immune system disorders, or other medical conditions
Check for changes in an existing blood disorder
A health care professional will take a blood sample from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial. You may feel a little sting when the needle goes in or out. This usually takes less than five minutes.
Usually there is no special preparation necessary for a complete blood count. But if your provider ordered other tests on your blood sample, you may need to fast (not eat or drink) for several hours before the test. Your provider will let you know if there are any special instructions to follow.
There is very little risk to having a blood test. You may experience slight pain or bruising at the spot where the needle went in, but most symptoms go away quickly.
A CBC counts the cells in your blood. There are many reasons your levels may not be in the normal range. For example:
Abnormal levels of red blood cells, hemoglobin, or hematocrit may be a sign of anemia, heart disease, or too little iron in your body.
Low white cell count may be a sign of an autoimmune disorder, bone marrow disorder, or cancer.
High white cell count may be a sign of an infection or a reaction to medicine.
If any of your levels are abnormal, it doesn't always mean you have a medical condition that needs treatment. Diet, activity level, medicines, a menstrual period, not drinking enough water, and other factors can affect the results. Talk with your provider to learn what your results mean.
A complete blood count is only one tool your health care provider uses to learn about your health. Your provider will consider your medical history, symptoms, and other factors to make a diagnosis. You may also need additional tests.
Complete Blood Count (CBC): MedlinePlus Medical Test [accessed on Jan 20, 2024]
Blood Tests - Blood Tests | NHLBI, NIH. Mar 24, 2022 [accessed on Jan 20, 2024]
Additional Materials (25)
Reticulocyte Count, Hemorrhage/Chronic Blood Loss
Reticulocytes are immature red blood cells (RBCs) released into the bloodstream from the bone marrow in which they developed. Normally, only a tiny percentage red blood cells circulating in the bloodstream are reticulocytes. The reticulocyte count rises, however, when bone marrow is called upon to produce more RBCs, in conditions such as heavy bleeding or certain types of anemia.
Image by TheVisualMD
Blood sample
During the blood collection process, medical personnel gather additional blood samples to test for an array of blood disorders and communicable diseases. Every unit of blood is rigorously tested before approved for transfusion into a patient.
Image by United States Marine Corps
Phlebotomy
Venipuncture (blood draw / collection) in the left arm of a male.
Image by MatthewLammers
Blood and Related Conditions
Blood and Related Conditions : Anemia results when there are too few red blood cells circulating in the bloodstream to deliver adequate oxygen to body tissues. There are different types and causes of anemia, including malnutrition, chronic bleeding, and diseases that result in red blood cells either being destroyed too quickly or produced too slowly.
Image by TheVisualMD
Components of Blood
Components of Blood : Our blood is composed of many different components, the largest categories being red and white blood cells (blood-clotting platelets are another key component) and the liquid portion known as blood plasma. A Complete Blood Count (CBC) includes several of the most basic, yet important, measurements of these components.
Image by TheVisualMD
Blood fractionation
Vial of separated blood. The middle layer is a type of sterile goo which separates the blood from the rest of what's drawn.
Image by Wheeler Cowperthwaite from Reno, USA
Whole Blood
A Red Cross whole blood donation before any separation
Image by Whoisjohngalt
White Blood Cells Rotation
This rotational interactive features five white blood cells. At the top left is a neutrophil (purple nucleus); center is a Monocyte-macrophage (orange nucleus); top right is a Lymphocyte (red nucleus); bottom left a Basophil (green nucleus); and bottom right an Eosinophil (yellow nucleus). These molecules are all part of a white blood cell count test. A white blood cell count is an important measure of this key component of the immune system; when the body is under attack, more WBCs are produced. White blood cells (also called leukocytes or WBCs) are in the front lines in the fight against harmful viruses, bacteria and even fungus. A white blood cell count is an important measure of this key component of the immune system; when the body is under attack, more WBCs are produced. Other factors, however, may also affect WBC counts, including allergies, chemotherapy, and other drugs, as well as leukemia.
Image by TheVisualMD
Medical Checkups
Image by TheVisualMD
Medical Checkups
Most doctors believe that people should have regular checkups as a part of preventive treatment. Regular health exams can help find problems before they begin, or in their early stages, when the chances of successful treatment are best.
Blood Pressure Reading: Photo Copyright 2005, James Gathany
Image by TheVisualMD
This browser does not support the video element.
Complete Blood Count, and Baselining Your Health
Video Topics : Our lifeblood consists of many components and a complete blood count (CBC) includes measurements of the fundamental elements. The largest categories are red and white blood cells (RBCs and WBCs) and cell fragments called platelets, which play roles in blood clotting. There are 20-30 trillion red blood cells in the body of an adult, each with a lifespan of about 100 days (RBCs contain an iron-containing protein called hemoglobin that enables them to carry oxygen to tissues throughout the body and then return carbon dioxide to the lungs). WBCs are in the front lines in the body's ongoing fight against harmful viruses, bacteria and even fungus; when a pathogen enters the body, WBCs mobilize in a coordinated defense response to eliminate, neutralize or mark the invader for destruction. The liquid portion of blood is called plasma and it carries nutrients, electrolytes, waste products, and hormones.
Video by TheVisualMD
Full Blood Count – what it tells your doctor about your health
Video by Pathology Tests Explained/YouTube
Complete Blood Count (CBC)
Video by Medicosis Perfectionalis/YouTube
Complete Blood Count
Video by Tom Wade MD/YouTube
high white blood cell count Video
Video by itbestshop/YouTube
Complete Blood Count pt1
Video by Med Immersion/YouTube
Complete Blood Count pt2
Video by Med Immersion/YouTube
This browser does not support the video element.
Normal Red Blood Cell (RBC) Count
An animation simulating a view of a healthy count of red blood cells as viewed in a slide projector or under a microscope. Initially, the screen in white with a circular black vignette along its borders. Then a still showing red blood cells slides up from the bottom left filling the screen and then comes into focus. The red blood cells resemble those taken from an scanning electron micrograph (SEM) and fill up the given space on the screen.
Video by TheVisualMD
This browser does not support the video element.
Anemic Blood Flow
Camera is stationary as it focuses on a capillary in a cell bed demonstrating anemic blood flow and it's lower red blood cell count.
Video by TheVisualMD
This browser does not support the video element.
Anemic Red Blood Cell (RBC) Count
An animation simulating a view of an unhealthy count of red blood cells as viewed in a slide projector or under a microscope. Initially, the screen in white with a circular black vignette along its borders. Then a still showing red blood cells on a light red background slides up from the bottom left filling the screen and then comes into focus. The red blood cells resemble those taken from an scanning electron micrograph (SEM). There are only a few red blood cells in this slide indicative of the low amount typical of some one who is anemic.
Video by TheVisualMD
This browser does not support the video element.
Anemic Red Blood Cell (RBC) Count
An animation simulating a close-up of an unhealthy count of red blood cells as viewed in a slide projector or under a microscope. Initially, the screen in white with a circular black vignette along its borders. Then a still showing red blood cells on a light red background slides up from the bottom left filling the screen and then comes into focus. Throughout the animation, the slide jitters a little. The red blood cells resemble those taken from an scanning electron micrograph (SEM). In this close up there are a few red blood cells along with a few white blood cells.
Video by TheVisualMD
Why Blood Tests Can Save Your Life
Video by Seeker+/YouTube
Introduction to lab values and normal ranges | Health & Medicine | Khan Academy
Video by khanacademymedicine/YouTube
Low blood counts and the risk of infection in cancer patients | Norton Cancer Institute
Video by Norton Healthcare/YouTube
Dr. Erba Describes Proper Diagnostic Testing of CML
Video by OncLiveTV/YouTube
Reticulocyte Count, Hemorrhage/Chronic Blood Loss
TheVisualMD
Blood sample
United States Marine Corps
Phlebotomy
MatthewLammers
Blood and Related Conditions
TheVisualMD
Components of Blood
TheVisualMD
Blood fractionation
Wheeler Cowperthwaite from Reno, USA
Whole Blood
Whoisjohngalt
White Blood Cells Rotation
TheVisualMD
Medical Checkups
TheVisualMD
Medical Checkups
TheVisualMD
2:12
Complete Blood Count, and Baselining Your Health
TheVisualMD
4:18
Full Blood Count – what it tells your doctor about your health
Pathology Tests Explained/YouTube
7:04
Complete Blood Count (CBC)
Medicosis Perfectionalis/YouTube
4:11
Complete Blood Count
Tom Wade MD/YouTube
8:22
high white blood cell count Video
itbestshop/YouTube
16:12
Complete Blood Count pt1
Med Immersion/YouTube
22:14
Complete Blood Count pt2
Med Immersion/YouTube
0:06
Normal Red Blood Cell (RBC) Count
TheVisualMD
0:07
Anemic Blood Flow
TheVisualMD
0:14
Anemic Red Blood Cell (RBC) Count
TheVisualMD
0:14
Anemic Red Blood Cell (RBC) Count
TheVisualMD
8:29
Why Blood Tests Can Save Your Life
Seeker+/YouTube
10:42
Introduction to lab values and normal ranges | Health & Medicine | Khan Academy
khanacademymedicine/YouTube
1:32
Low blood counts and the risk of infection in cancer patients | Norton Cancer Institute
Norton Healthcare/YouTube
2:39
Dr. Erba Describes Proper Diagnostic Testing of CML
OncLiveTV/YouTube
Red Blood Cells
Red Blood Cell (RBC) Count
Also called: Erythrocyte Count, RBC Count, Red Blood Count, Red Blood Cell Count, Red Count
A red blood cell (RBC) count is a blood test that measures the number of red blood cells in your blood. Red blood cells carry oxygen from your lungs to the rest of your body. An abnormal RBC count can be a sign of a serious health problem.
Red Blood Cell (RBC) Count
Also called: Erythrocyte Count, RBC Count, Red Blood Count, Red Blood Cell Count, Red Count
A red blood cell (RBC) count is a blood test that measures the number of red blood cells in your blood. Red blood cells carry oxygen from your lungs to the rest of your body. An abnormal RBC count can be a sign of a serious health problem.
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Your result is Normal.
Red blood cells (RBC) are made in the bone marrow and contain hemoglobin, a protein that carries oxygen to the tissues in the body. RBCs make up approximately 44% of the total blood volume.
Related conditions
A red blood cell (RBC) count measures the number of red blood cells, also known as erythrocytes, in your blood. Red blood cells carry oxygen from your lungs to every cell in your body. Your cells need oxygen to grow, reproduce, and stay healthy. An RBC count that is higher or lower than normal is often the first sign of an illness. So the test may allow you to get treatment even before you have symptoms.
Other names: erythrocyte count, red count
A red blood cell (RBC) count is almost always part of a complete blood count, a group of tests that measure many different parts and features of your blood. The RBC measurement is used to help diagnose red blood cell disorders, such as anemia, a condition in which your body does not make enough healthy red blood cells.
You may get this test as part of a complete blood count, which is often included in a routine checkup. You may also need this test if you have symptoms of a low or high red blood cell count.
Symptoms of a low red blood cell count include:
Weakness
Fatigue
Pale skin
Rapid heartbeat
Symptoms of a high red blood cell count include:
Headache
Dizziness
Vision problems
A health care professional will take a blood sample from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial. You may feel a little sting when the needle goes in or out. This usually takes less than five minutes.
You don't need any special preparations for a red blood cell (RBC) count.
There is very little risk to having a blood test. There may be slight pain or bruising at the spot where the needle was put in, but most symptoms go away quickly.
Your results will show whether you have a normal red blood cell count or a count that is too low or too high.
A low red blood cell count can be a sign of:
Anemia
Leukemia, a type of blood cancer
Malnutrition, a condition in which your body does not get the calories, vitamins, and/or minerals needed for good health
Multiple myeloma, a cancer of the bone marrow
Kidney failure
It may also be a sign of pregnancy.
A high red blood cell count can be a sign of:
Dehydration
Heart disease
Polycythemia vera, a bone marrow disease that causes too many red blood cells to be made
Scarring of the lungs, often due to cigarette smoking
Lung disease
Kidney cancer
If you have questions about your results, talk to your health care provider.
If results showed you had a low or a high red blood cell count, you may need more tests to help make a diagnosis. These include:
Reticulocyte count, a test that counts the number of reticulocytes in the blood. Reticulocytes are red blood cells that are still developing. These are also known as immature red blood cells.
Iron tests, which measure iron levels in the blood. Iron is essential for making red blood cells.
Vitamin B test, which measures the amount of one or more B vitamins in the blood. B vitamins are important for making red blood cells.
Red Blood Cell (RBC) Count: MedlinePlus Medical Test [accessed on Jan 20, 2024]
RBC count: MedlinePlus Medical Encyclopedia [accessed on Jan 20, 2024]
Red Blood Cell Count (RBC) Test - Testing.com. Sep 27, 2022 [accessed on Jan 20, 2024]
Normal reference ranges can vary depending on the laboratory and the method used for testing. You must use the range supplied by the laboratory that performed your test to evaluate whether your results are "within normal limits."
Additional Materials (19)
Red blood cells
Red blood cells
Image by John Kalekos of Massachusetts image distribution for Science and Learning
Red Blood Cell
This image shows two red blood cells. The red blood cell is also called an erythrocyte: erythro is Greek for \"red,\" cyte is Latin for \"cell.\" The disc-shaped RBCs have the critical job of transporting oxygen from the lungs to the body's cells and bringing carbon dioxide from the cells back to the lungs to be expelled.
Image by TheVisualMD
Red Blood Cell in Capillary
The cardiovascular system is vast network of arteries, veins and vessels that would extend 60,000 miles if stretched end-to-end. All but a tiny fraction of this vessel network is invisible to the naked eye. The smallest capillaries (from latin "hairlike") are so narrow that red blood cells must pass through in single file. Higher than normal blood iron levels have been linked to heart disease and the reason is believed to be the oxidative stress the excess iron places on the walls of the blood vessels. It is the biological counterpart of rust. There are 20-30 trillion red blood cells (RBCs) in an adult's body. The life span of RBCs, which are produced in bone marrow, is about 100 days, which means that 2 million die (and are replaced) each second, but in that short lifetime they can make 75,000 round trips between lungs, heart and tissues in the body.
Image by TheVisualMD
Blood Smear Showing Reduced Red Blood Cell Count
Individual blood cells were first detected and described in the 17th century. Later, red blood cells (RBCs) were counted manually from a blood smear, a thin film of blood prepared on a glass slide and examined under a microscope (blood analysis is now automated, though smears are still used to detect visible abnormalities and to check or confirm the results of other tests). Anemia results when there are too few RBCs in circulation because they are being destroyed too quickly or produced too slowly. Anemia can be temporary or long term and range from mild to severe. Folate (also known as vitamin B9) is necessary for red blood cell production and the prevention of anemia, as well as the metabolism of carbohydrates. But folate also plays key roles in the synthesis and maintenance of DNA and is especially important in cell division and growth in fetal development (deficiencies of the vitamin in pregnancy is a common cause of birth defects). Pernicious anemia is a disorder in which the body's loses its ability to utilize folate and vitamin B12.
Image by TheVisualMD
Red Blood Cell (RBC)
There are 20-30 trillion red blood cells (RBCs) in an adult's body. The life span of RBCs, which are produced in bone marrow, is about 100 days, which means that 2 million die (and are replaced) each second. In their short lifetimes, however, red blood cells can make 75,000 round trips between lungs, heart and tissues in the body.
Image by TheVisualMD
Red Blood Cell
The RBC is disc-shaped and concave on both sides. The concave shape increases the cells' surface area, which allows them to distribute more oxygen to the body's cells. The shape also enables the cells to bunch together more compactly, helping them travel through the bloodstream more efficiently. Some RBCs are a bit thicker or thinner, wider or longer than others, but can change their shape to suit the demands of their environment. The cell membranes of the RBCs are protein meshes that give them flexibility, allowing them to navigate the twists and turns of the blood vessel network. The nearly 300 million hemoglobin molecules contained within each RBC easily move and slide past each other within the cell, adjusting their positions to conform to the RBC's shifting shape. Diameter : 7 μm
Image by TheVisualMD
Capillary Revealing Red Blood Cell
A portion of a capillary wall has been cut away to reveal the red blood cells flowing within.
Image by TheVisualMD
Red Blood Cell and White Blood Cell
Medical visualization of red blood cells and leukocytes.
Image by TheVisualMD
Blood Smear Showing Normal Red Blood Cell Count
Individual blood cells were first detected and described in the 17th century. Later, red blood cells were counted manually from a blood smear, a thin film of blood prepared on a glass slide and examined under a microscope. Blood analysis is now automated, though blood smears are still used to detect visible abnormalities and to check or confirm the results of other tests. There are normally between 4.2-5.8 million red blood cells per microliter (about a drop), which means there are 20-30 trillion red blood cells circulating through the body of an adult.
Image by TheVisualMD
Tubule of Nephron Revealing Many Red Blood Cell
This image shows the cut distal convoluted tubule of nephron with surrounding capillaries cut to reveal many red blood cells and healthy amounts of Erythopoeitin, EPO, (yellow particles). Erythropoeitin, EPO, is produced by the endothelial cells of the capillaries and the fibroblasts in the interstitial tissue surrounding the distal tubules. Normally, the kidneys produce EPO in response to low oxygen levels in order to stimulate red blood cell production in the bone marrow. A normal amount of red blood cells allows for the delivery of an adequate supply of oxygen.
Image by TheVisualMD
Red Blood Cell in Capillary
This image shows red blood cells traveling through capillaries, the smallest blood vessels in the body.
Image by TheVisualMD
Tubule of Nephron Revealing Few Red Blood Cell
Our kidneys are remarkable filters. Each day, they filter about 200 quarts of blood to extract about 2 quarts of wastes, which is then eliminated as urine. The kidneys' delicate filtration units are called nephrons; each kidney has about a million nephrons, and within each nephron are dense forests of tiny capillaries called glomeruli, which remove waste products from the blood while preventing the loss of other components, including proteins, electrolytes and blood cells. The glomerular filtration rate is the amount of blood that is filtered by the glomeruli per minute.
Image by TheVisualMD
This browser does not support the video element.
Complete Blood Count, and Baselining Your Health
Video Topics : Our lifeblood consists of many components and a complete blood count (CBC) includes measurements of the fundamental elements. The largest categories are red and white blood cells (RBCs and WBCs) and cell fragments called platelets, which play roles in blood clotting. There are 20-30 trillion red blood cells in the body of an adult, each with a lifespan of about 100 days (RBCs contain an iron-containing protein called hemoglobin that enables them to carry oxygen to tissues throughout the body and then return carbon dioxide to the lungs). WBCs are in the front lines in the body's ongoing fight against harmful viruses, bacteria and even fungus; when a pathogen enters the body, WBCs mobilize in a coordinated defense response to eliminate, neutralize or mark the invader for destruction. The liquid portion of blood is called plasma and it carries nutrients, electrolytes, waste products, and hormones.
Video by TheVisualMD
Red Blood Cell (RBC) Indices (Anemia Labs)
Video by Nursing School Explained/YouTube
WellnessFX: Red Blood Cell Indices Part 1 with Bryan Walsh
Video by WellnessFX/YouTube
WellnessFX: Red Blood Cell Indices Part 2 with Bryan Walsh
Video by WellnessFX/YouTube
Red Blood Cells Nursing Considerations, Normal Range, Nursing Care, Lab Values Nursing
Video by NURSINGcom/YouTube
This browser does not support the video element.
Flowing Red Blood Cell (RBC)
Animation of red blood cells flowoing quicly through a blood vessel. The camera is positioned in the lumen of the vessel and the rbc's are flowing towards the viewer. The rbc and and lumen are rendered with muted colors to give it a softer look.
Video by TheVisualMD
This browser does not support the video element.
Red Blood Cell Development
This video explains red blood cell development, following a pluripotent stem cell to red blood cell.
Video by TheVisualMD
Red blood cells
John Kalekos of Massachusetts image distribution for Science and Learning
Red Blood Cell
TheVisualMD
Red Blood Cell in Capillary
TheVisualMD
Blood Smear Showing Reduced Red Blood Cell Count
TheVisualMD
Red Blood Cell (RBC)
TheVisualMD
Red Blood Cell
TheVisualMD
Capillary Revealing Red Blood Cell
TheVisualMD
Red Blood Cell and White Blood Cell
TheVisualMD
Blood Smear Showing Normal Red Blood Cell Count
TheVisualMD
Tubule of Nephron Revealing Many Red Blood Cell
TheVisualMD
Red Blood Cell in Capillary
TheVisualMD
Tubule of Nephron Revealing Few Red Blood Cell
TheVisualMD
2:12
Complete Blood Count, and Baselining Your Health
TheVisualMD
7:45
Red Blood Cell (RBC) Indices (Anemia Labs)
Nursing School Explained/YouTube
33:35
WellnessFX: Red Blood Cell Indices Part 1 with Bryan Walsh
WellnessFX/YouTube
28:05
WellnessFX: Red Blood Cell Indices Part 2 with Bryan Walsh
WellnessFX/YouTube
3:01
Red Blood Cells Nursing Considerations, Normal Range, Nursing Care, Lab Values Nursing
NURSINGcom/YouTube
0:12
Flowing Red Blood Cell (RBC)
TheVisualMD
0:31
Red Blood Cell Development
TheVisualMD
White Blood Cells
White Blood Count (WBC)
Also called: WBC, WBC Blood Test, White Blood Count, White Blood Cell Count, Leukocyte Count, Leukopenia Test, Leukocytosis Test
A white blood count measures the number of white cells in your blood. White blood cells are part of the immune system. A count that is too high or too low can indicate an infection, immune system disorder, or another health problem.
White Blood Count (WBC)
Also called: WBC, WBC Blood Test, White Blood Count, White Blood Cell Count, Leukocyte Count, Leukopenia Test, Leukocytosis Test
A white blood count measures the number of white cells in your blood. White blood cells are part of the immune system. A count that is too high or too low can indicate an infection, immune system disorder, or another health problem.
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Use the slider below to see how your results affect your
health.
4500
11000
Your result is Normal.
Normally, people produce about 100 billion white blood cells (WBCs) a day. The total white blood cell count normally ranges between 4,500 and 11,000 WBCs per microliter.
Related conditions
A white blood count measures the number of white cells in your blood. White blood cells are part of the immune system. They help your body fight off infections and other diseases.
When you get sick, your body makes more white blood cells to fight the bacteria, viruses, or other foreign substances causing your illness. This increases your white blood count.
Other diseases can cause your body to make fewer white blood cells than you need. This lowers your white blood count. Diseases that can lower your white blood count include some types of cancer and HIV/AIDS, a viral disease that attacks white blood cells. Certain medicines, including chemotherapy, may also lower the number of your white blood cells.
There are five major types of white blood cells:
Neutrophils
Lymphocytes
Monocytes
Eosinophils
Basophils
A white blood count measures the total number of these cells in your blood. Another test, called a blood differential, measures the amount of each type of white blood cell.
Other names: WBC count, white cell count, white blood cell count
A white blood count is most often used to help diagnose disorders related to having a high white blood cell count or low white blood cell count.
Disorders related to having a high white blood count include:
Autoimmune and inflammatory diseases, conditions that cause the immune system to attack healthy tissues
Bacterial or viral infections
Cancers such as leukemia and Hodgkin disease
Allergic reactions
Disorders related to having a low white blood count include:
Diseases of the immune system, such as HIV/AIDS
Lymphoma, a cancer of the bone marrow
Diseases of the liver or spleen
A white blood count can show if the number of your white blood cells is too high or too low, but it can't confirm a diagnosis. So it is usually done along with other tests, such as a complete blood count, blood differential, blood smear, and/or bone marrow test.
You may need this test if you have signs of an infection, inflammation, or autoimmune disease. Symptoms of infection include:
Fever
Chills
Body aches
Headache
Symptoms of inflammation and autoimmune diseases will be different, depending on the area of inflammation and type of disease.
You may also need this test if you have a disease that weakens your immune system or are taking medicine that lowers your immune response. If the test shows your white blood count is getting too low, your provider may be able to adjust your treatment.
Your newborn or older child may also be tested as part of a routine screening, or if they have symptoms of a white blood cell disorder.
A health care professional will take a blood sample from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial. You may feel a little sting when the needle goes in or out.
To test children, a health care provider will take a sample from the heel (newborns and young babies) or the fingertip (older babies and children). The provider will clean the heel or fingertip with alcohol and poke the site with a small needle. The provider will collect a few drops of blood and put a bandage on the site.
You don't need any special preparations for a white blood count.
After a blood test, you may have slight pain or bruising at the spot where the needle was put in, but most symptoms go away quickly.
There is very little risk to your baby or child with a needle stick test. Your child may feel a little pinch when the site is poked, and a small bruise may form at the site. This should go away quickly.
A high white blood count may mean you have one of the following conditions:
A bacterial or viral infection
An inflammatory disease such as rheumatoid arthritis
An allergy
Leukemia or Hodgkin disease
Tissue damage from a burn injury or surgery
A low white blood count may mean you have one of the following conditions:
Bone marrow damage. This may be caused by infection, disease, or treatments such as chemotherapy.
Cancers that affect the bone marrow
An autoimmune disorder, such as lupus (or SLE)
HIV/AIDS
If you are already being treated for a white blood cell disorder, your results may show if your treatment is working or whether your condition has improved.
If you have questions about your results, talk to your health care provider.
White blood count results are often compared with results of other blood tests, including a blood differential. A blood differential test shows the amount of each type of white blood cell, such as neutrophils or lymphocytes. Neutrophils mostly target bacterial infections. Lymphocytes mostly target viral infections.
A higher than normal amount of neutrophils is known as neutrophilia.
A lower than normal amount is known as neutropenia.
A higher than normal amount of lymphocytes is known as lymphocytosis.
A lower normal amount is known as lymphopenia.
White Blood Count (WBC): MedlinePlus Medical Test [accessed on Jan 20, 2024]
WBC count: MedlinePlus Medical Encyclopedia [accessed on Jan 20, 2024]
White Blood Cell Count (WBC Blood Test) - Testing.com. Sep 28, 2022 [accessed on Jan 20, 2024]
Normal reference ranges can vary depending on the laboratory and the method used for testing. You must use the range supplied by the laboratory that performed your test to evaluate whether your results are "within normal limits."
Additional Materials (37)
White Blood Cell Count: Bone Marrow
Disease or damage to the bone marrow, caused by infection, cancer, radiation treatment, or chemotherapy can lower white blood cell count by impairing the marrow's ability to produce new white blood cells.
Image by TheVisualMD
White Blood Cells, Bone Marrow
Bone marrow is constantly producing blood cells, including white blood cells and red blood cells as well platelets, which are cell fragments important for blood clotting. Disease and disorders of the bone marrow can, in turn, affect the production of blood cells. Both cancer and cancer treatment (chemotherapy and radiation) can also have an impact on the bone marrow's ability to produce blood cells.
Image by TheVisualMD
This browser does not support the video element.
Complete Blood Count, and Baselining Your Health
Video Topics : Our lifeblood consists of many components and a complete blood count (CBC) includes measurements of the fundamental elements. The largest categories are red and white blood cells (RBCs and WBCs) and cell fragments called platelets, which play roles in blood clotting. There are 20-30 trillion red blood cells in the body of an adult, each with a lifespan of about 100 days (RBCs contain an iron-containing protein called hemoglobin that enables them to carry oxygen to tissues throughout the body and then return carbon dioxide to the lungs). WBCs are in the front lines in the body's ongoing fight against harmful viruses, bacteria and even fungus; when a pathogen enters the body, WBCs mobilize in a coordinated defense response to eliminate, neutralize or mark the invader for destruction. The liquid portion of blood is called plasma and it carries nutrients, electrolytes, waste products, and hormones.
Video by TheVisualMD
The Immune System Explained I – Bacteria Infection
Video by Kurzgesagt – In a Nutshell/YouTube
Immune Response to Bacteria
Video by NIAID/YouTube
Immunology - Adaptive Immune System
Video by Armando Hasudungan/YouTube
Immune System - Natural Killer Cell
Video by Kyle Thornthwaite/YouTube
Your Immune System: Natural Born Killer - Crash Course Biology #32
Video by CrashCourse/YouTube
White Blood Cell and Red Blood Cell
Medical visualization of blood cells. Depicted are numerous red blood cells and a single white blood cell.
Image by TheVisualMD
White Blood Cell and Red Blood Cell
Medical visualization of blood cells. Depicted are numerous red blood cells and a single white blood cell.
Image by TheVisualMD
Red Blood Cell and White Blood Cell
Visualization of red blood cells and a white blood cell
Image by TheVisualMD
Sensitive content
This media may include sensitive content
Blood cells (from left to right: erythrocyte, thrombocyte, leukocyte)
A single drop of blood contains millions of red blood cells, white blood cells, and platelets. One of each type is shown here, isolated from a scanning electron micrograph.
Image by Electron Microscopy Facility at The National Cancer Institute at Frederick (NCI-Frederick)
Bone structure
Anatomy of the bone. The bone is made up of compact bone, spongy bone, and bone marrow. Compact bone makes up the outer layer of the bone. Spongy bone is found mostly at the ends of bones and contains red marrow. Bone marrow is found in the center of most bones and has many blood vessels. There are two types of bone marrow: red and yellow. Red marrow contains blood stem cells that can become red blood cells, white blood cells, or platelets. Yellow marrow is made mostly of fat.
Image by Smart Servier website
Blood Cells
Formed Elements of Blood
Image by Blausen.com staff (2014). \"Medical gallery of Blausen Medical 2014\"
Phagocytosis - C-reactive protein (CRP) is a substance made by the liver that is released into the bloodstream by inflammation and infection as part of the body's immune response.
C-reactive protein (CRP) is a substance made by the liver that is released into the bloodstream by inflammation and infection as part of the body's immune response. White blood cells are also mobilized by the immune system and CRP is believed to enhance the activity of the white blood cells called macrophages. Each type of white blood cell has its own specialized immune functions; macrophages, for example, basically engulf and \"eat\" foreign invaders such as bacteria, viruses and fungi. Macrophages in the spleen and the liver weed out old and defective red blood cells and break them into recyclables (iron, heme, and some globin) and wastes (such as bilirubin). The bilirubin is then used by the liver to produce bile, which is stored in the gallbladder and released into the small intestine to aid digestion.
Image by TheVisualMD
White blood cells
Immune cells surrounding hair follicles in mouse skin. These hair follicles are home to a diverse array of commensal bacteria.
Image by NIAID
Neutrophil
Neutrophil function, relationship to disease, and location in the human body. Credit: NIAID
Image by NIAID
Innate immune system
Image by US Gov
Macrophage Capturing Foreign Antigen
Cell-mediated immunity is an immune response that does not involve antibodies or complement but rather involves the activation of macrophages, natural killer cells (NK), antigen-specific cytotoxic T-lymphocytes, and the release of various cytokines in response to an antigen. Macrophages are white blood cells that engulf and digest cellular debris and pathogens
Image by TheVisualMD
Mast Cell
Mast cells produce histamine. Histamine is known for its role in inflammation. It affects a variety of behavior patterns including the sleep-wake cycle and food intake. Antihistamines may work at odds with inflammation and depression.
Image by TheVisualMD
Leukocytes
Image by OpenStax College
Innate immune system
Illustration of the Innate Immune System responding to injury.
Image by OpenStax College
Eosinophilia
Drawing of an eosinophil white blood cell
Image by Iceclanl
Two neutrophils among many red blood cells. Neutrophils are one type of cell affected by chronic granulomatous disease.
Image by Uploaded by Mgiganteus
Eosinophils
Eosinophil function, relationship to disease, and location in the human body.
Image by NIAID
Sensitive content
This media may include sensitive content
Blood Cells
This is a scanning electron microscope image from normal circulating human blood. One can see red blood cells, several white blood cells including lymphocytes, amonocyte, a neutrophil, and many small disc-shaped platelets. Red cells are nonnucleated and contain hemoglobin, an important protein that contains iron and allows the cell to carry oxygen to other parts of the body. They also carry carbon dioxide away from peripheral tissue to the lungs where it can be exhaled. The infection-fighting white blood cells are classified in two main groups: granular and agranular. All blood cells are formed in the bone marrow. There are two types of agranulocytes: lymphocytes, which fight disease by producing antibodies and thus destroying foreign material, and monocytes. Platelets are tiny cells formed in bone marrow and are necessary for blood clotting.
Image by Bruce Wetzel (photographer). Harry Schaefer (photographer), National Cancer Institute
Immune System and Autoimmune Diseases
Normally, an individual's immune system learns to identify and ignore all of the distinctive little structures found on that individual's own cells. Sometimes, however, it will make a mistake and identify its own body as foreign. If that happens, the immune system produces antibodies that attempt to destroy the body's own cells in the same way it would try to destroy a foreign invader.
Image by TheVisualMD
Eosinophils
Drawing of an eosinophil white blood cell
Image by BruceBlaus
Eosinophils
On the left there is a segmented polymorphonuclear neutrophil, on the right and below is one eosinophil leucocyte. For comparison the red blood cell have a diameter of 7-8 micrometers. The picture was taken with a Nikon Eclipse 600 microscope, magnification was 1000x.
Image by Davidcsaba Dr. David Csaba L.
Neutrophil action - Inflammation
Neutrophil granulocyte migrates from the blood vessel to the matrix, secreting proteolytic enzymes, in order to dissolve intercellular connections (for improvement of its mobility) and envelop bacteria through Phagocytosis.
Image by Uwe Thormann/Wikimedia
Neutrophil
Image by BruceBlaus
White Blood Cells
A type of immune cell. Most white blood cells are made in the bone marrow and are found in the blood and lymph tissue. White blood cells help the body fight infections and other diseases. Granulocytes, monocytes, and lymphocytes are white blood cells.
Image by Blausen.com staff (2014). "Medical gallery of Blausen Medical 2014"
high white blood cell count Video
Video by itbestshop/YouTube
What Are White Blood Cells | Health | Biology | FuseSchool
Video by FuseSchool - Global Education/YouTube
Learning to Decode Your Blood Test Results for Chronic Lymphocytic Leukemia (CLL)
Video by CLL Society/YouTube
WellnessFX: White Blood Cells And Differential with Bryan Walsh
Video by WellnessFX/YouTube
White Blood Count
White Blood Count
Image by TheVisualMD
White Blood Cell Count: Bone Marrow
TheVisualMD
White Blood Cells, Bone Marrow
TheVisualMD
2:12
Complete Blood Count, and Baselining Your Health
TheVisualMD
6:49
The Immune System Explained I – Bacteria Infection
Kurzgesagt – In a Nutshell/YouTube
1:47
Immune Response to Bacteria
NIAID/YouTube
14:59
Immunology - Adaptive Immune System
Armando Hasudungan/YouTube
3:02
Immune System - Natural Killer Cell
Kyle Thornthwaite/YouTube
15:02
Your Immune System: Natural Born Killer - Crash Course Biology #32
CrashCourse/YouTube
White Blood Cell and Red Blood Cell
TheVisualMD
White Blood Cell and Red Blood Cell
TheVisualMD
Red Blood Cell and White Blood Cell
TheVisualMD
Sensitive content
This media may include sensitive content
Blood cells (from left to right: erythrocyte, thrombocyte, leukocyte)
Electron Microscopy Facility at The National Cancer Institute at Frederick (NCI-Frederick)
Bone structure
Smart Servier website
Blood Cells
Blausen.com staff (2014). \"Medical gallery of Blausen Medical 2014\"
Phagocytosis - C-reactive protein (CRP) is a substance made by the liver that is released into the bloodstream by inflammation and infection as part of the body's immune response.
TheVisualMD
White blood cells
NIAID
Neutrophil
NIAID
Innate immune system
US Gov
Macrophage Capturing Foreign Antigen
TheVisualMD
Mast Cell
TheVisualMD
Leukocytes
OpenStax College
Innate immune system
OpenStax College
Eosinophilia
Iceclanl
Two neutrophils among many red blood cells. Neutrophils are one type of cell affected by chronic granulomatous disease.
Uploaded by Mgiganteus
Eosinophils
NIAID
Sensitive content
This media may include sensitive content
Blood Cells
Bruce Wetzel (photographer). Harry Schaefer (photographer), National Cancer Institute
Immune System and Autoimmune Diseases
TheVisualMD
Eosinophils
BruceBlaus
Eosinophils
Davidcsaba Dr. David Csaba L.
Neutrophil action - Inflammation
Uwe Thormann/Wikimedia
Neutrophil
BruceBlaus
White Blood Cells
Blausen.com staff (2014). "Medical gallery of Blausen Medical 2014"
8:22
high white blood cell count Video
itbestshop/YouTube
3:12
What Are White Blood Cells | Health | Biology | FuseSchool
FuseSchool - Global Education/YouTube
1:17:17
Learning to Decode Your Blood Test Results for Chronic Lymphocytic Leukemia (CLL)
CLL Society/YouTube
16:52
WellnessFX: White Blood Cells And Differential with Bryan Walsh
A platelet count test measures the number of platelets in your blood. Platelets, also known as thrombocytes, are small blood cells that are essential for blood clotting. Platelets may be counted to monitor or diagnose diseases, or to look for the cause of too much bleeding or clotting.
A platelet count test measures the number of platelets in your blood. Platelets, also known as thrombocytes, are small blood cells that are essential for blood clotting. Platelets may be counted to monitor or diagnose diseases, or to look for the cause of too much bleeding or clotting.
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Use the slider below to see how your results affect your
health.
(10³)/μL
50
150
450
Your result is Normal.
A normal platelet count ranges from 150,000 to 450,000 platelets per microliter of blood. Platelets are tiny blood cells that are made in the bone marrow from larger cells. When you are injured, platelets stick together to form a plug to seal your wound. This plug is called a blood clot.
Related conditions
Platelets, also known as thrombocytes, are small blood cells that are essential for blood clotting. Clotting is the process that helps you stop bleeding after an injury. There are two types of platelet tests: a platelet count test and platelet function tests.
A platelet count test measures the number of platelets in your blood. A lower than normal platelet count is called thrombocytopenia. This condition can cause you to bleed too much after a cut or other injury that causes bleeding. A higher than normal platelet count is called thrombocytosis. This can make your blood clot more than you need it to. Blood clots can be dangerous because they can block blood flow.
Other names: platelet count, thrombocyte count
A platelet count is most often used to monitor or diagnose conditions that cause too much bleeding or too much clotting. A platelet count may be included in a complete blood count, a test that is often done as part of a regular checkup.
You may need platelet count testing if you have symptoms of having too few or too many platelets.
Symptoms of too few platelets include:
Prolonged bleeding after a minor cut or injury
Nosebleeds
Unexplained bruising
Pinpoint sized red spots on the skin, known as petechiae
Purplish spots on the skin, known as purpura. These may be caused by bleeding under the skin.
Heavy and/or prolonged menstrual periods
Symptoms of too many platelets include:
Numbness of hands and feet
Headache
Dizziness
Weakness
Most platelet tests are done on a blood sample.
During the test, a health care professional will take a blood sample from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial. You may feel a little sting when the needle goes in or out. This usually takes less than five minutes.
You don't need any special preparations for a platelet count test.
There is very little risk to having a blood test. You may have slight pain or bruising at the spot where the needle was put in, but most symptoms go away quickly.
If your results show a lower than normal platelet count (thrombocytopenia), it may indicate:
A cancer that affects the blood, such as leukemia or lymphoma
A viral infection, such as mononucleosis, hepatitis, or measles
An autoimmune disease. This is a disorder that causes the body to attack its own healthy tissues, which can include platelets.
Infection or damage to the bone marrow
Cirrhosis
Vitamin B12 deficiency
Gestational thrombocytopenia, a common, but mild, low-platelet condition affecting pregnant women. It is not known to cause any harm to a mother or her unborn baby. It usually gets better on its own during pregnancy or after birth.
If your results show a higher than normal platelet count (thrombocytosis), it may indicate:
Certain types of cancer, such as lung cancer or breast cancer
Anemia
Inflammatory bowel disease
Rheumatoid arthritis
A viral or bacterial infection
Platelet Tests: MedlinePlus Medical Test [accessed on Jan 20, 2024]
Platelet Count (PLT) Blood Test - Testing.com. Dec 19, 2023 [accessed on Jan 20, 2024]
Platelet count: MedlinePlus Medical Encyclopedia [accessed on Jan 20, 2024]
Normal reference ranges can vary depending on the laboratory and the method used for testing. You must use the range supplied by the laboratory that performed your test to evaluate whether your results are "within normal limits."
Additional Materials (8)
Platelet Development
Illustration of Platelet Development
Image by OpenStax College
Sensitive content
This media may include sensitive content
Platelet Disorders
From left to right: erythrocyte, thrombocyte, leukocyte
Image by Electron Microscopy Facility at The National Cancer Institute at Frederick (NCI-Frederick)
Scheme of a blood sample after centrifugation
scheme of a blood sample after centrifugation
Image by KnuteKnudsen (talk)
Decode Your Blood Test: Platelets 💉 | Merck Manual Consumer Version
Video by Merck Manuals/YouTube
This browser does not support the video element.
Complete Blood Count, and Baselining Your Health
Video Topics : Our lifeblood consists of many components and a complete blood count (CBC) includes measurements of the fundamental elements. The largest categories are red and white blood cells (RBCs and WBCs) and cell fragments called platelets, which play roles in blood clotting. There are 20-30 trillion red blood cells in the body of an adult, each with a lifespan of about 100 days (RBCs contain an iron-containing protein called hemoglobin that enables them to carry oxygen to tissues throughout the body and then return carbon dioxide to the lungs). WBCs are in the front lines in the body's ongoing fight against harmful viruses, bacteria and even fungus; when a pathogen enters the body, WBCs mobilize in a coordinated defense response to eliminate, neutralize or mark the invader for destruction. The liquid portion of blood is called plasma and it carries nutrients, electrolytes, waste products, and hormones.
Video by TheVisualMD
Platelets Nursing Considerations, Normal Range, Nursing Care, Lab Values Nursing
Video by NURSINGcom/YouTube
Platelets Explained in Two Minutes
Video by American Red Cross/YouTube
The life and times of RBCs and platelets
Video by khanacademymedicine/YouTube
Platelet Development
OpenStax College
Sensitive content
This media may include sensitive content
Platelet Disorders
Electron Microscopy Facility at The National Cancer Institute at Frederick (NCI-Frederick)
Scheme of a blood sample after centrifugation
KnuteKnudsen (talk)
0:48
Decode Your Blood Test: Platelets 💉 | Merck Manual Consumer Version
Merck Manuals/YouTube
2:12
Complete Blood Count, and Baselining Your Health
TheVisualMD
3:54
Platelets Nursing Considerations, Normal Range, Nursing Care, Lab Values Nursing
NURSINGcom/YouTube
1:47
Platelets Explained in Two Minutes
American Red Cross/YouTube
10:35
The life and times of RBCs and platelets
khanacademymedicine/YouTube
Hemoglobin
Hemoglobin Blood Test
Also called: Hemoglobin, Hgb
A hemoglobin test measures the levels of hemoglobin in your blood. Hemoglobin is an iron-rich protein in red blood cells that carries oxygen. Abnormal levels may mean you have anemia or another blood disorder.
Hemoglobin Blood Test
Also called: Hemoglobin, Hgb
A hemoglobin test measures the levels of hemoglobin in your blood. Hemoglobin is an iron-rich protein in red blood cells that carries oxygen. Abnormal levels may mean you have anemia or another blood disorder.
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Use the slider below to see how your results affect your
health.
g/dL
13.8
17.2
Your result is Normal.
Heme, an iron-containing molecule, combines with globin proteins to form hemoglobin, which carries oxygen in red blood cells from the lungs to the rest of the body.
Related conditions
A hemoglobin test measures the levels of hemoglobin in your blood. Hemoglobin is a protein in your red blood cells that carries oxygen from your lungs to the rest of your body. If your hemoglobin levels are abnormal, it may be a sign that you have a blood disorder.
Other names: Hb, Hgb
A hemoglobin test is often used to check for anemia, a condition in which your body has fewer red blood cells than normal. If you have anemia, the cells in your body don't get all the oxygen they need. Hemoglobin tests are measured as part of a complete blood count (CBC).
Your health care provider may order the test as part of a routine exam, or if you have:
Symptoms of anemia, which include weakness, dizziness, and cold hands and feet
A family history of thalassemia, sickle cell anemia, or other inherited blood disorder
A diet low in iron and other minerals
A long-term infection
Excessive blood loss from an injury or surgical procedure
A health care professional will take a blood sample from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial. You may feel a little sting when the needle goes in or out. This usually takes less than five minutes.
You don't need any special preparation for a hemoglobin test. If your health care provider has ordered other tests on your blood sample, you may need to fast (not eat or drink) for several hours before the test. Your health care provider will let you know if there are any special instructions to follow.
There is very little risk to having a blood test. After the test, some people experience mild pain, dizziness, or bruising. These symptoms usually go away quickly.
There are many reasons your hemoglobin levels may not be in the normal range.
Low hemoglobin levels may be a sign of:
Different types of anemia
Thalassemia
Iron deficiency
Liver disease
Cancer and other diseases
High hemoglobin levels may be a sign of:
Lung disease
Heart disease
Polycythemia vera, a disorder in which your body makes too many red blood cells. It can cause headaches, fatigue, and shortness of breath.
If any of your levels are abnormal, it doesn't always mean you have a medical condition that needs treatment. Diet, activity level, medicines, a menstrual period, and other factors can affect the results. You may also have higher than normal hemoglobin levels if you live in a high altitude area. Talk with your provider to learn what your results mean.
Some forms of anemia are mild, while other types of anemia can be serious and even life threatening if not treated. If you are diagnosed with anemia, be sure to talk to your health care provider to find out the best treatment plan for you.
Hemoglobin Test: MedlinePlus Medical Test [accessed on Jan 20, 2024]
Hemoglobin: MedlinePlus Medical Encyclopedia [accessed on Jan 20, 2024]
Hemoglobin - Health Encyclopedia - University of Rochester Medical Center [accessed on Jan 20, 2024]
Normal reference ranges can vary depending on the laboratory and the method used for testing. You must use the range supplied by the laboratory that performed your test to evaluate whether your results are "within normal limits."
Additional Materials (16)
Hemoglobin | Human anatomy and physiology | Health & Medicine | Khan Academy
Video by Khan Academy/YouTube
Blood, Part 2 - There Will Be Blood: Crash Course A&P #30
Video by CrashCourse/YouTube
Haemoglobin
Video by Wellcome Trust/YouTube
Hemoglobin A1c & Diabetes
Video by DiabeTV/YouTube
Hemoglobin Molecule
Molecule of hemoglobin.
Image by TheVisualMD
Hemoglobin A1C Molecule
Hemoglobin is a protein found inside red blood cells that carries oxygen from the lungs to cells throughout the body. Hemoglobin also binds with glucose. Diabetics have too much glucose in the bloodstream and this extra glucose binds (or glycates) with hemoglobin. Glycated hemoglobin usually stays glycated for the life of the red blood cell (about 3 months). Therefore, the percentage of hemoglobin that is glycated (measured as A1C) reflects glucose levels that have affected red blood cells up to 3 months in the past. The hemoglobin A1C test measures the percentage of hemoglobin bound to blood sugar (glucose); the test is used to diagnose type 1 and type 2 diabetes. Because the test results reflect average blood sugar levels over a period of 2-3 months (rather than daily fluctuations), the hemoglobin A1C test is also used to gauge how well patients are managing their diabetes over time.
Image by TheVisualMD
Hemoglobin A1C: Red Blood Cells
Red blood cells use the iron-rich protein hemoglobin to carry oxygen from the lungs to cells throughout the body and return carbon dioxide to the lungs. The percentage of hemoglobin bound to blood glucose (hemoglobin A1C) is used to diagnose diabetes.
Image by TheVisualMD
Hemoglobin of Red Blood Cell
Hemoglobin is an iron-containing protein found in red blood cells that binds oxygen and carbon dioxide for transport and delivery to different parts of the body.
Image by TheVisualMD
Hemoglobin Molecule
Hemoglobin is an iron-rich protein that is packed inside RBCs. It is a structurally complex molecule that can change shape to either hold or release oxygen, depending on the body's need. There are close to 300 million hemoglobin molecules within each RBC.
Image by TheVisualMD
Hemoglobin Molecule Heme Group
A heme group in a hemoglobin molecule consists of an iron atom bound equally to four nitrogen atoms, all lying in one plane. The iron atom is the site of oxygen binding.
Image by TheVisualMD
This browser does not support the video element.
Hemoglobin Within Red Blood Cell (RBC)
A red blood cell rushes toward the camera, the camera enters the cell to focus on all of the hemoglobin molecules within
Video by TheVisualMD
Hemoglobin, Carbon Monoxide
Hemoglobin is an iron-containing protein that enables red blood cells to deliver oxygen from the lungs to cells throughout the body. But the same binding site on the hemoglobin molecule has an even stronger affinity for carbon monoxide, which is why we are so susceptible to poisoning by this deadly gas; carbon monoxide grabs all the binding sites and starves the body's tissues of oxygen
Image by TheVisualMD
This browser does not support the video element.
Hemoglobin A1c
The hemoglobin A1c test measures the percentage of hemoglobin bound to blood sugar (glucose); the test is used to diagnose type 1 and type 2 diabetes. Because the test results reflect average blood sugar levels over a period of 2-3 months (rather than daily fluctuations), the hemoglobin A1C test is also used to gauge how well patients are managing their diabetes over time.
Video by TheVisualMD
Hemoglobin A1c
The hemoglobin A1c test measures the percentage of hemoglobin bound to blood sugar (glucose); the test is used to diagnose type 1 and type 2 diabetes. Because the test results reflect average blood sugar levels over a period of 2-3 months (rather than daily fluctuations), the hemoglobin A1C test is also used to gauge how well patients are managing their diabetes over time.
Image by TheVisualMD
Hemoglobin: O2 Binding Hemoglobin
Hemoglobin normally binds to life-sustaining oxygen. But the same binding site on the hemoglobin molecule has an even stronger affinity for carbon monoxide, which is why we are so susceptible to poisoning by this deadly gas.
Image by TheVisualMD
HemoglobinA1C
Hemoglobin Test for O2 Binding Hemoglobin : A hemoglobin test is a measurement of your blood's oxygen-carrying capacity. High levels of hemoglobin can be the result of dehydration, lung disease and other conditions. Low levels of hemoglobin indicate that there is a shortage of red blood cells; this can be the result of RBCs being lost or destroyed too quickly or produced too slowly. Hemoglobin is an iron-containing protein that enables red blood cells to deliver oxygen from the lungs to cells throughout the body. But the same binding site on the hemoglobin molecule has an even stronger affinity for carbon monoxide, which is why we are so susceptible to poisoning by this deadly gas; carbon monoxide grabs all the binding sites and starves the body's tissues of oxygen.
Image by TheVisualMD
14:34
Hemoglobin | Human anatomy and physiology | Health & Medicine | Khan Academy
Khan Academy/YouTube
10:01
Blood, Part 2 - There Will Be Blood: Crash Course A&P #30
CrashCourse/YouTube
5:31
Haemoglobin
Wellcome Trust/YouTube
1:43
Hemoglobin A1c & Diabetes
DiabeTV/YouTube
Hemoglobin Molecule
TheVisualMD
Hemoglobin A1C Molecule
TheVisualMD
Hemoglobin A1C: Red Blood Cells
TheVisualMD
Hemoglobin of Red Blood Cell
TheVisualMD
Hemoglobin Molecule
TheVisualMD
Hemoglobin Molecule Heme Group
TheVisualMD
0:27
Hemoglobin Within Red Blood Cell (RBC)
TheVisualMD
Hemoglobin, Carbon Monoxide
TheVisualMD
0:27
Hemoglobin A1c
TheVisualMD
Hemoglobin A1c
TheVisualMD
Hemoglobin: O2 Binding Hemoglobin
TheVisualMD
HemoglobinA1C
TheVisualMD
Hematocrit
Hematocrit Blood Test
Also called: Hematrocit, HCT, Crit, Packed Cell Volume, PCV
Hematocrit is a blood test that measures how much of a person's blood is made up of red blood cells. Hematocrit levels that are too high or too low can be a sign of a blood disorder, dehydration, or other medical conditions that affect your blood.
Hematocrit Blood Test
Also called: Hematrocit, HCT, Crit, Packed Cell Volume, PCV
Hematocrit is a blood test that measures how much of a person's blood is made up of red blood cells. Hematocrit levels that are too high or too low can be a sign of a blood disorder, dehydration, or other medical conditions that affect your blood.
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Use the slider below to see how your results affect your
health.
%
40.7
50.3
Your result is Normal.
Normal hematocrit levels vary based on age and race. In adults, normal levels for men range from 41%-50%. For women, the normal range is slightly lower: 36%-44%.
Related conditions
A hematocrit test is a blood test that measures how much of your blood is made up of red blood cells. Red blood cells carry oxygen from your lungs to the rest of your body. The other parts of your blood include white blood cells (to help fight infection), platelets (to help make blood clots to stop bleeding), and a liquid called plasma.
Hematocrit levels that are too high or too low can be a sign of a blood disorder, dehydration, or other medical conditions that affect your blood.
Other names: HCT, packed cell volume, PCV, Crit; H and H (Hemoglobin and Hematocrit)
A hematocrit test is often part of a complete blood count (CBC). A CBC is a common blood test that measures the different parts of your blood. It is used to check your general health. It may also be used to help diagnose blood disorders, including anemia, a condition in which you don't have enough red blood cells, and polycythemia, an uncommon disorder in which you have too many red blood cells and your blood becomes too thick.
Your health care provider may order a hematocrit test as part of your regular checkup or to monitor your health if you are being treated for cancer or have an ongoing health condition. Your provider may also order this test if you have symptoms of a red blood cell disorder, such as anemia or polycythemia:
Symptoms of anemia (too few red blood cells) may include:
Shortness of breath
Weakness or fatigue
Headache
Dizziness
Arrhythmia (a problem with the rate or rhythm of your heartbeat)
Symptoms of polycythemia (too many red blood cells) may include:
Headache
Feeling light-headed or dizzy
Shortness of breath
Weakness or fatigue
Skin symptoms such as itching after a shower or bath, burning, or a red face
Heavy sweating, especially during sleep
Blurred or double vision and blind spots
Bleeding gums and heavy bleeding from small cuts
A health care professional will take a blood sample from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial. You may feel a little sting when the needle goes in or out. This usually takes less than five minutes.
You don't need any special preparations for a hematocrit test. If your provider has ordered more tests on your blood sample, you may need to fast (not eat or drink) for several hours before the test. Your provider will let you know if there are any special instructions to follow.
There is very little risk to having a hematocrit test or other type of blood test. You may have slight pain or bruising at the spot where the needle was put in, but most symptoms go away quickly.
Your hematocrit test results are reported as a number. That number is the percentage of your blood that's made of red blood cells. For example, if your hematocrit test result is 42, it means that 42% of your blood is red blood cells and the rest is white blood cells, platelets, and blood plasma.
A hematocrit level that's lower than normal may be a sign that:
Your body doesn't have enough red blood cells (anemia). There are many types of anemia that can be caused by different medical conditions.
Your body is making too many white blood cells, which may be caused by:
Bone marrow disease
Certain cancers, including leukemia, lymphoma, multiple myeloma, or cancers that spread to the bone marrow from other parts of the body
A hematocrit level that's higher than normal may be a sign that:
Your body is making too many red blood cells, which may be caused by:
Lung disease
Congenital heart disease
Heart failure
Polycythemia
Your blood plasma level is too low, which may be caused by:
Dehydration, the most common cause of a high hematocrit
Shock
If your results are not in the normal range, it doesn't always mean that you have a medical condition that needs treatment. Living at high altitudes where there's less oxygen in the air may cause a high hematocrit. That's because your body responds to low oxygen levels by making more red blood cells so that you get the oxygen you need.
Pregnancy can cause a low hematocrit. That's because the body has more fluid than normal during pregnancy, which decreases the percentage that's made of red blood cells.
To learn what your test results mean, talk with your provider.
Normal hematocrit levels will be different depending on your sex, age, and the altitude where you live. Ask your provider what hematocrit level is normal for you.
Hematocrit Test: MedlinePlus Medical Test [accessed on Jan 20, 2024]
Hematocrit: MedlinePlus Medical Encyclopedia [accessed on Jan 20, 2024]
Hematrocit Blood Test - Testing.com. Sep 13, 2022 [accessed on Jan 20, 2024]
Normal reference ranges can vary depending on the laboratory and the method used for testing. You must use the range supplied by the laboratory that performed your test to evaluate whether your results are "within normal limits."
Additional Materials (30)
This browser does not support the video element.
Complete Blood Count, and Baselining Your Health
Video Topics : Our lifeblood consists of many components and a complete blood count (CBC) includes measurements of the fundamental elements. The largest categories are red and white blood cells (RBCs and WBCs) and cell fragments called platelets, which play roles in blood clotting. There are 20-30 trillion red blood cells in the body of an adult, each with a lifespan of about 100 days (RBCs contain an iron-containing protein called hemoglobin that enables them to carry oxygen to tissues throughout the body and then return carbon dioxide to the lungs). WBCs are in the front lines in the body's ongoing fight against harmful viruses, bacteria and even fungus; when a pathogen enters the body, WBCs mobilize in a coordinated defense response to eliminate, neutralize or mark the invader for destruction. The liquid portion of blood is called plasma and it carries nutrients, electrolytes, waste products, and hormones.
Video by TheVisualMD
Vial of Centrifuged Blood
Blood is made up of red and white blood cell (as well as platelets), suspended in a liquid known as blood plasma. Plasma, which makes up 55% of our blood's volume, is a clear liquid (mainly water) that transports food molecules, hormones, waste as well as a wide range of dissolved chemicals. Red cells, which normally make up 40-50% of total blood volume, are produced continuously in our bone marrow at the rate of about 2-3 million cells per second. White cells make up a very small part of blood's volume-normally only about 1% in healthy people. This image shows two vials of centrifuged blood. The left vial shows healthy amount of red blood cells in female (36-44%) ; The right vial shows healthy amount of red blood cells in male (41-50%). The hematocrit (along with the hemoglobin test) is the central test to diagnosing anemia in that it indicates the amount of RBCs in the blood.
Image by TheVisualMD
Red Blood Cells, Bone Marrow
A skeleton may have a dry and lifeless Halloween image, but bone is actually dynamic, living tissue. Bone is not uniformly solid; within its interior is a network of cavities that house blood vessels and marrow. Bone marrow, particularly in larger bones, is where stem cells give rise to red blood cells (erythrocytes) as well as white blood cells (leukocytes) and blood clotting agents (platelets). As the source of blood cells, the bone marrow is critical to health. Disease or damage to bone marrow can result in either too many or too few blood cells.
Hematocrit Nursing Considerations, Normal Range, Nursing Care, Lab Values Nursing
Video by NURSINGcom/YouTube
Hematocrit, Dehydration
Blood is composed of cells (primarily red blood cells, but also white blood cells and cell fragments called platelets) along with a liquid portion known as plasma. The ratio of the volume of red blood cells to the volume of plasma is an important health indicator and is known as the hematocrit. The most common cause of a high hematocrit is dehydration, which is usually temporary and easily remedied by increasing fluid intake, thereby restores the balance between RBCs and blood plasma volume.
Image by TheVisualMD
Hematocrit, Anemia
Blood is composed of cells (primarily red blood cells, but also white blood cells and cell fragments called platelets) along with a liquid portion known as plasma. The ratio of the volume of red blood cells to the volume of plasma is an important health indicator and is known as the hematocrit. A low hematocrit usually indicates anemia, which occurs when red blood cells are being either destroyed too quickly or produced too slowly; with fewer red blood cells, less oxygen is delivered to body tissues.
Image by TheVisualMD
Vial of Blood for Hematocrit Test
This image is a vial of blood that has been centrifuged (and thus separated) to determine hematocrit. This vial shows, from top to bottom, 55% plasma, <1% white blood cells, <1% platelets , 45% red blood cells. Hematocrit measures how much of the blood, by volume, is taken up by RBCs. A normal range for hematocrit is 41 to 50 percent in men and 36 to 44 percent in women. In many cases, a reading below the normal range for hematocrit will lead to a diagnosis of CKD-related anemia.This other diagnostic test is the hemoglobin test, which measures the amount of hemoglobin molecules in the blood and is a good indicator of the body's ability to carry oxygen throughout the body.
Image by TheVisualMD
Hematocrit: Bone Marrow
Bone marrow produces about 2 million red blood cells (RBCs) a second to maintain a healthy hematocrit. Many conditions, including kidney disease, chemotherapy, and dietary deficiencies, can reduce RBC production, while others can result in too many RBCs.
Image by TheVisualMD
Hematocrit: Blood Cells
The hematocrit is another way to look at the health of red blood cells (RBCs). Blood is composed of cells (primarily RBCs) and a liquid portion called plasma. The proportions of RBCs and plasma must be kept in balance and this is what the hematocrit measures.
Image by TheVisualMD
Blood
Components of Blood : Blood is mostly made up of plasma and red and white blood cells. But it also contains many other substances as well, like platelets, hormones, nutrients such as glucose, and fats like cholesterol. Blood is the fluid of life, transporting oxygen from the lungs to body tissue and carbon dioxide from body tissue to the lungs.
Image by TheVisualMD
Hematocrit
Hematocrit Blood Vials : If you are at risk for cardiovascular disease, your doctor may order a cholesterol and triglyceride level test as well as a complete blood count (CBC). Abnormal results may be the first clue in determining risk of and in diagnosing cardiovascular disease.
Image by TheVisualMD
Blood Smear Showing Reduced Red Blood Cell Count
Individual blood cells were first detected and described in the 17th century. Later, red blood cells (RBCs) were counted manually from a blood smear, a thin film of blood prepared on a glass slide and examined under a microscope (blood analysis is now automated, though smears are still used to detect visible abnormalities and to check or confirm the results of other tests). Anemia results when there are too few RBCs in circulation because they are being destroyed too quickly or produced too slowly. Anemia can be temporary or long term and range from mild to severe. Folate (also known as vitamin B9) is necessary for red blood cell production and the prevention of anemia, as well as the metabolism of carbohydrates. But folate also plays key roles in the synthesis and maintenance of DNA and is especially important in cell division and growth in fetal development (deficiencies of the vitamin in pregnancy is a common cause of birth defects). Pernicious anemia is a disorder in which the body's loses its ability to utilize folate and vitamin B12.
Image by TheVisualMD
Blood Smear Showing Normal Red Blood Cell Count
Individual blood cells were first detected and described in the 17th century. Later, red blood cells were counted manually from a blood smear, a thin film of blood prepared on a glass slide and examined under a microscope. Blood analysis is now automated, though blood smears are still used to detect visible abnormalities and to check or confirm the results of other tests. There are normally between 4.2-5.8 million red blood cells per microliter (about a drop), which means there are 20-30 trillion red blood cells circulating through the body of an adult.
Image by TheVisualMD
This browser does not support the video element.
Red Blood Cells Carry Oxygen
This video focuses on one of the main components of blood, the red blood cell and its function to carry oxygen. The video begins with revealing the red blood cells and the heart that pumps the oxygenated blood to the rest of the body. Hemoglobin is the protein molecule found in these red blood cells that enable blood to transport oxygen. If the blood's capacity to transport oxygen to the tissues is reduced due to a decrease in the number of red blood cells, anemia may occur.
Video by TheVisualMD
Components of Blood
Components of Blood : Our blood is composed of many different components, the largest categories being red and white blood cells (blood-clotting platelets are another key component) and the liquid portion known as blood plasma. A Complete Blood Count (CBC) includes several of the most basic, yet important, measurements of these components.
Image by TheVisualMD
Blood and Related Conditions
Blood and Related Conditions : Anemia results when there are too few red blood cells circulating in the bloodstream to deliver adequate oxygen to body tissues. There are different types and causes of anemia, including malnutrition, chronic bleeding, and diseases that result in red blood cells either being destroyed too quickly or produced too slowly.
Image by TheVisualMD
Pellet of Lymphocyte Cells Created in the Centrifuge
This photograph shows Wendy Watford, Ph.D. holding a test tube containing isolated lymphocyte cells. The cells were spun in a centrifuge to create a pellet at the bottom of the test tube. The cells will be labeled with CFSE dye, which will stain the membranes of the cells. After culturing the cells for three days she will determine the number of cell divisions that have taken place by measuring the dilution of the CFSE dye. The purpose of the work is to measure the proliferation of lymphocytes under various conditions. The principal investigator for this work is John J. O’Shea, M.D., NIAMS Scientific Director.
Image by NIAMS/Photographer: Rhoda Baer
Red Blood Cells
Digital holographic microscopy (DHM) image of red blood cells.
Image by Egelberg (talk)
Test Tube
Between 5,000 and 8,000 blood serum, fecal, urine, viral and respiratory samples arrive six days a week from U.S. Air Force hospitals and clinics worldwide, as well as some other Department of Defense facilities, for analysis at the Epidemiology Laboratory Service, also known as the "Epi Lab" at the 711th Human Performance Wing’s United States Air Force School of Aerospace Medicine and Public Health at Wright Patterson AFB, Ohio.The lab is a Department of Defense reference laboratory offering clinical diagnostic, public health, and force health screening and testing. (U.S. Air Force photo by J.M. Eddins Jr.)
Image by U.S. Air Force photo by J.M. Eddins Jr.
Phlebotomy
This image was uploaded as part of Wiki Loves e-textbooks contest in Poland.
Image by Sean Michael Ragan
Red Blood Cells Carry Oxygen
This video focuses on one of the main components of blood, the red blood cell and its function to carry oxygen. The video begins with revealing the red blood cells and the heart that pumps the oxygenated blood to the rest of the body. Hemoglobin is the protein molecule found in these red blood cells that enable blood to transport oxygen. If the blood's capacity to transport oxygen to the tissues is reduced due to a decrease in the number of red blood cells, anemia may occur.
Image by TheVisualMD
Composition of Blood
Composition of Blood
Image by OpenStax College
Hematology | Hematocrit
Video by Ninja Nerd/YouTube
Erythrocyte indices (Hemoglobin, Hematocrit, MCV, MCH & MCHC) What Do These Lab Tests Mean?
Video by Medicosis Perfectionalis/YouTube
How to Interpret RBC Indices (e.g. hemoglobin vs. hematocrit, MCV, RDW)
Video by Strong Medicine/YouTube
Haematocrit or PCV
Video by LabsforLifeProject/YouTube
Packed cell volume/ Hematocrit
Video by Pathology Simplified/YouTube
Fetal hemoglobin and hematocrit | Human anatomy and physiology | Health & Medicine | Khan Academy
Also called: MCV, MCV Blood Test, Mean Corpuscular Volume, Mean RBC Volume
A mean corpuscular volume (MCV) blood test measures the size of your red blood cells. If blood cells are too small or too large, it may indicate a blood disorder.
MCV (Mean Corpuscular Volume) Test
Also called: MCV, MCV Blood Test, Mean Corpuscular Volume, Mean RBC Volume
A mean corpuscular volume (MCV) blood test measures the size of your red blood cells. If blood cells are too small or too large, it may indicate a blood disorder.
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Use the slider below to see how your results affect your
health.
fL
76
96
Your result is Normal.
A normal MCV indicates that the red blood cells are normal average size, or normocytic. Normal results vary based on the laboratory and the method used.
Related conditions
MCV stands for mean corpuscular volume. An MCV blood test measures the average size of your red blood cells.
Red blood cells carry oxygen from your lungs to every cell in your body. Your cells need oxygen to grow, reproduce, and stay healthy. If your red blood cells are too small or too large, it could be a sign of a blood disorder such as anemia, a lack of certain vitamins, or other medical conditions.
Other names: CBC with differential
An MCV blood test is often part of a complete blood count (CBC). A CBC is a common blood test that measures many parts of your blood, including red blood cells. It is used to check your general health.
An MCV test may also be used with other tests to help diagnose or monitor certain blood disorders, including anemia. There are many types of anemia. An MCV test can help diagnose which type of anemia you have.
Your health care provider may order a complete blood count, which includes an MCV test, as part of your regular checkup. You may also have the test if you have a chronic (long-lasting) condition that could lead to anemia or if you have the symptoms of anemia:
Shortness of breath
Weakness or fatigue
Headache
Dizziness
Arrhythmia (a problem with the rate or rhythm of your heartbeat)
During the test, a health care professional will take a blood sample from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial. You may feel a little sting when the needle goes in or out. This usually takes less than five minutes.
You don't need any special preparations for an MCV blood test. If your provider has ordered more tests on your blood sample, you may need to fast (not eat or drink) for several hours before the test. Your provider will let you know if there are any special instructions to follow.
There is very little risk to having a blood test. You may have slight pain or bruising at the spot where the needle was put in, but most symptoms go away quickly.
An MCV test alone cannot diagnose any disease. Your provider will use the results of your MCV, other test results, and your medical history to make a diagnosis.
If your results show that your red blood cells are smaller than normal, it may be a sign of:
Certain types of anemia, including iron-deficiency anemia, the most common type
Thalassemia, an uncommon genetic condition
If your results show that your red blood cells are larger than normal, it may be a sign of:
Pernicious anemia, which may be caused by:
A lack of vitamin B12
A disease that affects your body's ability to use vitamin B12, such as certain autoimmune diseases, celiac disease, or Crohn's disease.
Anemia caused by a lack of folic acid
Liver disease
It's also possible to have anemia with a normal MCV. This may happen if anemia is caused by conditions, such as:
A sudden loss of blood
Kidney failure
Aplastic anemia (uncommon)
If your MCV levels are not in the normal range, it doesn't always mean that you have a medical problem that needs treatment. Diet, activity level, medicines, a menstrual period, and other conditions can affect the test results. Talk with your health care provider to learn what your results mean.
If your provider thinks you may have anemia or another blood disorder, you may have other red blood cell tests with an MCV. These tests may include a red blood cell count and measurements of hemoglobin. All together, these tests are called red blood cell indices.
MCV (Mean Corpuscular Volume): MedlinePlus Medical Test [accessed on Jan 20, 2024]
Normal reference ranges can vary depending on the laboratory and the method used for testing. You must use the range supplied by the laboratory that performed your test to evaluate whether your results are "within normal limits."
Additional Materials (22)
Microcytic, normocytic, and macrocytic anemias | NCLEX-RN | Khan Academy
Video by khanacademymedicine/YouTube
Non-megaloblastic Macrocytic Anemia
Video by Medicosis Perfectionalis/YouTube
Microcytic anemia | Hematologic System Diseases | NCLEX-RN | Khan Academy
Video by khanacademymedicine/YouTube
Living with and Managing Iron-Deficiency Anemia
Video by NHLBI/YouTube
Hemolytic Anemia
Video by DrER.tv/YouTube
Medical School - Anemia Made Easy
Video by iMedicalSchool/YouTube
Iron deficency anemia diagnosis | Hematologic System Diseases | NCLEX-RN | Khan Academy
WellnessFX: Red Blood Cell Indices Part 1 with Bryan Walsh
Video by WellnessFX/YouTube
WellnessFX: Red Blood Cell Indices Part 2 with Bryan Walsh
Video by WellnessFX/YouTube
Blood Brain Barrier Endothelium
The blood-brain barrier keeps potentially toxic substances from entering the brain. The semipermeable membrane formed by the tightly spaced cells of capillaries in this area selectively screens out large molecules, while permitting the transport of essential nutrients such as glucose. The endothelium is the cellular lining of the blood vessel and is made up of endothelial cells connected to one another by tight junctions. These are the strongest cell-to-cell adhesions in the body. Toxic materials being transported in the blood are too large to pass through these junctions and exit the blood. Therefore, the brain is protected from exposure to many harmful substances. The barrier is does not, however, prevent fat-soluble materials from entering the brain; this includes alcohol and nicotine.
Image by TheVisualMD
Normal Blood Glucose Levels in Capillary
This image depicts a healthy capillary with normal glucose (pink) and insulin (yellow) levels. Capillaries, the smallest blood vessels in your body, are where nutrients are transferred from blood to cells, and waste from cells to blood. The body's cells depend on sugar in the blood, which is derived from carbohydrates, for food and energy. Allowing for the innumerable differences among individuals, the threshold for a normal blood-sugar (glucose) level in healthy people is 100 mg/dL; that is, 100 milligrams of glucose per deciliter of blood. Lower-than-normal levels characterize hypoglycemia and higher than normal levels characterize hyperglycemia.
Image by TheVisualMD
Cross-Section of Healthy Capillary Blood Vessel with Normal Glucose and Insulin Levels
This image depicts a healthy capillary. Capillaries are the smallest blood vessels in your body and are where the transfer of nutrients from blood to cells and wastes from cells to the blood takes place.The cells of the body depend on sugar in the blood, derived from carbohydrates, for food and energy. Allowing for the innumerable differences among individuals, the threshold for a normal blood-sugar (glucose) level in healthy people is 100 mg/dL; that is, 100 milligrams of glucose per deciliter of blood. Lower-than-normal levels characterize hypoglycemia and higher than normal levels hyperglycemia.
Image by TheVisualMD
Blood Vessels in the Brain
The Blood Brain Barrier and Astrocytes type 1
Image by Ben Brahim Mohammed
Cross-Section of Damaged Capillary Blood Vessel with Very High Glucose and Insulin Levels
This image depicts an unhealthy, damaged capillary with very high levels of insulin and glucose. Capillaries, the smallest blood vessels in your body, are where nutrients are transferred from blood to cells, and waste from cells to the blood The body's cells depend on sugar (glucose) in the blood, which is derived from carbohydrates, for food and energy. Without insulin, glucose is not able to enter cells to be used as fuel. Allowing for the innumerable differences among individuals, the threshold for a normal blood-sugar (glucose) level in healthy people is 100 mg/dL; that is, 100 milligrams of glucose per deciliter of blood. Higher than normal levels lead to hyperglycemia. Hyperglycemia is the hallmark of prediabetes (between 100 and 125 mg/dL) and diabetes (126 mg/dL and higher). It is caused by either too little insulin being released by the pancreas or the body's inability to use insulin properly. Hyperglycemia leads to microangiopathy, marked by endothelial cell apoptosis (programmed cell death), accumulation of AGEs (advanced glycation end products), and thickening of the basement membrane, which can lead to development of lesions, vasoconstriction, and altered vessel function
Blood Components
This image highlights the vital components of blood: 55% plasma Plasma is the liquid river that transports every blood cell to its destination. Oxygen-carrying RBCs couldn't move through arteries, veins and capillaries without it. Even though it is a watery, almost clear fluid, plasma contains many important substances, including blood-clotting agents called platelets and protective proteins called antibodies which help us fight infection. When the clotting agents are removed from blood plasma, it is called serum, which is essential in many life-saving medical situations such as transplant surgery and trauma. <1% white blood cells (wbcs or leukocytes) Some leukocytes are produced in the bone marrow, while others are generated in lymph nodes scattered throughout the body. They are far less numerous than their sister RBCs, but leukocytes are the bedrock of the immune system and are the body's front line of defense. Different types of leukocytes fight infections in different ways. Some target bacterial or fungal infections, while others respond to parasitic threats or allergic reactions. <1% platelets Platelets perform the vital function of clotting blood at wound sites. They are small, even in comparison to the other cells of your blood, but they pack a wallop when it comes to healing a scrape or staunching a more serious wound. When you cut yourself shaving, platelets arrive on the scene like your personal emergency medical team, creating a natural bandage of clotted blood, which eventually forms a scab. 45% red blood cells rbcs or erythrocytes) RBCs are produced in the bone marrow and perform the fundamental task of delivering oxygen to all of the body's cells. The vial is an example of the hematocrit, one of many tests that make up the complete blood count (CBC). Hematocrit measures the volume of RBCs in your blood. A normal hematocrit reading for women is between 36 to 44 percent; for men it's 41 to 50 percent.
Image by TheVisualMD
Test Tube Containing Blood
Visualization of a test tube containing blood. Blood comprises of 55% plasma, 1% platelets and white blood cells, and 45% red blood cells.
Image by TheVisualMD
Blood Smear Showing Reduced Red Blood Cell Count
Individual blood cells were first detected and described in the 17th century. Later, red blood cells (RBCs) were counted manually from a blood smear, a thin film of blood prepared on a glass slide and examined under a microscope (blood analysis is now automated, though smears are still used to detect visible abnormalities and to check or confirm the results of other tests). Anemia results when there are too few RBCs in circulation because they are being destroyed too quickly or produced too slowly. Anemia can be temporary or long term and range from mild to severe. Folate (also known as vitamin B9) is necessary for red blood cell production and the prevention of anemia, as well as the metabolism of carbohydrates. But folate also plays key roles in the synthesis and maintenance of DNA and is especially important in cell division and growth in fetal development (deficiencies of the vitamin in pregnancy is a common cause of birth defects). Pernicious anemia is a disorder in which the body's loses its ability to utilize folate and vitamin B12.
Image by TheVisualMD
Red Blood Cell in Capillary
The cardiovascular system is vast network of arteries, veins and vessels that would extend 60,000 miles if stretched end-to-end. All but a tiny fraction of this vessel network is invisible to the naked eye. The smallest capillaries (from latin "hairlike") are so narrow that red blood cells must pass through in single file. Higher than normal blood iron levels have been linked to heart disease and the reason is believed to be the oxidative stress the excess iron places on the walls of the blood vessels. It is the biological counterpart of rust. There are 20-30 trillion red blood cells (RBCs) in an adult's body. The life span of RBCs, which are produced in bone marrow, is about 100 days, which means that 2 million die (and are replaced) each second, but in that short lifetime they can make 75,000 round trips between lungs, heart and tissues in the body.
Image by TheVisualMD
Kidney and Stem Cell Creating Red Blood Cell. B12 is critical for the creation of red blood cells.
We are used to thinking of our kidneys mostly as hardworking filters that rid our bodies of wastes and excess water. But the kidneys are also constantly monitoring and adjusting levels of key substances in the blood, depending on what the body needs. Specialized cells in the kidney that are very sensitive to low oxygen levels, for example, produce a hormone called erythropoietin (EPO), which in turn promotes the production of red blood cells in the bone marrow. The boost in red blood cells increases the oxygen-carrying capacity of the blood.
Image by TheVisualMD
Healthy Capillary Blood Vessel
Cross-section of Healthy Capillary Blood Vessel with Normal Glucose and Insulin Levels
Cross-Section of Damaged Capillary Blood Vessel with Very High Glucose and Insulin Levels
1
2
3
Healthy Capillary Blood Vessel and and Damaged Capillary Blood Vessel Caused by High Levels of Blood Glucose
1) Healthy Capillary Blood Vessel - This image depicts a healthy capillary. Capillaries are the smallest blood vessels in your body. They can be so thin in diameter that blood cells have to bend in order to pass through. Capillaries are where the transfer of nutrients from the blood to cells, and the transfer of waste from cells to blood, takes place. In a healthy body, the blood vessels are smooth and elastic.
2) Cross-Section of Healthy Capillary Blood Vessel with Normal Glucose and Insulin Levels - This image depicts a healthy capillary. The body's cells depend on sugar in the blood, which is derived from carbohydrates, for food and energy. Allowing for the innumerable differences among individuals, the threshold for a normal blood sugar (glucose, pink) level in healthy people is 100 mg/dL; that is, 100 milligrams of glucose per deciliter of blood. Lower-than-normal levels characterize hypoglycemia and higher-than-normal levels characterize hyperglycemia. Without insulin (yellow), glucose is not able to enter cells to be used as fuel. Because of this, healthy insulin levels are a key factor in keeping blood glucose levels normal.
3) Cross-Section of Damaged Capillary Blood Vessel with Very High Glucose and Insulin Levels - This image depicts an unhealthy, damaged capillary with very high levels of insulin and glucose. Higher than normal levels of blood glucose lead to hyperglycemia. Hyperglycemia is the hallmark of prediabetes (between 100 and 125 mg/dL) and diabetes (126 mg/dL and higher). It is caused by either too little insulin being released by the pancreas or the body's inability to use insulin properly. Hyperglycemia leads to microangiopathy, marked by endothelial cell apoptosis (programmed cell death), accumulation of AGEs (advanced glycation end products), and thickening of the basement membrane, which can lead to the development of lesions, vasoconstriction, and altered vessel function
Interactive by TheVisualMD
5:57
Microcytic, normocytic, and macrocytic anemias | NCLEX-RN | Khan Academy
khanacademymedicine/YouTube
4:39
Non-megaloblastic Macrocytic Anemia
Medicosis Perfectionalis/YouTube
9:42
Microcytic anemia | Hematologic System Diseases | NCLEX-RN | Khan Academy
khanacademymedicine/YouTube
3:56
Living with and Managing Iron-Deficiency Anemia
NHLBI/YouTube
3:24
Hemolytic Anemia
DrER.tv/YouTube
3:16
Medical School - Anemia Made Easy
iMedicalSchool/YouTube
9:54
Iron deficency anemia diagnosis | Hematologic System Diseases | NCLEX-RN | Khan Academy
WellnessFX: Red Blood Cell Indices Part 1 with Bryan Walsh
WellnessFX/YouTube
28:05
WellnessFX: Red Blood Cell Indices Part 2 with Bryan Walsh
WellnessFX/YouTube
Blood Brain Barrier Endothelium
TheVisualMD
Normal Blood Glucose Levels in Capillary
TheVisualMD
Cross-Section of Healthy Capillary Blood Vessel with Normal Glucose and Insulin Levels
TheVisualMD
Blood Vessels in the Brain
Ben Brahim Mohammed
Cross-Section of Damaged Capillary Blood Vessel with Very High Glucose and Insulin Levels
Blood Components
TheVisualMD
Test Tube Containing Blood
TheVisualMD
Blood Smear Showing Reduced Red Blood Cell Count
TheVisualMD
Red Blood Cell in Capillary
TheVisualMD
Kidney and Stem Cell Creating Red Blood Cell. B12 is critical for the creation of red blood cells.
TheVisualMD
Healthy Capillary Blood Vessel and and Damaged Capillary Blood Vessel Caused by High Levels of Blood Glucose
TheVisualMD
CEA Test
CEA Test
Also called: Carcinoembryonic Antigen, CEA Assay, CEA Tumor Marker
A CEA (carcinoembryonic antigen) test measures CEA in a sample of blood or other body fluid. It helps check if treatment for certain cancers is working. The test is most commonly used in colorectal cancer.
CEA Test
Also called: Carcinoembryonic Antigen, CEA Assay, CEA Tumor Marker
A CEA (carcinoembryonic antigen) test measures CEA in a sample of blood or other body fluid. It helps check if treatment for certain cancers is working. The test is most commonly used in colorectal cancer.
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Use the slider below to see how your results affect your
health.
ng/mL
3
5
20
Your result is Normal.
Related conditions
CEA stands for carcinoembryonic antigen. CEA is a protein that is a type of "tumor marker." Tumor markers are substances that are often made by cancer cells or by normal cells in response to cancer.
High levels of CEA are normal in healthy, unborn babies. After birth, CEA levels become very low or disappear completely. So, healthy adults should have little or no CEA in their bodies.
Cancers that may cause high levels of CEA include cancers of the:
Colon and rectum (colorectal or bowel cancer)
Prostate
Ovary
Lung
Thyroid
Liver
Pancreas
Breast
If you've been diagnosed with a cancer that can cause high CEA levels, CEA testing may help your health care provider learn more about your cancer and chance of recovery. The test is often used with other tests to check if cancer treatment is working.
CEA tests are not used to screen for or diagnose cancer. That's because:
Cancers that often cause high CEA levels don't always cause high levels. You can have normal CEA test results even though you have one of these cancers.
Many other health problems that aren't cancer can make CEA levels rise, including certain conditions that affect your liver, digestion, or breathing.
Most CEA tests use a sample of your blood to measure your CEA level. Sometimes the test uses a sample of fluid from your spine, chest, or abdomen (belly), but this is less common.
A CEA test is mostly used in people who have been diagnosed with cancers that often increase CEA levels. It's most commonly used in colorectal cancer. A provider may order a CEA test along with other tests to:
Learn more about a cancer soon after it has been diagnosed. CEA levels can help predict the likelihood of recovery and/or the chance that cancer will come back after treatment.
Check how well cancer treatment is working.
See if cancer has returned after treatment.
If you've been diagnosed with a type of cancer that can cause high CEA levels, you may need CEA testing:
Before treatment to:
Help understand how serious your cancer is.
Help guide treatment decisions.
Get a measurement of your CEA level before treatment to compare with CEA levels after treatment.
During cancer treatment to see if the treatment working.
After treatment to check whether cancer has come back. You may need to have tests on a regular schedule.
CEA is usually measured with a blood sample. During a CEA blood test, a health care professional will take a blood sample from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial. You may feel a little sting when the needle goes in or out. This usually takes less than five minutes.
Sometimes, CEA is tested in other body fluids. For these tests, your provider will remove a small sample of fluid using a thin needle.
For a CEA blood test, you usually don't need to prepare. If you smoke, you may need to stop for a while before your test. That's because smoking increases CEA levels.
A CEA blood test has very little risk. You may have slight pain or bruising at the spot where the needle was put in, but most symptoms go away quickly.
To understand your CEA test results, your provider will consider the results of other tests and exams. Ask your provider to explain what your test results mean for your health and treatment.
If you had a test before starting cancer treatment, in general:
A low level of CEAmay mean your tumor is small and the cancer has not spread to other parts of your body. But some cancers don't make much CEA, so your provider may use other tests to learn more about how much cancer you have and if it's spread.
A high level of CEAmay mean you have a larger tumor and/or your cancer has spread. You'll need other tests to confirm how serious your cancer is.
If you had a test to monitor your cancer during or after treatment, your provider will compare your current CEA test results with your past test results. In general:
Decreases in CEA over time often mean that treatment is working.
Increases in CEA or high levels that stay highmay mean that treatment isn't working. For example, if you had surgery for colorectal cancer, these levels may mean that the entire tumor wasn't removed or the cancer is growing back.
Decreases in CEA after treatment followed by increasesmay mean cancer has come back.
CEA levels that remain high or increase after treatment don't always mean that treatment isn't working, or cancer is growing. So, if your CEA levels don't come down, your provider will likely order other tests to find out why.
If you have questions about your results, talk with your provider.
Labs use different methods to measure CEA. The test method can affect your results. So, its best to have your tests done the same way, and usually in the same lab. This allows your provider to compare your results over time. If you have questions about how your tests are done, ask your provider.
CEA Test: MedlinePlus Medical Test [accessed on Mar 09, 2023]
https://www.cancer.gov/about-cancer/diagnosis-staging/diagnosis/tumor-markers-fact-sheet [accessed on Mar 13, 2019]
https://www.labcorp.com/test-menu/21906/carcinoembryonic-antigen-cea [accessed on Oct 03, 2019]
Normal reference ranges can vary depending on the laboratory and the method used for testing. You must use the range supplied by the laboratory that performed your test to evaluate whether your results are "within normal limits."
Additional Materials (20)
Carcinoembryonic Antigen (CEA): CEA in Colorectal Cancer Staging and Treatment
CEA tests are not used to screen for colorectal cancer, but they're frequently performed after the cancer has been diagnosed. CEA is useful in staging--performing tests to determine if the cancer has spread within the intestine or to distant parts of the body. CEA may also be used for treatment planning, as elevated levels may indicate a poorer prognosis. After surgery, CEA levels may be measured periodically to see if the cancer has spread. It is important to note that CEA is not a perfect predictor of how a patient will respond to treatment, nor is it conclusive in determining if cancer has spread. The American Society of Clinical Oncologists (ASCO) states that CEA should not be used as the sole basis for decision-making in colorectal cancer.
Image by TheVisualMD
Carcinoembryonic Antigen (CEA): CEA Testing During Chemotherapy
Whether CEA is tested during systemic treatment for colorectal cancer depends on the stage of the cancer. After surgery, the American Society of Clinical Oncologists (ASCO) recommends that patients with stage II or stage III cancer have a CEA test every 3 months, for a minimum of 3 years. However, if the patient is receiving chemotherapy, CEA testing should be delayed until after chemotherapy is completed. On the other hand, CEA is the marker of choice for monitoring stage IV (metastatic) colorectal cancer during systemic treatment. Patients with metastatic cancer, in which the cancer has spread to distant parts of the body, should have a CEA test every 1-3 months during chemotherapy to see if the treatment is working and whether the cancer is still spreading. ASCO recommends other tests be done in conjunction with the CEA tests.
Image by TheVisualMD
The Importance of Good Bowel Preparation During Colonoscopy
Video by Johns Hopkins Medicine/YouTube
Colon cancer: Essential facts
Video by Institute for Cancer Genetics and Informatics/YouTube
The Colon and Colon Cancer
Video by Armando Hasudungan/YouTube
Colon Cancer: Don't Ignore Your Symptoms
Video by American Cancer Society/YouTube
Colorectal Cancer Screening
Video by Mechanisms in Medicine/YouTube
This browser does not support the video element.
Treating Colon Cancer
This animation explains how colon cancer forms and how it can be treated through chemotherapy and surgery.
Video by TheVisualMD
This browser does not support the video element.
Colorectal Cancer Screening
Colorectal cancer is one of the few preventable forms of cancer thanks to effective screening. For many people, screening for colorectal cancer is an unpleasant thought, but knowing your options and taking a pro-active approach especially if you're over 50 can save your life. In this video, you can learn the "ins and outs" of colonoscopy, as well as learn about a new technique called virtual colonoscopy, which uses high-tech CT scans to screen the colon.
Video by TheVisualMD
This browser does not support the video element.
Colorectal Cancer Clip 6
Colorectal Cancer Clip 6
Video by TheVisualMD
This browser does not support the video element.
Dr. O'Kieffe and patient on preparing for a colonoscopy
A recent colonoscopy patient and gastroenterologist Dr. Donald O'Kieffe of Metro Gastroenterology, Chevy Chase, MD, explain what's involved in the preparation for your screening.
Video by TheVisualMD
This browser does not support the video element.
Dr. Klein on who should be screened
Dr. Mark Klein, a radiologist and colorectal cancer screening specialist at Washington Radiology Associates in Washington, DC, discusses who should be screened for colorectal cancer, and when.
Video by TheVisualMD
Colon cancer staging
Colon cancer staging : After colon cancer has been diagnosed, the next step is to perform tests to determine if the cancer has spread within the intestine or to distant parts of the body. This is called staging. Staging helps the doctor to decide the most appropriate treatment for the cancer at its current stage.
Image by TheVisualMD
Colorectal Cancer Types of Surgery
Surgery is the main treatment for colorectal cancer. Polyps and very early stage cancers (Stage 0 and some early Stage I tumors) can be removed during a colonoscopy, using a variety of techniques. In late Stage I and in Stage II and III cancer, the cancerous part of the colon is removed surgically. The surgeon may perform a resection, consisting of a partial colectomy (removing the cancer and a small amount of healthy tissue around it) and an anastomosis (sewing the parts of the colon back together). Nearby lymph nodes may also be removed and biopsied. If it isn't possible to perform a resection (for instance, if the cancer is at the outlet of the rectum), a colostomy may be performed. In a colostomy, a portion of the large intestine is brought through the abdominal wall to carry stool out of the body, where it empties into a special bag. The colostomy may be temporary in order to allow the colon or rectum time to heal after surgery, or it may be permanent.
Image by TheVisualMD
Colon Anatomy & Function
Image by TheVisualMD
Colostomy
Colostomy Illustration
Image by Blausen.com staff. \"Blausen gallery 2014\". Wikiversity Journal of Medicine. DOI:10.15347/wjm/2014.010. ISSN 20018762
Colorectal Cancer
Colorectal cancer refers to cancer of the colon and cancer of the rectum. The colon is the longest part of the large intestine, and the rectum is the last several inches of the large intestine, closest to the anus.
Image by TheVisualMD
What Is Colorectal Cancer?
The process of cell growth in the body is normally an orderly one. Cells grow and divide as necessary to produce more cells as they are needed. Cells that are old or damaged die, and are replaced with new cells.
Image by TheVisualMD
Treating Colorectal Cancer
There are three main treatment options for colorectal cancer:
Image by TheVisualMD
Colorectal Cancer Spread to Body Stage 4
Cancer spreads in three ways: by invading surrounding tissue, by invading the lymph system and traveling through lymph vessels to other places in the body, and by invading veins and capillaries and traveling through the bloodstream to other places in the body. Stage IV: Cancer may have spread to nearby lymph nodes and has spread to other parts of the body, such as the liver or lungs. Stage IV colorectal cancer is not considered curable. Image 5 of 5.
Image by TheVisualMD
Carcinoembryonic Antigen (CEA): CEA in Colorectal Cancer Staging and Treatment
TheVisualMD
Carcinoembryonic Antigen (CEA): CEA Testing During Chemotherapy
TheVisualMD
1:23
The Importance of Good Bowel Preparation During Colonoscopy
Johns Hopkins Medicine/YouTube
2:49
Colon cancer: Essential facts
Institute for Cancer Genetics and Informatics/YouTube
10:05
The Colon and Colon Cancer
Armando Hasudungan/YouTube
6:06
Colon Cancer: Don't Ignore Your Symptoms
American Cancer Society/YouTube
2:42
Colorectal Cancer Screening
Mechanisms in Medicine/YouTube
3:45
Treating Colon Cancer
TheVisualMD
4:13
Colorectal Cancer Screening
TheVisualMD
0:05
Colorectal Cancer Clip 6
TheVisualMD
0:48
Dr. O'Kieffe and patient on preparing for a colonoscopy
Cancer spreads in three ways: by invading surrounding tissue, by invading the lymph system and traveling through lymph vessels to other places in the body, and by invading veins and capillaries and traveling through the bloodstream to other places in the body. Stage III: Cancer has spread to nearby tissues or organs and lymph nodes, but not to distant parts of the body.
Interactive by TheVisualMD
Stages of Colorectal Cancer
KEY POINTS
After colorectal cancer has been diagnosed, tests are done to find out if cancer cells have spread within the colon or rectum or to other parts of the body.
There are three ways that cancer spreads in the body.
Cancer may spread from where it began to other parts of the body.
To plan treatment, it is important to know whether cancer cells have spread within the colon or rectum or to other parts of the body. The process used to find out if cancer has spread is called staging. It is important to know the stage in order to plan treatment. The results of the tests used to diagnose cancer are often also used to stage the disease. (See the General Information section.)
In children, the cancer has often spread to the lymph nodes, outside the colon or rectum, or to other organs in the abdomen at diagnosis. The following tests and procedures may be used to find out if cancer has spread:
Chest x-ray: An x-ray of the organs and bones inside the chest. An x-ray is a type of energy beam that can go through the body and onto film, making a picture of areas inside the body.
PET scan (positron emission tomography scan): A procedure to find malignant tumor cells in the body. A small amount of radioactive glucose (sugar) is injected into a vein. The PET scanner rotates around the body and makes a picture of where glucose is being used in the body. Malignant tumor cells show up brighter in the picture because they are more active and take up more glucose than normal cells do.
MRI (magnetic resonance imaging): A procedure that uses a magnet, radio waves, and a computer to make a series of detailed pictures of areas of the body, such as the chest, abdomen, and pelvis. This procedure is also called nuclear magnetic resonance imaging (NMRI).
CT scan (CAT scan): A procedure that makes a series of detailed pictures of areas inside the body, such as the chest, taken from different angles. The pictures are made by a computer linked to an x-ray machine. A dye may be injected into a vein or swallowed to help the organs or tissues show up more clearly. This procedure is also called computed tomography, computerized tomography, or computerized axial tomography.
Bone scan: A procedure to check if there are rapidly dividing cells, such as cancer cells, in the bone. A very small amount of radioactive material is injected into a vein and travels through the bloodstream. The radioactive material collects in the bones with cancer and is detected by a scanner.
Bone scan. A small amount of radioactive material is injected into the child's vein and travels through the blood. The radioactive material collects in the bones. As the child lies on a table that slides under the scanner, the radioactive material is detected and images are made on a computer screen.
Cancer can spread through tissue, the lymph system, and the blood:
Tissue. The cancer spreads from where it began by growing into nearby areas.
Lymph system. The cancer spreads from where it began by getting into the lymph system. The cancer travels through the lymph vessels to other parts of the body.
Blood. The cancer spreads from where it began by getting into the blood. The cancer travels through the blood vessels to other parts of the body.
Cancer may spread from where it began to other parts of the body.
When cancer spreads to another part of the body, it is called metastasis. Cancer cells break away from where they began (the primary tumor) and travel through the lymph system or blood.
Lymph system. The cancer gets into the lymph system, travels through the lymph vessels, and forms a tumor (metastatic tumor) in another part of the body.
Blood. The cancer gets into the blood, travels through the blood vessels, and forms a tumor (metastatic tumor) in another part of the body.
The metastatic tumor is the same type of cancer as the primary tumor. For example, if colorectal cancer spreads to the bone, the cancer cells in the bone are actually colorectal cancer cells. The disease is metastatic colorectal cancer, not bone cancer.
Sometimes childhood colorectal cancer recurs (comes back) after treatment.
Childhood colorectal cancer may come back in the colon, rectum, or in other parts of the body.
Source: National Cancer Institute (NCI)
Additional Materials (5)
Colon cancer staging
Colon cancer staging : After colon cancer has been diagnosed, the next step is to perform tests to determine if the cancer has spread within the intestine or to distant parts of the body. This is called staging. Staging helps the doctor to decide the most appropriate treatment for the cancer at its current stage.
Image by TheVisualMD
Colorectal Cancer Staging
Video by Cook Medical Endoscopy Channel/YouTube
Metastasis: How Cancer Spreads
Video by National Cancer Institute/YouTube
Cancer Stages
Tumor grading is a system in which cancer cells are classified according to how abnormal their appearance is under a microscope and how quickly the tumor is likely to grow and spread. Histologic grade (differentiation) refers to how much the tumor cells resemble normal cells of the same tissue type. Nuclear grade refers to the size and shape of the nucleus in tumor cells and the percentage of tumor cells that are dividing. Grade 1 cells are well differentiated; that is, they resemble normal cells. Grade 1 cells tend to grow and multiply slowly. Grade 2 cells are less well differentiated. Grades 3 and 4 tumors are poorly differentiated or undifferentiated (are highly abnormal in appearance) and tend to be more aggressive and spread quickly.
Image by TheVisualMD
Cancer staging
Staging Cancer : Staging is the process of finding out the amount of cancer in the body and if it has spread. Most tumorous cancers are staged using the TNM system. In the TNM system, T = extent of the primary tumor, N = extent of spread to lymph nodes, M = presence of metastasis. After the TNM description has been decided, the cancer can be designated as Stage 0-IV. Stage 0 =carcinoma in situ. In Stage I, Stage II, and Stage III, higher numbers indicate more extensive disease, ie, greater tumor size, and/or spread of the cancer to nearby lymph nodes, and/or organs adjacent to the primary tumor. In Stage IV, the cancer has spread to another organ.
Image by TheVisualMD
Colon cancer staging
TheVisualMD
2:10
Colorectal Cancer Staging
Cook Medical Endoscopy Channel/YouTube
1:49
Metastasis: How Cancer Spreads
National Cancer Institute/YouTube
Cancer Stages
TheVisualMD
Cancer staging
TheVisualMD
Treatment
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This media may include sensitive content
Cancer Immunotherapy
Image by Rita Elena Serda - National Cancer Institute \ Duncan Comprehensive Cancer Center at Baylor College of Medicine
Sensitive content
This media may include sensitive content
Cancer Immunotherapy
Shown here is a pseudo-colored scanning electron micrograph of an oral squamous cancer cell (white) being attacked by two cytotoxic T cells (red), part of a natural immune response. Nanomedicine researchers are creating personalized cancer vaccines by loading neoantigens identified from the patient's tumor into nanoparticles. When presented with immune stimulants, this activates the patient's own immune system, leading to expansion of tumor-specific cytotoxic T cells.
Image by Rita Elena Serda - National Cancer Institute \ Duncan Comprehensive Cancer Center at Baylor College of Medicine
Childhood Colorectal Cancer - Treatment Option Overview
KEY POINTS
There are different types of treatment for children with colorectal cancer.
Children with colorectal cancer should have their treatment planned by a team of doctors who are experts in treating childhood cancer.
Four types of standard treatment are used:
Surgery
Radiation therapy
Chemotherapy
Immunotherapy
New types of treatment are being tested in clinical trials.
Targeted therapy
Treatment for childhood colorectal cancer may cause side effects.
Patients may want to think about taking part in a clinical trial.
Patients can enter clinical trials before, during, or after starting their cancer treatment.
Follow-up tests may be needed.
There are different types of treatment for children with colorectal cancer.
Some treatments are standard (the currently used treatment), and some are being tested in clinical trials. A treatment clinical trial is a research study meant to help improve current treatments or obtain information on new treatments for patients with cancer. When clinical trials show that a new treatment is better than the standard treatment, the new treatment may become the standard treatment.
Because cancer in children is rare, taking part in a clinical trial should be considered. Some clinical trials are open only to patients who have not started treatment.
Children with colorectal cancer should have their treatment planned by a team of doctors who are experts in treating childhood cancer.
Treatment will be overseen by a pediatric oncologist, a doctor who specializes in treating children with cancer. The pediatric oncologist works with other pediatric health professionals who are experts in treating children with cancer and who specialize in certain areas of medicine. This may include the following specialists and others:
Pediatrician.
Pediatric gastroenterologist.
Pediatric surgeon.
Radiation oncologist.
Pathologist.
Pediatric nurse specialist.
Social worker.
Rehabilitation specialist.
Psychologist.
Child-life specialist.
Four types of standard treatment are used:
Surgery
Surgery to remove the cancer is done if the cancer has not spread to other parts of the body at diagnosis.
Radiation therapy
Radiation therapy is a cancer treatment that uses high-energy x-rays or other types of radiation to kill cancer cells or keep them from growing. External radiation therapy uses a machine outside the body to send radiation toward the cancer.
Chemotherapy
Chemotherapy is a cancer treatment that uses drugs to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. When chemotherapy is taken by mouth or injected into a vein or muscle, the drugs enter the bloodstream and can reach cancer cells throughout the body (systemic chemotherapy). Chemotherapy using more than one drug is called combination chemotherapy.
Immunotherapy
Immunotherapy is a treatment that uses the patient’s immune system to fight cancer. Substances made by the body or made in a laboratory are used to boost, direct, or restore the body’s natural defenses against cancer.
Immune checkpoint inhibitor therapy is a type of immunotherapy. Some types of immune cells, such as T cells, and some cancer cells have certain proteins, called checkpoint proteins, on their surface that keep immune responses in check. When cancer cells have large amounts of these proteins, they will not be attacked and killed by T cells. Immune checkpoint inhibitors block these proteins and the ability of T cells to kill cancer cells is increased.
There are two types of immune checkpoint inhibitor therapy:
PD-1 immune checkpoint inhibitor. PD-1 is a protein on the surface of T cells that helps keep the body’s immune responses in check. When PD-1 attaches to another protein called PDL-1 on a cancer cell, it stops the T cell from killing the cancer cell. PD-1 inhibitors attach to PDL-1 and allow the T cells to kill cancer cells. Nivolumab has been used to treat children 12 years and older with recurrent colorectal cancer.Immune checkpoint inhibitor. Checkpoint proteins, such as PD-L1 on tumor cells and PD-1 on T cells, help keep immune responses in check. The binding of PD-L1 to PD-1 keeps T cells from killing tumor cells in the body (left panel). Blocking the binding of PD-L1 to PD-1 with an immune checkpoint inhibitor (anti-PD-L1 or anti-PD-1) allows the T cells to kill tumor cells (right panel).
CTLA-4 inhibitor. CTLA-4 is a protein on the surface of T cells that helps keep the body’s immune responses in check. When CTLA-4 attaches to another protein called B7 on a cancer cell, it stops the T cell from killing the cancer cell. CTLA-4 inhibitors attach to CTLA-4 and allow the T cells to kill cancer cells. Ipilimumab is used to treat children 12 years and older with recurrent colorectal cancer.Immune checkpoint inhibitor. Checkpoint proteins, such as B7-1/B7-2 on antigen-presenting cells (APC) and CTLA-4 on T cells, help keep the body’s immune responses in check. When the T-cell receptor (TCR) binds to antigen and major histocompatibility complex (MHC) proteins on the APC and CD28 binds to B7-1/B7-2 on the APC, the T cell can be activated. However, the binding of B7-1/B7-2 to CTLA-4 keeps the T cells in the inactive state so they are not able to kill tumor cells in the body (left panel). Blocking the binding of B7-1/B7-2 to CTLA-4 with an immune checkpoint inhibitor (anti-CTLA-4 antibody) allows the T cells to be active and to kill tumor cells (right panel).
New types of treatment are being tested in clinical trials.
This summary section describes treatments that are being studied in clinical trials. It may not mention every new treatment being studied.
Targeted therapy
Targeted therapy is a type of treatment that uses drugs or other substances to attack cancer cells. Targeted therapies usually cause less harm to normal cells than chemotherapy or radiation therapy do.
Targeted therapy is being studied for the treatment of childhood colorectal cancer that has recurred (come back).
Treatment for childhood colorectal cancer may cause side effects.
For information about side effects that begin during treatment for cancer, see our Side Effects page.
Side effects from cancer treatment that begin after treatment and continue for months or years are called late effects. Late effects of cancer treatment may include the following:
Physical problems.
Changes in mood, feelings, thinking, learning, or memory.
Second cancers (new types of cancer) or other conditions.
Some late effects may be treated or controlled. It is important to talk with your child's doctors about the possible late effects caused by some treatments.
Patients may want to think about taking part in a clinical trial.
For some patients, taking part in a clinical trial may be the best treatment choice. Clinical trials are part of the cancer research process. Clinical trials are done to find out if new cancer treatments are safe and effective or better than the standard treatment.
Many of today's standard treatments for cancer are based on earlier clinical trials. Patients who take part in a clinical trial may receive the standard treatment or be among the first to receive a new treatment.
Patients who take part in clinical trials also help improve the way cancer will be treated in the future. Even when clinical trials do not lead to effective new treatments, they often answer important questions and help move research forward.
Patients can enter clinical trials before, during, or after starting their cancer treatment.
Some clinical trials only include patients who have not yet received treatment. Other trials test treatments for patients whose cancer has not gotten better. There are also clinical trials that test new ways to stop cancer from recurring (coming back) or reduce the side effects of cancer treatment.
Follow-up tests may be needed.
Some of the tests that were done to diagnose the cancer or to find out the stage of the cancer may be repeated. Some tests will be repeated in order to see how well the treatment is working. Decisions about whether to continue, change, or stop treatment may be based on the results of these tests.
Some of the tests will continue to be done from time to time after treatment has ended. The results of these tests can show if your child's condition has changed or if the cancer has recurred (come back). These tests are sometimes called follow-up tests or check-ups.
Source: National Cancer Institute (NCI)
Additional Materials (11)
Colon Cancer Treatment
Video by Stanford Health Care/YouTube
Immune Checkpoint Inhibitors
Video by National Cancer Institute/YouTube
Dendritic cell-based immunotherapy
In dendritic cell therapy blood cells are removed from the body. The blood mononuclear cells are incubated with a tumour antigen or tumour cell lysates that contain many tumour antigens. The cells are also activated by use of immuno-stimulatory molecules. This process produces mature antigen-loaded dendritic cells that are returned to the original donor. The dendritic cells induce immune response to the tumour.
Image by Simon Caulton
Tumor microenvironment
During the elimination phase immune effector cells such as CTL’s and NK cells with the help of dendritic and CD4+ T-cells are able to recognize and eliminate tumor cells.
Image by Frontiers in Oncology
What is T-cell adoptive transfer Immunotherapy?
Cancer specific T-cells can be obtained by fragmentation and isolation of tumour infiltrating lymphocytes, or by genetically engineering cells from peripheral blood. The cells are activated and grown prior to transfusion into the recipient (tumour bearer).
Image by Simon Caulton
Finding New Ways to Help the Immune System Fight Cancer
Researchers are tapping into the innate immune system by harnessing dendritic cells to activate T-cell immunity, helping macrophages engulf cancer cells, and engineering natural killer cells to target cancer. Researchers are also investigating the gut microbiome’s role in immunity and targeting the microbiome for cancer therapy.
Image by National Cancer Institute (NCI)
Genomic information
This image was created by the NHS HEE Genomics Education Programme. For further information and resources please visit our website www.genomicseducation.hee.nhs.uk
Image by NHS HEE Genomics Education Programme
Cancer therapy by inhibition of negative immune regulation (CTLA4, PD1)
Tumor cells can either be eliminated by the immune system or escape detection. During the elimination phase, immune effector cells such as natural killer cells, with the help of dendritic and CD4+ T-cells, are able to recognize and eliminate tumor cells (left). As a result of heterogeneity, however, tumor cells which are less immunogenic are able to escape immunosurveillance (right).
Image by Frontiers in Oncology
Vaccine-Based Immunotherapy from Novel Nanoparticle Systems
Researchers at the Texas Center for Cancer Nanomedicine (TCCN) are creating particle-based vaccines for cancer therapy. The particles carry molecules that stimulate immune cells and cancer antigens (proteins) that direct the immune response. This scanning electron microscope image shows dendritic cells, pseudo-colored in green, interacting with T cells, pseudo-colored in pink. The dendritic cells internalize the particles, process the antigens, and present peptides to T cells to direct immune responses.
Image by Victor Segura Ibarra and Rita Serda, Ph.D. / National Cancer Institute
Finding New Ways to Help the Immune System Fight Cancer
National Cancer Institute (NCI)
Genomic information
NHS HEE Genomics Education Programme
Cancer therapy by inhibition of negative immune regulation (CTLA4, PD1)
Guido4
Tumor microenvironment
Frontiers in Oncology
Vaccine-Based Immunotherapy from Novel Nanoparticle Systems
Victor Segura Ibarra and Rita Serda, Ph.D. / National Cancer Institute
What is Monoclonal antibody therapy?
Ch1902 vector, Ramujana original raster
Treatment of Childhood Colorectal Cancer
Ipilimumab - Monoclonal antibodies for tumors; immunotherapy
Image by Fvasconcellos (talk · contribs)/Wikimedia
Ipilimumab - Monoclonal antibodies for tumors; immunotherapy
space-filling model of the Fab fragment of the monoclonal antibody ipilimumab (blue) bound to its target, CTLA-4 (pale green).
Image by Fvasconcellos (talk · contribs)/Wikimedia
Treatment of Childhood Colorectal Cancer
Treatment of newly diagnosed colorectal cancer in children may include the following:
Surgery to remove the tumor if it has not spread.
Radiation therapy and chemotherapy for tumors in the rectum or lower colon.
Combination chemotherapy, for advanced colorectal cancer.
Immunotherapy with immune checkpoint inhibitors (ipilimumab and nivolumab).
Children with certain familial colorectal cancer syndromes may be treated with the following:
Surgery to remove the colon before cancer forms.
Medicine to decrease the number of polyps in the colon.
Source: National Cancer Institute (NCI)
Additional Materials (1)
The Colorectal Center | Cincinnati Children's
Video by Cincinnati Children's/YouTube
4:17
The Colorectal Center | Cincinnati Children's
Cincinnati Children's/YouTube
Treatment of Recurrent Childhood Colorectal Cancer
Genomic information
Image by NHS HEE Genomics Education Programme
Genomic information
This image was created by the NHS HEE Genomics Education Programme. For further information and resources please visit our website www.genomicseducation.hee.nhs.uk
Image by NHS HEE Genomics Education Programme
Treatment of Recurrent Childhood Colorectal Cancer
Recurrent colorectal cancer has come back after it has been treated in the colon or rectum or in other parts of the body. Treatment of recurrent colorectal cancer in children may include the following:
A clinical trial that checks a sample of the patient's tumor for certain gene changes. The type of targeted therapy that will be given to the patient depends on the type of gene change.
Source: National Cancer Institute (NCI)
Additional Materials (15)
Targeted Therapy
A summary of targeted therapy. Patients and their diseases are profiled in order to identify the most effective treatment for their specific case.
Image by Simon Caulton
Targeted Therapy
A gram illustrating the disctinction between cancer stem cell targeted (above) and conventional (below) cancer therapies
Image by Peter Znamenskiy
Risk Factors for Colorectal Cancer
Video by Columbia University Department of Surgery/YouTube
Colorectal Cancers Rates Soar In Younger People | NBC Nightly News
Video by NBC News/YouTube
How Does Targeted Cancer Therapy Work?
Video by CancerIS/YouTube
Targeted Cancer Therapy vs. Traditional Chemo
Video by Lee Health/YouTube
Taking Hope from Molecularly Targeted Therapy
Video by American Association for Cancer Research/YouTube
Dr. Dy on Side Effects From Targeted Therapies in Clinical Trials
Video by Targeted Oncology/YouTube
Immunotherapy vs. targeted therapy for cancer treatment
Video by MD Anderson Cancer Center/YouTube
Targeted Cancer Therapy
Video by capathologists/YouTube
Cancer Treatment: Targeted Therapy
Video by Stand Up To Cancer/YouTube
Side Effects of Targeted and Immunotherapy Treatment (Conditions A-Z)
Video by Healthguru/YouTube
Cancer Therapy: Oral Medication Basics: Information for Patients and Families (Targeted Therapy)
Video by Cleveland Clinic/YouTube
Targeted Therapy
Image Caption : Antibody-dependent cell-mediated cytotoxicity. When the Fc receptors on natural killer (NK) cells interact with Fc regions of antibodies bound to cancer cells, the NK cell releases perforin and granzyme, leading to cancer cell apoptosis.
Image by Simon Caulton
Targeted Therapy
Monoclonal Antibody - Cetuximab mode of action
Image by Florian Schaub at Merck KGaA
Targeted Therapy
Simon Caulton
Targeted Therapy
Peter Znamenskiy
14:27
Risk Factors for Colorectal Cancer
Columbia University Department of Surgery/YouTube
1:59
Colorectal Cancers Rates Soar In Younger People | NBC Nightly News
NBC News/YouTube
4:01
How Does Targeted Cancer Therapy Work?
CancerIS/YouTube
2:10
Targeted Cancer Therapy vs. Traditional Chemo
Lee Health/YouTube
4:45
Taking Hope from Molecularly Targeted Therapy
American Association for Cancer Research/YouTube
1:53
Dr. Dy on Side Effects From Targeted Therapies in Clinical Trials
Targeted Oncology/YouTube
7:19
Immunotherapy vs. targeted therapy for cancer treatment
MD Anderson Cancer Center/YouTube
3:08
Targeted Cancer Therapy
capathologists/YouTube
0:50
Cancer Treatment: Targeted Therapy
Stand Up To Cancer/YouTube
1:10
Side Effects of Targeted and Immunotherapy Treatment (Conditions A-Z)
Healthguru/YouTube
9:39
Cancer Therapy: Oral Medication Basics: Information for Patients and Families (Targeted Therapy)