What Is Congenital Cytomegalovirus?
Source: Genetic and Rare Diseases (GARD) Information Center
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Congenital Cytomegalovirus
Congenital CMV (cCMV); Congenital CMV Infection; Fetal Cytomegalovirus Syndrome
Congenital CMV occurs when a mother is infected with cytomegalovirus during pregnancy and passes the infection to the fetus through the placenta. Most babies with congenital CMV never show signs or have health problems, but about 10% of babies will experience health problems and/or disabilities. Learn more about prevention and treatment.
Holding a Preemie
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Cytomegalovirus
Image by CDC/ Dr. Craig Lyerla
Source: Genetic and Rare Diseases (GARD) Information Center
Top 5 infections to avoid during pregnancy
Image by StoryMD/CDC
Cytomegalovirus, or CMV, is a common virus that infects people of all ages. Once CMV is in a person’s body, it stays there for life and can reactivate. A person can also be reinfected with a different type of the virus.
Most people infected with CMV show no signs or symptoms. That’s because a healthy person’s immune system usually keeps the virus from causing illness.
When a baby is born with CMV infection, it is called congenital CMV. Most babies with congenital CMV infection never show signs or have health problems. However, some babies can have health problems that are apparent at birth or that develop later during infancy or childhood.
Cytomegalovirus, or CMV, is the most common infectious cause of birth defects in the United States.
There is no way to eliminate your risk of getting CMV, but you may lessen your chances of getting it.
Most babies with congenital CMV infection never show signs or have health problems. However, some babies have health problems at birth or that develop later.
Source: Centers for Disease Control and Prevention (CDC)
Prenatal Cell-Free DNA Screening (cfDNA Screening)
Image by TheVisualMD
A pregnant woman can pass CMV to her unborn baby. The virus in the woman’s blood can cross through the placenta and infect the baby. This can happen when a pregnant woman is infected with CMV for the first time or is infected with CMV again during pregnancy.
People who have frequent contact with young children may be at greater risk of CMV infection because young children are a common source of CMV. By the age of five years, one in three children has been infected with CMV, but usually does not have symptoms. CMV can be present in a child’s body fluids for months after they become infected.
Most people with CMV infection have no symptoms and aren’t aware that they have been infected. A woman who is infected with CMV can pass the virus to her developing baby during pregnancy.
As a parent of a young child or a childcare provider, you may be able to lessen your risk of getting CMV by reducing contact with saliva and urine from babies and young children. The saliva and urine of children with CMV have high amounts of the virus. You can avoid getting a child’s saliva in your mouth by, for example, not sharing food, utensils, or cups with a child. Also, you should wash your hands after changing diapers. These cannot eliminate your risk of getting CMV but may lessen the chances of getting it.
Source: Centers for Disease Control and Prevention (CDC)
Newborn puts on earmuff
Image by Z. Abdeyazdan, S. Ghasemi, M. Marofi, N. Berjis
Some babies with congenital CMV infection have health problems that are apparent at birth or that develop later during infancy or childhood. In the most severe cases, CMV can cause the death of an unborn baby (pregnancy loss).
Some babies with congenital CMV infection have signs at birth. These signs include:
Some babies with signs of congenital CMV infection at birth may have long-term health problems, such as:
Some babies without signs of congenital CMV infection at birth may have hearing loss. Hearing loss may be present at birth or may develop later, even in babies who passed the newborn hearing test.
Source: Centers for Disease Control and Prevention (CDC)
Newborn hearing test
Image by U.S. Air Force photo/Staff Sgt. Ashley Hawkins
Hearing loss is common in babies with congenital CMV, even those without symptoms at birth.
Cytomegalovirus, or CMV, is the most common infectious cause of birth defects in the United States. About 1 out of 200 babies is born with congenital CMV.
One out of 5 babies with congenital CMV will have symptoms or long-term health problems, such as hearing loss. Hearing loss may progress from mild to severe during the first two years of life, which is a critical period for language learning. Over time, hearing loss can affect your child’s ability to develop communication, language, and social skills.
Babies who show signs of congenital CMV disease can be treated with medicines called antivirals. Antivirals may decrease the severity of hearing loss. Babies who get treated with antivirals should be closely watched by their doctor because of possible side effects.
Babies with congenital CMV may have hearing loss in one ear, and may later develop hearing loss in the other ear. Progression may occur through adolescence.
Children diagnosed with hearing loss should receive services such as speech or occupational therapy. These services help ensure they develop important communication, language, and social skills. Children with hearing loss can also learn other ways to communicate, such as using sign language, and to use devices such as hearing aids and cochlear implants. The earlier children with hearing loss start receiving services, the more likely they are to reach their full potential.
About 10% of babies with congenital CMV infection have signs at birth that include:
Source: Centers for Disease Control and Prevention (CDC)
Newborn Screening of blood Samples
Image by TheVisualMD
Congenital CMV infection can be diagnosed by testing a newborn baby’s saliva, urine (preferred specimens), or blood. These specimens must be collected for testing within two to three weeks after the baby is born in order to confirm a diagnosis of congenital CMV infection.
Source: Centers for Disease Control and Prevention (CDC)
Cytomegalovirus (CMV) Detected: Family Fact Sheet: Blood Spot Screen Result Notification
Document by Minnesota Newborn Screening Program
FINDING
The DNA of a virus, cytomegalovirus (CMV), was detected.
OTHER ASSOCIATED DISORDERS
None
CAUSE
CMV is a common virus that causes cold-like symptoms in children and adults. The virus can infect a baby before it is born causing the baby to be infected at birth.
EARLY SIGNS
Most newborns show no signs of cCMV disease. Some newborns have hearing loss, jaundice, a rash, a small head, or weak muscles.
TREATMENT
Most infants with congenital CMV will not need treatment. As some infants may develop hearing loss as they get older, it is recommend that all infants diagnosed with congenital CMV have regular audiology exams during early childhood. Regular monitoring may identify new signs and symptoms earlier, allowing for care and/or intervention that may be helpful.
Some infants with specific symptoms of congenital CMV may be eligible to receive antiviral medicine. It is important to discuss the risk and benefits of antiviral therapy with a pediatric infectious disease specialist.
DISORDER GROUP
Other blood spot disorders
SCREENING METHOD
Real-time quantitative polymerase chain reaction (qPCR)
Source: Minnesota Newborn Screening Program
Cytomegalovirus (CMV) Tests
Also called: CMV Tests, CMV IgG and IgM, Cytomegalovirus Antibody, Cytomegalovirus Serology, Cytomegalovirus IgG Antibody, Cytomegalovirus IgM Antibody
Cytomegalovirus (CMV) is a common type of virus. CMV tests look for signs of the virus in blood, sputum, or other body fluids. CMV doesn't cause health problems for most people. But it can be dangerous to newborns and people with immune system disorders.
Valganciclovir ball-and-stick
Image by MarinaVladivostok/Wikimedia
For babies with signs of congenital CMV infection at birth, antiviral medications, primarily valganciclovir, may improve hearing and developmental outcomes. Valganciclovir can have serious side effects and has only been studied in babies with signs of congenital CMV infection. There is limited information on the effectiveness of valganciclovir to treat infants with hearing loss alone.
Source: Centers for Disease Control and Prevention (CDC)
Breastfeeding and Herpes Simplex
Image by TheVisualMD / jrvalverde
Most people have been infected with cytomegalovirus (CMV), but do not have symptoms. If a pregnant woman is infected with CMV, she can pass it to her developing baby. This is called congenital CMV, and it can cause birth defects and other health problems.
You can pass CMV to your baby
If you are pregnant and have CMV, the virus in your blood can cross through your placenta and infect your developing baby. This is more likely to happen if you have a frst-time CMV infection while pregnant but can also happen if you have a subsequent infection during pregnancy.
You are not likely to be tested for CMV
It is not recommended that doctors routinely test pregnant women for CMV infection. This is because laboratory tests cannot predict which developing babies will become infected with CMV or have long-term health problems.
You may be able to reduce your risk
You may be able to lessen your risk of getting CMV by reducing contact with saliva and urine from babies and young children. The saliva and urine of children with CMV have high amounts of the virus. You can avoid getting a child’s saliva in your mouth by, for example, not sharing food, utensils, or cups with a child. Also, you should wash your hands after changing diapers. These cannot eliminate your risk of getting CMV, but may lessen the chances of getting it.
About 1 out of every 200 babies is born with congenital CMV. About 1 out of 5 of these babies will have birth defects or other long-term health problems.
Babies with congenital CMV may show signs at birth
Some signs that a baby might have congenital CMV infection when they are born are:
Tests on a baby’s saliva, urine, or blood done within two to three weeks after birth can confirm if the baby has congenital CMV.
Early treatment may help
Babies who show signs of congenital CMV at birth may be treated with medicines called antivirals. Antivirals may decrease the severity of health problems and hearing loss but should be used with caution due to side effects.
Long-term health problems may occur
Babies with signs of congenital CMV at birth are more likely to have long-term health problems, such as:
Some babies with congenital CMV but without signs of disease at birth may still have or develop hearing loss. Hearing loss may be present at birth or may develop later in babies who passed their newborn hearing test. Sometimes, hearing loss worsens with age.
Hearing checks and therapies are recommended
Children with congenital CMV should have regular hearing checks. Children with hearing loss should receive services such as speech or occupational therapy. These services help ensure they develop language, social, and communication skills.
The earlier your child can get hearing checks and therapies, the more he or she can benefit from them.
Source: Centers for Disease Control and Prevention (CDC)
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