Autoimmune progesterone dermatitis (APD) is primarily characterized by a recurrent skin rash that varies in severity depending on the phase of the menstrual cycle. The rash generally appears during the second half of the cycle when levels of the hormone, progesterone, begin to rise and it subsides shortly after menstruation. Although the exact underlying cause of APD is not well understood, it is thought to involve an abnormal immune reaction (autoimmune response) triggered by a woman's own progesterone.

Depending on the severity of the condition, treatment may include topical (applied to the skin) medications, systemic corticosteroids, hormone therapy to suppress the production of progesterone, and/or surgical removal of the ovaries.

Autoimmune progesterone dermatitis (APD) is primarily characterized by a recurrent skin rash that varies in severity depending on the phase of the menstrual cycle. The rash generally appears during the second half of the cycle when levels of the hormone, progesterone, begin to rise. Following menstruation, when the levels of progesterone naturally fall, the rash typically improves and may even completely resolve until the next cycle.

A variety of skin rashes are associated with APD, including:

• Hives
• Erythema multiforme
• Swelling beneath the skin (angioedema)
• Eczema-like rash
• Annular erythema
• Mouth sores

Rarely, APD may progress to progesterone-induced anaphylaxis.

The treatment or control of symptoms of autoimmune progesterone dermatitis (APD) varies. Mild cases might be successfully managed with use of antihistamines and/or corticosteroids.

Most methods of treatment focus on temporarily suppressing ovulation. This might be achieved through varying medications including: conjugated estrogen, ethinyl estradiol, tamoxifen, and danazol. Gonadotropin releasing hormone agonists have additionally had reported success in the literature; however as these medications can prompt symptoms of menopause, they might not be recommended for pre-menopausal patients. Progesterone desensitization, in which increasing doses of progesterone are administered via vaginal suppository, has been reported as a successful treatment in one case in the literature.

For severe cases in which the above treatment options are not successful, surgical removal of ovaries or oophorectomy is curative.